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Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report

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World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： Seungmee Lee Yu-Ra jeon Changmin Shin Sun-Young Kwon Sojin Shin Department of Obstetrics and Gynecology Keimyung University School of MedicineDaegu 42601South Korea Department of Pathology and Institute for Cancer Research Keimyung University School of MedicineDaegu 42601South Korea

BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic *** on neurotrophic tyrosine receptor kinase(NTRK)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent ***-TRK immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRK-fusion *** SUMMARY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRK IHC-positive but lacked NTRK gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic *** examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRK sarcoma with positive immunochemical pan-TRK ***,subsequent next generation sequencing revealed no NTRK gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage *** The clinical significance of NTRK gene fusion lies in potential treatment with TRK inhibitors for positive *** such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report

Effect of geogrid reinforcement on soft and medium dense soils

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Journal of Central South University 2011年第5期18卷 1638-1645页

作者： jeon Sang-Soo Department of Civil Engineering Construction Technology Research CenterINJE UniversityObang-dong 607KimhaeKyungsangnam-Do #621-749South Korea

The field tests were carried out to examine the reinforcement effect of a geogrid on various conditions of embankment height,the number of passages of vibratory roller,the number of reinforced layer of geogrid,and soil *** test results of the dynamic earth pressure indicate that the soil reinforced by geogrid is very effective to increase the stiffness of soil,especially in soft *** dynamic earth pressure ratio,which is defined as the ratio of dynamic earth pressure to self weight of soils,exponentially decreases as the embankment height *** dynamic earth pressure ratio increases up to 80% for soft soils reinforced by both one layer of geogrid in place of no reinforced soils and two layers in place of a single layer of geogrid.

关键词： dynamic earth pressure geogrid reinforced soils repetitive loading

Pull-out tests and slope stability analyses of nailing systems comprising single and multi rebars with grouted cement

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Journal of Central South University 2012年第1期19卷 262-272页

作者： Sang-Soo jeon Construction Technology Research Center Department of Civil EngineeringInje UniversityObang-dong 607KimhaeKyungsangnam-Do #621-749Korea

The pull-out capacities for soil nailing systems comprising of one single 29 mm diameter(type A) and four 16 mm diameter(type B) rebars with grouted cement were examined.A field test and numerical analysis for the type A and type B systems were carried out to investigate the pull-out capacities and the slope stability reinforcement efficiency in soil and rock *** results of the pull-out tests show the mobilized shear force and load transfer characteristics with respect to soil *** load-displacement relationship was examined for both type A and type B *** stability analyses were carried out to study the relationships between soil and nail reinforcement and bending stiffness as well as combined axial tension and shear *** of safety were calculated in relation to the number of nails and their outside *** soil and rock slopes were included in this evaluation.

关键词： soil nailing bending resistance pull-out test finite difference method

Damage Pattern Recognition of Spatially Distributed Slope Damages and Rainfall Using Optimal GIS Mesh Dimensions

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Journal of Mountain Science 2014年第2期11卷 336-344页

作者： Sang-Soo jeon Department of Civil & Urban Engineering Inje University

Damage assessment for slopes using geographical information system(GIS) has been actively carried out by researchers working on several government organizations and research institutes in Korea. In this study, 596 slope damages were examined to identify the types of damage associated with dip angles, dip directions, and heavy rainfall resulting from typhoons in South Korea. Heavy rainfall of 100 mm to 300 mm resulted in 80% at the investigated slope damages. A GIS database was developed for highways, rainfall, soil or rock geometry, and types of damage. A grid of rainfall intensity was generated from the records of maximum daily rainfall. Contours for slope damages and heavy rainfall using optimal GIS mesh dimensions were generated to visualize damage patterns and show substantially strong correlation of rainfall with slope damages. The combination of remote sensing with the GIS pattern recognition process described in this work are being expanded for a new generation of emergency response and rapid decision support systems.

关键词： Damage assessment Slope damages Rainfall GIS Typhoon

Roadbed behavior subjected to tilting-train loading at rail joint and continuous welded rail

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Journal of Central South University 2014年第7期21卷 2962-2969页

作者： jeon Sang-Soo Department of Civil&Urban Engineering Inje University

The tilting-train is very attractive to the railroad users in the world due to the advantage of high speed in curved track using pre-existing infrastructure of ***-train has a unique allowable speed and mechanism especially in curved *** this work,when tilting-train is operated with the allowable speed,the behavior of roadbed is evaluated by examining its settlement and bearing ***,the stability of roadbed is estimated as the roadbed is in the condition of soft soil influenced by the weather effects and cyclic train *** results show that the roadbed settlement satisfies the allowable settlement when the elastic moduli of upper roadbed and in-situ soil are greater than 3800 and 4600 kN/m2 for rail joint and 2300 and 3300 kN/m2 for continuous welded rail(CWR).

关键词： railway roadbed tilting-train bearing capacity settlement

Areas vulnerable to natural disasters and damage estimation of infrastructure in Busan, Korea

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Journal of Central South University 2014年第4期21卷 1499-1507页

作者： jeon Sang-Soo Department of Civil and Urban Engineering Inje University

Since the damages caused by disasters associated with climate anomalies and the diversification of the social structure increase every year, an efficient management system associated with a damage assessment of the areas vulnerable to disasters is demanded to prevent or mitigate the damages to infrastructure. The areas vulnerable to disasters in Busan, located at southeastern part of Korea, were estimated based on historical records of damages and a risk assessment of the infrastructure was performed to provide fundamental information prior to the establishment of the real-time monitoring system for infrastructure and establish disaster management system. The results are illustrated by using geographical information system(GIS) and provide the importance of the roadmap for comprehensive and specific strategy to manage natural disasters.

关键词： natural disaster damages risk assessment infrastructure disaster management system geographical information system

Design of multifunctional polymeric binders in silicon anodes for lithium‐ion batteries

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Carbon Energy 2024年第4期6卷 140-163页

作者： Masytha Nuzula Ramdhiny Ju‐Won jeon Department of Chemistry Kookmin UniversitySeoulRepublic of Korea Correspondence

Silicon(Si)is a promising anode material for lithium‐ion batteries(LIBs)owing to its tremendously high theoretical storage capacity(4200 mAh g−1),which has the potential to elevate the energy of ***,Si anodes exhibit severe volume change during lithiation/delithiation processes,resulting in anode pulverization and delamination with detrimental growth of solid electrolyte interface *** a result,the cycling stability of Si anodes is insufficient for commercialization in *** binders can play critical roles in Si anodes by affecting their cycling stability,although they occupy a small portion of the *** review introduces crucial factors influencing polymeric binders'properties and the electrochemical performance of Si *** particular,we emphasize the structure–property relationships of binders in the context of molecular design strategy,functional groups,types of interactions,and functionalities of ***,binders with additional functionalities,such as electrical conductivity and self‐healability,are extensively discussed,with an emphasis on the binder design principle.

关键词： conductivity lithium‐ion batteries molecular interactions polymeric binders self‐healability Si anodes

Flexible PVA/BMIMOTf/LLZTO composite electrolyte with liquid-comparable ionic conductivity for solid-state lithium metal battery

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Journal of Energy Chemistry 2022年第11期31卷 128-139,I0005页

作者： Hyesun jeon Hai Anh Hoang Dukjoon Kim School of Chemical Engineering Sungkyunkwan UniversitySuwonGyeonggi 16419Republic of Korea

Poly(vinyl alcohol)(PVA)/1-butyl-3-methylimidazolium trifluoromethanesulfonate(BMIMOTf)/Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO)solid-state composite electrolyte(SSCE)membranes were synthesized for solid-state lithium metal battery *** garnet-type LLZTO nanoparticles were surface-coated with the polydopamine layer of 8-10 nm thickness to enhance the dispersion status of LLZTO particles in the PVA *** hydrophilic BMIMOTf ionic liquid(IL)was added along with LLZTO nanoparticles to enhance the ionic conductivity and electrochemical stability of the SSCE *** synthesized composite electrolyte membrane containing 7 wt%of LLZTO and 60 wt%of BMIMOTf showed the outstanding Li+conductivity of 2×10^(-3)S cm^(-1)and the lithium transference number of 0.76 at room temperature in the firm and flexible solid state with the tensile strength of 8 *** a high single ion conduction characteristic led to the quite low interfacial resistance of 39Ωbetween the composite electrolyte and the lithium *** to these superior properties of composite membranes,the LiFePO_(4)|SSCE|Li cell exhibited an excellent discharge capacity of 165 mAh g^(-1)at 0.2 C,maintaining the coulombic efficiency of 98%after 100 cycles at room temperature.

关键词： Polymer-matrix composites(PMCs) Interface/interphase Surface treatments Solid-state lithium-ion batteries

Cold Signaling via the Two-Component Signaling System

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Molecular Plant 2013年第1期6卷 15-17页

作者： Jungmook Kim Jin jeon Department of Bioenergy Science and Technology Chonnam National University Buk-Gu Gwangju 500-757 Korea

Two-component signal transduction is commonly used as a stimulus-response coupling mechanism to allow organisms such as eubacteria, archea, and a few eukaryotes to sense and respond to changes in many different environmental conditions （Stock et al., 2000）. Typically, the histidine protein kinase senses extracellular stimuli by autophosphorylation and transfers a phosphoryl group to the response regu- lator, resulting in activation of downstream proteins that elicit a specific response. In Arabidopsis plants, a multi-step two-component system is well established as a key element of plant hormone cytokinin signaling （To and Kieber, 2008）.

关键词： Two-component system Signal system Protein kinase Autophosphorylation Cytokinins Signal transduction Coupling mechanism Eukaryotic cells