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基于网络药理学和分子对接的补肾固齿丸治疗肾虚血热型牙周病物质基础与作用机制研究

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天津中医药 2024年第2期41卷 249-257页

作者：樊媛芳熊开鹏务勇圣颜冬兰九芝堂股份有限公司长沙410221 成都九芝堂金鼎药业有限公司成都610101

[目的]通过网络药理学及分子对接分析,揭示了补肾固齿丸治疗肾虚血热型牙周病的有效物质基础及作用机制。[方法]通过中药系统药理学数据库与分析平台(TCMSP)等数据库及平台检索补肾固齿丸复方中各味药材的所有有效成分及相应靶标,在人... 详细信息

[目的]通过网络药理学及分子对接分析,揭示了补肾固齿丸治疗肾虚血热型牙周病的有效物质基础及作用机制。[方法]通过中药系统药理学数据库与分析平台(TCMSP)等数据库及平台检索补肾固齿丸复方中各味药材的所有有效成分及相应靶标,在人类基因数据库(Gene Cards)及在线《人类孟德尔遗传》(OMIM)平台检索疾病相关靶基因,构建补肾固齿丸“活性成分-成分对应靶标-牙周病靶标”网络,进一步筛选进行网络拓扑学分析,并对有效核心成分及关键靶标进行分子对接,分析小分子配体与受体的结合能力。[结果]筛选出12个活性成分,25个靶标,关键靶标3个,分别为雌激素受体(ESR1)、表皮生长因子受体(EGFR)、磷酸肌醇3-激酶α(PIK3CA)。这些成分及靶标基因通过对核受体活性、蛋白激酶活性、酶激活剂活性、生长因子结合、血红素结合、内肽酶活性、蛋白质同二聚活性等的调节,参与细胞肿瘤抗原(P53)及核因子κB(NF-κB)信号通路的调控过程对牙周病的治疗起到重要作用。分子对接分析发现,3个关键靶标与12个活性成分(Quercetin、Aureusidin、Physcion等)均具有一定的亲和力。[结论]补肾固齿丸通过复杂的网络调控对肾虚血热型牙周病的起到有效治疗作用,该研究为更进一步探索其治疗相关证候的作用机制及临床应用提供了研究思路和理论基础。

关键词：补肾固齿丸肾虚血热型牙周病网络药理学分子对接物质基础作用机制

The protective effect of cyclodextrin on the color quality and stability of Cabernet Sauvignon red wine

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Journal of Integrative Agriculture 2024年第1期23卷 310-323页

作者： Caiyun Liu Lulu wu Shuyue Fan yongsheng Tao Yunkui Li College of Enology Northwest A&F UniversityYangling 712100China Ningxia Helan Mountain’s East Foothill Wine Experiment and Demonstration Station of Northwest A&F University Minning 750104China

The impact of cyclodextrins(CDs)on wine quality and stability remains largely *** study systematically assessed the protective effect of the post-fermentation addition of CDs on color stability of red wine from the viewpoints of color characteristics,copigmentation and phenolic *** grey relational analysis(GRA)and principal component analysis(PCA)methods were employed to dissect the key effective determinants related to color *** addition of CDs induced a significant hyperchromic effect of 8.19-25.40%,a significant bathochromic effect and an enhancement of the color ***,the evolution of anthocyanin forms and the content of monomeric anthocyanins revealed that β-CD is a superior favorable cofactor during wine aging,but for long-term aging,2-HP-β-CD and 2-HP-γ-CD are more beneficial in promoting the formation of polymerized anthocyanins and color *** work provides an important reference for the use of CDs to enhance the color quality and stability of red wines.

关键词： cyclodextrins color properties copigmentation Helan Mountain’s East Foothill red wine aging

Systematic study on size and temporal dependence of micro-LED arrays for display applications

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Photonics Research 2023年第4期11卷 549-557页

作者： JUNYANG NIE ZHI ZHANG KONGJIE CHEN YIFENG LIU SHUANG HE ZHONGHANG HUANG XIAONING ZHANG JIE SUN FAN ZHANG yongsheng wu QUN YAN Faculty of Electronic and Information Engineering Xi’an Jiaotong UniversityXi’an 710049China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China and National and Local United Engineering Laboratory of Flat Panel Display TechnologyCollege of Physics and Information EngineeringFuzhou UniversityFuzhou 350100China Quantum Device Physics Laboratory Department of Microscience and NanotechnologyChalmers University of TechnologyGöteborg 41296Sweden Fujian Prima Optoelectronics Company Ltd. Fuzhou 350000China Rich Sense Electronics Technology Inc. Jinjiang 362200China

Micro-LEDs are one of the most promising candidates for next-generation displays,yet they are inconvenienced by the efficiency reduction induced by the sidewall defects when pursuing further scaled-down device *** have systematically investigated both the size and temporal dependence of ***-LED arrays with a mesa size ranging from 7 to 100μm were prepared for display *** luminance and external quantum efficiency(EQE)were measured and ***,micro-LED arrays with a smaller mesa size exhibit a higher EQE under 100 ns pulse duration operation when compared with longer pulse duration *** certain short-pulsed excitation,a 7×7μm^(2)micro-LED array even exhibits a>20%higher EQE as compared to the direct current(DC)or the long duration pulse operation *** thus concluded that the notorious efficiency reduction induced by sidewall defects in small-sized micro-LED arrays could be significantly reduced by applying short-pulse voltages.

关键词： arrays pulse size

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增强雷达信号处理技术应对干扰攻击的影响

电子技术（上海） 2024年第5期53卷 376-377页

作者：王泽明吴永胜黄亮郑程航张乐天 92682部队广东524000

阐述通过采用数字信号处理技术、自适应滤波器和机器学习算法,可以识别并应对不同类型的干扰攻击。成功案例表明,增强雷达信号处理技术是提高雷达系统性能和鲁棒性的关键因素。

关键词：雷达信号处理敌对干扰攻击数字信号处理自适应滤波器机器学习算法

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可控震源闭环控制技术简析

物探装备 2024年第2期34卷 103-105页

作者：武永生樊慧文槐永军王林超王洪涛中国石油集团东方地球物理勘探有限责任公司装备服务中心河北涿州072750

作为地震勘探重要激发源的可控震源在地震勘探中起着非常重要的作用,但是,可控震源本身包含机械、液压、地面多个非线性子系统,属多输入多输出系统非线性反馈范畴,难以控制,经典的开环控制不适用可控震源,如何利用精确线性化控制实现可... 详细信息

作为地震勘探重要激发源的可控震源在地震勘探中起着非常重要的作用,但是,可控震源本身包含机械、液压、地面多个非线性子系统,属多输入多输出系统非线性反馈范畴,难以控制,经典的开环控制不适用可控震源,如何利用精确线性化控制实现可控震源控制系统鲁棒全局稳定性是关键一环。本文针对可控震源振动器闭环系统做了阐述,重点介绍可控震源振动器闭环系统的架构、系统的多个闭环、工作原理、伺服闭环控制技术以及影响闭环控制系统的一些因素。

关键词：闭环控制振动器闭环加权

A method for passive sonar broadband target detection based on peak filtering in frequency-wavenumber domain

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Chinese Journal of Acoustics 2023年第3期42卷 270-287页

作者： NING Jiangbo LI Yu wu yongsheng CHI Cheng LI Zigao LI Shuqiu Institute of Acoustics Chinese Academy of SciencesBejing 100190 Key Laboratory of Science and Technology on Advanced Underwater Acoustic Signal Processing Chinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100049 Unit 92682PLA Zhanjiang 524000

Traditional detection of broadband targets in passive sonars has low output signalto-noise ratio and poor performance in a complex situation with multiple targets and strong interferences. To solve this problem, this paper proposes a target detection method based on the characteristic of the energy distribution of broadband signals in the frequency-wavenumber domain by using uniform linear array. The proposed method converts the array signal into the frequency-wavenumber domain and uses the characteristics of the width and the spatial distribution of the main lobes and the side lobes to discriminate the main lobes in the wavenumber domain. After discriminating the main lobes of the same target at different frequencies, the accumulation of main lobe energy and the number of main lobes are used as the azimuth spectra for target detection. The theoretical analysis and simulations show the proposed method only utilizes the main lobes which have prominent contributions to target detection, thereby reducing the influence of the side lobes dramatically and improving the detection performance significantly. The results of trial data processing show that the output signal-to-noise ratio of the proposed method can be increased by 5.58 dB compared to SPED and 8.73 dB compared to CED. In addition, the computing time is decreased by 46% compared to CED, which validates the superiority of the proposed method.

关键词： passive wave number

腾格里沙漠人工固沙植被区藓类植物形态演变特征

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中国沙漠 2024年第3期44卷 298-307页

作者：万雨晨刘彦平吴永胜贾鸿飞张甜高艳红杨昊天尤万学杜军贾荣亮中国科学院西北生态环境资源研究院沙坡头沙漠研究试验站甘肃兰州730000 中国科学院西北生态环境资源研究院临泽内陆河流域研究站甘肃兰州730000 中国科学院大学北京100049 内蒙古师范大学地理科学学院内蒙古呼和浩特010000 宁夏中卫沙坡头国家级自然保护区管理局宁夏中卫755700

形态演变特征能够反映植物体对环境变化的适应策略。为了解藓类植物适应干旱沙区环境演变的形态变化特征,以腾格里沙漠东南缘人工固沙植被区内的真藓(Bryum argenteum)、土生对齿藓(Didymodon vinealis)和齿肋赤藓(Syntrichia caninerv... 详细信息

形态演变特征能够反映植物体对环境变化的适应策略。为了解藓类植物适应干旱沙区环境演变的形态变化特征,以腾格里沙漠东南缘人工固沙植被区内的真藓(Bryum argenteum)、土生对齿藓(Didymodon vinealis)和齿肋赤藓(Syntrichia caninervis)为研究对象,采用空间代时间的方法,解析了不同植被年龄区(35、41、66年)的藓类植物在叶片、个体、种群和群落水平的形态特征和数量特征的变化规律。结果表明:随着植被年龄的增加,3种藓的形态性状呈现出一定的差异性。突出体现在土生对齿藓的叶面积、叶尖长和株高不断下降,而真藓和齿肋赤藓表现出非持续性变化,这可能与种内和种间的资源竞争有关。尽管如此,从整体特征来看,腾格里沙漠人工固沙植被区藓类植物在生态系统修复过程中普遍经历了由茎叶体小、密度大向茎叶体大、密度小的演变趋势。

关键词：藓类植物形态适应植被演替干旱区

NUMERICAL SIMULATION OF 1998 RED TIDE OF THE BOHAI SEA

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International Journal of Sediment Research 2002年第3期17卷 175-185页

作者： yongsheng wu,Zhao-Yin WANG Hydraulic Engineering Tsinghua University Beijing 100084 China Hydraulic Engineering Tsinghua University Beijing 100084 China

Algal bloom, known as red tide, has occurred frequently in the Bohai Sea in recent decades causing great economic losses to fisheries as well as having significant adverse impact on the environment. A 3-D Eco-Hydraulic model is developed to simulate the explosive propagation of diatom and dinoflagellate as a function of the concentration of various nutrients, river inflow, tide, temperature, wind, sunshine and rainfall. The model is intended to answer the questions of how the 1998 Bohai Sea red tide occurred, and to investigate how environmental factors, such as temperature, wind, rainfall, solar radiance, sea currents and nutrients, affect the algal bloom process. The parameters employed in the model are calibrated with the data collected in the periods 1982-1983 and 1992-1993. Results from the model indicate that eutrophication of the seawater is the basic condition for algal bloom, and that the 1998 red tide was triggered by the abnormal warm weather in August and September.

关键词： Algal bloom Eco-hydrodynamic model Bohai Sea Red tide Eutrophication

微波消解-电感耦合等离子体质谱(ICP-MS)法测定稀释沥青中23种元素

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中国无机分析化学 2024年第4期14卷 490-497页

作者：吴永盛徐金龙曾恒媛黄武郑羽茜庄姜云湛江海关技术中心广东湛江524000

稀释沥青是一种中间产品,主要用于生产沥青。目前测定稀释沥青中元素含量的方法较少,前处理过程繁琐。通过优化样品称样量、消解试剂、赶酸温度,选择合适的前处理方式;通过引入内标元素对非质谱干扰进行校正;通过调谐优化仪器参数,选择... 详细信息

稀释沥青是一种中间产品,主要用于生产沥青。目前测定稀释沥青中元素含量的方法较少,前处理过程繁琐。通过优化样品称样量、消解试剂、赶酸温度,选择合适的前处理方式;通过引入内标元素对非质谱干扰进行校正;通过调谐优化仪器参数,选择碰撞反应池He模式,采用干扰方程,选择合适同位素等手段对质谱干扰进行了校正;采用45 Sc、72 Ge、115 In、209 Bi作为内标元素,对方法的检出限、精密度、准确度等进行考察,建立了微波消解-电感耦合等离子体质谱法同时测定稀释沥青中铝、钒、铬、锰、铁、钴等23种元素的方法。在优化的实验条件下,23种元素在一定的质量浓度范围内与其信号强度呈线性关系,标准曲线线性良好,相关系数在0.999~1.000,方法的检出限在0.0005~1.0 mg/kg,方法用加标回收测定回收率,加标回收率在80.0%~110%,对稀释沥青样品平行测定7次,测定值的相对标准偏差在0.47%~3.1%。对进口稀释沥青中23种元素进行测定,满足国家标准对各项技术指标参数的要求,检出限低,选择性好,结果准确可靠,为稀释沥青类样品中多种元素分析测定提供了新的参考方法。

关键词：电感耦合等离子体质谱法稀释沥青微波消解碰撞反应