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Relationship between insulin resistance, obesity and serum prostate-specific antigen levels in healthy men

Asian Journal of Andrology 2010年第3期12卷 400-404,I0011页

作者： June Hyun Han Yong Taec Lee Kyung Won Kwak Seung Hyun Ahn In Ho Chang Soon Chul Myung Seung Young Oh Yong-Seong Lee wonyong kim Young-Woo Jin Tae-In Choi Sook Hee Sung Department of Urology KEPCO Medical Foundation Hanil General Hospital Seou1132-703 Korea Department of Urology Chung-Ang University Hospital Seoul 140-757 Korea Department of Urology Hyundae General Hospital Namyangju 472-865 Korea Department of Urology Hallym University Hangang Sacred Heart Hospital Seoul 150-719 Korea Department of Microbiology College of Medicine Chung-Ang University Seoul 156- 756 Korea Radiation Health Research Institute Korea Hydro ＆ Nuclear Power Co. LTD Seoul 132-703 Korea

The purpose of this study was to determine the relationship between insulin resistance, obesity and serum prostate-specific antigen （PSA） levels in healthy men with serum PSA level below 4 ng mL-1. The men included in the study cohort were 11 827 healthy male employees of the Korea Hydro and Nuclear Power Co., LTD who had undergone medical checkups including fasting glucose, fasting insulin and serum PSA between January 2003 and December 2008. Insulin resistance was calculated by homeostasis model assessment （HOMA [fasting glucose × fasting insulin]/22.5） and quantitative insulin sensitivity check index （QUICK/; 1/[log （fasting insulin）＋ log （fasting glucose）]）. Age-adjusted body mass index （BMI） was significantly increased according to increasing quartile of insulin resistance as determined by HOMA and QUICKI, respectively, in analysis of variance （ANOVA） test and Duncan＇s multiple comparison test （P 〈 0.001）, but age-adjusted serum PSA concentration was significantly decreased according to increasing quartile of insulin resistance as determined by HOMA and QUICK/（P 〈 0.001）. Age, BMI, insulin resistance by HOMA or QUICK/were significantly independent variables to serum PSA level in a multivariate linear regression analysis （P 〈 0.001）. Insulin resistance was a significant independent variable to serum PSA level along with BMI. Insulin resistance and BMI were negatively correlated with serum PSA level in healthy men. Insulin resistance was positively correlated with BMI.

关键词： body mass index insulin resistance metabolic syndrome X obesity prostate-specific antigen

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Graph Construction Method for GNN-Based Multivariate Time-Series Forecasting

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Computers, Materials & Continua 2023年第6期75卷 5817-5836页

作者： wonyong Chung Jaeuk Moon Dongjun kim Eenjun Hwang School of Electrical Engineering Korea UniversitySeoul02841Korea

Multivariate time-series forecasting(MTSF)plays an important role in diverse real-world *** achieve better accuracy in MTSF,time-series patterns in each variable and interrelationship patterns between variables should be considered ***,graph neural networks(GNNs)has gained much attention as they can learn both patterns using a *** accurate forecasting through GNN,a well-defined graph is ***,existing GNNs have limitations in reflecting the spectral similarity and time delay between nodes,and consider all nodes with the same weight when constructing *** this paper,we propose a novel graph construction method that solves aforementioned *** first calculate the Fourier transform-based spectral similarity and then update this similarity to reflect the time ***,we weight each node according to the number of edge connections to get the final graph and utilize it to train the GNN *** experiments on various datasets,we demonstrated that the proposed method enhanced the performance of GNN-based MTSF models,and the proposed forecasting model achieve of up to 18.1%predictive performance improvement over the state-of-the-art model.

关键词： Deep learning graph neural network multivariate time-series forecasting

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Transcription factor IRF8 controls Thl-like regulatory T-cell function

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Cellular & Molecular Immunology 2016年第6期13卷 785-794页

作者： wonyong Lee Hyeong Su kim Song Yi Baek Gap Ryol Lee Department of Life Science Sogang University 35 Baekbeom-ro Mapo-gu Seou1121-742 Korea

Recent studies have suggested that regulatory T （Treg） cells comprise a heterogeneous population that regulates various aspects of the immune response, and that Treg cells use the factors that are expressed in their target cells to regulate them. We searched for factors that regulate Thl response in Treg cells using a meta-analysis. In the process, we discovered that transcription factor interferon regulatory factor 8 （I RF8） was selectively expressed in Treg and Th I cells. IRF8-deficient Treg cells showed defective expression of CXCR3 and aberrant expression of the 114 and 1117genes. Upon treatment with alpha galactosyI-C18-ceramide （aGaI-C18-Cer）, IRF8-deficient mice showed defective Treg cell recruitment in the liver. Eliciting Thl immune response by anti-CD40 antibody injection in mice induced IRF8 expression in Treg cells. The expression of IRF8 was induced by Foxp3 in Treg cells, IRF8 had no effect on T-bet expression in Treg and vice versa. Thus, our results strongly suggest that IRF8 controls Thl immune response in Treg cells independent of T-bet.

关键词： CXCR3 IRF8 regulatory T cell Thl-like

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