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Suppression of Oxidative Stress of Modified Gongjin-Dan (WSY^1075) in Detrusor Underactivity Rat Model Bladder Outlet Induced by Obstruction

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Chinese Journal of Integrative Medicine 2018年第9期24卷 670-675页

作者： jin-Woo Jung Seung Hwan Jeon woong jin bae Su jin Kim Mun Su Chung Byung II Yoon Sae woong Choi U Syn Ha Sung Yeoun Hwang Sae woong Kim Department of Urology International St. Mary's Hospital Catholic Kwandong University College of Medicine Incheon Republic of Korea Institute for Bio-Medical Convergence College of Medicine Catholic Kwandong University Gangneungsi Gangwon-do Republic of Korea Department of Urology College of Medicine The Catholic University of Korea Seoul Republic of Korea Catholic Integrative Medicine Research Institute College of Medicine The Catholic University of Korea Seoul Republic of Korea Korea Bio Medical Science Institute Seoul Republic of Korea

Objective： To investigate the anti-oxidative stress and preventive effect of modified Gongjin-dan （WSY-1075） in a detrusor underactivity rat model. Methods： Rats were randomly allocated to three groups： sham- operated （control）, bladder outlet obstruction-induced detrusor underactivity （BOO-DU）, and BOO-DU with WSY-1075 （WSY） groups. WSY-1075 was orally administrated to rats 200 mg daily for 2 weeks pdor to the operation and 4 weeks after the operation. Bladder outlet obstruction was surgically induced in rats by ligation around the urethra avoiding total obstruction. Cystometrography was conducted on rats in each group for examination of bladders. Results： Compared with the control group, bladder outlet obstruction led to a significant increase in oxidative stress with consequent changes to molecular composition, and decrease in maximal detrusor pressure （P〈0.05）. WSY-1075 treatment significantly suppressed oxidative stress and prevented degenerative and dysfunctional changes in bladder, as compared with BOO-DU group （P〈0.05）. Conclusion： WSY-1075 had beneficial effect on prevention of BOO-DU.

关键词： detrusor underactivity anti-oxidant herbal

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Anti-inflammatory and Antimicrobial Effects of Anthocyanin Extracted from Black Soybean on Chronic Bacterial Prostatitis Rat Model

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Chinese Journal of Integrative Medicine 2018年第8期24卷 621-626页

作者： Byung Il Yoon woong jin bae Yong Sun Choi Su jin Kim U Syn Ha Sung-Hoo Hong Dong Wan Sohn Sae woong Kim Department of Urology International St Mary's HospitalThe Catholic Kwandong University of Korea Department of Urology College of MedicineThe Catholic University of Korea

Objective： To investigated the anti-inflammatory and antimicrobial effects of anthocyanins extracted from black soybean on the chronic bacterial prostatitis（CBP） rat ***： The SpragueDawley rats were divided into 4 groups,including control,ciprofloxacin,anthocyanins and anthocyanins with ciprofloxacin groups（n=8 in each group）.Then,drip infusion of bacterial suspension（Escherichia coli Z17O2：K1：H^-） into Sprague-Dawley rats was conducted to induce *** 4 weeks,results of prostate tissue,urine culture,and histological analysis on the prostate were analyzed for each ***： The use of ciprofloxacin,anthocyanins,and anthocyanins with ciprofloxacin showed statistically significant decreases in bacterial growth and improvements in the reduction of prostatic inflammation compared with the control group（P〈0.05）.The anthocyanins with ciprofloxacin group showed a statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the ciprofloxacin group（P〈0.05）.Conclusions： These results suggest that anthocyanins may have anti-inflammatory and antimicrobial effects,as well as a synergistic effect with ***,we suggest that the combination of anthocyanins and ciprofloxacin may be effective in treating CBP to obtain a higher rate of treatment success.

关键词： prostatitis anti-bacterial agents anthocyanins

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Inhibition of Proliferation of Prostate Cancer Cell Line DU-145 in vitro and in vivo Using Salvia miltiorrhiza Bunge

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Chinese Journal of Integrative Medicine 2020年第7期26卷 533-538页

作者： woong jin bae jin Bong Choi Kang Sup Kim U Syn Ha Sung Hoo Hong Ji Youl Lee Tae-Kon Hwang Sung Yeoun Hwang WANG Zhi-ping Sae woong Kim Department of Urology The Catholic University of KoreaCollege of MedicineSeoul(06591)Republic of Korea Catholic Integrative Medicine Research Institute College of MedicineThe Catholic University of KoreaSeoul(06591)Republic of Korea Korea Bio-Medical Science Institute Seoul(06106)Republic of Korea Department of Urology Second Hospital of Lanzhou UniversityLanzhou(730030)China

Objective:To investigate the antiproliferative activity of Salvia miltiorrhiza Bunge.(SM)on the castration-resistant prostate cancer(CRPC)cell line DU-145 in vitro and in ***:Prostate cancer cell line(DU-145)and normal prostate cell line(RWPE-1)were treated with SM at different concentrations(3.125,12.5,25 and 50μg/mL)to investigate the antiproliferative *** laddering analysis was performed to investigate the apoptosis of DU-145 *** mechanism was investigated by Western blot analysis of p53,Bcl-2,prostate specific antigen(PSA),and androgen receptor(AR).Six-week-old male BALB/c nude mice were randomly divided into normal control group(n=101)and treated group(n=101)which administered 500 mg/kg SM for 2 *** volumes were ***:Treatment with SM resulted in a dose-dependent decrease in cell number of DU-145 cells in comparison with *** laddering analysis indicated the apoptosis of DU-145 *** with SM increased the expression of p53 and reduced the expression of Bcl-2 *** levels of PSA were considerably reduced in SM-treated group compared to the controls,and a decrease in AR expression was observed when cells were treated with SM in the same pattern as a reduction in *** the tumour xenograft study,SM given once a day for 2 weeks significantly inhibited tumour ***:SM might contribute to the anticancer actions such as induction of apoptosis and inhibition of proliferation of prostate cancer cells.

关键词： apoptosis prostate cancer Salvia miltiorrhiza Bunge Chinese medicine

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Discovery of Pb-free hybrid organic-inorganic 2D perovskites using a stepwise optimization strategy

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npj Computational Materials 2022年第1期8卷 776-787页

作者： Byung Do Lee jin-woong Lee Minseuk Kim Woon bae Park Kee-Sun Sohn Department of Nanotechnology and Advanced Materials Engineering Sejong University209 Neungdong-roGwangjin-guSeoul143-747South Korea Department of Advanced Components and Materials Engineering Sunchon National UniversityChonnam57922Republic of Korea

The current status of 2D organic–inorganic hybrid perovskites for use in photovoltaic(PV)and light-emitting diode(LED)applications lags far behind their 3D ***,we propose a computational strategy for discovering novel perovskites with as few computing resources as possible.A tandem optimization algorithm consisting of an elitism-reinforced nondominated sorting genetic algorithm(NSGA-II)and a multiobjective Bayesian optimization(MOBO)algorithm was used for density functional theory(DFT)*** DFT-calculated band gap and effective mass were taken as objective functions to be optimized,and the constituent molecules and elements of a Ruddlesden–Popper(RP)structure(n=2)were taken as decision *** previously unknown RP perovskite candidates for PV and LED applications were discovered as a result of the NSGA-II/MOBO ***,more accurate DFT calculations based on the HSE06 exchange correlation functional and ab initio molecular dynamics(AIMD)were conducted for the discovered 2D perovskites to ensure their validity.

关键词： sorting optimization perovskite

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High-frequency supercapacitors with phosphorus-doped Ketjen black

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Journal of Energy Chemistry 2023年第7期82卷 464-474,I0010页

作者： Qing jin Mahima Khandelwal woong Kim Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea

Compact supercapacitors(SCs)have attracted attention for their great potential to replace bulky aluminum electrolytic capacitors(AECs)in alternating current(AC)line filtering ***,the fabrication of a high-frequency SC is reported using Ketjen black(KB)nanoparticles doped with phosphorus(P)to achieve a high areal capacitance of up to 2.26 mF cm^(-2)along with a high-rate capability,with a phase angle of-80.2°at 120 *** high performance of the phosphorus-doped KB(designated PKB)SC with a 6 M KOH aqueous electrolyte is associated with its increased surface wettability and additional capacitive sites provided by the *** functional theory(DFT)calculations further indicate that the P-doping enhances the interactions between the electrolyte ions and the carbon surface,thus leading to an improved electrochemical *** results suggest that the P-doped carbonbased SC could be highly favored in replacing conventional AECs in various high-frequency electronic devices.

关键词： Phosphorus doping Frequency response Wettability Supercapacitor AC line filtering DFT calculation

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Biogeochemical cyclic activity of bacterial arsB in arsenic-contaminated mines

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Journal of Environmental Sciences 2008年第11期20卷 1348-1355页

作者： CHANG jin-Soo KIM Kyoung-woong Department of Environment Science and Engineering Gwangju Institute of Science and Technology (GIST)261 Cheomdan-gwagiroBuk-guGwangjuRepublic of Korea.

Biogeochemical cyclic activity of the ars (arsenic resistance system) operon is arsB influx/effux encoded by the ecological of Pseudomonas *** suggests that studying arsenite-oxidizing bacteria may lead to a better understanding of molecular geomicrobiology,which can be applied to the bioremediation of arsenic-contaminated *** is the first report in which multiple arsB-binding mechanisms have been used on indigenous *** ArsB (strains OS-5; ABB83931; OS-19; ABB04282 and RW-28; ABB88574...

关键词： arsenic resistance bacteria arsB influx/efflux pump arsenic resistance system (ars) biogeochemical

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Reduced interface energy loss in non-fullerene organic solar cells using room temperature-synthesized SnO2 quantum dots

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Journal of Materials Science & Technology 2020年第17期52卷 12-19页

作者： In Su jin Minwoo Park Jae woong Jung Department of Advanced Materials Engineering for Information&Electronics Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 446-701Republic of Korea Department of Chemical and Biological Engineering Sookmyung Women's UniversitySeoul 04310Republic of Korea

We herein report the room temperature synthesis of colloidal SnO2 quantum dots and their application in non-fullerene organic solar cells as an excellent electron transport *** thiourea-assisted hydrolysis at room temperature affords the nanocrystalline SnO2 quantum dots with a diameter of 3-4 *** utilization of the SnO2 quantum dots as an electron transporting layer effectively reduces the interfacial trap density and charge recombination in the solar cell devices,leading to not only the reduced energy loss but also excellent photocurrent *** optimized organic solar cells employing SnO2 quantum dots with polyethylenimine ethoxylated achieves power conversion efficiencies up to 12.023%with a VOC,a JSC,and a FF of 0.89 V,18.89 mA cm^–2,and *** work suggest that the SnO2 quantum dot is a promising electron transporting material to construct efficient organic solar cells for practical *** work also demonstrates the key strategy for thiourea-assisted hydrolysis to synthesize fine and nanocrystalline SnO2 quantum dots.

关键词： Energy loss Organic solar cells Interface SnO2 Quantum dots

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Risk factors causing structural sequelae after anastomotic leakage in mid to low rectal cancer

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World Journal of Gastroenterology 2015年第19期21卷 5910-5917页

作者： woong bae Ji Jung Myun Kwak jin Kim Jun Won Um Seon Hahn Kim Department of Surgery Korea University College of Medicine

AIM: To investigate the risk factors causing structural sequelae after anastomotic leakage in patients with mid to low rectal ***: Prospectively collected data of consecutive subjects who had anastomotic leakage after surgical resection for rectal cancer from March 2006 to May 2013 at Korea University Anam Hospital were retrospectively analyzed. Two subgroup analyses were performed. The patients were initially divided into the sequelae(stricture, fistula, or sinus) and no sequelae groups and then divided into the permanent stoma(PS)and no PS groups. Univariate and multivariate analyses were performed to identify the risk factors of structural sequelae after anastomotic ***: Structural sequelae after anastomotic leakage were identified in 29 patients(39.7%).Multivariate analysis revealed that diversion ileostomy at the first operation increases the risk of structural sequelae [odds ratio(OR) = 6.741; P = 0.017].Fourteen patients(17.7%) had permanent stoma during the follow-up period(median, 37 mo). Multivariate analysis showed that the tumor level from the dentate line was associated with the risk of permanent stoma(OR = 0.751; P = 0.045).CONCLUSION: Diversion ileostomy at the first operation increased the risk of structural sequelae of the anastomosis, while lower tumor location was associated with the risk of permanent stoma in the management of anastomotic leakage.

关键词： Anastomotic leakage Permanent stoma Leakage sequelae rectal cancer Anastomotic leakagefate

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Simultaneously enhanced efficiency and ambient stability of inorganic perovskite solar cells by employing tetramethylammonium chloride additive in CsPbI2Br

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Journal of Materials Science & Technology 2022年第7期102卷 224-231页

作者： In Su jin Bhaskar Parida Jae woong Jung Department of Advanced Materials Engineering for Information and Electronics Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 446-701Republic of Korea Integrated Education Institute for Frontier Materials(BK21 Four) Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 446-701Republic of Korea

Although all-inorganic perovskites possess suitable bandgap and thermal stability for photovoltaic ap-plications,the unstable film morphologies,and poor moisture stabilities lag behind the organic-inorganic hybrid ***,we demonstrate that high qualityα-CsPbI_(2 ) Br films with improved phase sta-bility,high crystallinity,and pinhole-free film morphology was achieved by employing tetramethylammo-nium chloride(TMACl)as an *** a result,the TMACl-added CsPbI_(2) Br films exhibited high power conversion efficiency of 14.12%with an open-circuit voltage of 1.19 V,a short-circuit current density of 15.08 mA/cm^(2),and a fill factor of *** importantly,the TMACl addition imparts hydrophobicity to the film surface of CsPbI_(2) Br,which delivered excellent stability up to 30 days in the ambient condition and thermal stability at 85℃ for 156 h,***,the TMACl-added device also exhibited excellent PCE of 27.16%under indoor light source(1000 lux),which presents a promising approach for designing stable but high performance all-inorganic perovskite solar cells.

关键词： Inorganic perovskite solar cells CsPbI2Br Additive Tetramethylammonium chloride Efficiency

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Boosted Lithium-Ion Transport Kinetics in n-Type Siloxene Anodes Enabled by Selective Nucleophilic Substitution of Phosphorus

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Nano-Micro Letters 2024年第10期16卷 618-637页

作者： Se In Kim woong-Ju Kim jin Gu Kang Dong-Wan Kim School of Civil Environmental and Architectural EngineeringKorea University02841 SeoulSouth Korea Nanophotonics Research Center Korea Institute of Science and Technology02792 SeoulSouth Korea

Doped two-dimensional(2D)materials hold significant promise for advancing many technologies,such as microelectronics,optoelectronics,and energy ***,n-type 2D oxidized Si nanosheets,namely n-type siloxene(n-SX),are employed as Li-ion battery *** thermal evaporation of sodium hypophosphite at 275℃,P atoms are effectively incorporated into siloxene(SX)without compromising its 2D layered morphology and unique Kautsky-type crystal ***,selective nucleophilic substitution occurs,with only Si atoms being replaced by P atoms in the O_(3)≡Si-H *** resulting n-SX possesses two delocalized electrons arising from the presence of two electron donor types:(i)P atoms residing in Si sites and(ii)H *** doping concentrations are varied by controlling the amount of precursors or their mean free *** at 2000 mA g^(-1),the n-SX electrode with the optimized doping concentration(6.7×10^(19) atoms cm^(-3))delivers a capacity of 594 mAh g^(-1) with a 73%capacity retention after 500 *** improvements originate from the enhanced kinetics of charge transport processes,including electronic conduction,charge transfer,and solid-state *** approach proposed herein offers an unprecedented route for engineering SX anodes to boost Li-ion storage.

关键词： Li-ion battery Two-dimensional N-type siloxene Doping mechanism Kinetics

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