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Photonic control of ligand nanospacing in self-assembly regulates stem cell fate

Bioactive Materials 2024年第4期34卷 164-180页

作者： Sungkyu Lee Jounghyun Yoo Gunhyu Bae Ramar Thangam Jeongyun Heo Jung Yeon Park Honghwan Choi Chowon Kim Jusung An Jungryun Kim Kwang Rok Mun Seungyong Shin Kunyu Zhang Pengchao Zhao Yuri Kim Nayeon Kang Seong-Beom Han Dahee Kim Jiwon Yoon Misun Kang Jihwan Kim Letao Yang Solmaz Karamikamkar Jinjoo Kim Yangzhi Zhu Alireza Hassani Najafabadi Guosheng Song Dong-Hwee Kim Ki-Bum Lee Soong Ju Oh Hyun-Do Jung Hyun-Cheol Song woo young jang Liming Bian Zhiqin Chu Juyoung Yoon Jong Seung Kim Yu Shrike Zhang Yongju Kim Ho Seong jang Sehoon Kim Heemin Kang Department of Materials Science and Engineering Korea UniversitySeoul02841Republic of Korea Chemical and Biological Integrative Research Center Korea Institute of Science and TechnologySeoul02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea Department of Chemistry Korea UniversitySeoul02841Republic of Korea Materials Architecturing Research Center Korea Institute of Science and TechnologySeoul02792Republic of Korea School of Biomedical Sciences and Engineering Guangzhou International CampusSouth China University of TechnologyGuangzhou511442China Department of Chemistry and Chemical Biology Rutgers UniversityPiscatawayNJ08854USA Terasaki Institute for Biomedical Innovation Los AngelesCA90064USA State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha410082China Department of Biomedical-Chemical Engineering The Catholic University of KoreaGyeonggi-do14662Republic of Korea Electronic Materials Research Center Korea Institute of Science and TechnologySeoul02792Republic of Korea KIST-SKKU Carbon-Neutral Research Center Sungkyunkwan University(SKKU)Suwon16419Republic of Korea Department of Orthopedic Surgery Korea University Anam HospitalSeoul02841Republic of Korea Department of Electrical and Electronic Engineering and Joint Appointment with School of Biomedical Sciences The University of Hong KongHong Kong518057China Department of Chemistry and Nanoscience Ewha Womans UniversitySeoul03760Republic of Korea Division of Engineering in Medicine Department of MedicineBrigham and Women’s Hospital Harvard Medical SchoolCambridgeMA02139USA Division of Nano&Information Technology KIST SchoolKorea University of Science and Technology(UST)Seoul02792Republic of Korea College of Medicine Korea UniversitySeoul02841Republic of Korea Division of Materials Science and Engineering Hanyang UniversitySeoul04763Republic of Korea

Extracellular matrix(ECM)undergoes dynamic inflation that dynamically changes ligand nanospacing but has not been *** we utilize ECM-mimicking photocontrolled supramolecular ligand-tunable Azo^(+)self-assembly composed of azobenzene derivatives(Azo^(+))stacked via cation-πinteractions and stabilized with RGD ligand-bearing poly(acrylic acid).Near-infrared-upconverted-ultraviolet light induces cis-Azo^(+)-mediated inflation that suppresses cation-πinteractions,thereby inflating liganded *** inflation increases nanospacing of“closely nanospaced”ligands from 1.8 nm to 2.6 nm and the surface area of liganded selfassembly that facilitate stem cell adhesion,mechanosensing,and differentiation both in vitro and in vivo,including the release of loaded molecules by destabilizing water bridges and hydrogen bonds between the Azo^(+)molecules and loaded ***,visible light induces trans-Azo^(+)formation that facilitates cation-πinteractions,thereby deflating self-assembly with“closely nanospaced”ligands that inhibits stem cell adhesion,mechanosensing,and *** stark contrast,when ligand nanospacing increases from 8.7 nm to 12.2 nm via the inflation of self-assembly,the surface area of“distantly nanospaced”ligands increases,thereby suppressing stem cell adhesion,mechanosensing,and ***-term in vivo stability of self-assembly via real-time tracking and upconversion are *** tuning of ligand nanospacing can unravel dynamic ligand-cell interactions for stem cell-regulated tissue regeneration.

关键词： Dynamic self-assembly Ligand nanospacing In vivo tracking Stem cell adhesion Stem cell fate

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Development of genome engineering technologies in cattle: from random to specific

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Journal of Animal Science and Biotechnology 2018年第2期9卷 285-293页

作者： Soo-young Yum Ki-young Youn woo-Jae Choi Goo jang Department of Veterinary Clinical Science College of Veterinary Medicine and the Research Institute of Veterinary Science Seoul National University Farm Animal Clinical Training and Research Center Institute of Green Bio Science Technology Seoul National University Emergence Center for Food-Medicine Personalized Therapy System Advanced Institutes of Convergence Technology Seoul National University College of Veterinary Medicine Seoul National University

The production of transgenic farm animals(e.g., cattle) via genome engineering for the gain or loss of gene functions is an important undertaking. In the initial stages of genome engineering, DNA micro-injection into one-cell stage embryos(zygotes) followed by embryo transfer into a recipient was performed because of the ease of the ***, as this approach resulted in severe mosaicism and has a low efficiency, it is not typically employed in the cattle as priority, unlike in mice. To overcome the above issue with micro-injection in cattle, somatic cell nuclear transfer(SCNT) was introduced and successfully used to produce cloned livestock. The application of SCNT for the production of transgenic livestock represents a significant advancement, but its development speed is relatively slow because of abnormal reprogramming and low gene targeting efficiency. Recent genome editing technologies(e.g.,ZFN, TALEN, and CRISPR-Cas9) have been rapidly adapted for applications in cattle and great results have been achieved in several fields such as disease models and bioreactors. In the future, genome engineering technologies wil accelerate our understanding of genetic traits in bovine and wil be readily adapted for bio-medical applications in cattle.

关键词： Cattle CRISPR-Cas9 Genome engineering technologies Transgenesis Transposon

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Verification of Beam Models for Ionic Polymer-Metal Composite Actuator

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Journal of Bionic Engineering 2009年第3期6卷 232-238页

作者： Hoon Cheol Park Quoc Viet Nguyen jang woo Lee young Tai Yoo Artificial Muscle Research Center Konkuk University Department of Advanced Technology Fusion Konkuk University Department of Materials Chemistry and Engineering Konkuk University

Ionic Polymer-Metal Composite (IPMC) can work as an actuator by applying a few voltages.A thick IPMC actuator,where Nafion-117 membrane was synthesized with polypyrrole/alumina composite filler,was analyzed to verify the equivalent beam and equivalent bimorph beam *** blocking force and tip displacement of the IPMC actuator were measured with a DC power supply and young's modulus of the IPMC strip was measured by bending and tensile tests *** calculated maximum tip displacement and the young's modulus by the equivalent beam model were almost identical to the corresponding measured *** element analysis with thermal analogy technique was utilized in the equivalent bimorph beam model to numerically reproduce the force-displacement relationship of the IPMC *** results by the equivalent bimorph beam model agreed well with the force-displacement relationship acquired by the measured *** is confirmed that the equivalent beam and equivalent bimorph beam models are practically and effectively suitable for predicting the tip displacement,blocking force and young's modulus of IPMC actuators with different thickness and different composite of ionic polymer membrane.

关键词： jonic polymer-metal composite beam model displacement force

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Role of milk carbohydrates in intestinal health of nursery pigs: a review

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Journal of Animal Science and Biotechnology 2022年第3期13卷 628-641页

作者： Ki Beom jang Sung woo Kim Department of Animal Science North Carolina State UniversityRaleighNC 27695USA

Intestinal health is essential for the resistance to enteric diseases and for nutrient digestion and absorption to support *** intestine of nursery pigs are immature and vulnerable to external challenges,which cause negative impacts on the structure and function of the *** nutritional interventions,the benefits of milk are significant for the intestinal health of *** coproducts have traditionally been used in starter feeds to improve the growth of nursery pigs,but their use is somewhat limited due to the high costs and potential risks of excessive lactose on the ***,understanding a proper feeding level of milk carbohydrates is an important start of the feeding *** nursery pigs,lactose is considered a highly digestible energy source compared with plant-based starch,whereas milk oligosaccharides are considered bioactive compounds modulating intestinal immunity and ***,milk carbohydrates,mainly composed of lactose and oligosaccharides,have essential roles in the intestinal development and functions of nursery *** proper feeding levels of lactose in starter feeds could be variable by weaning age,body weight,or genetic *** of lactose and milk oligosaccharides have been broadly studied in human health and animal ***,this review focuses on the mechanisms of lactose and milk oligosaccharides affecting intestinal maturation and functions through modulation of enterocyte proliferation,intestinal immunity,and intestinal microbiota of nursery pigs.

关键词： Intestinal health Lactose Milk carbohydrates Milk oligosaccharides Nursery pig

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Segmented tomographic evaluation of structural degradation of carbon support in proton exchange membrane fuel cells

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Journal of Energy Chemistry 2022年第11期31卷 359-367,I0010页

作者： Jung A.Hong Min-Hyoung Jung Sung Yong Cho Eun-Byeol Park Daehee Yang young-Hoon Kim Sang-Hyeok Yang woo-Sung jang Jae Hyuck jang Hyo June Lee Sungchul Lee Hu young Jeong young-Min Kim Department of Energy Science Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Fuel Cell Core Parts Development Cell Hyundai Mobis Co.Ltd.Uiwang 16082Republic of Korea Electron Microscopy&Spectroscopy Team Korea Basic Science Institute(KBSI)Daejeon 34133Republic of Korea Graduate School of Semiconductor Materials and Devices Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea

The variation of the three-dimensional(3D)structure of the membrane electrode of a fuel cell during proton exchange cycling involves the corrosion/compaction of the carbon *** increasing degradation of the carbon structure continuously reduces the electrocatalytic performance of proton exchange membrane fuel cells(PEM-FCs).This phenomenon can be explained by performing 3D tomographic analysis at the ***,conventional tomographic approaches which present limited experimental feasibility,cannot perform such evaluation and have not provided sufficient structural information with statistical significance thus ***,a reliable methodology is required for the 3D geometrical evaluation of the carbon ***,we propose a segmented tomographic approach which employs pore network analysis that enables the visualization of the geometrical parameters corresponding to the porous carbon structure at a high *** approach can be utilized to evaluate the 3D structural degradation of the porous carbon structure after cycling in terms of local surface area,pore size distribution,and their 3D *** geometrical parameters of the carbon body were demonstrated to be substantially reduced owing to the cycling-induced *** information enables a deeper understanding of the degradation phenomenon of carbon supports and can contribute to the development of stable PEM-FC electrodes.

关键词： Electron tomography Fuel cell Proton exchange membrane Membrane electrode assembly Carbon corrosion

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Enhancement of Performance by Blade Optimization in Two-Stage Ring Blower

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Journal of Thermal Science 2010年第5期19卷 383-389页

作者： Choon-Man jang Gi-young Han Plant Research Division Korea Institute of Construction Technology dh-m co. ltd.626-5Bulmo-dongSeo-guIncheon404-270Korea

This paper describes the shape optimization of an impeller used for two-stage high pressure ring *** shape variables,which are used to define an impeller shape,are introduced to increase the blower *** pressure of a blower is selected as an object function,and the blade optimization is performed by a response surface ***-dimensional Navier-Stokes equations are introduced to analyze the internal flow of the blower and to find the value of object function for the training *** good agreement between experimental measurements and numerical simulation is obtained in the present *** the shape optimization,it is found that a hub height is effective to increase pressure in the ring *** pressure rise for the optimal two-stage ring blower is successfully increased up to 1.86% compared with that of reference at the design flow *** recirculation flow having low velocity is formed in both sides of the impeller outlet by different flow direction of the inlet and outlet of the *** flow field inside the ring blower is also analyzed and discussed.

关键词： Ring blower Blower performance Numerical simulation Blade optimization Response surface method

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Recommendation application for video head impulse test based on fuzzy logic control

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Journal of Central South University 2016年第5期23卷 1208-1214页

作者： NGUYEN Thi Anh Dao KIM Dae young LEE Sang Min KIM Kyu Sung Seong Ro Lee KWON jang woo Department of Computer and Information Engineering Inha University Department of Otorhinolaryngology Inha University Hospital Department of Electronic Engineering Inha University Department of Information and Electronics Engineering Mokpo National University

Vestibulo-ocular reflex(VOR) is an important biological reflex that controls eye movement to ensure clear vision while the head is in ***,VOR measurement is commonly done with a video head impulse test based on a velocity gain algorithm or a position gain algorithm,in which velocity gain is a VOR calculation on head and eye velocity,whereas position gain is calculated from head and eye *** aim of this work is first to compare the two algorithms' performance and to detect covert catch-up saccade,then to propose a stand-alone recommendation application for the patient's *** the first experiment,for ipsilesional and contralesional sides,the calculated position gain(0.94±0.17) is higher than velocity gain(0.84±0.19).Moreover,gain asymmetry of both lesion and intact sides using velocity gain is mostly higher than that from using position gain(four out of five subjects).Consequently,for subjects who have unilateral vestibular neuritis diagnosed from clinical symptoms and a vestibular function test,vestibular weakness is depicted by velocity gain much better than by position *** catch-up saccade and position gain then are used as inputs for recommendation applications.

关键词： vestibulo-ocular response video head impulse velocity gain position gain desaccade

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Organic solar cells for indoor power generation

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Science China Chemistry 2020年第1期63卷 1-2页

作者： Hwa Sook Ryu Han young woo Department of Chemistry College of Science Korea University

During last decades,organic solar cells(OSCs)have achieved remarkable advancements via extensive studies on the optimization of photovoltaic donor/acceptor(D/A)materials,device fabrication,and the D/A bulk heterojunction *** conversion efficiencies(PCEs)up to〜16%for single junction cells and over 17%PCEs were successfully demonstrated for tandem OSC devices[1,2].OSCs may find real industrial applications soon,including building integrated photovoltaics,portable power sources and indoor power generation for low power consumption electronic devices(i.e.,internet of things(IOT)sensors).Among them,indoor applications have great potentials because OSCs can convert indoor lights into electricity more efficiently compared to inorganic counterparts[3].

关键词： D/A power portable

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Effects of thickness of Al thermal spray coating for STS 304

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中国有色金属学会会刊：英文版 2009年第4期19卷 925-929页

作者： Min-Su HAN Yong-Bin woo Seok-Cheol KO young-Jae JEONG Seok-Ki jang Seong-Jong KIM Division of Marine Engineering Mokpo Maritime University Chungnam Regional Innovation Agency Jeonnam Techno Park

Thermal spray coating presents a sacrificial-anode cathodic protection method since differences between the potentials of materials are *** a base metal is exposed to seawater,due to defect in the thermal spray coating,the metal is protected by the sacrificial anodic characteristics of the coating layer because micro-cells formed by the base metal and the thermal spray coating act as cathodes and anodes,*** coating thickness has little effect on the surface morphology of the ***,the electrochemical properties with the increasing of coating thickness present good results.

关键词：涂层厚度热喷涂 STS 金属接触电化学性能保护方法牺牲阳极阳极涂层

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Standardization of apple cancellation test for neglect patients in Korea:An observational study

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World Journal of Clinical Cases 2023年第22期11卷 5236-5243页

作者： woo-Hyuk jang Jong-Sik jang Department of Occupational Therapy College of Health ScienceKangwon National UniversitySamcheok-si 25949Gangwon-doSouth Korea

BACKGROUND Neglect can be divided into two types using apple cancellation test(apple test):Egocentric neglect(EN)and allocentric neglect(AN).However,in South Korea,apple test results and decision criteria are still largely dependent on tests by foreign *** To establish a new South Korea standard and improve the accuracy of neglect assessment,the apple experiment was standardized in this *** This study was conducted on 223 healthy subjects for a total of 7 mo from August 2021 to February *** was carried out using the original apple test developed by Bickerton in *** scoring for the apple test,total omission error refers to the number of missed targets(full apple)in the entire test sheet(left,middle,and right area).The score for EN is the difference between the correct number of right area and the correct number of left area(excluding the middle area).For AN,the score is difference between the number of left opening apples and number of right opening apples(including the middle area).Linear regression analysis was used for standardization using the general characteristics of subjects and the results of the apple *** The cut-off score,which is the standard value indicating the pathological condition by combining the results of all subjects,is as follows:Total omission error(5),error for EN(2),and error for AN(2).Also,differences in cut-off score according to age were *** This study will be helpful in facilitating a more accurate differential diagnosis of neglect.

关键词： Apple cancellation test Egocentric neglect Allocentric neglect Brain injury Standardization

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