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Type ⅡB human skeletal muscle fibers positively correlate with bone mineral density irrespective to age

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Chinese Medical Journal 2010年第21期123卷 3009-3014页

作者： Wing-Hoi Cheung Wing-Sze lee Ling Qin Ning Tang Vivian Wing-Yin Hung Kwok-Sui Leung Department of Orthopaedics and Traumatology The Chinese University of Hong Kong Shatin Hong Kong China

Background Age-associated decrease in type ⅡA/B human skeletal muscle fibers was detected in human biopsies in our previous study. The relationship between change in muscle fiber typing and bone mineral density （BMD） is, however,unknown either cross-sectionally or longitudinally. We therefore conducted a cross-sectional study to investigate their correlation using human muscle *** Forty human subjects aged （53.4±20.2） years were recruited. Histomorphometric parameters of their muscle biopsies were measured by ATPase staining and image analysis, including average area percentage, fiber number percentage, mean fiber area, and area percentage of connective tissues. Hip and spine BMD was measured by dual-energy X-ray absorptiometry. Partial correlation with adjusting age was *** Type ⅡB muscle fiber was found positively correlated with hip BMD irrespective to age and demonstrated significantly stronger relationship with BMD among all fiber types, in terms of its cross-sectional area （r=0.380, P=0.029）and size （r=0.389, P=0.025）. Type ⅡA muscle fibers associated with hip BMD in mean fiber area only （r=0.420, P=0.015）.Conclusions Type ⅡB muscle fiber may play an important role in maintaining bone quality. This may also be a relatively more sensitive fiber type of sarcopenia and osteoporosis. These findings further consolidate the muscle-bone relationship.

关键词： type ⅡB muscle fiber bone mineral density muscle biopsy sarcopenia osteoporosis

Super-resolving material microstructure image via deep learning for microstructure characterization and mechanical behavior analysis

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npj Computational Materials 2021年第1期7卷 867-877页

作者： Jaimyun Jung Juwon Na Hyung Keun Park Jeong Min Park Gyuwon Kim Seungchul lee Hyoung Seop Kim Department of Materials AI&Big-Data Korea Institute of Materials Science(KIMS)Changwon-siRepublic of Korea Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)PohangRepublic of Korea Department of Materials Science and Engineering Pohrepresent the average grainang University of Science and Technology(POSTECH)PohangRepublic of Korea Graduate School of Artificial Intelligence Pohang University of Science and Technology(POSTECH)PohangRepublic of Korea Graduate Institute of Ferrous Technology Pohang University of Science and Technology(POSTECH)PohangRepublic of Korea

The digitized format of microstructures,or digital microstructures,plays a crucial role in modern-day materials ***,the acquisition of digital microstructures through experimental means can be unsuccessful in delivering sufficient resolution that is necessary to capture all relevant geometric features of the *** resolution-sensitive microstructural features overlooked due to insufficient resolution may limit one’s ability to conduct a thorough microstructure characterization and material behavior analysis such as mechanical analysis based on numerical ***,a highly efficient super-resolution imaging based on deep learning is developed using a deep super-resolution residual network to super-resolved low-resolution(LR)microstructure data for microstructure characterization and finite element(FE)mechanical *** characterization and FE model based mechanical analysis using the super-resolved microstructure data not only proved to be as accurate as those based on high-resolution(HR)data but also provided insights on local microstructural features such as grain boundary normal and local stress distribution,which can be only partially considered or entirely disregarded in LR data-based analysis.

关键词： microstructure Microstructure analysis

The RNA Pol Ⅱ sub-complex hsRpb4/7 is required for viability of multiple human cell lines

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Protein & Cell 2012年第11期3卷 846-854页

作者： Yang Zhao Kim K.C.Li King Pan Ng Chi Ho Ng Kevin A.W.lee Division of Life Science The Hong Kong University of Science and TechnologySai KungHong Kong S.A.R.China

The evolutionarily conserved RNA Polymerase Ⅱ Rpb4/7 sub-complex has been thoroughly studied in yeast and impacts gene expression at multiple levels including transcription,mRNA processing and *** addition Rpb4/7 exerts differential effects on gene expression in yeast and Rpb4 is not obligatory for yeast(***)*** roles for human(hs)Rpb4/7 have not been extensively described and we have probed this question by depleting hsRpb4/7 in established human cell lines using RNA *** find that Rpb4/7 protein levels are inter-dependent and accordingly,the functional effects of depleting either protein are ***4/7 exhibits gene-specific effects and cells initially remain viable upon hsRpb4/7 *** prolonged hsRpb4/7 depletion is cytotoxic in the range of cell lines *** cell death occurs by an unknown mechanism and in some cases is accompanied by a pronounced elongated cell *** conclusion we provide evidence for a gene-specific role of hsRpb4/7 in human cell viability.

关键词： RNA PolymeraseⅡ hsRpb4/7 sub-complex gene expression cell viability cell shape

Gulf Resources Focuses on Environmentally Friendly Components

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China Chemical Reporter 2009年第18期20卷 25-25页

作者： Amy lee

Gulf Resources is a leading provider ofbromine, crude salt and a portfolio of variousspecialty chemicals throughout China andbecame a U.S. publicly traded company inDecember 2006. Its products are necessarycomponents for China’s flourishing oil andpapermaking industries. The company has abromine production capacity to an estimated34 700 t/a.

关键词： chemicals provider publicly crude revenue portfoli

Ameliorative effects of human adipose tissue-derived mesenchymal stem cells on myelin basic protein-induced experimental autoimmune encephalomyelitis in Lewis rats

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Neural Regeneration Research 2011年第16期6卷 1205-1210页

作者： Myung-Soon Ko Hyeong-geun Park Young-Min Yun Jeong Chan Ra Taekyun Shin Kyoung-Kap lee College of Veterinary Medicine Jeju National University Stem Cell Research Center RNL BIO Co.Ltd.

Mesenchymal stem cells have been previously shown to exert an immunomodulatory function. The present study sought to investigate the effects of multipotential human adipose tissue-derived mesenchymal stem cells （hAdMSCs） on disease progression and cytokine expression in Lewis rats with experimental autoimmune encephalomyelitis （EAE） induced by myelin basic protein. The duration of EAE paralysis in the group treated on day 7 posfimmunization with 5 × 10^6 hAdMSCs was significantly reduced compared with the vehicle-treated controls and the 1 x 106 hAdMSC- treated group. The duration of EAE paralysis in the groups treated with 5 × 10^6 hAdMSCs on both day 1 and day 7 postimmunization was significantly reduced compared with the vehicle-treated controls and the groups treated with 5 × 10^6 hAdMSCs on both day 7 and day 10 postimmunization. The mRNA expression of interleukin-10 and indoleamine 2, 3-dioxygenase was significantly decreased in the hAdMSC-treated group compared with the vehicle-treated group. These findings suggest that the ameliorative effects of hAdMSCs on EAE symptoms operate in a dose- and time-dependent manner and can be mediated in part by the ample production of anti-inflammatory cytokines.

关键词： experimental autoimmune encephalomyelitis human adipose tissue mesenchymal stem cells intedeukin-10 interferon-gamma indoleamine 2, 3-dioxygenase neural regeneration

Position-resolved Surface Characterization and Nanofabrication Using an Optical Microscope Combined with a Nanopipette/Quartz Tuning Fork Atomic Force Microscope

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Nano-Micro Letters 2014年第1期6卷 70-79页

作者： Sangmin An Baekman Sung Haneol Noh Corey Stambaugh Soyoung Kwon Kunyoung lee Bongsu Kim Qhwan Kim Wonho Jhe Center for Nano-Liquid Department of Physics and AstronomySeoul National University National Institute of Standards and Technology

In this work, we introduce position-resolved surface characterization and nanofabrication using an optical microscope(OM) combined with a nanopipette-based quartz tuning fork atomic force microscope(nanopipette/QTF-AFM) system. This system is used to accurately determine substrate position and nanoscale phenomena under ambient conditions. Solutions consisting of 5 nm Au nanoparticles, nanowires, and polydimethylsiloxane(PDMS) are deposited onto the substrate through the nano/microaperture of a pulled pipette. Nano/microscale patterning is performed using a nanopipette/QTF-AFM, while position is resolved by monitoring the substrate with a custom OM. With this tool, one can perform surface characterization(force spectroscopy/microscopy) using the quartz tuning fork(QTF) sensor. Nanofabrication is achieved by accurately positioning target materials on the surface, and on-demand delivery and patterning of various solutions for molecular architecture.

关键词： Surface characterization Nanopipette QTF-AFM Optical microscope

SIZ1-Mediated SUMOylation of TPR1 Suppresses Plant Immunity in Arabidopsis

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Molecular Plant 2019年第2期12卷 215-228页

作者： De Niu Xiao-Li Lin Xiangxiong Kong Gao-Ping Qu Bin Cai Jiyoung lee Jing Bo Jin Key Laboratory of Plant Molecular Physiology Institute of Botany Chinese Academy of Sciences Beijing 100093 China University of Chinese Academy of Sciences Beijing 100049 China Biological Resource Center Korea Research In stitute of Bioscie nee and Biotech no logy Jeon geup 56212 South Korea

Plant immune responses are tightly regulated to ensure their appropriate deployment. Overexpression of TOPLESS-RELATED 1 (TPR1), a SUPPRESSOR OF npr1-1, CONSTITUTIVE 1 (SNC1)-interacting protein, results in autoimmunity that reduces plant growth and development. However, how TPR1 activity is regulated remains unknown. Loss of function of SIZ1, a (SUMO) E3 ligase, induces an autoimmune response, partially due to elevated SNC1 levels. Here we show that SNC1 expression is upregulated in Arabidopsis thaliana siz1-2 due to positive-feedback regulation by salicylic acid. SIZ1 physically interacts with TPR1 and facilitates its SUMO modification. The K282 and K721 residues in TPR1 serve as critical SUMO attachment sites. Simultaneous introduction of K282R and K721R substitutions in TPR1 blocked its SUMOylation, enhaneed its transcriptional co-repressor activity, and increased its association with HISTONE DEACETYLASE 19 (HDA19), suggesting that SUMOylation of TPR1 represses its transcriptional co-repressor activity and inhibits its interaction with HDA19. In agreement with this finding, the simultaneous introduction of K282R and K721R substitutions enhanced TPR1 mediated immunity, and the tpr1 mutation partially suppressed autoimmunity in siz1-2. These results demonstrate that SIZ1-mediated SUMOylation of TPR1 represses plant immunity, which at least partly contributes to the suppression of autoimmunity under nonpathogenic conditions to ensure proper plant development.

关键词： immune response SIZ1 SUMO E3 ligase SUMO modification TOPLESS

The Seismic Risk Assessment and Seismic Zoning of the Hong Kong Region

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Earthquake Research in China 1997年第2期11卷 17-34页

作者： C F lee Department of Civil and Structural Engineering University of Hong Kong

The Hong Kong-Kowloon Block,which has been uplifted continually and is stable since the late Cretaceous-Paleogene period,is identified and determined as a potential source with a maximum credible magnitude of M=5.5,while the late Cretaceous-Paleogene fault basins located around the Hong Kong-Kowloon Block are determinated as a potential source with a maximum credible magnitude of M≥6.0 based on the characteristics of seismo-tectonic activities in Hong Kong and its adjacent *** attenuation law of peak ground acceleration(PGA)and standard response spectra of acceleration(β)with damping 5% underlain by basement were determined by comparing the Chinese continent with the western *** the similarity of tectonic environment of continental earthquakes,potential source with credible seismic magnitude of 5.0-7.5,and considering ground motion saturation near the *** near source attenuation model of acceleration and response spectrum also reflect the field of Intensity distribution in East

关键词： acceleration magnitude continent tectonic Cretaceous basement trending similarity attenuation geologic

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针刀治疗肩周炎的临床疗效观察

针刀治疗肩周炎的临床疗效观察

作者：李玠沅（Jieyuan lee）广州中医药大学

学位级别：硕士

目的:本研究观察针刀疗法治疗肩周炎的临床疗效,并与常规电针疗法对比,基于疼痛视觉模拟评分(VAS)、Constant-Murley评分法、日常生活能力评定表(ADL)等客观量表指标进行评估,初步探讨、评价针刀于治疗肩周炎方面的具体疗效、临床价值... 详细信息

目的:本研究观察针刀疗法治疗肩周炎的临床疗效,并与常规电针疗法对比,基于疼痛视觉模拟评分(VAS)、Constant-Murley评分法、日常生活能力评定表(ADL)等客观量表指标进行评估,初步探讨、评价针刀于治疗肩周炎方面的具体疗效、临床价值及时效性,基于现代解剖探讨针刀治疗肩周炎的作用机理,为临床应用提供治疗肩周炎不同的选择及更有力的循证医学证据。方法:1.患者来源:于广州中医药大学第一附属医院针灸科、骨科的门诊和住院部招募62名符合实验条件的患者,最终有60名患者完成实验。2.分组:按照随机数表将患者随机分配至针刀组(实验组)和电针组(对照组),其中实验组所有患者均采用针刀治疗,每周1次,疗程3周,共3次治疗;对照组所有患者采用电针治疗,每周治疗3次,疗程3周,共9次治疗。选取治疗前、治疗后、治疗后1个月作为观察节点采集数据。3.量表:采用Constant-Murley评分法、视觉疼痛评分法(VAS)以及日常生活能力评定表(ADL),对2组患者治疗前后疼痛、关节活动功能、抬肩位置、肌力、日常生活能力等进行评价。4.最终采集的所有数据汇总为excel,由SPSS23.0进行数据分析处理。结果:研究开始前对两组受试对象的性别、年龄、病程等基本资料进行统计学检验,差异均不具有显著性(P>0.05),并对两组患者治疗前Constant-Murley、VAS评分及日常生活能力量表评分进行分析,差异不显著(P>0.05),提示组间有可比性。1.两组在功能、症状评分方面,进行组间对比,可见实验组的Constant-Murley评分、VAS评分在治疗后及治疗后一个月与对照组相比均具有显著性(P0.05),两组有可比性。而治疗后及治疗后一个月,实验组的生活能力评分结果均优于对照组(P<0.05)。3.疗效方面,治疗后的针刀治疗组的有效率达93.34%,优于电针治疗的80.00%,治疗后1个月的疗效维持针刀组93.34%,电针组80.00%,无明显变化。结论:1.针刀能松解局部粘连状态,解除肩部冻结情况,改善血循环,促进机体的恢复,显著缓解疼痛和关节活动受限等症状,其整体疗效优于电针。2.除了针对相关症状的治疗之外,还能提高生活和工作质量,缓解临床症状所致的心理压力,整体上改善生存状况。

关键词：肩周炎针刀疗法针灸电针临床疗效