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Milk fat globule epidermal growth factor 8 alleviates liver injury in severe acute pancreatitis by restoring autophagy flux and inhibiting ferroptosis in hepatocytes

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World Journal of Gastroenterology 2024年第7期30卷 728-741页

作者： Qing Cui Hang-Cheng Liu wu-Ming Liu Feng Ma Yi Lv Jian-Cang Ma Rong-qian wu Yi-Fan Ren Department of Cardiology Xi’an Central Hospital Affiliated to Xi’an Jiaotong UniversityXi’an 710003Shaanxi ProvinceChina Department of General Surgery The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina National Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical EngineeringFirst Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Vascular Surgery The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina

BACKGROUND Liver injury is common in severe acute pancreatitis(SAP).Excessive autophagy often leads to an imbalance of homeostasis in hepatocytes,which induces lipid peroxidation and mitochondrial iron deposition and ultimately leads to *** previous study found that milk fat globule epidermal growth factor 8(MFG-E8)alleviates acinar cell damage during SAP via binding toαvβ3/5 ***-E8 also seems to mitigate pancreatic fibrosis via inhibiting chaperone-mediated *** To speculate whether MFG-E8 could also alleviate SAP induced liver injury by restoring the abnormal autophagy *** SAP was induced in mice by 2 hly intraperitoneal injections of 4.0 g/kg L-arginine or 7 hly injections of 50μg/kg cerulein plus ***8-knockout mice were used to study the effect of MFG-E8 deficiency on SAPinduced liver ***,a specificαvβ3/5 integrin inhibitor,was used to investigate the possible mechanism of *** The results showed that MFG-E8 deficiency aggravated SAP-induced liver injury in mice,enhanced autophagy flux in hepatocyte,and worsened the degree of *** MFG-E8 reduced SAP-induced liver injury in a dose-dependent ***,MFG-E8 mitigated excessive autophagy and inhibited ferroptosis in liver *** abolished MFG-E8’s beneficial effects in SAP-induced liver *** MFG-E8 acts as an endogenous protective mediator in SAP-induced liver ***-E8 alleviates the excessive autophagy and inhibits ferroptosis in hepatocytes by binding to integrinαVβ3/5.

关键词： Autophagy flux Ferroptosis Liver injury Milk fat globule epidermal growth factor 8 αvβ3/5 integrins Acute pancreatitis

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Influence of sintering time on microstructure and properties of hot oscillatory pressing sintered W–Cu refractory alloys

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Tungsten 2024年第2期6卷 323-332页

作者： Zi-qian wu Wei Zhao Ka Gao Shi-Hao Du Qing-Quan Kong De-Jian Sun Yang Gao School of Materials Science and Engineering Zhengzhou University of AeronauticsZhengzhou 450015China School of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of General Medicine Changhai HospitalShanghai 200000China Hubei Key Laboratory of Mechanical Transmission and Manufacturing Engineering Wuhan University of Science and TechnologyWuhan 430081China Sichuan Province Engineering Technology Research Center of Powder Metallurgy Chengdu UniversityChengdu 610106China

W–Cu refractory alloys are widely used in aerospace,aviation,electronics,power,and other fi ***,because of its large melting point diff erence between alloy elements,the conventional powder metallurgy method required a long time of high temperature sintering is very likely to cause low density and abnormal grain size ***,90W-10Cu refractory alloys were successfully prepared by hot oscillatory pressing(HOP)under diff erent sintering time in this *** the infl uence of sintering time on the microstructure,grain size,density,Vickers hardness,room-tensile property,and electrical conductivity of the W–Cu refractory alloy was systematically *** results showed that during the short sintering time(30–90 min),the density,Vickers hardness,tensile strength,and electrical conductivity of the W–Cu refractory alloy increased signifi cantly to 98.7%,163.29 HV 30,507.3 MPa,and 14.2%International Annealed Copper Standard with the sintering time increasing,respectively,while its grain size showed no obvious *** the sintering time further increased to 120 min,the density was basically consistent with the sintering time of 90 ***,the prolonged high temperature sintering resulted in the grain growth of the samples,which caused the deterioration of the Vickers hardness,room-tensile strength,and conductivity properties of the W–Cu refractory *** the same sintering time,the density,Vickers hardness,and electrical conductivity of the HOP sintered W–Cu refractory alloy were signifi cantly higher than those of the HP sintered *** was indicated that high density,fi ne-grain,and excellent properties W–Cu refractory alloys could be prepared by hot oscillatory pressing under appropriate sintering time.

关键词： W–Cu refractory alloy Hot oscillatory pressing Sintering time Microstructure Property

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Passive daytime radiative cooling coatings with renewable self-cleaning functions

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Chinese Chemical Letters 2024年第2期35卷 257-262页

作者： qian wu Yubo Cui Guifeng Xia Jinlong Yang Shuming Du Xinhong Xiong Li Yang Dong Xu Xu Deng Jiaxi Cui Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Yangtze Delta Region Institute (Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China Beijing Key Laboratory of Power Generation System Functional Material CHN Energy New Energy Technology Research Institute Ltd.Beijing 102209China Institute for Advanced Study Chengdu UniversityChengdu 610106China

Passive daytime radiative cooling(PDRC)technology is emerging as one of the most promising solutions to the global problem of spacing cooling,but its practical application is limited due to reduced cooling effectiveness caused by daily wear and tear,as well as dirt *** tackle this problem,we report a novel strategy by introducing a renewable armor structure for prolonging the anti-fouling and cooling effectiveness properties of the PDRC *** armor structure is designed by decorating fluorinated hollow glass microspheres(HGM)inside rigid resin composite *** HGM serve triple purposes,including providing isolated cavities for enhanced solar reflectance,reinforcing the matrices to form robust armored structures,and increasing thermal *** the coatings are worn,the HGM on the surface expose their concave cavities with numerous hydrophobic fragments,generating a highly rough surface that guarantee the superhydrophobic *** coatings show a high sunlight reflectance(0.93)and thermal emittance(0.94)in the long-wave infrared window,leading to a cooling of 5℃ below ambient temperature under high solar flux(∼900 W/m^(2)).When anti-fouling functions are reduced,they can be regenerated more than 100 cycles without compromising the PDRC function by simple wearing ***,these coatings can be easily prepared using a one-pot spray method with low-cost materials,exhibit strong adhesion to a variety of substrates,and demonstrate exceptional environmental ***,we anticipate their immediate application opportunities for spacing cooling.

关键词： Superhydrophobic Passive radiative cooling Wearing Regeneration Glass resin armor

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Effects of Inoculation with Phosphate Solubilizing Bacteria on the Physiology,Biochemistry,and Expression of Genes Related to the Protective Enzyme System of Fritillaria taipaiensis ***

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Phyton-International Journal of Experimental Botany 2024年第2期93卷 247-260页

作者： Zhifen Shi Fumei Pan Xiaotian Kong Jiaqi Lang Mingyan Ye qian wu Guangzhi Wang Liang Han Nong Zhou College of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu611130China College of Pharmacy Dali UniversityDali671000China College of Food and Biological Engineering Chongqing Three Gorges UniversityChongqing404120China Diqing Tibetan Autonomous Prefecture Institute of Plateau Biology Diqing674400China Chongqing Institute of Medicinal Plant Cultivation Chongqing408435China

Fritillaria taipaiensis *** is a widely used medicinal herb in treating pulmonary *** recent years,its wild resources have become scarce,and the demand for efficient artificial cultivation has significantly *** article is the first to apply phosphate solubilizing bacteria isolated from the rhizosphere soil of *** *** to the cultivation process of *** *** aim is to identify suitable reference strains for the artificial cultivation and industrial development of *** *** by examining the effects of various phosphate solubilizing bacteria and their combinations on photosynthesis,physiological and biochemical properties,and gene expression related to the protective enzyme system in *** *** experiment,conducted in pots at room temperature,included a control group(CK)and groups inoculated with inorganic phosphorussolubilizing bacteria:W1(Bacillus cereus),W2(Serratia plymuthica),W12(Bacillus cereus and Serratia plymuthica),and groups inoculated with organophosphorus-solubilizing bacteria:Y1(Bacillus cereus),Y2(Bacillus cereus),Y12(Bacillus cereus and Bacillus cereus),totaling seven *** to CK,most growth indices in the bacterial addition groups showed significant differences,with W12 achieving the highest values in all indices except the leaf area *** content of photosynthetic pigments,photosynthetic parameters,and osmoregulatory substances increased variably in each bacterial treatment group.W12 exhibited the highest content of chlorophyll a and soluble protein,while W1 had the highest free proline *** activities of peroxidase(POD),superoxide dismutase(SOD),and catalase(CAT)in all inoculated groups were higher than in CK,with significant changes in SOD and CAT *** malondialdehyde(MDA)content in all inoculated groups was lower than in CK,with Y12 being the lowest,at approximately 30%of *** expression corresponding to these three enzymes also increased var

关键词： Fritillaria taipaiensis P.Y.Li phosphate solubiliozing bacteria photosynthesis physiology and biochemistry protective enzymes

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Surface ozone in global cities:A synthesis of basic features,exposure risk,and leading meteorological driving factors

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Geography and Sustainability 2024年第1期5卷 64-76页

作者： Jinmian Ni Jiming Jin Yanwen Wang Bin Li qian wu Yanfei Chen Shenwen Du Yilin Li Chao He College of Resources and Environment Yangtze UniversityWuhan 430100China Hubei Key Laboratory of Petroleum Geochemistry and Environment Yangtze UniversityWuhan 430100China School of Resource and Environmental Science Wuhan UniversityWuhan 430079China Economics and Management College China University of GeosciencesWuhan 430074China

Long-term exposure to high surface ozone(O_(3))concentrations,a complex oxidative atmospheric pollutant,can adversely impact human *** on O_(3)monitoring data from 261 cities worldwide in 2020,generalized additive model(GAM)and spatial data analysis(SDA)methods were applied in this study to quantitatively evaluate the spatiotemporal distribution of O_(3)concentration,exposure risk,and dominant meteorological *** indicated that over 40%of the cities worldwide were exposed to harmful O_(3)concentration ranges(40-60μg/m^(3)),with most cities distributed in China and ***,significant seasonal variations in global O_(3)concentrations were observed,presenting as summer(45.6μg/m^(3))>spring(47.3μg/m^(3))>autumn(38.0μg/m^(3))>winter(33.6μg/m^(3)).Exposure analysis revealed that approximately 12.2%of the population in 261 cities were exposed to an environment with high O_(3)concentrations(80-160μg/m^(3)),with about 36.32 million people in major ***,the persistent increase in high O_(3)levels worldwide is a critical factor contributing to threats to human ***,GAM results indicated temperature,relative humidity,and wind speed as primary determinants of O_(3)*** synergy of meteorological factors is critical for understanding O_(3)*** findings are important for enforcing robust air quality policies and mitigating public risk.

关键词： Ozone pollution Spatiotemporal variation Exposure risk GAM Meteorological factors

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乾隆朝内府制仿古铜镜研究三议

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故宫博物院院刊 2024年第3期 69-84,140页

作者：吴倩故宫博物院器物部

清代是中国铜镜日趋衰落的时期,但宫廷内府制作铜镜具有特殊性。其中,仿古铜镜是宫廷制镜的重要构成,尤以乾隆朝最盛。本文基于乾隆朝三个宫廷仿古铜镜个案,探讨其形制纹饰设计的种类与来源,分析了制作仿古镜的机构与程序,以及宫廷收贮... 详细信息

清代是中国铜镜日趋衰落的时期,但宫廷内府制作铜镜具有特殊性。其中,仿古铜镜是宫廷制镜的重要构成,尤以乾隆朝最盛。本文基于乾隆朝三个宫廷仿古铜镜个案,探讨其形制纹饰设计的种类与来源,分析了制作仿古镜的机构与程序,以及宫廷收贮方式与贮藏地点,认为乾隆朝内府制仿古铜镜的设计与制造既崇古又创新,具有独特细腻的艺术风格。

关键词：清代青铜器造办处

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Diversity and Application of Herbaceous Flowers in Urban Road Greening in Hefei City

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Journal of Landscape Research 2024年第3期16卷 63-65,69页

作者： HU Wenjuan ZHAO Zhiyan wu qian XU Huaxue Department of Architecture and Landscape Design Anhui Xinhua UniversityHefeiAnhui 230088China

In urban road greening,the planting of ground cover flowers is essential,and herbaceous flowers are an important *** the investigation on the diversity of herbaceous flowers in urban road green spaces of Hefei City,the types,colors,application frequency and planting of herbaceous flowers in urban road green spaces were statistically analyzed,and the application forms of herbaceous flowers in the road greening of Hefei City were *** characteristics and problems of herbaceous flowers in the road greening of Hefei City were found,and some development suggestions were put forward.

关键词： Urban road green space Herbaceous flowers Diversity Application form Hefei City

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Calenderable Supramolecular Perfluorogels for facile fabrication of slippery coatings

Calenderable Supramolecular Perfluorogels for facile fabrica...

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2024第五届全国功能高分子材料学术研讨会

作者：杨莉 Yuanlai Fang qian wu Yijun Zheng Jiaxi Cui

Supramolecular gels are important soft materials showing applications in a wide range fields from biomedicine to oil exploration. The fast and effective construction of antibacterial surfaces,or imparting antibacterial properties to non-antibacterial objects in daily life（such as door handle） is of great significance to effectively curb the spread of *** develop a facile method to prepare calenderable supramolecular perfluorogels from porous polytetrafluoroethylene（pPTFE）.It can be fabricated into porous substrates by stretching. The porous PTFE has 3D fibrous network structures in which the fibrils with diameters of tens to hundreds of nanometers are connected by nodes. The obtained perfluorogels show not only extraordinary mechanical properties,including high strength（>4.2 MPa） and modulus（>9.5 MPa）,extremely good stretchability（6240 %） and malleability（>2300%）,but also good anti-fouling and antibacterial ***,the perfluorogel can be easily calendered onto various shapes of objects by hands as antibacterial ***,the coatings show interesting compression-induced recovery in surface slipperiness after overlayer liquid is *** materials used in our method,*** and the perfluorinated liquid,are readily very common and available in supermarkets,we envision their immediate opportunities in various conditions.

关键词： supramolecular perfluorogels slippery coating calenderable antibacterial

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代谢性疾病与嗅觉改变及其机制进展

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上海交通大学学报（医学版） 2024年第1期44卷 131-136页

作者：吴倩李华婷上海交通大学医学院附属第六人民医院内分泌代谢科上海市糖尿病研究所上海市糖尿病重点实验室上海市糖尿病临床医学中心上海200233 上海交通大学医学院上海200025

代谢性疾病发病机制复杂,其患病率逐年上升且发病趋向年轻化,已成为全球重要的公共卫生问题。嗅觉是一种重要的感觉功能,在个体的营养和生活质量方面发挥着重要作用。肥胖与嗅觉功能可以相互影响,嗅觉功能受到营养状况的影响,同时在食... 详细信息

代谢性疾病发病机制复杂,其患病率逐年上升且发病趋向年轻化,已成为全球重要的公共卫生问题。嗅觉是一种重要的感觉功能,在个体的营养和生活质量方面发挥着重要作用。肥胖与嗅觉功能可以相互影响,嗅觉功能受到营养状况的影响,同时在食物摄入、能量消耗和脂质代谢的调节过程中也发挥重要作用,而2型糖尿病、阻塞性睡眠呼吸暂停综合征等代谢性疾病患者也存在嗅觉功能障碍。代谢性疾病出现嗅觉改变的机制包括高血糖、胰岛素抵抗等代谢状态的改变,这些改变可引起肽类激素、脂肪细胞因子和神经递质的调节异常,这些中介分子可能在代谢性疾病和嗅觉功能障碍之间发挥作用;代谢性疾病所产生的血管与神经病变也会引起嗅觉神经的直接损伤或神经传导异常;代谢性疾病导致的肠道菌群紊乱也是引起嗅觉功能障碍的潜在机制。同时,认知功能障碍是代谢性疾病的重要并发症,嗅觉功能障碍是代谢性疾病出现认知障碍的前驱临床表现,有助于疾病的早期识别和评估。该文对代谢性疾病与嗅觉变化之间的关系及其潜在机制的研究现状作一综述。

关键词：肥胖糖尿病嗅觉功能代谢性疾病认知障碍

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基于文献数据化的科研机构历时画像构建研究

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情报理论与实践 2024年第7期47卷 88-96页

作者：胡潜吴茜董寒宇华中师范大学信息管理学院湖北武汉430079

[目的/意义]提出基于文献数据化的科研机构历时画像构建方法,为科研机构发展历程的全景动态刻画、科技竞争情报工作中的机构类竞争对手分析提供支持。[方法/过程]按照画像实现一般流程,首先构建科研机构历时画像标签体系,提出科研机构... 详细信息

[目的/意义]提出基于文献数据化的科研机构历时画像构建方法,为科研机构发展历程的全景动态刻画、科技竞争情报工作中的机构类竞争对手分析提供支持。[方法/过程]按照画像实现一般流程,首先构建科研机构历时画像标签体系,提出科研机构历时画像时间窗划分思路;在此基础上,构建基于文献数据化的科研机构历时画像生成模型,并通过期刊论文进行画像方法效果验证。[结果/结论]实证证明,所构建的科研机构历时画像生成模型具有可行性且效果良好,能够系统地展示科研机构属性特征的动态演化。

关键词：文献数据化科研机构机构画像机构历时画像

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