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优化制动转矩分布以提高四轮驱动混合电动车辆的稳定性(二)

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传动技术 2010年第1期24卷 22-25,30页

作者： D-h Kin j-M Kim S-h hwany h-S Kim 介眉 School of Mechanical Engineering Sungkyunkwan UniversitySuwon

四轮驱动混合电动车辆稳定性控制逻辑建议采用后马达能量回收制动和一个电液制动器(EhB)。采用一个通常的算法,求得能量回收制动和EhB转矩之间最佳的转矩分布。根据已知输入的所要求的偏转转矩和道路摩擦系数,用该通常算法计算出最佳能... 详细信息

四轮驱动混合电动车辆稳定性控制逻辑建议采用后马达能量回收制动和一个电液制动器(EhB)。采用一个通常的算法,求得能量回收制动和EhB转矩之间最佳的转矩分布。根据已知输入的所要求的偏转转矩和道路摩擦系数,用该通常算法计算出最佳能量回收制动转矩和最佳的EhB转矩。基于最佳的制动转矩分布,相应驾驶员转向角和车辆速度,用模糊控制算法,车辆稳定控制逻辑建议形成所要求的偏转转矩,去补偿侧滑角和偏转率的误差。对单车道变更机动性用比较固定能量回收制动和最佳能量回收制动,判断车辆稳定性控制逻辑的性能。由仿真结果可以看到,在满足车辆稳定性的情况下,最佳能量回收制动可以比固定的能量回收制动增大能量回收。

关键词：四轮驱动混合电动车辆能量回收制动车轮稳定性控制

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水杨酸类药理的新进展

山西医药杂志 1960年第1期 104-106页

作者： M.j.h 史密斯景仑

序言许多植物的树皮、叶子和种子中含有天然的水杨酸类化合物,这些水杨酸类化合物都是最古老的药物。希波克拉底(hippocrates)、塞尔萨斯(CeIsus)和格林(GaIeu)都曾用过含水杨甙的柳树叶,治疗各种溃疡、丹毒和子宫下垂。在中世纪和文艺... 详细信息

序言许多植物的树皮、叶子和种子中含有天然的水杨酸类化合物,这些水杨酸类化合物都是最古老的药物。希波克拉底(hippocrates)、塞尔萨斯(CeIsus)和格林(GaIeu)都曾用过含水杨甙的柳树叶,治疗各种溃疡、丹毒和子宫下垂。在中世纪和文艺复兴时代里,含有水杨酸类的植物在生药中占有很重要的地位。现代水杨酸药物的历史开始于1874年,当时合成了水杨酸,发现了水杨酸的防腐和解热作用,对风湿热特殊疗效也于1876年被公认,同年发现了乙(?)水杨

关键词：风湿热水梅酸类锡酸盐锡化合物皮盾风湿病风湿性疾病激素解热作用脑垂体前叶动物酸衍生物龙胆酸

Plant peroxisomes at the crossroad of NO and h2O2 metabolism

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journal of Integrative Plant Biology 2019年第7期61卷 803-816页

作者： Francisco j.Corpas Luis A.del Río josé M.Palma Group of Antioxidants Free Radicals and Nitric Oxide in Biotechnology Food and Agriculture Department of Biochemistry Cell and Molecular Biology of Plants Estación Experimental del Zaidín CSIC

Plant peroxisomes are subcellular compartments involved in many biochemical pathways during the life cycle of a plant but also in the mechanism of response against adverse environmental *** organelles have an active nitro-oxidative metabolism under physiological conditions but this could be exacerbated under stress ***,peroxisomes have the capacity to proliferateand also undergo biochemical adaptations depending on the surrounding cellular *** important characteristic of peroxisomes is that they have a dynamic metabolism of reactive nitrogen and oxygen species(RNS and ROS)which generates two key molecules,nitric oxide(NO)and hydrogen peroxide(h2O2).These molecules can exert signaling functions by means of post-translational modifications that affect the functionality of target molecules like proteins,peptides or fatty *** review provides an overview of the endogenous metabolism of ROS and RNS in peroxisomes with special emphasis on polyamine and uric acid metabolism as well as the possibility that these organelles could be a source of signal molecules involved in the functional interconnection with other subcellular compartments.

关键词： Plant peroxisomes NO h2O2 metabolism

Comparison of the chloride channel activator lubiprostone and the oral laxative Polyethylene Glycol 3350 on mucosal barrier repair in ischemic-injured porcine intestine

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World journal of Gastroenterology 2008年第39期14卷 6012-6017页

作者： Adam j Moeser Prashant K Nighot Birgit Roerig Ryuji Ueno Anthony T Blikslager Department of Population health and Pathobiology College of Veterinary MedicineNorth Carolina State UniversityRaleigh NC 27606United States Department of Clinical Sciences College of Veterinary MedicineNorth Carolina State UniversityRaleigh NC 27606United States Sucampo Pharmaceuticals IncBethesda MD 20814United States

AIM： To investigate the effects of lubiprostone and Polyethylene Glycol 3350 （PEG） on mucosal barrier repair in ischernic-injured porcine intestine. METhODS： Ileum from 6 piglets （approximately 15 kg body weight） was subjected to ischemic conditions by occluding the local rnesenteric circulation for 45 min in vivo. Ileal tissues from each pig were then harvested and mounted in Ussing chambers and bathed in oxygenated Ringer＇s solution in vitro. Intestinal barrier function was assessed by measuring transepithelial electrical resistance （TER） and mucosal-to-serosal fluxes of ^3h-rnannitol and ^14C-inulin. Statistical analyses of data collected over a 120-min time course included 2-way ANOVA for the effects of time and treatment on indices of barrier function. RESULTS： Application of 1μmol/L lubiprostone to the rnucosal surface of ischemic-injured ileum in vitro induced significant elevations in TER compared to nontreated tissue. Lubiprostone also reduced mucosal-toserosal fluxes of ^3h-rnannitol and ^14C-inulin. Alternatively, application of a polyethylene laxative （PEG, 20 rnmol/L） to the mucosal surface of ischernic tissues significantly increased flux of ^3h-rnannitol and ^14C-inulin. CONCLUSION： This experiment demonstrates that lubiprostone stimulates recovery of barrier function in ischemic intestinal tissues whereas the PEG laxative had deleterious effects on mucosal repair. These results suggest that, unlike osmotic laxatives, lubiprostone stimulates repair of the injured intestinal barrier.

关键词： Intestinal ischemia Barrier function Permeability Laxative Polyethylene Glycol

定量临床核心脏病学(第2部分):应用进展及新技术

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中华核医学与分子影像杂志 2022年第9期42卷 568-576页

作者： Piotr j.Slomka jonathan B.Moody Robert j.h.Miller jennifer M.Renaud Edward P.Ficaro Ernest V.Garcia 王丽(译) 杨敏福(审校) Department of Imaging(Division of Nuclear Medicine) Medicineand Biomedical SciencesCedars-Sinai Medical CenterLos AngelesCA INVIA Medical Imaging Solutions Ann ArborMI Department of Cardiac Sciences University of CalgaryCalgaryABCanada Division of Cardiology Department of Internal MedicineUniversity of MichiganAnn ArborMI Department of Radiology and Imaging Sciences Emory UniversityAtlantaGA 首都医科大学附属北京朝阳医院核医学科北京100020

定量分析已广泛用于核心脏病学图像的处理和解读、改进疾病诊断和危险分层。该文为继续教育文章(含2部分)的第2部分,将对新兴的定量分析工具的临床潜在应用进行综述,介绍机械运动同步性、心室功能、灌注和融合显像定量分析技术,对PET和S... 详细信息

定量分析已广泛用于核心脏病学图像的处理和解读、改进疾病诊断和危险分层。该文为继续教育文章(含2部分)的第2部分,将对新兴的定量分析工具的临床潜在应用进行综述,介绍机械运动同步性、心室功能、灌注和融合显像定量分析技术,对PET和SPECT评估心肌血流量的新方法进行讨论。心肌活性、微钙化定量检测及心脏结节病和心脏淀粉样变的定量评估亦在文中描述。人工智能在改善图像分析、提高疾病诊断效能和风险预测方面的潜在作用将在文末进行论述。上述新技术的临床潜在应用及优化实施方法将在文中重点阐述。

关键词：核心脏病学心肌血流量定量人工智能相位分析

Autoregressive neural networks with exogenous variables for indoor temperature prediction in buildings

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Building Simulation 2021年第1期14卷 165-178页

作者： Benoit Delcroix jérôme Le Ny Michel Bernier Muhammad Azam Bingrui Qu jean-Simon Venne Department of Mechanical Engineering Polytechnique Montréal2500 Chemin de PolytechniqueMontréalQCH3T 1J4Canada Department of Electrical Engineering and GERAD Polytechnique Montréal2500 Chemin de PolytechniqueMontréalQCH3T 1J4Canada Smart Building Lab BrainBox AIMontréalQCCanada

Thermal models of buildings are helpful to forecast their energy use and to enhance the control of their mechanical ***,these models are building-specific and require a tedious,error-prone and time-consuming development effort relying on skilled building energy *** to white-box and gray-box models,data-driven(black-box)models require less development time and a minimal amount of information about the building *** this paper,autoregressive neural network models are compared to gray-box and black-box linear models to simulate indoor *** models are trained,validated and compared to actual experimental data obtained for an existing commercial building in Montreal(QC,Canada)equipped with roof top units for air *** show that neural networks mimic more accurately the thermal behavior of the building when limited information is available,compared to gray-box and black-box linear *** gray-box model does not perform adequately due to its under-parameterized nature,while the linear models cannot capture non-linear phenomena such as radiative heat transfer and ***,the neural network models outperform the alternative models in the presented application,reaching a coefficient of determination R2 up to 0.824 and a root mean square error down to 1.11℃,including the error propagation over time for a 1-week period with a 5-minute *** considering a 50-hour time horizon,the best neural networks reach a much lower root mean square error of around 0.6℃,which is suitable for applications such as model predictive control.

关键词： thermal model building simulation experimental validation multi-layer perceptron linear vs.non-linear black-box vs.gray-box

Recent advances and future challenges in the use of nanoparticles for the dispersal of infectious biofilms

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journal of Materials Science & Technology 2021年第25期84卷 208-218页

作者： Shuang Tian henny C.van der Mei Yijin Ren henk j.Busscher Linqi Shi State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of EducationInstitute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin300071China University of Groningen and University Medical Center Groningen Department of Biomedical EngineeringAntonius Deusinglaan 19713 AVGroningenthe Netherlands University of Groningen and University Medical Center Groningen Department of OrthodonticsHanzeplein 19700 RBGroningenthe Netherlands

Increasing occurrence of intrinsically antimicrobial-resistant,human pathogens and the protective biofilm-mode in which they grow,dictates a need for the alternative control of infectious *** bacteria utilize dispersal mechanisms to detach parts of a biofilm as part of the biofilm life-cycle during times of nutrient scarcity or *** here identify recent advances and future challenges in the development of dispersants as a new infection-control ***(DNase)and other extracellular enzymes can disrupt the extracellular matrix of a biofilm to cause ***,a variety of small molecules,reactive oxygen species,nitric oxide releasing compounds,peptides and molecules regulating signaling pathways in biofilms have been described as *** their own,dispersants do not inhibit bacterial growth or kill bacterial *** natural,as well as artificial dispersants,are unstable and hydrophobic which necessitate their encapsulation in smart nanocarriers,like p h-responsive micelles,liposomes or *** on their composition,nanoparticles can also possess intrinsic dispersant *** dispersed from an infectious biofilm end up in the blood circulation where they are cleared by host immune ***,this sudden increase in bacterial concentration can also cause *** antibiotic loading of nanoparticles with dispersant properties or combined administration of dispersants and antibiotics can counter this ***,biofilm remaining after dispersant administration appears more susceptible to existing *** part of the natural biofilm life-cycle,no signs of"dispersant-resistance"have been *** are therewith promising for the control of infectious biofilms.

关键词： Dispersant Enzymes EPS eDNA Antibiotic resistance Dispersal mechanism Nanoparticles

Structure determination for small precipitates in high-strength aluminum

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Structure determination for small precipitates in high-stren...

全国有色金属理化检验学术报告会

作者： j.h.Chen~*,C.L.Wu~**,Y.h.j.ang~***,S.B.Wang~****,j.Z.Liu~***** * Center for high-Resolution Electron Microscopy,College of Materials Science and Engineering,hunan University,Changsha City 410082,China

We firstly highlight some of recent techniques in modern transmission electron microscopy (TEM).These include through-focus exit-wavefunction reconstruction(TF-EWR) in high-resolution TEM(hRTEM),hRTEM with a spherical aberration(Cs) corrector for the objective lens,high-angle annular dark-field(hAADF) scanning TEM(hAADF STEM). Then by examples,we demonstrate our practices of using these techniques,in association

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Impressionism

Impressionism