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Journal of Mountain Science 2014年第3期11卷 578-591页

作者： Hosung kim Seung woo LEE Chan-Young YUNE Gihong kim Department of Civil Engineering Gangneung-Wonju National University

This paper describes a geographic information system(GIS)-based method for observing changes in topography caused by the initiation, transport, and deposition of debris flows using highresolution light detection and ranging(LiDAR) digital elevation models(DEMs) obtained before and after the debris flow events. The paper also describes a method for estimating the volume of debris flows using the differences between the LiDAR DEMs. The relative and absolute positioning accuracies of the LiDAR DEMs were evaluated using a real-time precise global navigation satellite system(GNSS) positioning method. In addition, longitudinal and cross-sectional profiles of the study area were constructed to determine the topographic changes caused by the debris flows. The volume of the debris flows was estimated based on the difference between the LiDAR DEMs. The accuracies of the relative and absolute positioning of the two LiDAR DEMs were determined to be ±10 cm and ±11 cm RMSE, respectively, which demonstrates the efficiency of the method for determining topographic changes at an scale equivalent to that of field investigations. Based on the topographic changes, the volume of the debris flows in the study area was estimated to be 3747 m3, which is comparable with the volume estimated based on the data from field investigations.

关键词： Debris flow Topographic change LiDAR DEM Volume estimation Global navigation satellitesystem (GNSS)

Enhancement of mechanical and tribological performance of Ti-6Al-4V alloy by laser surface alloying with Inconel 625 and SiC precursor materials

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Friction 2024年第9期12卷 2089-2107页

作者： Hao-Ran CHENG Ki-Hoon shin Hong Seok kim Department of Mechanical Engineering Graduate School of Seoul National University of Science and TechnologySeoul 01811Republic of Korea Department of Mechanical and Automotive Engineering Seoul National University of Science and TechnologySeoul 01811Republic of Korea

This study focused on producing metal matrix composite(MMC)coatings on Ti–6Al–4V alloy through laser surface alloying using a novel combination of Inconel 625 and SiC precursor *** ratios of alloying powders were examined to evaluate surface properties such as microhardness,wear resistance,and friction coefficient,along with analyzing the phase composition and microstructure of the *** in situ synthesized MMC coatings exhibited the presence ofα-Ti,NiTi,NiTi_(2),and TiC ***,Ti_(5)Si_(3)andα-Ti/Ti_(5)Si_(3)eutectic structures were observed when the SiC content exceeded 20%.In comparison to the titanium substrate,the MMC coating significantly enhanced microhardness by over threefold and reduced wear by 95%.However,it was crucial to carefully select the appropriate combination of alloying powders to avoid a substantial decrease in friction performance and excessive formation of *** a comparative analysis of experimental results,the optimal precursor material composition was identified as 85%Inconel 625 and 15%*** study demonstrated the effective utilization of Inconel 625 and SiC alloying materials to enhance the surface properties of titanium alloys,thereby expanding their application in challenging environments.

关键词： titanium alloy Inconel 625 SiC ceramic laser surface alloying metal matrix composite(MMC)

Mending the broken in amyotrophic lateral sclerosis: DNA damage and repair in motor neuron degeneration

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Neural Regeneration Research 2021年第1期16卷 104-105页

作者： Byung woo kim Lee J.Martin Department of Pathology Division of Neuropathologythe Pathobiology Graduate Training ProgramJohns Hopkins University School of MedicineBaltimoreMDUSA Department of Neuroscience Johns Hopkins University School of MedicineBaltimoreMDUSA

Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative disease that causes paralysis and respiratory failure(Petrov et al.,2017).The driving mechanisms are unknown,and there are no effective treatments(Petrov et al.,2017).Aging and a few gene mutations,a common one being missense mutations in superoxide dismutase-1(SOD1),are risk factors for ALS(Figure 1).The recent Food and Drug Administration approval of edaravone for the treatment of ALS putatively supports a role for oxidative and nitrative stresses in the disease processes(Figure 1A).DNA damage,abnormalities in DNA repair,and other nuclear abnormalities are implicated also in the pathogenesis of human ALS(Bradley and Krasin,1982;kim et al.,2020).

关键词： al. damage degeneration

Decomposition kinetics of dimethyl methylphospate(chemical agent simulant) by supercritical water oxidation

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Journal of Environmental Sciences 2006年第1期18卷 13-16页

作者： Bambang VERIANSYAH Jae-Duck kim Youn-woo LEE Supercritical Fluid Research Laboratory Korea Institute of Science and Technology(KIST) 39-1 Hawolgok-dong Seoungbuk-gu Seoul 136-791 Korea. School of Chemical and Biological Engineering Seoul National University(SNU) San 56-1 Sillim-dong Gwanak-gu Seoul 151-744 Korea

Supercritical water oxidation （SCWO） has been drawing much attention due to effectively destroy a large variety of high-risk wastes resulting from munitions demilitarization and complex industrial chemical. An important design consideration in the development of supercritical water oxidation is the information of decomposition rate. In this paper, the decomposition rate of dimethyl methylphosphonate（DMMP）, which is similar to the nerve agent VX and GB（Sarin） in its structure, was investigated under SCWO conditions. The experiments were performed in an isothermal tubular reactor with a H2O2 as an oxidant. The reaction temperatures were ranged from 398 to 633℃ at a fixed pressure of 24 MPa. The conversion of DMMP was monitored by analyzing total organic carbon （TOC） on the liquid effluent samples. It is found that the oxidative decomposition of DMMP proceeded rapidly and a high TOC decomposition up to 99.99% was obtained within 11 s at 555℃. On the basis of data derived from experiments, a global kinetic equation for the decomposition of DMMP was developed. The model predictions agreed well with the experimental data.

关键词： supercritical water oxidation kinetics chemical agent DMMP

Let-7 miRNA and CDK4 siRNA co-encapsulated in Herceptin-conjugated liposome for breast cancer stem cells

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Asian Journal of Pharmaceutical Sciences 2020年第4期15卷 472-481页

作者： Jeong Hyun shin Dae Hwan shin Jin Seok kim College of Pharmacy Sookmyung Women’s UniversitySeoul 04310Republic of Korea College of Pharmacy Chungbuk National UniversityCheongju 28160Republic of Korea

Recently,breast cancer stem cells(BCSCs)have rapidly emerged as a novel target for the therapy of breast cancer as they play critical roles in tumor growth,maintenance,metastasis,and ***-7 miRNA is known to be downregulated in a variety of cancers,especially BCSCs,whereas CDK4 being overexpressed in human epidermal growth factor receptor 2(HER-2)overexpressing tumor *** this study,let-7 miRNA and CDK4-specific siRNA were chosen as therapeutic agents and co-encapsulated in Herceptinconjugated cationic liposomes for breast cancer *** size,zeta potential,and encapsulation efficacy of mi/siRNA-loaded PEGylated liposome conjugated with Herceptin(Her-PEG-Lipo-mi/siRNA)were 176 nm,28.1 mV,and 99.7%±0.1%,*** cellular uptake(86%)was observed by fluorescence microscopy when SK-BR-3 cells were treated with Her-PEG-Lipo-mi/***,the increased amount of let-7a mRNA and decreased amount of cellular CDK4 mRNA were observed by qRT-PCR when SK-BR-3 cells were treated with Her-PEG-Lipo-mi/siRNA,which was even more so when SK-BR-3 stem cells were used(197 vs 768 times increase for let-7a,62%vs 68%decrease for CDK4).Growth inhibition(65%)andmigration arrest(0.5%)of the cellswere achieved by the treatment of the cells with Her-PEG-Lipo-mi/siRNA,but not withmi/siRNA complex or other *** conclusion,an efficient liposomal delivery system for the combination of miRNA and siRNA to target the BCSCs was developed and could be used as an efficacious therapeuticmodality for breast cancer.

关键词： Let-7 miRNA CDK4 siRNA Liposomes Breast cancer stem cells

Recovery of cerium from glass polishing slurry

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Journal of Rare Earths 2011年第11期29卷 1075-1078页

作者： Jong-Young kim Ung-Soo kim Myeong-Seop Byeon woo-Kyu Kang Kwang-Teak Hwang woo-Seok Cho Icheon Branch Korea Institute of Ceramic Engineering and TechnologyGyeongchung Rd.Sindun-MyeonIcheon-siKyeonggi-do 467-843Korea RANCO Cheongju-siChungcheongbuk-doKorea

Cerium was extracted from rare earth slurry waste used for polishing a glass ***,glass frit and flocculant were removed by froth flotation and *** recovered rare earth slurry exhibited almost the same particle size distribution as original slurry,which could be reused as slurry for glass *** the rare earth slurry,the cerium solution was obtained by an oxidative thermal treatment and subsequent chemical *** cerium solution was further purified up to 94% by selective precipitation of rare earth species.

关键词： cerium separation waste polishing slurry rare earths

Experimental Investigation and Numerical Analysis to Develop Low-Energy Large-Midwater Trawls

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China Ocean Engineering 2017年第6期31卷 700-708页

作者： Jihoon LEE Taeho kim Chun-woo LEE Subong PARK Division of Marine Technology Chonnam National University Yeosu 550-749 Korea Division of Marine Production System Management Pukyong National University Busan 608-737 Korea Department of Fisheries Physics Pukyong National University Busan 608-737 Korea

Fuel consumption in fisheries is a primary concern because of its effects on the environment and the costs incurred by fishermen. Many studies have been conducted to reduce the fuel consumption in fishing operations. Fuel consumption due to fishing gear during a fishing operation is generally related to the hydrodynamic resistance on the gear. This means that fuel consumption is proportional to the drag created by the towing speed. Based on numerical methods, this study suggests a new approach to reduce fuel consumption in fisheries. The results of the simulation are in good agreement with those of model experiments. The total as well as partial resistance forces on the gear are calculated by simulation. The simulation results suggest improved materials and gear structure for reducing the hydrodynamic forces on the gear while maintaining gear performance. The method for assessing the gear performance involves measuring the height and width of the net mouth. Furthermore, this study investigates the efficiency of a low-energy trawl from an economic point of view. The findings of this study will be useful in reducing greenhouse gas （GHG） emissions in fishing operations, and thereby contribute toward lowering fishing costs by saving fuel.

关键词： low-energy fishing gear numerical methods greenhouse gasesemission hydrodynamic resistance fuelconsumption

Super-resolution localization photoacoustic microscopy using intrinsic red blood cells as contrast absorbers

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Light(Science & Applications) 2019年第1期8卷 212-222页

作者： Jongbeom kim Jin Young kim Seungwan Jeon Jin woo BAIK Seong Hee Cho Chulhong kim Departments of Creative IT Engineering Electrical EngineeringMechanical Engineeringand Interdisciplinary Bioscience and BioengineeringPohang University of Science and Technology(POSTECH)77 Cheongam-roNam-guPohangGyeongbuk 37673Republic of Korea

Photoacoustic microscopy(PAM)has become a premier microscopy tool that can provide the anatomical,functional,and molecular information of animals and humans in ***,conventional PAM systems suffer from limited temporal and/or spatial ***,we present a fast PAM system and an agent-free localization method based on a stable and commercial galvanometer scanner with a custom-made scanning mirror(L-PAM-GS).This novel hardware implementation enhances the temporal resolution significantly while maintaining a high signal-to-noise ratio(SNR).These improvements allow us to photoacoustically and noninvasively observe the microvasculatures of small animals and humans in ***,the functional hemodynamics,namely,the blood flow rate in the microvasculature,is successfully monitored and quantified in *** importantly,thanks to the high SNR and fast B-mode rate(500 Hz),by localizing photoacoustic signals from captured red blood cells without any contrast agent,unresolved microvessels are clearly distinguished,and the spatial resolution is improved by a factor of 2.5 in ***-GS has great potential in various fields,such as neurology,oncology,and pathology.

关键词： resolution absorber scanner

Efficacy of soy protein concentrate replacing animal protein supplements in mucosa-associated microbiota, intestinal health, and growth performance of nursery pigs

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Animal Nutrition 2023年第3期14卷 235-248页

作者： Zixiao Deng Marcos Elias Duarte Sung woo kim Department of Animal Science North Carolina State UniversityRaleighNC 27695USA

This study investigated the effects of using soy protein concentrate (SPC) to replace animal protein supplements on mucosa-associated microbiota,intestinal health,and growth performance of nursery ***-six newly weaned pigs (BW=6.4±0.6 kg) were allotted to 5 treatments in a randomized complete block *** were fed for 35 d in 3 phases (P;1,2,3) for 10,12,13 d,*** treatments were:(1) basal diet with fish meal (P1:4%,P2:2%,and P3:1%),poultry meal (P1:10%,P2:8%,and P3:4%),and blood plasma (P1:4%,P2:2%,and P3:1%),where SPC replacing none (NC);(2) basal diet with SPC replacing fish meal (RFM);(3) basal diet with SPC replacing poultry meal (RPM);(4) basal diet with SPC replacing blood plasma (RBP);and (5) basal diet with SPC replacing all animal protein supplements (PC).Growth performance was recorded for each *** were euthanized on d 35 to collect jejunal mucosa and tissue to evaluate intestinal health and microbiota,and ileal digesta to measure apparent ileal digestibility (AID) of *** were analyzed using the MIXED procedure of ***,RFM,RPM,and RBP did not affect growth performance,whereas PC decreased (P<0.05) ADG and *** RPM increased (P<0.05) Prevotella stercorea and decreased (P<0.05) Helicobacter *** PC decreased (P<0.05) ***,whilst increasing (P<0.05) Prevotella copri,Propionibacterium acnes,and Pelomonas *** RFM tended to increase (P=0.096) immunoglobulin A in the *** PC tended to decrease (P=0.078) jejunal crypt cell *** were no differences in the villus height,AID of nutrients,intestinal inflammation,and intestinal oxidative stress among *** conclusion,SPC can replace fish meal,poultry meal,or blood plasma individually without affecting growth performance and intestinal health,and AID of nutrients of nursery *** SPC replacing poultry meal benefitted intestinal health by reducing *** and increasing ***,SPC replac

关键词： Blood plasma Fish meal Intestinal health Nursery pigs Poultry meal Soy protein concentrate

A Power-Aware Branch Predictor by Accessing the BTB Selectively

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Journal of Computer Science & Technology 2005年第5期20卷 607-614页

作者： Cheol Hong kim Sung woo Chung Chu Shik Jhon Mobile System Laboratory Department of Electrical Engineering and Computer Science Seoul National University Seoul 151-742 Korea Department of Computer Science University of Virginia Charlottesville Virginia 22904 U.S.A.

Microarchitects should consider power consumption, together with accuracy, when designing a branch predictor, especially in embedded processors. This paper proposes a power-aware branch predictor, which is based on the gshare predictor, by accessing the BTB （Branch Target Buffer） selectively. To enable the selective access to the BTB, the PHT （Pattern History Table） in the proposed branch predictor is accessed one cycle earlier than the traditional PHT if the program is executed sequentially without branch instructions. As a side effect, two predictions from the PHT are obtained through one access to the PHT, resulting in more power savings. In the proposed branch predictor, if the previous instruction was not a branch and the prediction from the PHT is untaken, the BTB is not accessed to reduce power consumption. If the previous instruction was a branch, the BTB is always accessed, regardless of the prediction from the PHT, to prevent the additional delay/accuracy decrease. The proposed branch predictor reduces the power consumption with little hardware overhead, not incurring additional delay and never harming prediction accuracy. The simulation results show that the proposed branch predictor reduces the power consumption by 29-47%.

关键词： branch predictor BTB embedded processor low power design PHT