PURPOSE: Toward improved glioblastoma muhiforme treatment, we determined whether celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, could enhance glioblastoma radiosensitivity by inducing tumor necrosis and inhi...
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PURPOSE: Toward improved glioblastoma muhiforme treatment, we determined whether celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, could enhance glioblastoma radiosensitivity by inducing tumor necrosis and inhibiting tumor angiogenesis。METHODS AND MATERIALS: U-87MG ceils treated with celecoxib, irradiation, or both were assayed for clonogenic survival and anglogenie factor protein analysis (angiopoietin-1, angiopoietin-2, and vascular endothelial growth factor [VEGF])。In vivo, survival of mice intracranially implanted with U-87MG ceils and treated with celeeoxib and/or irradiation was monitored。Isolated tumors were assessed for tumor necrosis and tumor microvascular density by yon WiUiebrand' s factor (vWF) immunohistochemical staining。RE- SULTS: Celeeoxib (4 and 30 microM; 24, 48, and 72 h) enhanced U-87MG ceil radiosensitivity by significantly reducing clonogenic survival of irradiated cells。Angiopoietin-1 and VEGF proteins were decreased, whereas angiopoietin-2 expression increased after 72 h of celeeoxib alone and when combined with irradiation。
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