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Extended lymph node dissection in robot-assisted radical prostatectomy： lymph node yield and distribution of metastases

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Asian Journal of Andrology 2014年第6期16卷 824-828页

作者： Kwang Hyun Kim Sey Kiat Lim Kyo Chul Koo woong kyu han Sung Joon Hong Koon Ho Rha Department of Urology Urological Science Institute Yonsei University College of Medicine Seoul Korea Department of Urology Ewha Womans University School ot Medicine Seoul Korea.

In this study, we reported our experience performing robotic extended lymph node dissection （eLND） in patients with prostate cancer. A total of 147 patients with intermediate and high-risk prostate cancer who underwent robotic eLND from May 2008 to December 2011 were included in this analysis. The dissection template extended to the ureter crossing the iliac vessels. We assessed lymph node yield, lymph node positivity, and perioperative outcomes. Lymph node positivity was also evaluated according to the number of lymph nodes （LNs） removed （〈22 vs 〉22）. The median number of LNs removed was 22 （11-51）, and 97 positive LNs were found in 24 patients （16.3%）. While the obturator fossa was the most common site for LN metastases （42.3%, 41/97）, the internal iliac area was the most common area for a single positive LN packet （20.8%, 5/24）. Eight patients （33.3%, 8/24） had positive LNs at the common iliac area. The incidence of positive LNs did not differ according to the number of LNs removed. Complications associated with eLND occurred in 21 patients （14.3%） and symptomatic lymphocele was found in five patients （3.4%）. In conclusion, robotic eLND can be performed with minimal morbidity. Furthermore, LN yield and the node positive rate achieved using this robotic technique are comparable to those of open series. In addition, the extent of dissection is more important than the absolute number of LNs removed in eLND, and the robotic technique is not a prohibitive factor for performing eLND.

关键词： lymph node excision prostatectomy prostatic neoplasm robotics

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Highly Elastic,Bioresorbable Polymeric Materials for Stretchable,Transient Electronic Systems

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Nano-Micro Letters 2024年第6期16卷 1-13页

作者： Jeong‑woong Shin Dong‑Je Kim Tae‑Min Jang Won Bae han Joong Hoon Lee Gwan‑Jin Ko Seung Min Yang Kaveti Rajaram Sungkeun han Heeseok Kang Jun Hyeon Lim Chan‑Hwi Eom Amay J.Bandodkar hanul Min Suk‑Won Hwang KU‑KIST Graduate School of Converging Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea SK Hynix 2091Gyeongchung‑daeroBubal‑eupIcheon‑siGyeonggi‑do 17336Republic of Korea hanwha Systems Co. Ltd.188Pangyoyeok‑roBundang‑guSeongnam‑siGyeonggi‑do 13524Republic of Korea Department of Electrical and Computer Engineering North Carolina State UniversityRaleighNC 27606USA Center for Advanced Self‑Powered Systems of Integrated Sensors and Technologies(ASSIST) North Carolina State UniversityRaleighNC 27606USA Department of Integrative Energy Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea Biomaterials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang‑ro 14‑gilSeongbuk‑guSeoul 02792Republic of Korea Semiconductor R&D Center Samsung Electronics Co.Ltd.Hwaseong‑siGyeonggi‑do 18448Republic of Korea Center for Advanced Biomolecular Recognition Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Substrates or encapsulants in soft and stretchable formats are key components for transient,bioresorbable electronic systems;however,elastomeric polymers with desired mechanical and biochemical properties are very limited compared to nontransient ***,we introduce a bioresorbable elastomer,poly(glycolide-co-ε-caprolactone)(PGCL),that contains excellent material properties including high elongation-at-break(<1300%),resilience and toughness,and tunable dissolution *** of PGCLs as polymer matrices,in combination with conducing polymers,yields stretchable,conductive composites for degradable interconnects,sensors,and actuators,which can reliably function under external *** of device components with wireless modules demonstrates elastic,transient electronic suture system with on-demand drug delivery for rapid recovery of postsurgical wounds in soft,time-dynamic tissues.

关键词： Biodegradable elastomer Conductive polymer composites Biomedical device Transient electronics

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Surgical Repair of Ventricular Septal Defect in Neonates: Indications and Outcomes

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Congenital Heart Disease 2024年第1期19卷 69-83页

作者： Jae Hong Lee Sungkyu Cho Jae Gun Kwak Hye Won Kwon woong-han Kim Mi Kyoung Song Sang-Yun Lee Gi Beom Kim Eun Jung Bae Department of Thoracic and Cardiovascular Surgery Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsanKorea Department of Thoracic and Cardiovascular Surgery Seoul National University Children’s HospitalSeoulKorea Department of Pediatrics Seoul National University Children’s HospitalSeoulKorea

Background:The optimal surgical timing and clinical outcomes of ventricular septal defect(VSD)closure in neo-nates remain *** aimed to evaluate the clinical outcomes of VSD closure in neonates(age≤30 days).Methods:We retrospectively reviewed 50 consecutive neonates who underwent VSD closure for isolated VSDs between August 2003 and June *** for the procedure included congestive heart failure/failure to thrive and pulmonary *** adverse events(MAEs)were deﬁned as the composite of all-cause mortality,reoperation,persistent atrioventricular block,and signiﬁcant(≥grade 2)valvular ***:The median age and body weight at operation were 26.0 days(interquartile range[IQR],18.8–28.3)and 3.7 kg(IQR,3.3–4.2),*** median follow-up duration was 110.4 months(IQR,56.8–165.0).Seven patients required preoperative respiratory support,andﬁve had signiﬁcant(≥grade 2)preoperative valvular *** early mortality occurred due to irreversible cardiogenic shock;no late mortality was *** reopera-tion was due to hemodynamically signiﬁcant residual VSD at 103.8 months *** overall survival,freedom from reoperation,and freedom from MAE at 15-years were 98.0%,96.3%,and 94.4%,***-operative mechanical ventilation was associated with a longer duration of postoperative mechanical ventilation(p<0.001)and a longer length of intensive care unit stay(p<0.001).Conclusions:VSD closure with favorable outcomes without morbidities is feasible even in ***,neonates requiring preoperative respiratory support may require careful postoperative management considering the long-term postoperative ***,surgical VSD closure might be indicated earlier in neonates with respiratory compromise.

关键词： Ventricular septal defect neonate early surgery neonatal surgery

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Effect of external beam radiotherapy on patency of uncovered metallic stents in patients with inoperable bile duct cancer

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Hepatobiliary & Pancreatic Diseases International 2014年第4期13卷 423-427页

作者： Jun kyu Lee Won Kwon Kwack Sang Hyub Lee Jin Hee Jung Jae Hyun Kwon In woong han Jin Ho Lee Departments of Internal Medicine Dongguk University Ilsan Hospital College of Medicine Dongguk University Department of Internal Medicine and Liver Research Institute Seoul National University Hospital College of Medicine Seoul National University Radiology Dongguk University Ilsan Hospital Surgery Dongguk University Ilsan Hospital

BACKGROUND： Although biliary decompression with metallic stenting is the preferred treatment for inoperable bile duct cancer（BDC）, maintenance of patency is still *** tried to assess the effectiveness and safety of external beam radiotherapy（EBRT） for prolonging stent patency in patients having uncovered metallic ***： We retrospectively reviewed 50 patients who received endoscopic stenting, of whom 18 received EBRT（RT group） and 32 did not（non-RT group）.RESULTS： No difference was found in baseline characteristics between the two groups. Although stent patency was longer in the RT group than that in the non-RT group（140.7±51.3 vs136.4±34.9 days, P=0.94）, the difference was not statistically significant. There were a lower rate of stent occlusion（27.8% vs50.0% of patients, P=0.12） and a longer overall survival（420.1 ±73.2 vs 269.1±41.7 days, P=0.11） in the RT group than in the non-RT group, and the difference again was not statistically significant. The development of adverse reactions did not differ（55.6% vs 53.1% of patients, P=0.91）. There was no serious adverse reaction in both groups（P=0.99）.CONCLUSIONS： EBRT did not significantly improve stent patency in patients with inoperable BDC having uncovered metallic stents. However, EBRT was safe. Future trials withrefined protocols for better efficacy are expected.

关键词： bile duct cancer radiotherapy survival self-expandable metallic stent patency

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Publisher Correction to:Highly Elastic,Bioresorbable Polymeric Materials for Stretchable,Transient Electronic Systems

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Nano-Micro Letters 2024年第8期16卷 417-417页

作者： Jeong‑woong Shin Dong‑Je Kim Tae‑Min Jang Won Bae han Joong Hoon Lee Gwan‑Jin Ko Seung Min Yang Kaveti Rajaram Sungkeun han Heeseok Kang Jun Hyeon Lim Chan‑Hwi Eom Amay JBandodkar hanul Min Suk‑Won Hwang KU‑KIST Graduate School of Converging Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea SK Hynix 2091Gyeongchung‑daeroBubal‑eupIcheon‑siGyeonggi‑do 17336Republic of Korea hanwha Systems Co. Ltd.188Pangyoyeok‑roBundang‑guSeongnam‑siGyeonggi‑do 13524Republic of Korea Department of Electrical and Computer Engineering North Carolina State UniversityRaleighNC 27606USA Center for Advanced Self‑Powered Systems of Integrated Sensors and Technologies(ASSIST) North Carolina State UniversityRaleighNC 27606USA Department of Integrative Energy Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea Biomaterials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang‑ro 14‑gilSeongbuk‑guSeoul 02792Republic of Korea Semiconductor R&D Center Samsung Electronics Co.Ltd.Hwaseong‑siGyeonggi‑do 18448Republic of Korea Center for Advanced Biomolecular Recognition Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Due to typesetting mistake,hanul Min was missed to be denoted as a corresponding author in the *** type-setter apologizes for *** original article has been *** Access This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons licence,and indicate if changes were *** images or other third party material in this article are included in the article’s Creative Commons licence,unless indicated otherwise in a credit line to the *** material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use,you will need to obtain permission directly from the copyright holder.

关键词： Creative Elastic Highly

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Development of temperature-robust damage factor based on sensor fusion for a wind turbine structure

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Frontiers of Structural and Civil Engineering 2015年第1期9卷 42-47页

作者： Jong-woong PARK Sung-han SIM Jin-Hak YI Hyung-Jo JUNG Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL 61801 USA School of Urban and Environmental Engineering Ulsan National Institute of Science and Technology (UNIST) Ulsan 689- 798Republic of Korea Coastal Development & Ocean Engineering Research Division Korea Institute of Ocean Science and Technology Ansan 426-744Republic of Korea Department of Civil and Environmental Engineering KAIST Daejeon 305-701 Republic of Korea

Wind power systems have gained much attention due to the relatively high reliability, maturity in technology and cost competitiveness compared to other renewable alternatives. Advances have been made to increase the power efficiency of the wind turbines while less attention has been focused on structural integrity assessment of the structural systems. Vibration-based damage detection has widely been researched to identify damages on a structure based on change in d^mmic characteristics. Widely spread methods are natural frequency-based, mode shape-based, and curvature mode shape-based methods. The natural frequency-based methods are convenient but vulnerable to environmental temperature variation which degrades damage detection capability; mode shapes are less influenced by temperature variation and able to locate damage but requires extensive sensor instrumentation which is costly and vulnerable to signal noises. This study proposes novelty of damage factor based on sensor fusion to exclude effect of temperature variation. The combined use of an accelerometer and an inclinometer was considered and damage factor was defined as a change in relationship between those two measurements. The advantages of the proposed method are： 1） requirement of small number of sensor, 2） robusmess to change in temperature and signal noise and 3） ability to roughly locate damage. Validation of the proposed method is carried out through numerical simulation on a simplified 5 MW wind turbine model.

关键词： sensor fusion damage detection structural health monitoring

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Concordant Atrioventricular Connection to L-Looped Ventricles with the Left Ventricle on Top of the Right Ventricle in Situs Solitus:A Case Report with 3D Modelling and Printing

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Congenital Heart Disease 2022年第4期17卷 393-398页

作者： Mi Kyoung Song Gi Beom Kim woong han Kim Whal Lee Eun-Jung Bae Department of Pediatrics Seoul National University Children’s HospitalSeoul National University College of MedicineSeoulKorea Department of Thoracic and Cardiovascular Surgery Seoul National University Children’s HospitalSeoulKorea Department of Radiology and the Institute of Radiation Medicine Seoul National University HospitalSeoulKorea

We report the case of a rare complex cardiac anomaly involving situs solitus,concordant atrioventricular connection with left-hand ventricular topology,and L-looped *** ventricles had a superior-inferior relationship with an inferiorly located right ventricle,which had a double outlet with far posteriorly located great *** left atrium was elongated,with juxta-positioned atrial appendages on the right *** 3D-printed model using a computed tomography scan taken on the fourth day of birth demonstrated the anatomy clearly and helped us decide on the surgical management.

关键词： Double outlet right ventricle superior-inferior ventricle L-looped ventricles 3D printing

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Effect of solid-solution strengthening on deformation mechanisms and strain hardening in medium-entropy V_(1-x)Cr_(x)CoNi alloys

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Journal of Materials Science & Technology 2022年第13期108卷 270-280页

作者： Hyun Chung Dae woong Kim Woo Jin Cho Heung Nam han Yuji Ikeda Shoji Ishibashi Fritz Körmann Seok Su Sohn Department of Materials Science and Engineering Korea UniversitySeoul 02841South Korea Center for High Entropy Alloys Pohang University of Science and TechnologyPohang 37673South Korea Department of Materials Science and Engineering and Research Institute of Advanced Materials Seoul National UniversitySeoul 08826South Korea Institute for Materials Science University of StuttgartPfaffenwaldring 55Stuttgart 70569Germany Computational Materials Design Max-Planck-Institut für Eisenforschung GmbHMax-Planck-Strabe 1Düsseldorf 40237Germany Research Center for Computational Design of Advanced Functional Materials(CD-Fmat) National Institute of Advanced Industrial Science and Technology(AIST)TsukubaIbaraki 305-8568Japan Department of Materials Science and Engineering Delft University of TechnologyMekelweg2Delft 2628 CDthe Netherlands

High-and medium-entropy alloys(HEAs and MEAs)possess high solid-solution *** investigations have been conducted on its impact on yield strength,however,there are limited reports regarding the relation between solid-solution strengthening and strain-hardening *** addition,no attempt has been made to account for the dislocation-mediated plasticity;most works focused on twinning-or transformation-induced plasticity(TWIP or TRIP).In this work we reveal the role of solidsolution strengthening on the strain-hardening rate via systematically investigating evolutions of deformation structures by controlling the Cr/V ratio in prototypical V_(1-x)Cr_(x)CoNi *** the TWIP of CrCoNi with the dislocation slip of V_(0.4)Cr_(0.6)CoNi,the hardening rate of CrCoNi was superior to slip-band refinements of V_(0.4)Cr_(0.6)CoNi due to the dynamic Hall-Petch ***,as V content increased further to V_(0.7)Cr_(0.3)CoNi and VCoNi,their rate of slip-band refinement in V_(0.7)Cr_(0.3)CoNi and VCoNi with high solid-solution strength surpassed that of *** it is generally accepted in conventional alloys that deformation twinning results in a higher strain-hardening rate than dislocation-mediated plasticity,we observed that the latter can be predominant in the former under an activated huge solid-solution strengthening *** high solid-solution strength lowered the cross-slip activation and consequently retarded the dislocation rearrangement rate,i.e.,the dynamic *** delay in the hardening rate decrease,therefore,increased the strain-hardening rate,results in an overall higher strain-hardening rate of V-rich alloys.

关键词： Medium-entropy alloy Tensile property Solid-solution strength Strain-hardening rate Stacking fault energy

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Second to fourth digit ratio： a predictor of adult penile ength

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Asian Journal of Andrology 2011年第5期13卷 710-714页

作者： In Ho Choi Khae Hawn Kim han Jung Sang Jin Yoon Soo woong Kim Tae Beom Kim Department of Urology Gachon University Gil Hospital Incheon Korea Department of Urology Seoul National University College of Medicine Seoul Korea

The second to fourth digit ratio （2D：4D） has been proposed as a putative biomarker for prenatal testosterone and covaries with the sensitivity of the androgen receptor （AR）. Both prenatal testosterone and the AR play a central role in penile growth. In this study, we investigated the relationship between digit ratio and penile length. Korean men who were hospitalized for urological surgery at a single tertiary academic centre were examined in this study, and 144 men aged 20 years or older who gave informed consent were prospectively enrolled. Right-hand second- and fourth-digit lengths were measured by a single investigator prior to measurement of penile length. Under anaesthesia, flaccid and stretched penile lengths were measured by another investigator who did not measure nor have any the information regarding the digit lengths. Univariate and multivariate analysis using linear regression models showed that only height was a significant predictive factor for flaccid penile length （univariate analysis： r=0. 185, P=-0.026; multivariate analysis： r=-0.172, P=0.038） and that only digit ratio was a significant predictive factor for stretched penile length （univariate analysis： r=-0.216, P=0.009; multivariate analysis： r=-0.201, P=0.024; stretched penile length=-9.201 xdigit ratio ＋ 20.577）. Based on this evidence, we suggest that the digit ratio can predict adult penile size and that the effects of prenatal testosterone may in part explain the differences in adult penile length.

关键词： digit ratio flaccid penile length stretched penile length

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Role of Surgery on Growth of Tricuspid Valve in Pulmonary Atresia with Intact Ventricular Septum:Mid-Term Results of Modified Right-Ventricular Overhauling Procedure

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Congenital Heart Disease 2023年第3期18卷 325-336页

作者： Jae Gun Kwak Eung Re Kim Taeyoung Yun Sungkyu Cho Chang-Ha Lee woong-han Kim Department of Thoracic and Cardiovascular Surgery Seoul National University Children’s HospitalCollege of MedicineSeoul National UniversitySeoulKorea 2Department of Thoracic and Cardiovasclar SurgerySejong General HospitalBucheonGyeonggiKorea

Objectives:To access the effectiveness of our modified right-ventricular overhauling procedure on tricuspid valve(TV)growth in patients with pulmonary atresia with intact ventricular septum(PAIVS).Methods:We retrospectively reviewed 21 patients with PAIVS who underwent modified right ventricular overhauling(mRVoh)between 2008 and 2019 at two *** mRVoh consisted of wide resection of hypertrophied infundibular and trabecular muscle,peeling off fibrotic endocardial tissue in the right ventricle(RV)cavity,surgical pulmonary valvotomy,and Blalock-Taussig shunt or banding of ductus arteriosus under cardiopulmonary *** TV annulus sizes were measured and analyzed using echocardiography before and after ***:No mortalities were observed during a median follow-up of 3 years(interquartile range:1.3–4.7 years)of follow-up were *** was performed at a median age of 163.5 days(range:21–560 days),including seven neonates and two infants(hanged during the period after mRVoh(−2.03 to−1.61,p=0.028)compared with the period before mRVoh(−2.51→–2.03,p=0.575)after percutaneous intervention ***:mRVoh in PAIVS patients was positively associated with TV annular growth,and it was more effective than percutaneous RVOT widening interventions without mRVoh.

关键词： Congenital heart disease cyanotic heart disease pulmonary atresia with intact ventricular septum right ventricular overhauling

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