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Arabidopsis thaliana RECEPTOR DEAD KINASE1 Functions as a Positive Regulator in Plant Responses to ABA

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Molecular Plant 2017年第2期10卷 223-243页

作者： Dhinesh Kumar Ritesh Kumar Dongwon Baek Tae-Kyung Hyun woo sik chung Dae-Jin Yun Jae-Yean Kim Division of Applied Life Sciences Plant Molecular Biology and Biotechnology Research Center Gyeongsang National University Jinju 660-701 Korea Department of Industrial Plant Science and Technology Conege of Agricultural Life and Environmental Sciences Chungbuk National University Cheongju 28644Korea These authors contributed equally to this article.

Abscisic acid （ABA） is a major phytohormone involved in important stress-related and developmental plant processes. Membrane-delimited ABA signal transduction plays an important role in early ABA signaling, but the molecular mechanisms connecting core signaling components to the plasma membrane remain un- clear. Plants have evolved a large number of receptor-like kinases （RLKs） to modulate diverse biological processes by perceiving extracellular stimuli and activating downstream signaling responses. In this study, a putative leucine-rich repeat-RLK gene named RECEPTOR DEAD KINASE1 （AtRDK1） was identified and characterized in Arabidopsis thaliana. RDK1 promoter-GUS analysis revealed that RDK1 is expressed ubiq- uitously in the various tissues in Arabidopsis, and its expression is mainly induced by ABA. In the presence of ABA, RDKl-deficient rdkl-1 and rdkl-2 lines showed significant resistance in cotyledon greening and root growth, whereas RDKl-overexpressing lines showed enhanced sensitivity. Consistently, the expres- sion of ABA-responsive genes was significantly downregulated in rdkl mutant seedlings, which were also hypersensitive to drought stress with increased water loss. Interestingly, RDK1 was found to be an atypical kinase localized to the plasma membrane and did not require its kinase activity during ABA-mediated inhi- bition of seedling development. Accordingly, RDK1 interacted in the plasma membrane with type 2C protein phosphatase ABSClSIC ACID INSENSITIVE1 （ABI1）; this interaction was further enhanced by exogenous application of ABA, suggesting that RDKl-mediated recruitment of ABI1 onto the plasma membrane is important for ABA signaling. Taken together, these results reveal an important role for RDK1 in plant responses to abiotic stress conditions in an ABA-dependent manner.

关键词： ABA abiotic stress Arabidopsis atypical kinases protein phosphatases receptor-like kinases

Applying heteroatom co-doped carbon nanotube for manifesting high performance in the electrochemical reduction of aqueous nitrogen oxide by gold nanoparticles

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Nano Research 2024年第3期17卷 1151-1164页

作者： Jane chung Haibo Yin Rong Wang Yunlong Wang Junyang Zhang Yue Peng Joung woo Han Seongyun Ryu Junhua Li State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China EHS Research Center Samsung Electronics Co.Ltd.Gyeonggi-do 18448Republic of Korea

Electrochemical NO-to-NH_(3) under ambient conditions could be a viable alternative having advantages in terms of energy consumption and exhaust gas recycling of NO,replacing a traditional ammonia synthesis method of the Haber–Bosch *** synthesizing boron(B-)and nitrogen(N-)co-doped carbon nanotube(CNT)based gold(Au)catalysts,B-dopants elevate the conductivity of carbon nanotube by sp2 hybridization on graphene and implant B–N domains within the graphene layer,and result in facilitating the embedding amount of Au accompanied by high dispersibility with low particle *** density functional theory(DFT)calculations elucidate that the electron cloud transmitted from B-dopant to the active site of Au induces the Lewis acidic site,and the O-distal pathway occurs following a spontaneous *** of the electron-deficient B-doping area accompanied by N-defects and B–O edges retains the major valence state of Au as Au^(δ+),and suppresses hydrogen evolution reaction(HER)by repulsing the hindrance of H*.This record exhibits the highest faradaic efficiency(FE)of 94.7%,and NH_(3) yield rate of 1877.4μg·h^(-1)·mg_(cat)^(-1),which is the optimal yield over energy consumption in the field of the ambient reduction of aqueous NO.

关键词： boron heteroatom nitrogen defect gold nanoparticles valence states of gold electrochemical NO-to-NH3

Absence of enhancement in a lesion does not preclude primary central nervous system T-cell lymphoma:A case report

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World Journal of Clinical Cases 2024年第2期12卷 374-382页

作者： Chan-Seop Kim Chi-Hoon Choi Kyung sik Yi Yook Kim Jisun Lee Chang Gok woo Young Hun Jeon Department of Radiology Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Pathology Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Radiology Seoul National University HosptialSeoul 03080South Korea

BACKGROUND Primary central nervous system lymphoma(PCNSL)is a non-Hodgkin lymphoma that originates in the central nervous system(CNS)and is exclusively limited to the *** most PCNSLs are diffuse large B-cell lymphomas,primary CNS T-cell lymphomas(PCNSTLs)are *** typically demonstrate some degree of enhancement on contrast-enhanced magnetic resonance imaging(MRI).To the best of our knowledge,non-enhancing PCNSTL has not been reported *** SUMMARY A 69-year-old male presented to the neurology department with complaints of mild cognitive impairment and gradual onset of left lower leg weakness over a span of two *** MRI showed asymmetric T2-hyperintense lesions within the *** enhancement was observed on the contrast-enhanced T1 *** initial diagnosis was neuro-Behçet’s *** high-dose steroid therapy,no alterations in the lesions were identified on initial *** patient’s symptoms deteriorated *** MRI performed one month after the initial scan revealed an increased lesion ***,brain biopsy confirmed the diagnosis of *** patient underwent definitive combined ***,the patient developed bacteremia and died of septic shock approximately three months after *** The absence of enhancement in the lesion did not rule out PCNSTL.A biopsy approach is advisable for pathological confirmation.

关键词： Central nervous system neoplasms Non-Hodgkin Lymphoma T-cell Lymphoma Primary central nervous system lymphoma Primary central nervous system T-cell lymphoma Case report

Overexpression of Arabidopsis YUCCA6 in Potato Results in High-Auxin Developmental Phenotypes and Enhanced Resistance to Water Deficit

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Molecular Plant 2013年第2期6卷 337-349页

作者： Jeong Im Kim Dongwon Baek Hyeong Cheol Park Hyun Jin Chun Dong-Ha Oh Min Kyung Lee Joon-Yung Cha Woe-Yeon Kim Min Chul Kim woo sik chung Hans J. Bohner Sang Yeol Lee Ray A. Bressan Shin-woo Lee Dae-Jin Yun Department of Biochemistry Purdue University West Lafayette IN 47907 USA Division of Applied Life Science (BK21 and WCU Program) Plant Molecular Biology and Biotechnology Research Center Gyeongsang National UniversityJinju 660-701 Republic of Korea Department of Plant Biology University of Illinois at Urbana-Champaign Urbana IL USA Department of Agronomy and Medicinal Plant Resources Gyeongnam National University of Science and Technology Jinju 660-758 Korea Faculty of Science King Abdulaziz University Jeddah 21589 KSA Department of Horticulture Purdue University West Lafayette IN 47907 USA

Indole-3-acetic acid （IAA）, a major plant auxin, is produced in both tryptophan-dependent and tryptophan-independent pathways. A major pathway in Arabidopsis thaliana generates IAA in two reactions from tryptophan. Step one converts tryptophan to indole-3-pyruvic acid （IPA） by tryptophan aminotransferases followed by a rate-limiting step converting IPA to IAA catalyzed by YUCCA proteins. We identified eight putative StYUC （Solanum tuberosum YUCCA） genes whose deduced amino acid sequences share 50%-70% identity with those of Arabidopsis YUCCA proteins. All include canonical, conserved YUCCA sequences： FATGY motif, FMO signature sequence, and FAD-binding and NADP-binding sequences. In addition, five genes were found with -50% amino acid sequence identity to Arabidopsis trypto-phan aminotransferases. Transgenic potato （Solanum tuberosum cv. Jowon） constitutively overexpressing Arabidopsis AtYUC6 displayed high-auxin phenotypes such as narrow downward-curled leaves, increased height, erect stature, and longevity. Transgenic potato plants overexpressing AtYUC6 showed enhanced drought tolerance based on reduced water loss. The phenotype was correlated with reduced levels of reactive oxygen species in leaves. The results suggest a func-tional YUCCA pathway of auxin biosynthesis in potato that may be exploited to alter plant responses to the environment.

关键词： Solanum tuberosum potato Arabidopsis thaliana yuc6-1D YUCCA, StYUCCA, StTAA, auxin, drought.

Rheostatic Control of ABA Signaling through HOS15-Mediated OST1 Degradation

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Molecular Plant 2019年第11期12卷 1447-1462页

作者： Akhtar Ali Jae Kyoung Kim Masood Jan Haris Ali Khan Irfan Ullah Khan Mingzhe Shen Junghoon Park Chae Jin Lim Shah Hussain Dongwon Baek Kai Wang woo sik chung Vicente Rubio Sang Yeol Lee Zhizhong Gong Woe Yeon Kim Ray ABressan Jose MPardo Dae-Jin Yun Department of Biomedical Science&Engineering Konkuk UniversitySeoul 05029South Korea Department of Mathematical Sciences Korea Advanced Institute of Science and TechnologyDaejeon 34131Korea Division of Applied Life Science Plant Molecular Biology and Biotechnology Research CenterGyeongsang National UniversityJinju 660-701South Korea State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China Centro Nacional de Biotecnologia-CSIC Darwin 3.Campus de la UAM.Cantoblanco28049 MadridSpain Department of Horticulture and Landscape Architecture Purdue University625 Agriculture Mall DriveWest LafayetteIN 47907-2010USA lnstituto de Bioquimica Vegetal y Fotosintesis cicCartujaCSIC-Universidad de SevillaAmericoVespucio 49Sevilla 41092Spain

Dehydrating stresses trigger the accumulation of abscisic acid(ABA),a key plant stress-signaling hormone that activates Snf1-Related Kinases(SnRK2s)to mount adaptive ***,the regulatory circuits that terminate the SnRK2s signal relay after acclimation or post-stress conditions remain to be ***,we show that the desensitization of the ABA signal is achieved by the regulation of OST1(SnRK2.6)protein stability via the E3-ubiquitin ligase *** ABA signal,HOS15-induced degradation of OST1 is inhibited and stabilized OST1 promotes the stress *** the ABA signal terminates,protein phosphatases ABI1/2 promote rapid degradation of OST1 via ***,we found that even in the presence of ABA,OST1 levels are also depleted within hours of ABA signal *** unexpected dynamics of OST1 abundance are then resolved by systematic mathematical modeling,demonstrating a desensitizing feedback loop by which OST1-induced upregulation of ABI1/2 leads to the degradation of *** model illustrates the complex rheostat dynamics underlying the ABA-induced stress response and desensitization.

关键词： ABA signaling drought stress HOS15 OST1 ABI1/2 protein degradation and stability

Effectiveness of sensory integration therapy in children,focusing on Korean children:A systematic review and meta-analysis

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World Journal of Clinical Cases 2024年第7期12卷 1260-1271页

作者： Seri Oh Jong-sik Jang A-Ra Jeon Geonwoo Kim Mihwa Kwon Bahoe Cho Narae Lee Department of Occupational Therapy Kangwon National University Graduate SchoolSamcheok 25949South Korea Department of Occupational Therapy Kangwon National UniversitySamcheok 25949South Korea Department of Occupational Therapy Ju-Ju Children Development CenterNonsansi 32985Chungcheongnam-doSouth Korea Department of Occupation Therapy Suwon Women’s UniversityGyeonggi-do 16632South Korea Hijam Center for Development of Children Ochang 28117South Korea Department of Occupational Therapy U1 UniversityChung-cheong bukdo 25949South Korea

BACKGROUND Sensory integration intervention is highly related to the child's effective interaction with the environment and the child's ***,various sensory integration interventions are being applied,but research methodological problems are arising due to unsystematic *** study aims to present the optimal intervention protocol by presenting scientific standards for sensory integration intervention through *** To prove the effectiveness of sensory integration therapy,examine the latest trend of sensory integration studies in Korea,and provide clinical evidence for sensory integration *** The database of Korean search engines,including RISS,KISS,and DBpia,was used to search for related literature published from 2001 to October *** keywords,“Children”,“Sensory integration”,“Integrated sensory”,“Sensorymotor”,and“Sensory stimulation”were used in this ***,a meta-analysis was conducted on 24 selected studiesRISS,KISS,and DBpia,was used to search for related literature published from 2001 to October *** keywords,“Children”,“Sensory integration”,“Integrated sensory”,“Sensorymotor”,and“Sensory stimulation”were used in this ***,a meta-analysis was conducted on 24 selected *** Sensory integration intervention has been proven effective in children with cerebral palsy,autism spectrum disorder,attention deficit/hyperactivity disorder,developmental disorder,and intellectual disability in relation to the diagnosis of *** sensory integration therapies,1:1 individual treatment with a therapist or a therapy session lasting for 40 min was most *** terms of dependent variables,sensory integration therapy effectively promoted social skills,adaptive behavior,sensory processing,and gross motor and fine motor *** The results of this study may be used as therapeutic evidence for sensory integration intervention in the clinical field of occupational therapy for

关键词： Children Meta-analysis Occupational therapy Sensory integration Sensory processing Social skills

Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-Young Park Chulhwan Kwak Yoonji Lee Dae-Geun Song Jae woo Jung Haesong Lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun Hae Lee Wonsik Kim Soyeon Kim Chang-Duck Jun Jeanho Yun Sun Choi Hyun-woo Rhee Kwang-Hyeon Liu Jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

Antioxidant and anti-inflammatory roles of tea polyphenols in inflammatory bowel diseases

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Food Science and Human Wellness 2022年第3期11卷 502-511页

作者： Van-Long Truong woo-sik Jeong Food and Bio-industry Research Institute School of Food Science&BiotechnologyCollege of Agriculture and Life SciencesKyungpook National UniversityDaegu 41566Korea

Polyphenols,including phenolic acids,flavonoids,and procyanidins,are abundant in food and beverage derived from ***(Camellia sinensis)is particularly rich in polyphenols(e.g.,catechins,theaflavins,thearubigins,gallic acid,and flavonols),which are thought to contribute to the health benefits of *** intake of tea polyphenols has been described to prevent and/or attenuate a variety of chronic pathological conditions like cardiovascular diseases,neurodegenerative diseases,diabetes,and *** review focuses on established antioxidant and anti-inflammatory properties of tea polyphenols and underlying mechanisms of their involvement in inflammatory bowel diseases(IBD).Tea polyphenols act as efficient antioxidants by inducing an endogenous antioxidant defense system and maintaining intracellular redox *** polyphenols also regulate signaling pathways such as nuclear factor-κB,activator protein 1,signal transducer and activator of transcriptions,and nuclear factor E2-related factor 2,which are associated with IBD *** pieces of evidence have indicated that tea polyphenols enhance epithelial barrier function and improve gut microbial dysbiosis,contributing to the management of inflammatory ***,this study suggests that supplementation of tea polyphenols could prevent inflammatory conditions and improve the outcome of patients with IBD.

关键词： Antioxidant Anti-inflammation Epithelial barrier function Inflammatory bowel diseases Gut microbiota Tea polyphenols

Accelerating Falcon Post-Quantum Digital Signature Algorithm on Graphic Processing Units

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计算机、材料和连续体（英文） 2023年第4期75卷 1963-1980页

作者： Seog chung Seo Sang woo An Dooho Choi Kookmin University Seoul02707Korea Telecommunications Technology Association(TTA) Gyeonggi-do13591Korea Korea University Sejong30019Korea

Since 2016,the National Institute of Standards and Technology(NIST)has been performing a competition to standardize post-quantum cryptography(PQC).Although Falcon has been selected in the competition as one of the standard PQC algorithms because of its advantages in short key and signature sizes,its performance overhead is larger than that of other lattice-based *** study presents multiple methodologies to accelerate the performance of Falcon using graphics processing units(GPUs)for server-side *** GPU porting significantly degrades performance because the Falcon reference codes require recursive functions in its sampling ***,an iterative sampling approach for efficient parallel processing is *** this study,the Falcon software applied a fine-grained execution model and reported the optimal number of threads in a thread ***,the polynomial multiplication performance was optimized by parallelizing the number-theoretic transform(NTT)-based polynomial multiplication and the fast Fourier transform(FFT)-based ***,dummy-based parallel execution methods have been introduced to handle the thread divergence *** presented Falcon software on RTX 3090 NVIDA GPU based on the proposed methods with Falcon-512 and Falcon-1024 parameters outperform at 35.14,28.84,and 34.64 times and 33.31,27.45,and 34.40 times,respectively,better than the central processing unit(CPU)reference implementation using Advanced Vector Extensions 2(AVX2)instructions on a Ryzen 95900X running at 3.7 GHz in key generation,signing,and verification,***,the proposed Falcon software can be used in servers managing multiple concurrent clients for efficient certificate verification and be used as an outsourced key generation and signature generation server for Signature as a Service(SaS).

关键词： DSA Falcon GPU CUDA software optimization