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Risk factors for hepatocellular carcinoma in patients with drug-resistant chronic hepatitis B

World Journal of Gastroenterology 2013年第40期19卷 6834-6841页

作者： Chung Hwan Jun Hyoung Ju Hong Min woo Chung Seon Young Park Sung Bum Cho Chang Hwan Park Young Eun Joo Hyun Soo Kim Sung Kyu choi Jong Sun Rew Department of Internal Medicine Chonnam National University Medical SchoolGwangju 501-757South Korea

AIM:To investigate the risk factors and characteristics of hepatocellular carcinoma(HCC) in the patients with drug-resistant chronic hepatitis B(CHB).METHODS:A total of 432 patients with drug-resistant CHB were analyzed retrospectively from January 2004to December 2012. The patients were divided into two groups:the HCC group(n = 57) and the non-HCC group(n = 375). Two groups compared using logistic regression for various patients and viral characteristics in order to identify associated risk factors for ***,patient and tumor characteristics of HCC patients with na ve CHB(N group,n = 117) were compared to the HCC group(R group,n = 57) to identify any difference in HCC characteristics between ***:A significant difference was found for age,platelet count,alpha-fetoprotein(AFP),positivity of HBeAg,seroconversion rate of HBeAg,virologic response,the Child-Pugh score,presence of rtM204I,and the duration of antiviral treatment in non-HCC and HCC group. Cirrhosis,age(> 50 years),HBeAg(+),virologic non-responder status,and rtM204I mutants were independent risk factors for the development of HCC. The R group had lower serum C-reactive protein(CRP) and AFP levels,earlier stage tumors,and a shorter mean tumor surveillance period than the N group. However,the total follow-up duration was not significantly different between the two ***:13.2% of patients with drug-resistant CHB developed HCC. Age,cirrhosis,YIDD status,HBeAg status,and virologic response are associated with risk of HCC. Patients with drug-resistant CHB and these clinical factors may benefit from closer HCC surveillance.

关键词： Carcinoma Hepatocellular Hepatitis B Drug resistance Risk factors Characteristics

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Different risk factors for advanced colorectal neoplasm in young adults

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World Journal of Gastroenterology 2016年第13期22卷 3611-3620页

作者： Ji Yeon Kim Yoon Suk Jung Jung Ho Park Hong Joo Kim Yong Kyun Cho Chong Il Sohn woo Kyu Jeon Byung Ik Kim Kyu Yong choi Dong Il Park Comprehensive Health Care Center Korea Cancer Center Hospital Korea Institute of Radiological and Medical Sciences Department of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine

AIM: To compare the risk of developing advanced colorectal neoplasm(ACRN) according to age in ***: A total of 70428 Koreans from an occupational cohort who underwent a colonoscopy between 2003 and 2012 at Kangbuk Samsung Hospital were retrospectively selected. We evaluated and compared odds ratios(OR) for ACRN between the young-adults(YA < 50 years) and in the older-adults(OA ≥ 50 years). ACRN was defined as an adenoma ≥ 10 mm in diameter, adenoma with any component of villous histology, high-grade dysplasia, or invasive ***: In the YA group, age(OR = 1.08, 95%CI: 1.06-1.09), male sex(OR = 1.26, 95%CI: 1.02-1.55), current smoking(OR = 1.37, 95%CI: 1.15-1.63), family history of colorectal cancer(OR = 1.46, 95%CI: 1.01-2.10), diabetes mellitus related factors(OR = 1.27, 95%CI: 1.06-1.54), obesity(OR = 1.23, 95%CI: 1.03-1.47), CEA(OR = 1.04, 95%CI: 1.01-1.09) and low-density lipoprotein-cholesterol(OR = 1.01, 95%CI: 1.01-1.02) were related with an increased risk of ACRN. However, age(OR = 1.08, 95%CI: 1.06-1.09), male sex(OR = 2.12, 95%CI: 1.68-2.68), current smoking(OR = 1.38, 95%CI: 1.12-1.71), obesity(OR = 1.34, 95%CI: 1.09-1.65) and CEA(OR = 1.05, 95%CI: 1.01-1.09) also increased the risk of ACRN in the OA ***: The risks of ACRN differed based on age group. Different colonoscopic screening strategies are appropriate for particular subjects with risk factors for ACRN, even in subjects younger than 50 years.

关键词： Young-adult Advanced colorectal neoplasm Risk factors Age Metabolic abnormality

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Negative impact of sedation on esophagogastric junction evaluation during esophagogastroduodenoscopy

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World Journal of Gastroenterology 2014年第18期20卷 5527-5532页

作者： Eun Soo Kim Ho Young Lee Yoo Jin Lee Bo Ram Min Jae Hyuk choi Kyung Sik Park Kwang Bum Cho Byoung Kuk Jang woo Jin Chung Jae Seok Hwang Division of Gastroenterology and Hepatology Department of Internal MedicineKeimyung University School of MedicineDaegu 700-712South Korea

AIM: To compare the esophagogastric junction (EGJ) areas observed in sedated and non-sedated patients during esophagogastroduodenoscopy (EGD).

关键词： Esophagogastric junction Endoscopy Esophagus Propofol Midazolam

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Silicon electronic-photonic integrated 25 Gb/s ring modulator transmitter with a built-in temperature controller

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Photonics Research 2021年第4期9卷 507-513页

作者： Minkyu Kim Min-Hyeong Kim Youngkwan Jo Hyun-Kyu Kim Stefan Lischke Christian Mai Lars Zimmermann woo-Young choi Department of Electrical and Electronic Engineering Yonsei University03722 SeoulRepublic of Korea Samsung Electronics Hwasung18448 Gyeonggi-doRepublic of Korea IHP Im Technologiepark 2515236 Frankfurt(Oder)Germany Technische Universität Berlin Einsteinufer 2510587 BerlinGermany

We demonstrate a silicon electronic–photonic integrated 25 Gb/s nonreturn-to-zero transmitter that includes driver circuits,depletion-type Si ring modulator,Ge photodetector,temperature sensor,on-chip heater,and temperature controller,all monolithically integrated on a 0.25μm photonic BiCMOS technology *** integrated transmitter successfully provides stable and optimal 25 Gb/s modulation characteristics against external temperature fluctuation.

关键词： Gb/s modulator BiCMOS

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AC Scheduling Based on Thermodynamics of Indoor for On-Campus Small Data

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Journal of Power and Energy Engineering 2015年第4期3卷 282-288页

作者： Hyun Duck choi Soon woo Rhee Choon Ki Ahn Myo Taeg Lim School of Electrical Engineering Korea University Seoul Republic of Korea

This paper proposes a new day-ahead control scheme of an air conditioning (AC) based on thermodynamic model of indoor-temperature. The thermodynamic model of indoor-temperature can be achieved by modified first-order thermal dynamic equation. For the practical verification of proposed model, we implemented the home energy management system (HEMS) in the laboratory and used real experiment data sets. The proposed model can be represented by a state-space model of indoor-temperature and its parameters are obtained by least square algorithm. Through the proposed thermodynamic model, indoor-temperature can be predicted closely, and a behavior pattern of AC can also be achieved. This research involves the experimental verification of the proposed approach and communication architecture between the aggregator and a system user in a laboratory environment.

关键词： Home Energy Management System (HEMS) Least-Square Convex Optimization Demand Response (DR) Air-Conditioning (AC)

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Analgesic efficacy of median nerve stimulation in mice with chemotherapy-induced peripheral neuropathy via modulation of brain-derived neurotrophic factor expression

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Journal of Traditional Chinese Medicine 2023年第4期43卷 686-694页

作者： Dong-wook Kang Jae-Gyun choi Hee Ju Song Jaehyuk Kim Miae Lee Taehee Kim Suk-Yun Kang Yeonhee Ryu Hwa Seung Yoo Jin Sun Lee Jin Bong Park Sang Do Lee Hyun-woo Kim Department of Physiology and Medical Science College of Medicine and Brain Research InstituteChungnam National UniversityDaejeon 35015Republic of Korea KM Fundamental Research Division Korea Institute of Oriental Medicine Daejeon 34054Republic of Korea East-West Cancer Center Dunsan Korean Medicine Hospital of Daejeon UniversityDaejeon 35234Republic of Korea Department of Surgery Chungnam National University HospitalDaejeon 35015Republic of Korea Laboratory of Veterinary Pharmacology College of Veterinary Medicine and Research Institute for Veterinary ScienceSeoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea

OBJECTIVE:Chemotherapeutic agents such as docetaxel(DTX)can trigger chemotherapy-induced peripheral neuropathy(CIPN),which is characterized by unbearable *** study was designed to investigate the analgesic effect and related neuronal mechanism of low-frequency median nerve stimulation(LFMNS)on DTX-induced tactile hypersensitivity in ***:To produce CIPN,DTX was administered intraperitoneally 4 times,once every 2 d,to male ICR *** was performed on the wrist area,and the pain response was measured using von Frey filaments on both hind *** blot and immunofluorescence staining were performed using dorsal root ganglion and spinal cord samples to measure the expression of brainderived neurotrophic factor(BDNF).RESULTS:Repeated LFMNS significantly attenuated the DTX-induced abnormal sensory response and suppressed the enhanced expression of BDNF in the DRG neurons and spinal dorsal ***:LFMNS might be an effective nonpharmaceutical option for treating patients suffering from CIPN via regulating the expression of peripheral and central BDNF.

关键词： analgesia brain-derived neurotrophic factor chemotherapy-induced peripheral neuropathy docetaxel nerve stimulation

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Gastric cancer patients at high-risk of having synchronous cancer

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World Journal of Gastroenterology 2006年第16期12卷 2588-2592页

作者： Jun Ho Lee Ja Seong Bae Keun Won Ryu Jong Seok Lee Sook Ryun Park Chan Gyoo Kim Myoung Cheorl Kook Il Ju choi Young woo Kim Jae-Gahb Park Jae-Moon Bae Research Institute & Hospital National Cancer Center809 Madul-dongIlsandong-guGoyang-siGyeonggi-do411-769Korea

AIM： To identify patients with a high-risk of having a synchronous cancer among gastric cancer patients. METHODS： We retrospectively analyzed the prospective gastric cancer database at the National Cancer Center, Korea from December 2000 to December 2004. The clinicopathological characteristics of patients with synchronous cancers and those of patients without synchronous cancers were compared. Multivariate analysis was performed to identify the risk factors for the presence of a synchronous cancer in gastric cancer patients. RESULTS： 111 of 3291 gastric cancer patients （3.4%） registered in the database had a synchronous cancer. Among these 111 patients, 109 had a single synchronous cancer and 2 patients had two synchronous cancers. The most common form of synchronous cancer was colorectal cancer （42 patients, 37.2%） followed by lung cancer （21 patients, 18.6%）. Multivariate analyses revealed that elderly patients with differentiated early gastric cancer have a higher probability of a synchronous cancer. CONCLUSION： Synchronous cancers in gastric cancer patients are not infrequent. The physicians should try to find synchronous cancers in gastric cancer patients, especially in the elderly with a differentiated early gastric

关键词： Synchronous cancer Gastric cancer Colorectal cancer

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Bidirectional rotating direct-current triboelectric nanogenerator with self-adaptive mechanical switching for harvesting reciprocating motion

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International Journal of Extreme Manufacturing 2024年第4期6卷 324-335页

作者： Donghan Lee Joonmin Chae Sumin Cho Jong woo Kim Awais Ahmad Mohammad Rezaul Karim Moonwoo La Sung Jea Park Dongwhi choi Department of Mechanical Engineering(Integrated Engineering Program) Kyung Hee University1732 Deogyeong-daeroYonginGyeonggi 17104Republic of Korea Department of Chemistry University of LahoreLahorePakistan Department of Mechanical Engineering College of EngineeringKing Saud UniversityRiyadh 11421Saudi Arabia School of Mechanical Engineering Korea University of Technology and Education1600 Chungjeol-roCheonanChungnam 31253Republic of Korea

Amid the growing interest in triboelectric nanogenerators(TENGs)as novel energy-harvesting devices,several studies have focused on direct current(DC)TENGs to generate a stable DC output for operating electronic ***,owing to the working mechanisms of conventional DC TENGs,generating a stable DC output from reciprocating motion remains a ***,we propose a bidirectional rotating DC TENG(BiR-TENG),which can generate DC outputs,regardless of the direction of rotation,from reciprocating *** distinct design of the BiR-TENG enables the mechanical rectification of the alternating current output into a rotational-direction-dependent DC ***,it allows the conversion of the rotational-direction-dependent DC output into a unidirectional DC output by adapting the configurations depending on the rotational *** to these tailored design strategies and subsequent optimizations,the BiR-TENG could generate an effective unidirectional DC *** of the BiR-TENG for the reciprocating motions of swinging doors and waves were demonstrated by harnessing this *** study demonstrates the potential of the BiR-TENG design strategy as an effective and versatile solution for energy harvesting from reciprocating motions,highlighting the suitability of DC outputs as an energy source for electronic devices.

关键词： direct-current triboelectric nanogenerator mechanical rectification self-adaptive mechanical design harvesting reciprocation motion

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Distributed Sensor Network Based on RFID System for Localization of Multiple Mobile Agents

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Wireless Sensor Network 2011年第1期3卷 1-9页

作者： Byoung-Suk choi Joon-woo Lee Ju-Jang Lee Kyoung-Taik Park 不详

This paper presents a distributed wireless sensor network for multiple mobile agents localization. Localization of mobile agents, such as mobile robots, humans, and moving objects, in an indoor space is essential for robot-robot interaction (RRI) and human-robot interaction (HRI). The standard localization system, which is based on sensors installed in the robot body, is not suitable for multiple agents. Therefore, the concept of sensor network, which uses wireless sensors distributed in a specified space, is used in this study. By analyzing related studies, two solutions are proposed for the localization of mobile agents including humans: a new hardware system and a new software algorithm. The first solution focuses on the architectural design of the wireless sensor network for multiple agent localization. A passive RFID system is used, and then the architecture of the sensor network is adapted to suit the target system. The second solution centers on a localization algorithm based on the sensor network. The proposed localization algorithm improves the accuracy in the multiple agent localization system. The algorithm uses the displacement conditions of the mobile agents and the recognition changes between the RFID tags and RFID reader. Through experiments using a real platform, the usefulness of the proposed system is verified.

关键词： Multiple Robot Localization Distributed Sensor Network RFID System

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Burning Mouth Syndrome: Patient Profiles, Clinical Symptoms, Affecting Associated Factors, and Treatment Responses

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International Journal of Otolaryngology and Head & Neck Surgery 2018年第4期7卷 237-248页

作者： Byung woo Lim Hae Dong Kim Jin Soon Chang Ick Soo choi Department of Otorhinolaryngology-Head and Neck Surgery Ilsan Paik Hospital Inje University College of Medicine Ilsanseo-gu Goyang-si Korea Department of Otorhinolaryngology-Head and Neck Surgery Seoul Paik Hospital Inje University College of Medicine Jung-gu Seoul Korea

Background: The clinical characteristics of burning mouth syndrome (BMS) are not fully understood. We investigated the profiles of BMS patients, characteristics associated with BMS, and the available treatment methods and their effects. Methods: Seventy-four BMS patients without oral mucosal lesions were enrolled. Their medical history, medications taken, and symptom scores were investigated via questionnaires. Laboratory investigations of parameters potentially associated with BMS were performed. Regarding treatment, 0.01% dexamethasone gargle, amitriptyline, and clonazepam were administered individually or in combination, depending on the degree of symptom improvement. Symptoms were scored from 0 - 10 points;these scores were used to evaluate treatment efficacy and patient satisfaction. Results: Mean age of the patients was 63.6 ± 14.2 years;mean symptom prevalence period was 15.5 ± 24.7 months. BMS was not significantly associated with a history of hypertension, diabetes, or any specific medications. Treatment reduced the symptoms of 85.1% subjects (63/74). Conclusions: Contrary to that in previous studies, we observed significant improvements in BMS patients following combination treatment with dexamethasone gargle, amitriptyline, and clonazepam.

关键词： Burning Mouth Syndrome Dexamethasone Amitriptyline Clonazepam

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