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Therapeutic strategies of three-dimensional stem cell spheroids and organoids for tissue repair and regeneration

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Bioactive Materials 2023年第1期19卷 50-74页

作者： woochan kim Yonghyun Gwon Sunho Park Hyoseong kim Jangho kim Department of Convergence Biosystems Engineering Chonnam National UniversityGwangju61186Republic of Korea Department of Rural and Biosystems Engineering Chonnam National UniversityGwangju61186Republic of Korea Interdisciplinary Program in IT-Bio Convergence System Chonnam National UniversityGwangju61186Republic of Korea

Three-dimensional(3D)stem cell culture systems have attracted considerable attention as a way to better mimic the complex interactions between individual cells and the extracellular matrix(ECM)that occur in ***,3D cell culture systems have unique properties that help guide specific functions,growth,and processes of stem cells(e.g.,embryogenesis,morphogenesis,and organogenesis).Thus,3D stem cell culture systems that mimic in vivo environments enable basic research about various tissues and *** this review,we focus on the advanced therapeutic applications of stem cell-based 3D culture systems generated using different engineering ***,we summarize the historical advancements of 3D cell culture systems and discuss the therapeutic applications of stem cell-based spheroids and organoids,including engineering techniques for tissue repair and regeneration.

关键词： 3D stem cell culture Spheroid Organoid Tissue repair Tissue regeneration

Novel Sensing Hole Recovery with Expanded Relay Node Capability

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Computer Systems Science & Engineering 2023年第1期44卷 663-675页

作者： Moonseong kim woochan Lee Department of IT Convergence Software Seoul Theological UniversityBucheon14754Korea Department of Electrical Engineering Incheon National UniversityIncheon22012Korea

The occurrence of‘sensing holes’not only hinders seamless data col-lection but also leads to misinterpretation of information in certain areas under extensive data *** order to overcome this,various sensor relocation stra-tegies have been proposed,but the existing relocation strategies revealed pro-blems such as the ping-pong,shaded area,network disconnection,*** paper conducted research on relocation protocols in a distributed environment that is very suitable for real-world situations and efficiently recovering the problem of sensing ***,a simulation was performed on the distribution of the shaded area for data collection,which is a problem with the existing representative relo-cation *** that,a data collection capability was newly added to the relay node,which had been in charge of only communication between cluster zones so far,and with this additional functionality,the performance of the revised sensor relocation algorithm was dramatically improved to overcome the existing *** addition,the performance and validity of the proposed algorithm were verified through various simulations.

关键词： Hopping sensor mobile internet of things relocation protocol relay node simulation

Success Rate Queue-Based Relocation Algorithm of Sensory Network to Overcome Non-Uniformly Distributed Obstacles

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Computers, Materials & Continua 2020年第11期65卷 1181-1201页

作者： Sooyeon Park Moonseong kim woochan Lee Department of Electrical Engineering Incheon National UniversityIncheon22012Korea Department of Liberal Arts Seoul Theological UniversityBucheon14754Korea

With the recent development of big data technology that collects and analyzes various data,the technology that continuously collects and analyzes the observed data is also drawing ***,its importance is growing in data collection in areas where people cannot *** general,it is not easy to properly deploy IoT wireless devices for data collection in these areas,and it is also inappropriate to use general wheel-based mobile devices for ***,researches have been actively carried out on hopping moving models in place of wheel-based movement for the inaccessible *** majority of studies,however,so far have unrealistic assumptions that all IoT devices know the overall state of the network and the current state of each ***,various physical terrain environments,such as coarse gravel and sand,can change from time to time,and it is impossible for all devices to recognize these changes in *** this paper,with the migration success rate of IoT hopping devices being relocated,the method of estimating the varying environment is *** method can actively reflect the changing environment in real-time and is a realistic distributed environment-based relocation protocol on behalf of non-realistic,theory-based relocation ***,one of the significant contributions of this paper is to evaluate its performance using the OMNeT++simulation tool for the first time in the world to reflect actual physical environmental *** to previous studies,the proposed protocol was able to actively reflect the state of the surrounding environment,which resulted in improved migration success rates and higher energy efficiency.

关键词： Mobile IoT hopping sensor sensory data networking relocation protocol simulation

Hopping-Aware Cluster Header Capability for Sensor Relocation in Mobile IoT Networks

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Intelligent Automation & Soft Computing 2023年第5期36卷 1613-1625页

作者： Moonseong kim Jaeyoung Park Young-Joon kim woochan Lee Department of IT Convergence Software Seoul Theological UniversityBucheon14754Korea Department of Computer Engineering Hongik UniversitySeoul04066Korea Department of Electronic Engineering Gachon UniversitySeongnam13120Korea Department of Electrical Engineering Incheon National UniversityIncheon22012Korea

Mobile sensor nodes such as hopping sensors are of critical importance in data ***,the occurrence of sensing holes is unavoidable due to the energy limitation of the ***,it is evident that the relocation of mobile sensors is the most desirable method to recover the sensing *** previous research conducted by the authors so far demonstrated the most realistic hopping sensor relocation scheme,which is suitable for the distributed *** previous studies,the cluster header plays an essential role in detecting the sensing hole and requesting the neighboring cluster to recover the sensing hole that occurred in the sensor ***,the limitations of the cluster header in the previously proposed relocation protocol are not fully *** the cluster header jumps more frequently than non-header nodes,its energy con-sumption is relatively high compared to other ***,it is most likely to lead to header node failure and can lead to data loss on the *** this paper,the jumping ability and energy consumption of the cluster header are seriously *** ability to replace cluster headers in case of failure is also *** results show that the data collection time can be further increased,which demonstrates the validity of the proposed algorithms.

关键词： Hopping sensor mobileinternetofthings relocationprotocol header node numericalsimulation

Parallel Iterative FEM Solver with Initial Guess for Frequency Domain Electromagnetic Analysis

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Intelligent Automation & Soft Computing 2023年第5期36卷 1585-1602页

作者： woochan Lee Woobin Park Jaeyoung Park Young-Joon kim Moonseong kim Department of Electrical Engineering Incheon National UniversityIncheon22012Korea Department of Computer Engineering Hongik UniversitySeoul04066Korea Department of Electronic Engineering Gachon UniversitySeongnam13120Korea Department of IT Convergence Software Seoul Theological UniversityBucheon14754Korea

The finite element method is a key player in computational electromag-netics for designing RF(Radio Frequency)components such as *** frequency-domain analysis is fundamental to identify the characteristics of the *** the conventional frequency-domain electromagnetic analysis using FEM(Finite Element Method),the system matrix is complex-numbered as well as indeﬁ*** iterative solvers can be faster than the direct solver when the solver convergence is guaranteed and done in a few ***,such complex-numbered and indeﬁnite systems are hard to exploit the merit of the iterative *** is also hard to beneﬁt from matrix factorization techniques due to varying system matrix parts according to ***,it is hard to adopt conventional iterative solvers even though the system matrix is sparse.A new parallel iterative FEM solver for frequency domain analysis is implemented for inhomogeneous waveguide structures in this *** this implementation,the previous solution of the iterative solver of Matlab(Matrix Laboratory)employ-ing the preconditioner is used for the initial guess for the next step’s solution *** overlapped parallel stage using Matlab’s Parallel Computing Toolbox is also proposed to alleviate the cold starting,which ruins the convergence of early steps in each parallel *** experiments based on waveguide structures have demonstrated the accuracy and efﬁciency of the proposed scheme.

关键词： Computational electromagnetics numerical simulation ﬁnite element method parallel processing iterative solvers