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Journal of Traditional Chinese Medicine 2024年第3期44卷 545-553页

作者： JIN Xiao wu Bingxin LIN Miaoyang ZHONG Biying LIN Luoqi XU danping Department of Traditional Chinese Medicine the First Affiliated Hospital of Jinan UniversityJinan University Department of Cardiology Second Clinical College of Guangzhou University of Chinese Medicine Department of Traditional Chinese Medicine the Eighth Affiliated HospitalSun Yat-Sen University

OBJECTIVE: To evaluate the clinical efficacy and safety of Shenzhu Guanxin recipe granules(参术冠心颗粒, SGR) in treating patients with intermediate coronary lesions(ICL), and to investigate the potential mechanism though a transcriptome sequencing approach. METHODS: ICL patients with Qi deficiency and phlegm stasis were adopted and randomly assigned to a case group or a control by random number generator in a 1∶1 randomization ratio to evaluate the clinical efficacy. RESULTS: There was no significant difference between the two groups in coronary computed tomography angiography related indexes in the two groups before and after intervention. Through the gene chip expression analysis, it is finally concluded that there are 355 differential mRNAs(190 up-regulated genes and 165 down regulated genes) when compared the SGR group and placebo group. Through protein-protein interaction network analysis of differentially expressed genes, 10 hub genes were finally obtained: CACNA2D2, CACNA2D3, DNAJC6, FGF12, SGSM2, CACNA1G, LRP6, KIF25, OXTR, UPB1. CONCLUSIONS: SGR combined with Western Medicine can be safely used to treat ICL patients with Qi deficiency and phlegm stasis. The possible mechanism of action and relevant gene loci and pathway were proposed.

关键词： Shenzhu Guanxin recipe granules deficiency and phlegm stasis gene expression profiling intermediate coronary lesions

Boosted sustained-release with iron-based MOF-derived mesoporouscarbon-spheres as a nitroimidazole drugs carrier

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Particuology 2024年第3期86卷 269-280页

作者： danping wu Jiaying Zou Junyi Chen Yan Li Na Ma Wei Dai College of Chemistry and Materials Science Zhejiang Normal UniversityJinhua321004China College of Life Sciences Zhejiang Normal UniversityJinhua321004China College of Geography and Environmental Sciences Zhejiang Normal UniversityJinhua321004China

Metal-organic framework(MoF)with a buildable internal structure has aroused great interest focus as self-sacrificing precursors of porous carbon(PC).However,as a drug carrier,the MOF-derived PC developed thus far are generally composed of irregular powder shape due to their crystalline nature,which consequently causing the cerebral infarction,cerebral thrombosis,and other blood diseases.In this article,we propose a novel approach to constructing amorphous carbon microspheres(AcMs)by dis-torting the topological network through hydrothermal treatment precursors of MIL-101(Fe).Then,a distinctive MIL-101(Fe)-derived spherical porous carbons(MSPC)is achieved through high temperature calcination toward ACMs.Effects of the glucose initial concentration and hydrothermal treatment time on the sphericity of the as-prepared mesoporous MsPC were investigated in depth.And the loading capacities and sustained-release performances of nitroimidazole drugs over MsPC through simulation internal environment of human body at different pH values was systematically evaluated.The nitro-imidazole drugs loading rate and release time of MsPC are 10% and 17 h under preferred process.Furthermore,the MSPC exhibited very low toxicity on Hela cells and 293T cells at the concentrations tested(10-800μg mL^(-1)).This study,therefore,supports the potential of the mesoporous carbon spheres as a carrierfor nitroimidazole drug delivery.

关键词： Ornidazole Metronidazole Carbon spheres Sustained-release performance Biocompatibility

自制宣教视频联合放松训练对颅脑损伤CT检查患者配合度、心理感受负担及操作时间的影响观察

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中国医药指南 2024年第9期22卷 41-43页

作者：吴丹萍福建医科大学附属泉州第一医院泉州362000

目的观察自制宣教视频联合放松训练对颅脑损伤CT检查患者配合度、心理感受负担及操作时间的影响。方法选取2020年12月至2022年12月在本院行CT检查的96例颅脑损伤患者,采用随机分组法分为两组,其中观察组48例,对照组48例。对照组采用常... 详细信息

目的观察自制宣教视频联合放松训练对颅脑损伤CT检查患者配合度、心理感受负担及操作时间的影响。方法选取2020年12月至2022年12月在本院行CT检查的96例颅脑损伤患者,采用随机分组法分为两组,其中观察组48例,对照组48例。对照组采用常规护理模式,观察组在其基础上采用自制宣教视频联合放松训练护理。比较两组患者配合度、心理感受负担[自我感受负担量表(SPBS)、抑郁自评量表(SDS)和焦虑自评量表(SAS)评分]及操作时间。结果干预后,观察组配合度高于对照组(P<0.05),SPBS、SDS和SAS评分低于对照组(P<0.05),操作时间短于对照组(P<0.05)。结论颅脑CT检查患者应用自制宣教视频联合放松训练方法,可有效提高患者配合度,减轻其心理感受负担及减少操作时间。

关键词：宣教视频放松训练颅脑损伤 CT检查

Well-construction of Zn_(2)SnO_(4)/SnO_(2)@ZIF-8 core-shell hetero-structure with efficient photocatalytic activity towards tetracycline under restricted space

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Chinese Journal of Chemical Engineering 2022年第12期52卷 45-55页

作者： Jiafei wu Yuning Jin danping wu Xiaoying Yan Na Ma Wei Dai Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Life ScienceZhejiang Normal UniversityJinhua 321004China National Center for Nanoscience and Technology Beijing 100190China College of Geography and Environmental Sciences Zhejiang Normal UniversityJinhua 321004China

Nowadays,efficient removal of antibiotic(e.***.tetracycline,TC) from water bodies has been of great global concern.Hereby,a novel Zn_(2)SnO_(4)/SnO_(2)@ZIF-8 photo-catalyst was first synthesized by a facile selfassembly in-situ growth method.Zn_(2)SnO_(4)/SnO_(2)@ZIF-8 exhibits a remarkable photocatalytic activity towards TC under visible-light driven with a rapid rate constant of 1.5 × 10^(-2)min^(-1), and a removal efficiency of 81.2%,which is superior to some catalysts in the literature.Importantly,the photocatalytic activity of Zn_(2)SnO_(4)/SnO_(2)@ZIF-8 could still remain ~77% after the fifth cycle,indicating its good stability and reusability.The remarkable performances of adsorption and photocatalytic were attributed to associative effects of catalytic activity of Zn_(2)SnO_(4)/SnO_(2)and the unique porous nanostructure and stability of ZIF-8.This work could aid the future design and preparation of novel MOFs composite catalysts for efficient elimination of antibiotics from water.

关键词： Degradation Catalyst Tetracycline ZIF-8 Zn_(2)SnO_(4)/SnO_(2) Adsorption

Effectiveness and safety of red yeast rice predominated by monacolin Kβ-hydroxy acid form for hyperlipidemia treatment and management

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Journal of Traditional Chinese Medicine 2022年第2期42卷 264-271页

作者： CHEN Benjian HUANG Xiaodan PENG Huiting LI Yishi CAO Yongtao wu Huanlin XU danping Department of Medical Guangdong Provincial Hospital of Chinese MedicineThe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China the Second Clinical College Guangzhou University of Chinese MedicineGuangzhou 510405China the First Clinical College Guangzhou University of Chinese MedicineGuangzhou 510405China Department of Mathematical&Computer Sciences Indiana University of PennsylvaniaIndiana 15705PAUSA Department of Cardiology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 350122China Department of Traditional Chinese Medicine the Eighth Affiliated HospitalSunYat-Sen UniversityShenzhen 518033China

OBJECTIVE:To assess the lipid-lowering activity and safety of a dietary supplement containing monacolin Kβ-hydroxy acid form(MKA),Heye(Folium Nelumbinis),and Cangzhu(Rhizoma Atractylodis Lanceae),compared to lifestyle modifications.METHODS:Totally 117 subjects with moderate to severe dyslipidemia(according to Chinese guidelines)and low CV risk were randomly assigned into three treatment groups:lifestyle modification(LM),LM plus a low dosage of MKA,LM plus a high dosage of MKA,and treated for 60 d.The primary endpoint was the reduction of low density lipoprotein cholesterol(LDL-C)and total cholesterol(TC).Safeties along with Traditional Chinese Medicine Syndromes were assessed through the study.RESULTS:A low dosage of MKA along with lifestyle modifications caused a significant decrease in LDL-C by 15.6%on average(95%CI,9.6%to 21%)with,a decrease in TC by 15.3%on average(95%CI,9.26%to 21.4%),and a decrease in non-HDL-C by 35.4%(95%CI,25.76%to 41.34%).Weak evidence of a reduction of triglycerides but an increment of HDL-C was observed in patients with severe hyperlipidemia.No severe adverse events occurred during the study.CONCLUSION:Our results confirm the LDL-C and TC lowering properties of MKA is clinically meaningful.It also produces a significant reduction of non-HDL-C,and slightly effects on TG and HDL-C as well.

关键词： hydroxy acids lovastatin hyperlipidemias cholesterol cardiovascular prevention lifestyle modifications red yeast rice

中国式现代化进程中学校体育高质量发展的逻辑、使命与路径

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辽宁体育科技 2024年第2期46卷 107-112页

作者：李健吴丹平李煜韩富强江华西南大学体育学院重庆400799 重庆邮电大学体育学院重庆400065 成都市青羊区教育科学研究院四川成都610014

推进学校体育高质量发展是落实中国式教育现代化的必要环节和加快建设中国式现代化体育强国的重要内容。运用文献资料法,以中国式现代化引领学校体育高质量发展为研究对象,探究中国式现代化进程中学校体育高质量发展的内在逻辑、使命任... 详细信息

推进学校体育高质量发展是落实中国式教育现代化的必要环节和加快建设中国式现代化体育强国的重要内容。运用文献资料法,以中国式现代化引领学校体育高质量发展为研究对象,探究中国式现代化进程中学校体育高质量发展的内在逻辑、使命任务,并提出实践路径。毫不动摇坚持党的领导,实施健康中国和体育强国战略;深刻把握学校体育发展和中华民族传承的历史脉络;领悟党的二十大精神内核,深化中国式现代化教育理论;基于国外优势比较和国内社会发展形式变化的战略考量共同构成了学校体育高质量发展的内在逻辑。学校体育高质量发展的“四大使命任务”即培养德智体美劳全面发展的社会主义建设者和接班人;以学校体育高质量发展赋能人民终身幸福和美好生活;学校体育高质量发展助推中国式现代化体育强国战略实施进程;厚植爱国主义情怀和文化认同树立学校体育文化自信。学校体育高质量发展实践路径:以顶层设计统领政策内容细化,执行长效反馈机制;以课程改革构建学校体育生态,提升以体育人成效;以社会资源补齐学校体育短板,协调资源均衡发展;以评价监管落实多元主体参与,家校政社协同育人。

关键词：中国式现代化高质量发展体育强国学校体育体教融合

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专科护士多层次复合型管理方案的构建与实践

中华护理杂志 2024年第7期59卷 842-847页

作者：霍晓鹏张红梅赖小星郑丹萍叶雅雯张馨月赵亚芳吴欣娟中国医学科学院北京协和医院护理部北京市100730 中国医学科学院北京协和医院保健医疗部北京市100730 中国医学科学院北京协和医院国际医疗部北京市100730 中国医学科学院北京协和医院急诊科北京市100730 中国医学科学院北京协和医院眼科病房北京市100730

目的构建专科护士多层次复合型管理方案,并探讨其在专科护士培养中的实践效果。方法构建专科护士多层次复合型管理方案,包括设立金字塔分层培养模式,探索横向拓宽、纵向延伸、深向发展的专科护士叠加培养机制,构建多方位临床评价及量化... 详细信息

目的构建专科护士多层次复合型管理方案,并探讨其在专科护士培养中的实践效果。方法构建专科护士多层次复合型管理方案,包括设立金字塔分层培养模式,探索横向拓宽、纵向延伸、深向发展的专科护士叠加培养机制,构建多方位临床评价及量化考核体系,并于2021年7月—2023年8月应用于北京市某三级甲等综合医院442名专科护士管理中,比较该方案应用前后专科护士核心能力的差异。结果实施专科护士多层次复合型管理方案后,专科护理的质量明显提升,专科护士核心能力的总分及创新、管理、专业发展3个维度得分均高于应用前(P<0.05)。结论专科护士多层次复合型管理方案能够有效提升专科护士的核心能力,从而促进专科护理的高质量发展。

关键词：专科护士分层培养护理管理研究

Investigation on the relationship between the fine particle emission and crystallization characteristics of gypsum during wet flue gas desulfurization process

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Journal of Environmental Sciences 2017年第5期29卷 303-310页

作者： danping Pan Hao wu Linjun Yang Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education Southeast University Nanjing 210096 Jangsu Province China

The relationship between the fine particles emitted after desulfurization and gypsum crystals in the desulfurization slurry was investigated,and the crystallization characteristics varying with the operation parameters and compositions of the desulfurization slurry were discussed.The results showed that the fine particles generated during the desulfurization process were closely related to the crystal characteristics in the desulfurization slurry by comparison of their morphology and elements. With the higher proportion of fine crystals in the desulfurization slurry,the number concentration of fine particles after desulfurization was increased and their particle sizes were smaller,indicating that the optimization of gypsum crystallization was beneficial for the reduction of the fine particle emission. The lower p H value and an optimal temperature of the desulfurization slurry were beneficial to restrain the generation of fine crystals in the desulfurization slurry. In addition,the higher concentrations of the Fe3＋ions and the F- ions in the desulfurization slurry both promoted the generation of fine crystals with corresponding change of the morphology and the effect of the Fe3＋ ions was more obvious.With the application of the desulfurization synergist additive,it was beneficial for the inhibition of fine crystals while the thinner crystals were generated.

关键词： Wet flue gas desulfurization Fine particle Gypsum crystallization Emission

DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS-STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis

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Acta Pharmaceutica Sinica B 2022年第1期12卷 262-273页

作者： Yuanyuan Wang Bin Wei danping Wang Jingjing wu Jianhua Gao Haiqing Zhong Yang Sun Qiang Xu Wen Liu Yanhong Gu Wenjie Guo Department of Oncology the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Cancer Rehabilitation Center Jiangsu Province HospitalNanjing 210029China Department of Oncology the Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical UniversityHuai'an 223300China State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing 210023China

Gastrointestinal mucositis is one of the most debilitating side effects of the chemotherapeutic agent irinotecan(CPT-11). Andrographolide, a natural bicyclic diterpenoid lactone, has been reported to possess anti-colitis activity. In this study, andrographolide treatment was found to significantly relieve CPT-11-induced colitis in tumor-bearing mice without decreasing the tumor suppression effect of CPT-11. CPT-11 causes DNA damage and the release of double-stranded DNA(ds DNA) from the intestine, leading to cyclic-GMP-AMP synthase(c GAS)-stimulator of interferon genes(STING)-mediated colitis, which was significantly decreased by andrographolide both in vivo and in vitro. Mechanistic studies revealed that andrographolide could promote homologous recombination(HR) repair and downregulate ds DNA-c GAS-STING signaling and contribute to the improvement of CPT-11-induced gastrointestinal mucositis. These results suggest that andrographolide may be a novel agent to relieve gastrointestinal mucositis caused by CPT-11.

关键词： CPT-11 Gastrointestinal mucositis Andrographolide Homologous recombination cGAS-STING

不同膳食暴露评估方法在上海市居民镉暴露风险评估中的应用

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上海预防医学 2024年第3期36卷 224-229页

作者：蔡华罗宝章秦璐昕邱丹萍杨京津宋夏徐碧瑶朱珍妮刘弘吴春峰上海市疾病预防控制中心上海200336

【目的】综合评估上海市居民镉内外暴露水平及健康风险。【方法】应用2种膳食污染物暴露评估方法[总膳食研究(TDS)和食物频率法问卷调查(FFQ)]计算食品样品镉含量,估算上海市普通居民每日膳食镉暴露,应用联合国粮农组织和世界卫生组织(W... 详细信息

【目的】综合评估上海市居民镉内外暴露水平及健康风险。【方法】应用2种膳食污染物暴露评估方法[总膳食研究(TDS)和食物频率法问卷调查(FFQ)]计算食品样品镉含量,估算上海市普通居民每日膳食镉暴露,应用联合国粮农组织和世界卫生组织(WHO)下的食品添加剂联合专家委员会制定的暂定每月耐受摄入量(PTMI,25μg·kg^(-1),按体重计)评价上海市普通居民镉暴露健康风险。通过秩和检验比较不同地区、年龄、性别、吸烟状况和体重指数(BMI)人群间的膳食镉和尿镉差异,通过相关性分析探讨镉内外暴露关联。【结果】1300名调查对象的尿镉均值为0.542μg·L^(-1),中心城区和城郊接合地区人群尿镉水平高于远郊地区人群,高年龄组尿镉水平高于低年龄组,吸烟人群尿镉高于非吸烟人群(均P<0.01)。2种膳食评估方法显示上海市居民每日膳食镉暴露的均值为0.306和0.090μg·kg^(-1),分别有3.69%和0.85%的居民膳食镉摄入量超出PTMI标准。相关性分析显示,调整了吸烟状况、年龄、性别、BMI因素后,基于FFQ的膳食镉暴露与尿镉水平均呈正相关。【结论】上海市居民膳食镉暴露主要来源于蔬菜、水产、谷类和薯类,总体处于低风险水平,基于FFQ和风险监测数据的膳食暴露评估方法可有效估算长期镉暴露。

关键词：镉膳食暴露总膳食研究食物频率法问卷调查风险评估