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Th1-type cellular immune response in neonates induced by Group B streptococcus

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Th1-type cellular immune response in neonates induced by Gro...

第十三届全国免疫学学术大会

作者： Yanqing Lin Bingxin Hu Meiqun Luo Jianbin Ye danlin wu Junjie Wen Yan Li Yunshan Ning Southern Medical University

Background: Group B streptococcus(GBS) is one of the main pathogens of perinatal *** neonates infected with GBS in utero can suffer from sepsis, pneumonia, and *** innate immunity and adaptive immunity mediated by CD4T cells are activated in GBS-infected neonates, but the immune characteristics and the differentiation mechanism of CD4T cell are rarely *** the mechanism of GBS-induced differentiation of na?ve CD4T cells is crucial to elucidate the immune defense mechanism of neonates after ***: The Bio-Plex assay for detecting the cytokines and chemokines of 182 cases of neonatal umbilical cord blood, including 80 cases of GBS negative control group and 102 cases of GBS colonized group(43 symptomatic cases and 59 asymptomatic cases).Meanwhile, the na?ve CD4 T cells from neonatal umbilical cord blood were co-cultured with autologous monocytes stimulated by GBS, and master transcription factors were analyzed by ***: Compared to the control group detected by Bio-Plex, IFN-γ and CXCL10 in GBS-colonized group increased significantly, and IL-6 and IL-1β increased significantly only in symptomatic *** co-culture of na?ve CD4T cells, GBS and monocytes, Th1-related transcription factor T-bet was up-regulated, while Th2, Th17, Treg-related transcription factor GATA, RORγt and FoxP3 were ***: The INF-γ-producing Th1 cells is primary cellular immune response in neonates induced GBS.

关键词： Group B Streptococcus Th1-type cell differentiation INF-γ

水泥水化过程计算机模拟研究——CEMHYD3D系统分析与模拟实现

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材料导报 2007年第4期21卷 100-103页

作者：吴丹琳王培铭同济大学先进土木工程材料教育部重点实验室上海200092

分析了水泥水化过程计算机模拟这一领域最有代表性的模拟系统——CEMHYD3D的建模过程,以CCRLCement133水泥为例,对不同水灰比条件下的水泥水化过程进行了实际模拟计算,对水化热、水化程度、水化过程中主要反应物和产物的变化情况进行了... 详细信息

分析了水泥水化过程计算机模拟这一领域最有代表性的模拟系统——CEMHYD3D的建模过程,以CCRLCement133水泥为例,对不同水灰比条件下的水泥水化过程进行了实际模拟计算,对水化热、水化程度、水化过程中主要反应物和产物的变化情况进行了预测。研究表明,CEMHYD3D的模拟结果与实验所揭示的规律一致性较好,尤其是该软件在物相成分变化规律方面的预测对于水化机理的研究很有意义。

关键词：水泥水化计算机模拟水化程度水化热水化产物

Immunodominant CD4+T cell responses to Helicobacter pylori Lpp20

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Immunodominant CD4+T cell responses to Helicobacter pylori L...

第十二届全国免疫学学术大会

作者： Li Yan Ye Jianbin wu danlin Wen Junjie Zeng Shuang Wen Yuemei Jiang Yin Xi Yue Ning Yunshan Southern Medical University

Background:Antigen-specific CD4 T cells play an essential role in the immunopathogenesis of Helicobacter pylori(***) ***20,a conserved lipoprotein of H pylori,has been considered as one of major protective *** previous studies identified two Lpp20 H-2 d restricted CD4 T cell epitopes,which induced protective immunological response in mice against H pylori *** is an important feature of antibacterial cellular immune ***,few are known to immunodominant Lpp20-specific CD4 T cell response and Lpp20 CD4 T cell epitopes has not yet *** present study,we try to investigate the immunodominant CD4 T cells response to Lpp20 in ***-infected ***:Lpp20-specific CD4 T cells were expanded with autologous patient peripheral blood mononuclear cells that had been incubated with recombinant Lpp20 and characterized using 27 overlapping 18 mer synthetic peptides spanning the sequence of ***,the most potent core sequence of 18 mer peptides recognized by Lpp20-specific CD4 T cells was further identified using a set of 13 mer N-and C-terminus extended or truncated overlapping peptides covering the initially detected 18 mer ***:The immunodominant CD4 T cells responses specific to L and L were observed in most H pylori-infected *** patient H1,the immunodominant CD4 T cells responding to the L18-mer peptides recognized two 13-mer peptides(L and L).For patient H6,the immunodominant CD4 T cells responding to the L18-mer peptides recognized two 13-mer peptides(L and L).Conclusions:The characteristics of HLA class Ⅱ restriction to these immunodominant Lpp20 CD4 T cell epitptops and the correlation with various gastritis are under study,which will provide insight into mechanisms of protective immunity and vaccine design.

关键词： Helicobacter pylori Lpp20 CD4+ T cell immunodominant epitope

The role of Notch signaling in the macrophage during Helicobacter pylori infection

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The role of Notch signaling in the macrophage during Helicob...

第十三届全国免疫学学术大会

作者： Junjie Wen Jianbin Ye danlin wu JInling Xie Bingxin Hu Meiqun Luo Yanqing Lin Yunshan Ning Yan Li Southern Medical University

Background: Recent data have indicated that the Notch signal pathway is an important bridge between antigen-presenting cells(APCs) and T cell communication circuits and plays a central role in driving the immune system to overcome ***, the role of Notch signaling in the macrophages during Helicobacter pylori(***) infection remains ***: To test whether *** infection regulates the expression of Notch molecules in ***: quantitative real-time PCR was performed and mRNA expression levels of Notch receptors and ligands were evaluated after macrophages were challenged with ***(MOI 10:1 and 50:1).Notch signaling inhibitor GSI, was used to block Notch signaling in the co-culture of macrophage and ***: The expression of Notch receptor Notch3 and Notch ligands(DLL1, DLL4 and Jagged1) were up-regulated significantly following *** challenge macrophages, while the expression of other Notch receptors(Notch1, notch2 and notch4) and ligand(Jagged2) were not observed ***, the Notch3 and the Notch downstream target gene Hes1 were significantly *** up-regulation of ***-induced Notch receptors and ligands was decreased in macrophage after GSI blocked Notch ***: Notch signaling is pivotal in the activation of macrophage during *** infection and further studies should be investigated to develop new therapeutic targets based on Notch signaling.

关键词： Helicobacter pylori Notch signaling macrophage

用于海外河油田调驱的有机铬交联聚合物弱凝胶体系及性能评价

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油田化学 2016年第3期33卷 437-441页

作者：王健张庆王丹翎吴丰豆油气藏地质及开发工程国家重点实验室(西南石油大学) 四川成都610500 西南石油大学石油工程学院四川成都610500

为降低海外河油田油井含水率,改善水驱开发效果,针对油藏条件用部分水解聚丙烯酰胺(HPAM)和有机铬交联剂配制了有机铬交联聚合物弱凝胶,研究了弱凝胶的耐温、耐盐、抗剪切性、注入性、封堵性及吸水剖面改善能力。研究结果表明,在油藏温... 详细信息

为降低海外河油田油井含水率,改善水驱开发效果,针对油藏条件用部分水解聚丙烯酰胺(HPAM)和有机铬交联剂配制了有机铬交联聚合物弱凝胶,研究了弱凝胶的耐温、耐盐、抗剪切性、注入性、封堵性及吸水剖面改善能力。研究结果表明,在油藏温度70℃下,配方为2000 mg/L HPAM+100 mg/L有机铬交联剂弱凝胶调驱体系的成胶时间为3 d,成胶强度为C级。弱凝胶具有较好的耐温性、抗盐性及抗剪切性,耐温可达90℃,抗盐可达3621.2 mg/L。岩心流动实验结果表明,弱凝胶体系的注入性和封堵性良好,可提高采收率10.4%数12.7%;吸水剖面改善能力较好,对非均质性岩心的吸水剖面改善率大于90%。

关键词：部分水解聚丙烯酰胺有机铬交联剂弱凝胶性能评价海外河油田

Notch信号通路在肿瘤免疫中对巨噬细胞的调控作用

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免疫学杂志 2019年第4期35卷 356-362,368页

作者：吴丹琳叶健斌温俊杰宁云山李妍南方医科大学检验与生物技术学院广州510515

巨噬细胞依据不同的肿瘤微环境发挥促癌或抑癌作用,肿瘤相关巨噬细胞(tumor-associated macrophages,TAMs往往与大部分肿瘤的不良预后相关。巨噬细胞如何成为TAMs以及TAMs如何与肿瘤细胞相互作用并影响肿瘤的发生发展是肿瘤研究中的热... 详细信息

巨噬细胞依据不同的肿瘤微环境发挥促癌或抑癌作用,肿瘤相关巨噬细胞(tumor-associated macrophages,TAMs往往与大部分肿瘤的不良预后相关。巨噬细胞如何成为TAMs以及TAMs如何与肿瘤细胞相互作用并影响肿瘤的发生发展是肿瘤研究中的热点问题之一。已证实Notch信号通路参与调控TAMs的分化和功能,但Notch信号如何调控TAMs并使其发挥促癌或抑癌的功能仍有待挖掘。因此,本综述总结了目前Notch信号通路对TAMs分化和功能调控以及对肿瘤微环境的影响,讨论了TAMs、肿瘤细胞以及肿瘤微环境中其他细胞之间通过Notch信号介导的直接或间接的相互作用。对巨噬细胞中Notch信号通路的深入研究将有助于研发出更有效的治疗肿瘤的免疫干预方法。

关键词： Notch 巨噬细胞肿瘤相关巨噬细胞肿瘤免疫

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土壤物证鉴定中的微观测试与表征技术

中国粉体技术 2014年第3期20卷 64-66页

作者：吴丹琳丁敏菊刘贤萍赵丕琪同济大学土木工程学院上海200092 上海市公安局物证鉴定中心上海200083 上海市公安局上海市现场物证重点实验室--省部共建国家重点实验室基地上海200083 同济大学材料科学与工程学院上海201804

在司法物证检验鉴定中,为了鉴别2种未知土壤物证的来源性问题,采用X射线荧光光谱、X射线衍射和激光粒度分析,对样品进行测试和对比。结果表明,2种样品在化学组成、矿物组成和粒径特征方面均存在较大差异,二者虽然当时取自同一案发现场,... 详细信息

在司法物证检验鉴定中,为了鉴别2种未知土壤物证的来源性问题,采用X射线荧光光谱、X射线衍射和激光粒度分析,对样品进行测试和对比。结果表明,2种样品在化学组成、矿物组成和粒径特征方面均存在较大差异,二者虽然当时取自同一案发现场,但是它们之前的来源是不同的。

关键词：土壤物证测试方法化学组成矿物组成粒径分布

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SiO_2固体酸微球制备及催化性能研究

化工新型材料 2017年第10期45卷 148-150页

作者：吴洁曾丹林裴阳沈康文陈诗渊武汉科技大学化工学院湖北省煤转化与新型炭材料重点实验室武汉430081

以纳米二氧化硅(SiO_2)为载体,采用浸渍法制得SiO_2固体酸微球。探讨不同反应条件对SiO_2微球的影响,研究磺化温度和时间对SiO_2固体酸微球酸量和酯化率的影响,并采用傅里叶红外光谱(FT-IR)、X射线衍射(XRD)对SiO_2微球、SiO_2固体酸微... 详细信息

以纳米二氧化硅(SiO_2)为载体,采用浸渍法制得SiO_2固体酸微球。探讨不同反应条件对SiO_2微球的影响,研究磺化温度和时间对SiO_2固体酸微球酸量和酯化率的影响,并采用傅里叶红外光谱(FT-IR)、X射线衍射(XRD)对SiO_2微球、SiO_2固体酸微球进行表征。结果表明:在磺化时间为4h、磺化温度为220℃、SiO_2微球与浓硫酸按1∶10固液配合比(质量比)的条件下,制得的SiO_2固体酸微球的粒径为180nm,总酸量达到4.53mmol/g,对乙酸和乙醇酯化反应的催化效率达到80.75%。

关键词： SiO2微球固体酸浸渍酯化

Sex-dependent alterations in extracellular vesicles linking chronic spinal cord injury to brain neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第2期20卷 483-484页

作者： Yun Li Junfang wu Department of Anesthesiology&Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA

Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability *** in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth *** survival changes have led neurotrauma researchers to examine how SCI interacts with brain *** health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.

关键词： alterations inflammation injury