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Computational analysis of antigenic epitopes of avian influenza A (H7N9) viruses

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Science China(Life Sciences) 2015年第7期58卷 687-693页

作者： LIU Mi SONG TingRui HUA Sha wu aiping JIANG TaiJiao Institute of Biophysics Chinese Academy of Sciences University of Chinese Academy of Sciences

Influenza virus can rapidly change its antigenicity, via mutation in the hemagglutinin(HA) protein, to evade host immunity. The emergence of the novel human-infecting avian H7N9 virus in China has caused widespread concern. However, evolution of the antigenicity of this virus is not well understood. Here, we inferred the antigenic epitopes of the HA protein from all H7 viruses, based on the five well-characterized HA epitopes of the human H3N2 virus. By comparing the two major H7 phylogenetic lineages, i.e., the Eurasian lineage and the North American lineage, we found that epitopes A and B are more frequently mutated in the Eurasian lineage, while epitopes B and C are more frequently mutated in the North American lineage. Furthermore, we found that the novel H7N9 virus(derived from the Eurasian lineage) isolated in China in the year 2013, contains six frequently mutated sites on epitopes that include site 135, which is located in the receptor binding domain. This indicates that the novel H7N9 virus that infects human may already have been subjected to gradual immune pressure and receptor-binding variation. Our results not only provide insights into the antigenic evolution of the H7 virus but may also help in the selection of suitable vaccine strains.

关键词： antigenic epitope antigenic evolution hemagglutinin influenza H7N9 virus

Progress and Challenge in Computational Identification of Influenza Virus Reassortment

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Virologica Sinica 2021年第6期36卷 1273-1283页

作者： Xiao Ding Luyao Qin Jing Meng Yousong Peng aiping wu Taijiao Jiang Center for Systems Medicine Institute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China College of Biology Hunan Provincial Key Laboratory of Medical VirologyHunan UniversityChangsha 410082China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Guangzhou 510005China Suzhou Institute of Systems Medicine SuzhouJiangsu 215123China

Genomic reassortment is an important evolutionary mechanism for influenza *** this process,the novel viruses acquire new characteristics by the exchange of the intact gene segments among multiple influenza virus genomes,which may cause flu endemics and epidemics within or even across *** to the safety and ethical limitations of the experimental studies on influenza virus reassortment,numerous computational researches on the influenza virus reassortment have been done with the explosion of the influenza virus genomic data.A great amount of computational methods and bioinformatics databases were developed to facilitate the identification of influenza virus *** this review,we summarized the progress and challenge of the bioinformatics research on influenza virus reassortment,which can guide the researchers to investigate the influenza virus reassortment events reasonably and provide valuable insight to develop the related computational identification tools.

关键词： Influenza virus Reassortment Bioinformatics Identification Database

消毒供应中心对外来医疗器械全程质量管理的效果分析

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实用医技杂志 2024年第4期31卷 300-302页

作者：王砾燕格格武爱苹赵媛武警山西总队医院消毒供应科太原030006

目的查看消毒供应中心对外来医疗器械全程质量管理的应用效果。方法择取我院骨科外来医疗器械作为本文调查样本,共收取480件,将其随机分为对照组和实验组,其中对照组的240件外来医疗器械采用医院消毒供应中心(CSSD)传统模式进行清洗消... 详细信息

目的查看消毒供应中心对外来医疗器械全程质量管理的应用效果。方法择取我院骨科外来医疗器械作为本文调查样本,共收取480件,将其随机分为对照组和实验组,其中对照组的240件外来医疗器械采用医院消毒供应中心(CSSD)传统模式进行清洗消毒灭菌;实验组的240件外来医疗器械实施全程质量管理后清洗消毒灭菌;数据评价包括:不同管理模式应用于外来医疗器械清洗灭菌效果,通过问卷的方式来分析医护人员对器械使用的满意情况。结果实验组清洗合格率为98.3%、性能完好率为99.2%,灭菌合格率100%;对照组的清洗合格率为91.7%、性能完好率为94.2%,灭菌合格率97.5%,差异有统计学意义(P<0.05)。实验组的科室满意度为98.3%高于对照组85.0%,差异有统计学意义(χ^(2)=27.994,P<0.05)。结论消毒供应中心对外来医疗器械实施清洗灭菌期间采用全程质量管理,可明显提高外来医疗器械的清洗灭菌质量,有效保证外来医疗器械的临床安全使用。

关键词：设备和供应消毒供应中心外来医疗器械质量管理

Tuning electronic structure of Ni_(3)S_(2) with tungsten doping for high-performance electrooxidation of 5-hydroxymethylfurfural

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Science China Chemistry 2023年第12期66卷 3636-3644页

作者： Shuangyue Wang Ganceng Yang Yanqing Jiao Yue Liu Chungui Tian aiping wu Haijing Yan Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080China

Electrooxidation of the biomass derivative 5-hydroxymethylfurfural (HMF) is a highly promising approach for attaining versatile value-added chemicals (e.g.,2,5-furandicarboxylic acid,FDCA).Ni-based sulfides are promising electrocatalysts for HMF electrooxidation reaction (HMFOR).However,the HMFOR activity of Ni-based catalysts is far from satisfactory due to the unfavorable adsorption of HMF and OH^(*).Herein,we propose controlled W doping to effectively modify the electronic configuration of nanostructured Ni_(3)S_(2) to manipulate adsorption of HMF and OH^(*),for efficiently converting HMF into *** and theoretical calculations indicate the incorporation of high-valence W results in the upshift of d-band center of Ni_(3)S_(2),which facilitates the adsorption and dissociation of water to produce more OH^(*).Meanwhile,the high-valence W has strong electron-withdrawing ability and attracts electrons from Ni,leading to the elevated Ni valence,which is beneficial to optimizing the adsorption energy of *** concurrently contribute to the superb HMFOR *** a result,W_(20)-Ni_(3)S_(2)@NF with optimal W dopant exhibits a low driving potential (1.34 V *** at 10 mA cm^(-2)),accompanying with the 100% HMF conversion,99.2%FDCA selectivity,and 97.3%Faraday *** work provides a design principle for HMFOR electrocatalysts by modulating the adsorption behaviors of HMF and OH^(*)via rational electronic structure engineering.

关键词： 5-hydroxymethylfurfural electrooxidation W doping Ni-based sulfides electronic structure adsorption energy

Small-sized tungsten nitride anchoring into a 3D CNT- rGO framework as a superior bifunctional catalyst for the methanol oxidation and oxygen reduction reactions

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Nano Research 2016年第2期9卷 329-343页

作者： Haijing Yan Meichen Meng Lei Wang aiping wu Chungui Tian Lu Zhao Honggang Fu Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People's Republic of China Heilongjiang University Harbin 150080 China

The application of direct methanol fuel cells （DMFC） is hampered by high cost, low activity, and poor CO tolerance by the Pt catalyst. Herein, we designed a fancy 3D hybrid by anchoring tungsten nitride （WN） nanoparticles （NPs）, of about 3 nm in size, into a 3D carbon nanotube-reduced graphene oxide framework （CNT-rGO） using an assembly route. After depositing Pt, the contacted and strongly coupled Pt-WN NPs were formed, resulting in electron transfer from Pt to WN. The 3D Pt-WN/CNT-rGO hybrid can be used as a bifunctional electrocatalyst for both methanol oxidation reaction （MOR） and oxygen reduction reaction （ORR）. In MOR, the catalysts showed excellent CO tolerance and a high mass activity of 702.4 ***-1, 2.44 and 3.81 times higher than those of Pt/CNT-rGO and Pt/C（JM） catalysts, respectively. The catalyst also exhibited a more positive onset potential （1.03 V）, higher mass activity （151.3 ***-1）, and better cyclic stability and tolerance in MOR than ORR. The catalyst mainly exhibited a 4e-transfer mechanism with a low peroxide yield. The high activity was closely related to hybrid structure. That is, the 3D framework provided a favorable path for mass-transfer, the CNT-rGO support was favorable for charge transfer, and strongly coupled Pt-WN can enhance the catalytic activity and CO-tolerance of Pt. Pt-WN/CNT-rGO represents a new 3D catalytic platform that is promising as an electrocatalyst for DMFC because it can catalyze both ORR and MOR in an acidic medium with good stability and highly efficient Pt utilization.

关键词： small-sized tungste nnitride 3D CNT-rGO bifunctional catalyst methanol oxidation reaction oxygen reduction reaction

Synchronous regulation of morphology and electronic structure of FeNi-P nanosheet arrays by Zn implantation for robust overall water splitting

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Nano Research 2023年第4期16卷 5733-5742页

作者： Li Sun Ying Dang aiping wu Chungui Tian Dongxu Wang Haijing Yan Yachen Gao Honggang Fu Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080China Key Laboratory of Electronics Engineering College of Heilongjiang ProvinceHeilongjiang UniversityHarbin 150080China Chemistry and Chemical Engineering Institute Qiqihar UniversityQiqihar 161006China

FeNi-based phosphides are one of the most hopeful electrocatalysts,whereas the significant challenge is to achieve prominent bifunctional catalytic activity with low voltage for water *** morphology and electronic structure of FeNi-based phosphides can intensively dominate effective catalysis,therefore their simultaneous regulating is extremely ***,a robust bifunctional catalyst of Zn-implanted FeNi-P nanosheet arrays(Zn-FeNi-P)vertically well-aligned on Ni foam is successfully fabricated by Zn implanting *** Zn fulfills the role of electronic donor due to its low electronegativity to enhance the electronic density of FeNi-P for optimized water dissociation ***,the implantation of Zn into FeNi-P can effectively regulate morphology of the catalyst from thick and irregular nanosheets to ultrathin lamellar structure,which generates enriched catalytic active sites,leading to accelerating electron/mass transport ***,the designed Zn-FeNi-P catalyst manifests remarkable hydrogen evolution reaction(HER)activity with low overpotentials of 55 and 225 mV at 10 and 200 mA·cm^(−2),which is superior to the FeNi-P(82 mV@10 mA·cm^(−2)and 301 mV@200 mA·cm^(−2)),and even out-performing the Pt/C catalyst at a high current density>200 mA·cm^(−2).Moreover,the oxygen evolution reaction(OER)activity of Zn-FeNi-P also has dramatically improved(207 mV@10 mA·cm^(−2))comparable to FeNi-P(221 mV@10 mA·cm^(−2))and RuO_(2)(239 mV@10 mA·cm^(−2)).Noticeably,an electrolyzer based on Zn-FeNi-P electrodes requires a low cell voltage of 1.47 V to achieve 10 mA·cm^(−2),far beyond the catalytic activities of FeNi-P||FeNi-P(1.51 V@10 mA·cm^(−2))and the benchmark RuO_(2)||Pt/C couples(1.56 V@10 mA·cm^(−2)).This Zn-implanting strategy paves a new perspective for the development of admirable bifunctional catalysts.

关键词： Zn-implanted FeNi-P nanosheet arrays regulating morphology and electron density bifunctional catalyst overall water splitting

The cellular immunotherapy of integrated photothermal anti-oxidation Pde Se nanoparticles in inhibition of the macrophage inflammatory response in rheumatoid arthritis

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Acta Pharmaceutica Sinica B 2021年第7期11卷 1993-2003页

作者： Chuping Zheng aiping wu Xinyun Zhai Hong Ji Zhikang Chen Xu Chen Xiyong Yu Key Laboratory of Molecular Target&Clinical Pharmacology and the State Key Laboratory of Respiratory Disease Pharmacological Group School of Pharmaceutical Sciences&the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China The First Affiliated Hospital Jinan UniversityGuangzhou 510632China Nankai University School of Materials Science&EngineeringTianjin Key laboratory of Rare earth materials&applicationsCenter of Rare earth&Inorganic functional materialsTianjin 300350China

Reducing the inflammatory response is a major goal in the therapy of rheumatoid arthritis(RA).Herein,we integrated palladium nanoparticles(Pd NPs)with selenium nanoparticles(Se NPs)and obtained a multiple nanosystem(Pd@Se-HA NPs)that could simultaneously scavenge hydroxyl radicals(·OH)and provide a photothermal *** Pd@Se-HA NPs were constructed by a simple selfassembly method in which Se NPs were electrostatically bonded to Pd NPs;hyaluronic acid(HA)was linked to the NPs by ester bonding to provide macrophage targeting *** experiments show that the combined therapy of eliminating·OH with Se NPs and utilizing PTT with Pd NPs could effectively reduce the inflammatory response in macrophages more effectively than either individual NP *** addition,the outer layer of HA could specifically target the CD44 receptor to enhance the accumulation of Pd@Se NPs at the lesion,further enhancing the therapeutic *** treatment for 15 days,the Pd@Se-HA NPs nearly eliminated the inflammatory response in the joints of mice in an induced RA model,and prevented joint damage and degradation.

关键词： Rheumatoid arthritis Inflammatory response Photothermal therapy Anti-oxidation therapy Core-shell structure

Coevolution signals capture the specific packing of secondary structures in protein architecture

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Protein & Cell 2014年第6期5卷 480-483页

作者： Deng, Lizong Dong, Xiaoxi wu, aiping Song, Tingrui Jiang, Taijiao Chinese Acad Sci Inst Biophys Natl Lab Biomacromol Key Lab Prot & Peptide Pharmaceut Beijing 100101 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China

Decoding protein structural characteristics and formation is essential to the understanding of its function. Despite the diversity and enormity of protein universe, the dissection of known protein structures has identified regular secondary structure elements （SSEs）, namely, a-helix and β-strand, that constitute the basic structural elements of protein universe （Levitt and Chothia, 1976）. As a remarkable characteristics of the overall topology of a polypeptide, the specific spatial arrangement of these SSEs is a hallmark of the protein tertiary conformation （Murzin et al., 1995）.

关键词： Specific Packing Physiochemical Property Protein Structure Prediction Protein Universe Protein Topology

A dual-active Co-CoO heterojunction coupled with Ti_(3)C_(2)-MXene for highly-performance overall water splitting

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Nano Research 2022年第1期15卷 238-247页

作者： Dezheng Guo Xin Li Yanqing Jiao Haijing Yan aiping wu Ganceng Yang Yu Wang Chungui Tian Honggang Fu Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People's Republic of China Heilongjiang UniversityHarbin 150080China Department of Cardiovascular Medicine Heilongjiang Provincial HospitalHarbin 150080China

Development of cost-effective and highly-efficient bifunctional hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)catalysts is crucial for overall water splitting in practical ***,we proposed a novel non-noble metal bifunctional,HER/OER electrocatalyst by synergistically coupling a dual-active Co-based heterojunction(Co-CoO)with high conductive and stable two-dimensional Ti_(3)C_(2)-MXene(defined as Co-CoO/Ti^(3)CrMXene).A series of characterizations and theoretical calculations'verify that the synergistic effect of metallic Co with HER activity and Coo with OER performance leads to superb bifunctional catalytic performance,and Ti_(3)C_(2)-MXene can enhance electrical conductivity and prevent the aggregation of the Co-based catalysts,thereby improving both the activity arid ***-Co0/Ti_(3)C_(2)-MXene presents low onset potential(11onse1)of 8 mV and,Tafel slope of 47 mV·dec^(-1) for HER(close to that of Pt/C)and 17onset of 196 mV and Tafel slope of 47 mV·dec^(-1) for OER(superior to:that of Ru02).Assembled as an electrolyzer,Co-CoO/Ti_(3)C_(2)-MXene shows a low voltage of 1.55 V at 10 mA·cm^(-2),high Faradaic efficiency and remarkable *** can be driven by a solar cell of-1.55 V for consecutive production of hydrogen and oxygen gases.

关键词： overall water splitting MXene Co-CoO heterojunction electrocatalysis