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Vascular reconstruction of a ruptured and infected aneurysm of extracranial carotid artery

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Chinese Medical Journal 2008年第7期121卷 671-672页

作者： SONG Jin-qiu ZHANG Jian YIN Ming-di SHAN Shao-yin wu Bin DUAN zhi-quan XIN Shi-jie Department of General Surgery Section of Vascular Surgery FirstHospital China Medical University Shenyang Liaoning 110001China

Extracranial carotid artery aneurysm represents an ,uncommon vascular condition with relatively higherincidence in China than in the West.1 The complication with infection and rupture is even rarer, but potentially lethal. Management of this condition is challenging but urgent because of high risks for embolization, generalized sepsis, further expansion, rupture, and life threatening.L2 We present an exceptional case of carotid aneurysm at bifurcation complicated with rupture and infection and discuss the pathogenesis and various aspects of diagnosis and surgical management.

关键词： carotid artery aneurysm rupture

银杏叶提取物调节TGF-β1/HGF信号通路对单侧输尿管梗阻小鼠肾纤维化的影响

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现代生物医学进展 2024年第16期24卷 3039-3045页

作者：吴志全杜斯斯王延鑫马江涛贺泽威宋伟波石家庄市妇幼保健院儿科河北石家庄050019 威县第二人民医院儿科河北邢台054700 邢台市人民医院儿科河北邢台054031

目的:探究银杏叶提取物(GBE)调节转化生长因子β1(TGF-β1)/肝细胞生长因子(HGF)信号通路对单侧输尿管梗阻(UUO)小鼠肾纤维化的影响。方法:采用单侧输尿管结扎术法构建UUO小鼠模型,造模成功后将小鼠随机分为模型组、厄沙贝坦组(20 mg/kg... 详细信息

目的:探究银杏叶提取物(GBE)调节转化生长因子β1(TGF-β1)/肝细胞生长因子(HGF)信号通路对单侧输尿管梗阻(UUO)小鼠肾纤维化的影响。方法:采用单侧输尿管结扎术法构建UUO小鼠模型,造模成功后将小鼠随机分为模型组、厄沙贝坦组(20 mg/kg)、GBE低、中、高剂量组(25 mg/kg、50 mg/kg、100 mg/kg),每组10只;另取10只小鼠为假手术组(仅分离左侧输尿管但不结扎)。检测肾功能指标:β-N-乙酰氨基葡萄糖苷酶(NAG)、肌酐(Scr)、尿素氮(BUN);酶联免疫吸附试验(ELISA)法检测血清肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β、IL-6水平;苏木精-伊红(HE)染色观察肾脏组织病理变化;马森(Masson)染色观察肾脏组织纤维化情况;免疫组化法检测α-平滑肌肌动蛋白(α-SMA)、TGF-β1表达;Western blot检测肾脏组织Ⅰ型胶原(Col-Ⅰ)、α-SMA、TGF-β1、细胞信号转导分子2(Smad2)、磷酸化Smad2(p-Smad2)、HGF蛋白表达。结果:相比于假手术组,模型组小鼠肾脏组织肾小管腔扩张或萎缩,炎症细胞浸润,胶原纤维沉积明显,NAG、Scr、BUN、TNF-α、IL-1β、IL-6、肾纤维化水平、Col-Ⅰ、α-SMA、TGF-β1、p-Smad2/Smad2表达明显升高,HGF蛋白表达明显下降(P<0.05);相较于模型组,厄沙贝坦组和GBE低、中、高剂量组小鼠肾组织病理损伤减轻,胶原沉积纤维减少,NAG、Scr、BUN、TNF-α、IL-1β、IL-6、肾纤维化水平、Col-Ⅰ、α-SMA、TGF-β1、p-Smad2/Smad2表达明显降低,HGF蛋白表达明显升高(P<0.05),其中厄沙贝坦组和EG高剂量组改善最为显著。结论:GBE能减轻肾功能损伤,抑制炎症反应,改善UUO小鼠的肾纤维化,其作用机制可能与调节TGF-β1/HGF信号通路平衡有关。

关键词：单侧输尿管梗阻肾纤维化银杏叶提取物 TGF-β1/HGF信号通路炎症反应

Neutron irradiation influence on high-power thyristor device under fusion environment

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Nuclear Science and Techniques 2024年第4期35卷 65-81页

作者： Wei Tong Hua Li Meng Xu zhi-quan Song Bo Chen School of Electrical Engineering and Automation Hefei University of TechnologyHefei 230009China Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China

Because of their economy and applicability,high-power thyristor devices are widely used in the power supply systems for large fusion *** high-dose neutrons produced by deuterium–tritium(D–T)fusion reactions are irradiated on a thyristor device for a long time,the electrical characteristics of the device change,which may eventually cause irreversible *** this study,with the thyristor switch of the commutation circuit in the quench protection system(QPS)of a fusion device as the study object,the relationship between the internal physical structure and external electrical parameters of the irradiated thyristor is ***,a series of targeted thyristor physical simulations and neutron irradiation experiments are conducted to verify the accuracy of the theoretical *** addition,the effect of irradiated thyristor electrical characteristic changes on the entire QPS is studied by accurate simulation,providing valuable guidelines for the maintenance and renovation of the QPS.

关键词： Fusion device Neutron irradiation effects Thyristor Quench protection

Effect of Mo and cold forging deformation on strength and ductility of cobalt-based alloy L605

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Journal of Iron and Steel Research International 2024年第7期31卷 1811-1823页

作者： Zhong-lin Wang zhi-hua Gong quan Li Han-sheng Bao School of Materials and Metallurgy Inner Mongolia University of Science and TechnologyBaotou 014017Inner MongoliaChina Institute of Special Steels Central Iron and Steel Research Institute Co.Ltd.Beijing 100081China

Mo element was added to cobalt-based alloy L605,and cold forging deformation was *** effects of the addition and cold forging deformation on the microstructure and mechanical properties of the alloy were studied by thermodynamic calculation,electron backscatter diffraction,transmission electron microscopy,and X-ray *** stacking fault energy(SFE)of the alloy decreased after the addition,and the formation of stacking faults and intersections were promoted to improve the strength and *** tensile strength of the alloy with Mo increased from 1190 to 1702 MPa after 24%cold deformation,producing significant work *** strengthening mechanism is strain-induced martensitic transformation(SIMT)and deformation *** alloy,combined with Mo and after 24%deformation,had both high strength and ductility in comparison with the original cobalt-based alloy *** is attributed to the lower SFE which caused the increase in stacking fault *** the tensile process,theε-hcp phase was easily generated at the stacking fault to reduce the stress concentration and increase the *** SIMT by adjusting the density of stacking faults can improve the mechanical properties of cobalt-based ***ε-hcp phase,the interaction between deformation twins and dislocations,and the interaction between e-hcp phases during cold forging deformation caused local stress concentration,lowering ductility and toughness.

关键词： Cobalt-based alloy-Stacking fault energy Strain-induced martensitic transformation Deformation twin Cold forging deformation

Focal nodular hyperplasia of the liver in 86 patients

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Hepatobiliary & Pancreatic Diseases International 2007年第1期6卷 52-57页

作者： Shen, Ying-Hao Fan, Jia wu, zhi-quan Ma, Zeng-Chen Zhou, Xin-Da Zhou, Jian Qiu, Shuang-Jian Qin, Lun-Xiu Ye, Qin-Hai Sun, Hui-Chuan Huang, Xiao-wu Tang, Zhao-You Fudan Univ Zhongshan Hosp Dept Liver Surg Shanghai 200032 Peoples R China

BACKGROUND: Focal nodular hyperplasia (FNH), the second most common benign hepatic tumor after hemangioma, is characterized by a stellate central scar and hyperplastic nodules. Although some large FNH may be associated with significant symptoms, more frequently they are discovered incidentally on physical examination or the work-up of unrelated symptoms. Since its nature and pathogenesis are still controversial, accurate diagnosis of FNH based on clinical presentation and radiographic studies is difficult. The purpose of this study was to explore the diagnosis and treatment of FNH. METHODS: Eighty-six FNH patients confirmed pathologically were treated at the Liver Cancer Institute in our hospital from 1996 to 2006. Their clinical manifestions, imaging presentation, pathological findings, and surgical results were analyzed retrospectively. RESULTS: Of the 86 patients with 99 foci, 54 were male and 32 female, with a mean age of 37 years. Eighty patients had a single solitary focus and 6 had multiple foci. Tumor diameter was less than 5 cm in 69 patients, 5-10 cm in 15, and more than 10 cm in 2. The overall rate of correct preoperative diagnosis was 59.3% (51/86) including 32.9% (26/79) by color Doppler flow imaging (CDFI), 60.3% (35/58) by CT, and 77.4% (24/31) by MRI. All the 86 patients underwent resection with good curative effect. CONCLUSIONS: CT and MRI are important diagnostic methods for FNH but it is difficult to make a definite preoperative diagnosis for partial classical and all non-classical FNH patients. We suggest that patients with clinical symptoms or with indefinite diagnosis should accept surgical removal.

关键词： liver focal nodular hyperplasia diagnosis treatment

TSC prediction and dynamic control of BOF steelmaking with state-of-the-art machine learning and deep learning methods

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Journal of Iron and Steel Research International 2024年第1期31卷 174-194页

作者： Tian-yi Xie Cai-dong Zhang quan-lin Zhou zhi-qiang Tian Shuai Liu Han-jie Guo Material Technology Research Institute Hesteel GroupShijiazhuang050023HebeiChina Tangsteel Company Hesteel GroupTangshan063611HebeiChina School of Artificial Intelligence Beijing Technology and Business UniversityBeijing100048China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China

Mathematical(data-driven)models based on state-of-the-art(SOTA)machine learning and deep learning models and data collected from 12,786 heats were established to predict the values of temperature,sample,and carbon(TSC)test,including temperature of molten steel(TSC-Temp),carbon content(TSC-C)and phosphorus content(TSC-P),which made prepa-ration for eliminating the TSC *** maximize the prediction accuracy of the proposed approach,various models with different inputs were implemented and compared,and the best models were applied to the production process of a Hesteel Group steelmaking plant in China in the *** number of tabular features(hot metal information,scrap,additives,blowing practices,and preset values)was expanded,and time series(off-gas profiles and blowing practice curves)that could reflect the entire steelmaking process were introduced as ***,the latest machine learning models(LightGBM,CatBoost,TabNet,and NODE)were used to make predictions with tabular features,and the best coefficient of determination R^(2)values obtained for TSC-P,TSC-C and TSC-Temp predictions were 0.435(LightGBM),0.857(Cat-Boost)and 0.678(LightGBM),respectively,which were higher than those of classic models(backpropagation and support vector machine).Then,making predictions was performed by using SOTA time series regression models(SCINet,DLinear,Informer,and MLSTM-FCN)with original time series,SOTA image regression models(NesT,CaiT,ResNeXt,and GoogLeNet)with resized time series,and the proposed Concatenate-Model and Parallel-Model with both tabular features and time *** optimization and comparisons,it was finally determined that the Concatenate-Model with MLSTM-FCN,SCINet and Informer as feature extractors performed the best,and its R^(2)values for predicting TSC-P,TSC-C and TSC-Temp reached 0.470,0.858 and 0.710,*** field test accuracies for TSC-P,TSC-C and TSC-Temp were 0.459,0.850 and 0.685,respectively.A related importance analysis was carri

关键词： BOF steelmaking In-blow prediction TSC test Machine learning Deep learning Field application

Design study of charge-stripping scheme of heavy ion beams for HIAF-BRing

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Nuclear Science and Techniques 2024年第5期35卷 30-41页

作者： Jun-Jie Zhang zhi-You Xu Jin-quan Zhang Wen-Wen Ge Liang-Ting Sun Huan-Yu Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

Charge strippers play an essential role in heavy-ion accelerators by stripping the projectile ions to higher charge states to enhance the acceleration efficiency downstream of the *** the high-energy mode of the booster ring(BRing)of the high-intensity heavy-ion accelerator facility,the pre-accelerated ions from the iLinac will be stripped by a carbon foil to higher charge states and then injected into the *** key parameters of the stripper and stripped ions were calculated,and the influence of stripping on the beam quality was *** get high stripping efficiencies,the foil thicknesses and resultant charge state distributions for the typical ions were determined by the code *** equilibrium thickness was obtained for the U beam,while the stripper thicknesses for the Xe and Kr beams were determined based on a compromise between the stripped charge states and the stripping *** energy loss,energy straggling,and emittance growth due to stripping have a non-negligible impact on the transport of the stripped beams and the injection of the ***,these parameters were simulated by *** addition,the foil’s temperature evolution,which greatly affects the foil lifetime,was simulated by *** maximum temperature of the foil bombarded by the U and Xe beams with the nominal parameters will exceed the safe value in terms of the impact of evaporation on the foil’s *** the foil temperature constraint,the highest tolerable beam intensity and the injected ion number into the ring were derived for different beam *** results of this paper will present important reference data for the optimization design and commissioning of the beamline and injection to the BRing for the stripped ions.

关键词： High-intensity heavy-ion accelerator facility Charge stripper Energy spread Thermal analysis Emittance growth Injection turns

Expression and significant roles of the long non-coding RNA CASC19/miR-491-5p/HMGA2 axis in the development of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3559-3584页

作者： Li-Xiang Zhang Pan-quan Luo zhi-Jian Wei A-Man Xu Tao Guo Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Anhui Provincial Key Laboratory of Digestive Disease Hefei 230031Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Anhui Public Health Clinical Center Hefei 230000Anhui ProvinceChina

BACKGROUND Gastric cancer(GC)is a common malignant tumor,long non-coding RNA and microRNA(miRNA)are important regulators that affect tumor proliferation,metastasis and chemotherapy resistance,and thus participate in tumor ***19 is a new bio-marker which can promote tumor invasion and ***,the mechanism by which CASC19 affects the progression of GC through miRNA is not *** To explore the role of the CASC19/miR-491-5p/HMGA2 regulatory axis in *** To explore the expression and prognosis of CASC19 in GC through clinical samples,and investigate the effects of inhibiting CASC19 on the proliferation,migration,invasion and other functions of GC cells through cell counting Kit-8(CCK-8),ethynyldeoxyuridine,Wound healing assay,Transwell,Western blot and flow cytometry *** effect of miR-491-5p and HMGA2 in GC were also *** regulatory relationship between CASC19 and miR-491-5p,miR-491-5p and HMGA2 were validated through Dual-luciferase reporter gene assay and reverse transcription *** CCK-8,Transwell,Wound healing assay,flow cytometry and animal experiments verify the role of CASC19/miR-491-5p/HMGA2 regulatory *** The expression level of CASC19 is related to the T stage,N stage,and tumor size of *** of the expression of CASC19 can inhibit the ability of proliferation,migration,invasion and EMT conversion of GC cells,and knocking down the expression of CASC19 can promote the apoptosis of GC *** the expression of miR-491-5p can inhibit the proliferation of GC cells,miR-491-5p mimics can inhibit EMT conversion,and promote the apoptosis of GC cells,while decreasing the expression of miR-491-5p can promote the proliferation and EMT conversion and inhibit the apoptosis of GC *** expression of HMGA2 in GC tissues is higher than that in adjacent *** the same time,the expression level of HMGA2 is related to the N and T stages of the *** the level of HMGA2 can pr

关键词： Gastric cancer Long non-coding RNA CASC19 miR-491-5p HMGA2 Prognosis

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超临界600MW汽轮机的演进和特点

汽轮机技术 2006年第2期48卷 90-92页

作者：吴智泉中国水利电力物资有限公司北京100045

介绍了超临界600MW汽轮机的演进历程,对国内汽轮机厂的机型在其主要技术规范、结构特点、轴系稳定性、选材、防固粒冲蚀措施、防汽隙振荡措施、热应力计算和控制功能、运行和启动方式等方面进行分析比较,同时给出与亚临界汽轮机的主要... 详细信息

介绍了超临界600MW汽轮机的演进历程,对国内汽轮机厂的机型在其主要技术规范、结构特点、轴系稳定性、选材、防固粒冲蚀措施、防汽隙振荡措施、热应力计算和控制功能、运行和启动方式等方面进行分析比较,同时给出与亚临界汽轮机的主要区别。

关键词：超临界汽轮机 600MW 特点