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Molecular Characteristics of Cockroach Allergens

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Cellular & Molecular Immunology 2005年第3期2卷 177-180页

作者： Mey-fann Lee DepanmentofEducationandResearchTaichungVeteransGeneralHospital Taiwan Department of Education and Research Taichung Veterans General Hospital Taiwan China.

Cockroaches, commonly found in urban dwellings worldwide, have long been considered vectors of various infectious diseases and cockroach allergens are one of the major etiologic risk factors for IgE-mediated allergic respiratory illness throughout the world. A high prevalence of cockroach hypersensitivity in atopic （20-55 %） and asthmatic （49-60 %） populations has been documented. Cockroach allergens with molecular weights ranging from 6 to 120 kD have been identified by various standard immunochemical techniques. This article covers the characteristics of major cockroach allergens that have been purified, sequenced, cloned, and produced as recombinant proteins. Cellular ＆ Molecular Immunology. 2005;2（3）： 177-180.

关键词： hypersensitivity asthma cockroach cockroach allergen cloning recombinant protein

Nosocomial infection and spread of SARS-CoV-2 infection among hospital staff,patients and caregivers

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World Journal of Clinical Cases 2022年第34期10卷 12559-12565页

作者： Chih-Chien Cheng Li-Yun fann Yi-Chang Chou Chia-Chen Liu Hsiao-Yun Hu Dachen Chu Department of Education and Research Taipei City HospitalTaipei 116009Taiwan Department of Nursing Taipei City HospitalTaipei 106243Taiwan Department of Education and Research Taipei City HospitalTaipei 106109Taiwan School of Medicine College of MedicineFu Jen Catholic UniversityTaipei 106109Taiwan

BACKGROUND There are difficulties in diagnosing nosocomial transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection in hospital settings. Furthermore, mortality of cases of nosocomial infection(NI) with SARS-CoV-2 is higher than that of the general infected population. In the early stage of the pandemic in Taiwan, as patients were not tested for SARS-CoV-2 at admission, NIs often go undetected. Strictly applying the systematic polymerase chain reaction(PCR) screening, as a standard infection control measure was subsequently implemented to reduce NI incidence. However, evidence on risk factors for SARS-CoV-2 NIs among healthcare workers(HCWs) and caregivers is *** To assess NI incidence of SARS-CoV-2 among hospital staff, hospitalized patients, and caregivers, and the transmission routes of clusters of *** This descriptive retrospective analysis at our hospital from May 15 to August 15, 2021 included data on 132 SARS-CoV-2 NIs cases among hospital staff, inpatients, and caregivers who previously tested negative but subsequently identified with a positive SARS-CoV-2 reverse transcriptase-PCR(RT-PCR) test results, or a hospital staff who tested positive following routine SARS-CoV-2 RT-PCR test. Chi-square tests were performed to compare the differences between hospital staff and private caregivers, and between clusters and sporadic *** Overall, 9149 patients and 2005 hospital staff members underwent routine SARS-CoV-2 RT-PCR testing, resulting in 12 confirmed cluster and 23 sporadic infections. Among the index cases of the clusters, three(25%) cases were among hospital staff and nine(75%) cases were among other contacts. Among sporadic infections, 21(91%) cases were among hospital staff and two(9%) cases were among other contacts(P < 0.001). There was an average of 8.08 infections per cluster. The secondary cases of cluster infection were inpatients(45%), hospital staff(30%), and caregivers(25%). Private

关键词： COVID-19 SARS CoV-2 Cross infection Incidence Retrospective studies Infection control

Hepatitis B virus persistent infection-related single nucleotide polymorphisms in HLA regions are associated with viral load in hepatoma families

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World Journal of Gastroenterology 2021年第37期27卷 6262-6276页

作者： Ai-Ru Hsieh Cathy S J fann Hung-Chun Lin Jennifer Tai Sen-Yung Hsieh Dar-In Tai Department of Statistics Tamkang UniversityNew Taipei City 25137Taiwan Institute of Biomedical Sciences Academia SinicaNankangTaipei 11529Taiwan Division of Hepatology Department of Gastroenterology and HepatologyChang Gung Memorial HospitalLinkou Medical CenterTaoyuan 33305Taiwan

BACKGROUND Genome-wide association studies from Asia indicate that HLA-DP and HLA-DQ loci are important in persistent hepatitis B virus(HBV)*** of the key elements for HBV-related carcinogenesis is persistent viral replication and *** To examine genetic and nongenetic factors with persistent HBV infection and viral load in families with hepatocellular carcinoma(HCC).METHODS The HCC families included 301 hepatitis B surface antigen(HBsAg)carriers and 424 noncarriers born before the nationwide vaccination program was initiated in *** HBV-related single nucleotide polymorphisms(SNPs)—rs477515,rs9272105,rs9276370,rs7756516,and rs9277535—were *** associated with persistent HBV infection and viral load were analyzed by a generalized estimating *** In the first-stage persistent HBV study,all SNPs except rs9272105 were associated with persistent infection.A significantly higher area under the reciprocal operating characteristic curve for nongenetic factors vs genetic factors(P<0.001)suggests that the former play a major role in persistent HBV *** the second-stage viral load study,we added 8 HBsAg carriers born after *** 309 HBsAg carriers were divided into low(n=162)and high viral load(n=147)groups with an HBV DNA cutoff of 105 cps/***,relationship to the index case,rs477515,rs9272105,and rs7756516 were associated with viral *** on the receiver operating characteristic curve analysis,genetic and nongenetic factors affected viral load equally in the HCC family cohort(P=0.3117).CONCLUSION In these east Asian adults,the mechanism of persistent HBV infection-related SNPs was a prolonged viral replication phase.

关键词： Generalized estimating equation Genetic polymorphism Genome-wide association study Hepatitis B surface antigen Hepatitis B virus Replication

Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第5期23卷 876-884页

作者： Ai-Ru Hsieh Cathy SJ fann Chau-Ting Yeh Hung-Chun Lin Shy-Yi Wan Yi-Cheng Chen Chia-Lin Hsu Jennifer Tai Shi-Ming Lin Dar-In Tai Graduate Institute of Biostatistics China Medical University Institute of Biomedical Sciences Academia Sinica Division of Hepatology Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital Kaohsiung Medical University College of Medicine

AIM To explore factors associated with persistent hepatitis B virus (HBV) infection in a cohort of hepatocellular carcinoma (HCC)-affected families and then investigate factors that correlate with individual viral load among hepatitis B surface antigen (HBsAg)-positive relatives. METHODS questionnaire. Demographics, relationship to index case, HBsAg status of mothers and index cases were evaluated for association with the HBV persistent infection or viral load by generalized estimating equation analysis. RESULTS Among 729 relatives enrolled, parent generation (P = 0.0076), index generation (P = 0.0044), mothers positive for HBsAg (P = 0.0007), and HBsAg-positive index cases (P = 5.98 x 10(-8)) were associated with persistent HBV infection. Factors associated with HBV viral load were evaluated among 303 HBsAg-positive relatives. Parent generation (P = 0.0359) and sex (P = 0.0007) were independent factors associated with HBV viral load. The intra-family HBV viral load was evaluated in families clustered with HBsAg-positive siblings. An intra-family trend of similar HBV viral load was found for 27 of 46 (58.7%) families. Male offspring of HBsAg-positive mothers (P = 0.024) and older siblings were associated with high viral load. CONCLUSION Sex and generation play important roles on HBV viral load. Maternal birth age and nutritional changes could be the reasons of viral load difference between generations.

关键词： Familial generation Sex Hepatitis B virus Perinatal infection Viral replication

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一枝红杏出墙来

时尚时间 2010年第5期 60-65页

作者： Jeff fann

也许是看到一夜之间京城杨柳吐芽后的欣喜，也许是受到周末陪女友在小区广场放风筝时轻松心情的渲染，从小生长在北方的我，竟是第一次如此深刻地感受悄然而至的春。春天临近，无论眼里看到什么，都会首先和这生机盎然的时令联系在一起... 详细信息

也许是看到一夜之间京城杨柳吐芽后的欣喜，也许是受到周末陪女友在小区广场放风筝时轻松心情的渲染，从小生长在北方的我，竟是第一次如此深刻地感受悄然而至的春。春天临近，无论眼里看到什么，都会首先和这生机盎然的时令联系在一起。“春色满园关不住，一枝红杏出墙来”，这就是在我看到Cornelius＆Cie手表的一刹那，脑海中浮现出的句子。

关键词：墙杏 Cie 广场小区