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Research 2021年第1期2021卷 460-468页

作者： Jihoon Chung Myunghwan Song Seh-Hoon Chung woojin choi Sanghyun Lee Zong-Hong Lin Jinkee Hong Sangmin Lee School of Mechanical Engineering Chung-Ang University84Heukseok-roDongjak-guSeoulRepublic of Korea Department of Chemical&Biomolecular Engineering College of EngineeringYonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Institute of Biomedical Engineering and Department of Power Mechanical Engineering National Tsing Hua University101Section 2Kuang-Fu RoadHsinchu 30013Taiwan

Piezoelectric nanogenerators(PENGs)and triboelectric nanogenerators(TENGs)are representative technologies that can harvest mechanical *** general,piezoelectric/triboelectric hybrid generators can harvest considerable energy with a limited input;however,PENGs and TENGs entail different requirements for harvesting ***,PENGs produce a large output when a large mechanical strain is applied,and TENGs require a large surface area to produce a high ***,it is necessary to develop an innovative strategy in terms of the structural design to satisfy the requirements of both PENGs and *** this study,we developed a triangulated cylinder origami-based piezoelectric/triboelectric hybrid generator(TCOHG)with an origami structure to enable effective energy *** proposed structure consists of a vertical contactseparation TENG on the surface of the triangulated cylinder,PENG on the inner hinge,and rotational TENG on the top substrate to harvest mechanical energy from each *** generator could produce a separate electrical output with a single *** TCO-HG could charge a 22μF commercial capacitor and power 60 LEDs when operated.

关键词： harvesting cylinder generator

Multivalent network modifier upregulates bioactivity of multispecies biofilm-resistant polyalkenoate cement

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Bioactive Materials 2022年第8期7卷 219-233页

作者： Ji-Yeong Kim woojin choi Utkarsh Mangal Ji-Young Seo Tae-Yun Kang Joohee Lee Taeho Kim Jung-Yul Cha Kee-Joon Lee Kwang-Mahn Kim Jin-Man Kim Dohyun Kim Jae-Sung Kwon Jinkee Hong Sung-Hwan choi Department of Orthodontics Institute of Craniofacial DeformityYonsei University College of Dentistry50-1 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea BK21 FOUR Project Yonsei University College of Dentistry50-1 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Department and Research Institute of Dental Biomaterials and Bioengineering Yonsei University College of Dentistry50-1 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Johns Hopkins University 3400 N.Charles St.Mason HallBaltimoreMD 21218USA Department of Oral Microbiology and Immunology School of Dentistry and Dental Research InstituteSeoul National UniversitySeoul 08826Republic of Korea Department of Conservative Dentistry Oral Science Research CenterYonsei University College of Dentistry50-1 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

Polyalkenoate cement(PAC)is a promising material for regenerative hard tissue *** ionically rich glass component of PAC encourages bioactive interaction *** release of essential ***,PAC bioactivity is restricted owing to(i)structurally inherent cationic network formers and(ii)surface bacterial biofilm *** two factors cause a deficiency in ion release,further complicated by secondary infections and premature therapeutic ***,a multivalent zwitterionic network modifier(mZM)is presented for upregulation of ionic exchange and bioactivity *** introducing a non-zero charged mZM into PACs,an increase in the proportion of non-bridging oxygen *** network modification promotes ion channel formation,causing a multiple-fold increase in ion release and surface deposition of hydroxy-carbonate apatite(ca.74%).Experiments ex vivo and animal models also demonstrate the efficient remineralization ability of the ***,divalent cationic interaction results in bacterial biofilm reduction(ca.68%)while also influencing a shift in the biofilm species composition,which favors commensal ***,PAC modification with mZM offers a promising solution for upregulation of bioactivity,even aiding in customization by targeting site-specific regenerative therapy in future applications.

关键词： Multivalent network modifier Bioactive materials Glass polyalkenoate cement Ion release Remineralization Multispecies biofilm resistance

Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： Eunhee Kim Rudolph ETanzi Se Hoon choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan choi Soo-Ho choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Flow-based queue management for fairness control in high-bandwidth network

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Science China(Information Sciences) 2016年第6期59卷 261-263页

作者： Wonjun choi Ramneek SEKHON woojin SEOK Department of Science and Technology Information Science Korea University of Science & Technology Department of Advanced KREONET Application Support Korea Institute of Science and Technology Information

Dear editor,With the development of information equipment and growth of broadband network,the progress of Internet has changed from the network with modem speed in the past to the *** essential problem in the use of the network in a variety of fields is to use the network resource efficiently distributing the limited bandwidth[1].If congestion occurs in high-bandwidth network,slow rate flow and fast rate flow will experience

关键词： Flow-based queue management for fairness control in high-bandwidth network high

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

Room-temperature sputtered electrocatalyst WSe2 nanomaterials for hydrogen evolution reaction

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Journal of Energy Chemistry 2020年第8期29卷 107-111,I0004页

作者： Jae Hyeon Nam Myeong Je Jang Hye Yeon Jang woojin Park Xiaolei Wang Sung Mook choi Byungjin Cho Department of Advanced Material Engineering Chungbuk National UniversityChungdae-ro 1Seowon-GuCheongjuChungbuk 28644Republic of Korea Surface Technology Department Korea Institute of Materials Science797 ChangwonDaeroSungsan-guChangwon 51508Republic of Korea Advanced Materials Engineering Korea University of Science and Technology(UST)217 Gajeong-roYuseong-guDaejeon 34113Republic of Korea Department of Chemical and Materials Engineering University of Alberta9211116 Street NWEdmontonAlberta T6C 1H9Canada

The low-temperature physical vapor deposition process of atomically thin two-dimensional transition metal dichalcogenide(2D TMD) has been gaining attention owing to the cost-effective production of diverse electrochemical catalysts for hydrogen evolution reaction(HER) applications. We, herein, propose a simple route toward the cost-effective physical vapor deposition process of 2D WSe2 layered nanofilms as HER electrochemical catalysts using RF magnetron sputtering at room temperature(<27℃). By controlling the variable sputtering parameters, such as RF power and deposition time, the loading amount and electrochemical surface area(ECSA) of WSe2 films deposited on carbon paper can be carefully determined. The surface of the sputtered WSe2 films are partially oxidized, which may cause spherical-shaped particles. Regardless of the loading amount of WSe2, Tafel slopes of WSe2 electrodes in the HER test are narrowly distributed to be ~120–138 mV dec-1, which indicates the excellent reproducibility of intrinsic catalytic activity. By considering the trade-off between the loading amount and ECSA, the best HER performance is clearly observed in the 200 W-15 min sample with an overpotential of 220 mV at a current density of 10 mA cm-2. Such a simple sputtering method at low temperature can be easily expanded to other 2D TMD electrochemical catalysts, promising potentially practical electrocatalysts.

关键词： Two dimensional nanomaterials Sputtering WSe2 nanofilm Electrocatalyst Hydrogen evolution reaction

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Antibiofilm and antithrombotic hydrogel coating based on superhydrophilic zwitterionic carboxymethyl chitosan for blood-contacting devices

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Bioactive Materials 2024年第4期34卷 112-124页

作者： Dong Uk Lee Mukhammad Kayumov Junghun Park Se Kye Park Yeongkwon Kang Yejin Ahn woojin Kim Seung Hwa Yoo Jun-Kyu Park Bong-Gi Kim Yong Suk Oh In-Seok Jeong Dong Yun choi Biomedical Manufacturing Technology Center Korea Institute of Industrial TechnologyYeongcheon38822Republic of Korea Department of Thoracic and Cardiovascular Surgery Chonnam National University Hospital and Medical SchoolGwangju61469Republic of Korea Research Institute of Advanced Materials Seoul National UniversitySeoul08826Republic of Korea Department of Organic and Nano System Engineering Konkuk UniversitySeoul05029Republic of Korea Department of Quantum System Engineering Jeonbuk National UniversityJeonju-si54896Republic of Korea IMT Inc. Gwangju61086Republic of Korea Department of Mechanical Engineering Changwon National UniversityChangwon51140Republic of Korea

Blood-contacting devices must be designed to minimize the risk of bloodstream-associated infections,thrombosis,and intimal lesions caused by surface ***,achieving effective prevention of both bloodstream-associated infections and thrombosis poses a challenge due to the conflicting nature of antibacterial and antithrombotic activities,specifically regarding electrostatic *** study introduced a novel biocompatible hydrogel of sodium alginate and zwitterionic carboxymethyl chitosan(ZW@CMC)with antibacterial and antithrombotic activities for use in *** ZW@CMC hydrogel demonstrates a superhydrophilic surface and good hygroscopic properties,which facilitate the formation of a stable hydration layer with low *** zwitterionic-functionalized CMC incorporates an additional negative sulfone group and increased negative charge density in the carboxyl *** augmentation enhances electrostatic repulsion and facilitates the formation of hydration *** leads to exceptional prevention of blood clotting factor adhesion and inhibition of biofilm ***,the ZW@CMC hydrogel exhibited biocompatibility with tests of in vitro cytotoxicity,hemolysis,and catheter ***,in vivo tests of antithrombotic and systemic inflammation models with catheterization indicated that ZW@CMC has significant advantages for practical applications in cardiovascular-related and sepsis *** study opens a new avenue for the development of chitosan-based multifunctional hydrogel for applications in blood-contacting devices.

关键词： Zwitterionic Hydrogel Blood-clotting Antimicrobial Sepsis

On Rayleigh expansion for nonlinear long water waves

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Journal of Hydrodynamics 2019年第6期31卷 1115-1126页

作者： Wooyoung choi Department of Mathematical Sciences New Jersey Institute of TechnologyNewarkNJ 07102-1982USA

We consider strongly nonlinear long waves on the surface of a homogeneous fluid *** modifying the formulation for the high-order spectral(HOS)method for waves in water of finite depth,we present a higher-order nonlinear system for the surface elevation and the velocity potential on the free surface to describe the two-dimensional evolution of large amplitude long *** is shown that the resulting system preserves the Hamiltonian structure of the Euler equations and can be transformed to the strongly nonlinear long-wave model for the depth-averaged *** to truncation of the linear dispersion relation for water waves,both the system for the surface velocity potential and that for the depth-averaged velocity are ill-posed when the order of approximation is odd and even,*** avoid this ill-posedness,fully dispersive models are also *** the same order approximation,the long-wave model is found more effective for numeral studies of large amplitude long waves than the finite-depth model.

关键词： Long surface gravity waves strongly nonlinear waves Hamiltonian system regularized model