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Supramolecular complex glycoconjugate vaccine generates self-enhancement effects for carbohydrate antigen delivery

Chinese Chemical Letters 2024年第2期35卷 317-322页

作者： Han Lin Yanchun Li Kun Zhou Dan Li Hangyan Yu Jie Zhao Haofei Hong Zhifang Zhou Zhimeng wu Key Laboratory of Carbohydrate Chemistry & Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China

Targeting delivery of tumor-associated carbohydrate antigen(TACA)-based vaccine to antigen-presenting cells(APCs)mediated by endogenous antibodies can improve the immunogenicity of ***,an essential requirement of this approach is to generate high titers of endogenous antibodies in vivo through pre-immunization,which complicates the immunization procedure and may cause side ***,we report a new generation of APC-targeting TACA-based supramolecular complex vaccine,assembled by sialyl Thomsen-nouveau-bovine serum albumin-adamantine(sTn-BSA-Ada)and heptavalent rhamnose(Rha)-modifiedβ-cyclodextrin(β-CD)via host-guest *** complex vaccine retained anti-Rha antibodies recruiting capability and facilitated the APCs uptake of the vaccine via the interaction of the Fc-domain with the Fc receptors on *** demonstrate that direct immunization of complex vaccine elicited anti-Rha and anti-sTn specific immune response synchronously,generating a novel self-enhancement effect that can improve the antigen delivery to APCs in high *** structure-activity relationship(SAR)study proved that complex vaccine 4 with polyethylene glycol 6(PEG 6)linker in host molecule provoked a robust and specific sTn immune response comparable to the pre-immunization *** antisera induced by complex vaccine,either through direct immunization or pre-immunization,exhibited equal potency of cytotoxicity against the sTn expression cancer *** study provides a general platform for TACA-based vaccines with self-enhancement effects without the need for pre-immunization.

关键词： Glycoconjugate vaccine Endogenous antibody APC-targeting Supramolecular complex sTn antigen

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Tuning hot carrier transfer dynamics by perovskite surface modification

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Chinese Chemical Letters 2024年第10期35卷 457-460页

作者： Chenghao Ge Peng Wang Pei Yuan Tai wu Rongjun Zhao Rong Huang Lin Xie Yong Hua School of Materials and Energy Yunnan UniversityKunming 650091China Department of Physics Center for Optoelectronics Engineering ResearchYunnan UniversityKunming 650091China

Understanding the role of perovskite surface passivators in hot carriers transfer dynamics is important to develop highly efficient perovskite solar cells(PSCs).In this work,we have designed and synthesized a naphthalimide-based organic small molecule(NCN)for perovskite surface defect *** reveal that the introduction of NCN not only reduces the density of perovskite defect-state,but also promotes hot carriers(HCs)cooling in perovskite through the transient absorption spectroscopy *** HCs cooling permits HCs transfer from perovskite layer into NCN layer,thus resulting in the decreased charge-carrier recombination in NCN-treated *** expected,the power conversion efficiency(PCE)of PSCs with NCN is enhanced to 22.02%from 19.95%for the control *** findings are relevant for developing highly efficient PSCs.

关键词： Perovskite solar cells Interface passivation Hot carrier Charge recombination Stability Naphthalimide

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Interstitial carbon induces enriched Cu^(δ+) sites in Cu_(2)O nanoparticles to facilitate CO_(2) electroreduction to C_(2+) products

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Nano Research 2024年第8期17卷 7013-7019页

作者： Haoran Wang Rongbo Sun Peigen Liu Haohui Hu Chen Ling Xiao Han Yi Shi Xusheng Zheng Geng wu Xun Hong Center of Advanced Nanocatalysis(CAN) Department of Applied ChemistryHefei National Laboratory for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Sinochem Holdings Co Ltd Xiongan New AreaHebei 071700China National Synchrotron Radiation Laboratory(NSRL) University of Science and Technology of ChinaHefei 230029China

The electrochemical CO_(2) reduction reaction(CO_(2)RR)holds significant promise in advancing carbon *** catalysts for the electrochemical CO_(2)RR to multi-carbon(C_(2+))products(e.g.,C_(2)H_(4))under industrial-level current density is urgently needed and ***,we report the Cu_(2)O nanoparticles doped with interstitial carbon atoms(denoted as C-Cu_(2)O NPs)for the conversion of CO_(2) to C_(2+)*** interstitial carbon promotes the C-Cu_(2)O NPs to possess abundant unsaturated Cu–O bonds,leading to a high-density Cu^(δ+)(0<δ<1)*** obtained C-Cu_(2)O NPs exhibited significant Faradic efficiency(FE)of C_(2+) products approaching 76.9%and a partial current density reaching 615.2 mA·cm^(–2)under an industrial-level current density of 800 mA·cm^(–2).Furthermore,the efficient electrosynthesis of C_(2)H_(4) achieved an FE of 57.4%with a partial current density of 459.2 mA·cm^(–2).In situ electrochemical attenuated total reflection Fourier transform infrared spectroscopy and in situ Raman spectroscopy analyses revealed that C-Cu_(2)O NPs stabilized the intermediate*CO and facilitated C–C coupling,leading to increased selectivity towards C_(2+) products.

关键词： CO_(2) electroreduction C-C coupling interstitial carbon *CO coverage industrial-level current density

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A 128×128 SPAD LiDAR sensor with column-parallel 25 ps resolution TA-ADCs

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Journal of Semiconductors 2024年第8期45卷 34-40页

作者： Na Tian Zhe Wang Kai Ma Xu Yang Nan Qi Jian Liu Nanjian wu Runjiang Dou Liyuan Liu State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100049China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

This paper presents a design of single photon avalanche diode(SPAD)light detection and ranging(LiDAR)sensor with 128×128 pixels and 128 column-parallel time-to-analog-merged-analog-to-digital converts(TA-ADCs).Unlike the conventional TAC-based SPAD LiDAR sensor,in which the TAC and ADC are separately implemented,we propose to merge the TAC and ADC by sharing their capacitors,thus avoiding the analog readout noise of TAC’s output buffer,improving the conversion rate,and reducing chip *** reverse start-stop logic is employed to reduce the power of the *** in a 180 nm CMOS process,our prototype sensor exhibits a timing resolution of 25 ps,a DNL of+0.30/−0.77 LSB,an INL of+1.41/−2.20 LSB,and a total power consumption of 190 mW.A flash LiDAR system based on this sensor demonstrates the function of 2D/3D imaging with 128×128 resolution,25 kHz inter-frame rate,and sub-centimeter ranging precision.

关键词： 3D imaging CMOS imagers direct time-of-flight(dTOF) time-to-analog converter(TAC)

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A dynamic regulation of nitrogen on floret primordia development in wheat

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The Crop Journal 2024年第1期12卷 271-280页

作者： Zhen Zhang Yujing Li Yuxun wu Xiaoyu Zheng Xiaolei Guo Wan Sun Zhencai Sun Zhimin Wang Yinghua Zhang College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China College of Biological Sciences China Agricultural UniversityBeijing 100193China Engineering Technology Research Center for Agriculture in Low Plain Areas Cangzhou 061800HebeiChina

Nitrogen(N)fertilization is critical for spike and floret development,which affects the number of fertile florets per spike(NFFs).However,the physiological regulation of the floret development process by N fertilization is largely unknown.A high temporal-resolution investigation of floret primordia number and morphology,dry matter,and N availability was conducted under three N fertilization levels:0(N0),120(N1)and 240(N2)kg ha^(−1).Interestingly,fertile florets at anthesis stage were determined by those floret primordia with meiotic ability at booting stage:meiotic ability was a threshold that predicted whether a floret primordium became fertile or abortive *** the developmental rate of the 4th floret primordium in the central spikelet was accelerated and then they acquired meiotic ability,the NFFs increased gradually as N application increased,but the increase range decreased under *** were no differences in spike N concentration among treatments,but leaf N concentration was increased in the N1 and N2 ***,dry matter accumulation and N content of the leaf and spike in the N1 and N2 treatments was increased as compared to ***,optimal N fertilization increased leaf N availability and transport of assimilates to spikes,and allowed more floret primordia to acquire meiotic ability and become fertile florets,finally increasing *** was no difference in leaf N concentration between N1 and N2 treatment,whereas soil N concentration at 0–60 cm soil layers was higher in N2 than in N1 treatment,implying that there was still some N fertilization that remained ***,improving the leaf’s ability to further use N fertilizer is vital for greater NFFs.

关键词： Fertile florets Floret primordia Grain number Meiotic ability Morphological development

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A distinct“repair”role of regulatory T cells in fracture healing

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Frontiers of Medicine 2024年第3期18卷 516-537页

作者： Tingting wu Lulu Wang Chen Jian Zhenhe Zhang Ruiyin Zeng Bobin Mi Guohui Liu Yu Zhang Chen Shi Department of Pharmacy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Hubei Province Clinical Research Center for Precision Medicine for Critical Illness Wuhan430022China Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Regulatory T cells(Tregs)suppress immune responses and ***,we described the distinct nonimmunological role of Tregs in fracture *** recruitment from the circulation pool,peripheral induction,and local expansion rapidly enriched Tregs in the injured *** Tregs in the injured bone displayed superiority in direct osteogenesis over Tregs from lymphoid *** depletion of Tregs compromised the fracture healing process,which leads to increased bone *** addition,bone callus Tregs showed unique T-cell receptor *** was the most overexpressed protein in bone callus Tregs,and it can directly facilitate the proliferation and differentiation of osteogenic precursor cells by activation of phosphatidylinositol 3-kinase/protein kinase B signaling *** results of loss-and gain-function studies further evidenced that amphiregulin can reverse the compromised healing caused by Treg *** also enriched in patient bone callus and amphiregulin can promote the osteogenesis of human pre-osteoblastic *** findings indicate the distinct and nonredundant role of Tregs in fracture healing,which will provide a new therapeutic target and strategy in the clinical treatment of fractures.

关键词： regulatory T cells fracture healing amphiregulin non-union osteogenesis

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基于物联网的远程实验室系统架构设计

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物联网技术 2014年第7期4卷 80-82页

作者：于翔吴梦轩张劲中邢益轩赵海滨天津城建大学天津300384

介绍了基于物联网技术的远程操作应用系统的设计方法。该系统由虚拟化系统与计算机控制仪器组成,可提供远程仪器使用服务。采用该系统能降低试验成本,使实验室中的仪器通过互联网获得广泛利用,并通过小规模平台建设来验证关键技术环节... 详细信息

介绍了基于物联网技术的远程操作应用系统的设计方法。该系统由虚拟化系统与计算机控制仪器组成,可提供远程仪器使用服务。采用该系统能降低试验成本,使实验室中的仪器通过互联网获得广泛利用,并通过小规模平台建设来验证关键技术环节的可行性。

关键词：虚拟化物联网远程实验室

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Application of controlled-release urea increases maize N uptake,environmental benefits and economic returns via optimizing temporal and spatial distributions of soil mineral N

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Pedosphere 2024年第1期34卷 222-235页

作者： Mingxue SUN Juan LI Lili ZHANG Xiaomeng SU Ning LIU Xiaori HAN Songjiang wu Zhentao SUN Xiangdong YANG Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences/State Key Laboratory of Efficient Utilization of Arid and Semi-arid Arable Land in Northern China/Key Laboratory of Plant Nutrition and FertilizerMinistry of Agriculture and Rural AffairsBeijing 100081China Agricultural Development Service Center of Zhuanghe Zhuanghe 116499China Agricultural Technology Extension Center Wafangdian 116300China College of Land and Environment Shenyang Agricultural UniversityShenyang 100866China

The creation of controlled-release urea (CRU) is a potent substitute for conventional fertilizers in order to preserve the availability of nitrogen (N) in soil,prevent environmental pollution,and move toward green *** main objectives of this study were to assess the impacts of CRU’s full application on maize production and to clarify the connection between the nutrient release pattern of CRU and maize nutrient *** order to learn more about the effects of CRU application on maize yields,N uptake,mineral N (N_(min)) dynamics,N balance in soil-crop systems,and economic returns,a series of field experiments were carried out in 2018–2020 in Dalian City,Liaoning Province,*** were 4 different treatments in the experiments:no N fertilizer input (control,CK);application of common urea at 210 kg ha^(-1)(U),the ideal fertilization management level for the study site;application of polyurethane-coated urea at the same N input rate as U (PCU);and application of PCU at a 20% reduction in N input rate (0.8PCU).Our findings showed that using CRU (i.e.,PCU and 0.8 PCU) may considerably increase maize N absorption,maintain maize yields,and increase N use efficiency (NUE) compared to *** grain yield showed considerable positive correlations with total N uptake in leaf in U and 0.8 PCU,but negative correlations with that in PCU,indicating that PCU caused excessive maize absorption while 0.8 PCU could achieve a better yield response to N ***,PCU was able to maintain N fertilizer in the soil profile 0–20 cm away from the fertilization point,and higher N_(min)content was observed in the 0–20 cm soil layer at various growth stages,particularly at the middle and late growing stages,optimizing the temporal and spatial distributions of N_(min).Additionally,compared to that in U,the apparent N loss rate in PCU was reduced by 36.2%,and applying CRU (PCU and 0.8 PCU) increased net profit by 8.5% to 15.2% with less labor and fertilization *** was co

关键词： apparent N loss fertilization management green agriculture maize yield N balance N use efficiency

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Connecting cellular mechanisms and extracellular vesicle cargo in traumatic brain injury

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Neural Regeneration Research 2024年第10期19卷 2119-2131页

作者： Nikita Ollen-Bittle Austyn D.Roseborough Wenxuan Wang Jeng-liang D.wu Shawn N.Whitehead Department of Anatomy and Cell Biology Western UniversityLondonONCanada Schulich School of Medicine and Dentistry Western UniversityLondonONCanada Deparment of Clinical Neurological Sciences Western UniversityLondonONCanada

Traumatic brain injury is followed by a cascade of dynamic and complex events occurring at the cellular level. These events include: diffuse axonal injury, neuronal cell death, blood-brain barrier break down, glial activation and neuroinflammation, edema, ischemia, vascular injury, energy failure, and peripheral immune cell infiltration. The timing of these events post injury has been linked to injury severity and functional outcome. Extracellular vesicles are membrane bound secretory vesicles that contain markers and cargo pertaining to their cell of origin and can cross the blood-brain barrier. These qualities make extracellular vesicles intriguing candidates for a liquid biopsy into the pathophysiologic changes occurring at the cellular level post traumatic brain injury. Herein, we review the most commonly reported cargo changes in extracellular vesicles from clinical traumatic brain injury samples. We then use knowledge from animal and in vitro models to help infer what these changes may indicate regrading cellular responses post traumatic brain injury. Future research should prioritize labeling extracellular vesicles with markers for distinct cell types across a range of timepoints post traumatic brain injury.

关键词： axonal injury biomarkers blood-brain barrier chronic traumatic encephalopathy extracellular vesicles glial activation neuroinflammation traumatic brain injury

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A novel strain of Levilactobacillus brevis PDD-5 isolated from salty vegetables has beneficial effects on hyperuricemia through anti-inflammation and improvement of kidney damage

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Food Science and Human Wellness 2024年第2期13卷 898-908页

作者： Jue Xu Maolin Tu Xiankang Fan Yuxing Guo Tao Zhang Xiaoqun Zeng Zhendong Cai Zhen wu Daodong Pan State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Ningbo UniversityNingbo 315211China Key Laboratory of Animal Protein Food Deep Processing Technology of Zhejiang Province College of Food and Pharmaceutical SciencesNingbo UniversityNingbo 315211China Department of Food Science and Technology School of Food Science and Pharmaceutical EngineeringNanjing Normal UniversityNanjing 210023China

Hyperuricemia is a metabolic disorder caused by abnormal purine metabolism,resulting in abnormally high serum uric *** this study,a novel Levilactobacillus brevis PDD-5 isolated from salty vegetables was verified with the function of alleviating *** relevant effects of *** PDD-5 in lowering uric acid were analyzed by in vitro and in vivo *** results showed that the *** PDD-5 has(68.86±15.46)%of inosine uptake capacity and(95.75±3.30)%of guanosine uptake capacity in *** administration of *** PDD-5 to hyperuricemia rats reduced uric acid,creatinine,and urea nitrogen in serum,as well as decreased inosine and guanosine levels in the intestinal contents of *** of relevant markers in the kidney by ELISA kits revealed that *** PDD-5 alleviated oxidative stress and ***,the gene expression of uric acid transporter 1(URAT1)and glucose transporter 9(GLUT9)was down-regulated,and the gene expression of organic anion transporter 1(OAT1)was up-regulated after treatment with *** *** blot analysis showed that *** PDD-5 alleviated hyperuricemia-induced kidney injury through the NLRP3 *** se findings suggest that *** PDD-5 can lower uric acid,repair kidney damage,and also has the potential to prevent uric acid nephropathy.

关键词： Lactic acid bacteria Purine nucleoside Hyperuricemia Uric acid nephropathy

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