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Perilesional reorganization of motor function in stroke patients

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Neural Regeneration Research 2010年第21期5卷 1668-1672页

作者： Sung Ho jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

Perilesional reorganization is an important recovery mechanism for stroke patients because it yields good motor outcomes. However, perilesional reorganization remains poorly understood. The scientific basis for stroke rehabilitation can be established when detailed mechanisms of recovery are clarified. In addition, studies at the subcortical level remain in the early stages. Therefore, the present study suggested that additional investigations should focus on perilesional reorganization at the subcortical level, identifying the critical period for this mechanism and determining treatment strategies and modalities to facilitate development. The present study reviews literature focused on perilesional reorganization in stroke patients with regard to demonstration, clinical characteristics, and rehabilitative aspects, as well as previous studies of perilesional reorganization at cortical and subcortical levels.

关键词： stroke motor recovery functional MRI diffusion tensor imaging brain plasticity reorganization

Medial reorganization of motor function in corona radiata following middle cerebral artery infarction A case report

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Neural Regeneration Research 2009年第9期4卷 668-671页

作者： Sung Ho jang Department of Physical Medicine & Rehabilitation Yeungnam University College of Medicine

Peri-lesional reorganization is one of the motor recovery mechanisms following stroke. A 23-year-old female who presented with complete paralysis of the right extremities at the onset of infarct in the left middle cerebral artery territory was included. She slowly recovered some function, and could extend the affected knee with resistance after 9 months. Diffusion tensor tractography, functional MRI, and transcranial magnetic stimulation testing were performed at 7 years after onset. Results showed that diffusion tensor tractography of the affected （left） hemisphere passed through the medial corona radiata at, or around, the wall of the lateral ventricle. The contralateral primary sensorimotor cortex was activated during affected knee movements. The motor-evoked potential, which was obtained from the affected leg, exhibited corticospinal tract characteristics. Results indicated that motor function of the affected leg recovered via the corticospinal tract, which descended through the corona radiata medial to the infarct. The motor function of the affected leg was reorganized to the medial corona radiata following infarct to the middle cerebral artery territory.

关键词： functional magnetic resonance imaging stroke cortical reorganization motor recovery diffusion tensor tractography transcranial maanetic stimulation

Unusual long-term motor recovery in a patient with corona radiata infarct

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Neural Regeneration Research 2010年第17期5卷 1353-1356页

作者： Sung Ho jang Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityDaegu 705-717Republic of Korea

The majority of motor recovery following stroke occurs within 6 months after *** present study examined a patient with a corona radiata infarct,who exhibited an unusual long-term recovery（24 months after onset）.The patient was a 64-year-old female,who presented with severe paralysis of the left extremities resulting from a corona radiate *** recovery from the weakness progressed slowly over a 24-month period following onset,even at 6-12 months after *** tensor tractography at 2 weeks from onset showed disruption of the corticospinal tract of the affected hemisphere resulting from the ***,at 12 and 24 months after onset,the corticospinal tract was elongated to the cortex level,as shown by diffusion tensor tractography.A 2-week transcranial magnetic stimulation showed no motor-evoked potential for the affected hemisphere,but a motor-evoked potential of the corticospinal tract was observed at12 and 24 *** results suggest that motor function recovery in cerebral infarct patients can occur at least up to 24 months after stroke onset.

关键词： stroke motor recovery cerebral infarct diffusion tensor tractography transcranial magnetic stimulation diffusion tensor imaging

Isolated corticospinal tract in a patient with intracerebral hemorrhage A diffusion tensor tractography and transcranial magnetic stimulation study

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Neural Regeneration Research 2011年第7期6卷 558-560页

作者： Sung Ho jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

Diffusion tensor tractography allows visualization of the corticospinal tract （CST） in three dimensions. Transcranial magnetic stimulation offers a unique advantage in that it can distinguish between the corticospinal tract and the non-CST by analyzing the characteristics of a motor-evoked potential. A 15 year-old female showed right hemiparesis, due to intracerebral hemorrhage in the left corona radiata, and the posterior limb of the internal capsule. Diffusion tensor tractography revealed that the tracts of both hemispheres originated from the precentral gyrus, and descended through the known CST pathway. Specifically, the tract of the affected hemisphere descended through an isolated area in the leukomalactic lesion at the posterior limb level. In addition, the characteristics of the motor-evoked potential obtained from the right hand when stimulating the hot spot of the left motor cortex corresponded to a CST. In conclusion, we report on a patient with intracerebral hemorrhage who showed an isolated CST in a leukomalactic lesion. This result suggests the importance of saving the adjacent area or penumbra around a hematoma after an intracerebral hemorrhage.

关键词： stroke motor recovery corticospinal tract magnetic stimulation diffusion tensor im-aging

Spared integrity of corticospinal tract within a pontine infarct A diffusion tensor tractography study

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Neural Regeneration Research 2010年第20期5卷 1552-1554页

作者： Sung Ho jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Daegu 705-717 Republic of Korea

Integrity of the corticospinal tract is mandatory for good recovery of impaired motor function in patients who have suffered a stroke.A 67-year-old left hemiparetic female showed an infarct in the right *** months after onset,motor function of the affected extremities recovered rapidly to a nearly complete *** tensor tractography of both hemispheres showed that the corticospinal tract originated from the primary sensori-motor cortex and descended through the known corticospinal tract *** tract of the affected（right）hemisphere descended through an area within the pontine *** diffusion tensor tractography results suggest that from the onset,the integrity of the corticospinal tract appears to have been spared within the pontine infarct.

关键词： pontine infarct diffusion tensor imaging corticospinal tract stroke motor recovery

Recent advances in electronic devices for monitoring and modulation of brain

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Nano Research 2021年第9期14卷 3070-3095页

作者： Yong Won Kwon Yoon Sun Jun Young-Geun Park Jiuk jang jang-Ung Park Nano Science Technology Institute Department of Materials Science and EngineeringYonsei UniversitySeoul 03722Republic of Korea Center for Nanomedicine Institute for Basic Science(IBS)Seoul 03722Republic of Korea Graduate Program of Nano Biomedical Engineering(NanoBME) Advanced Science InstituteYonsei UniversitySeoul 03722Republic of Korea

The brain is actuated by billions of neurons with trillions of interconnections that regulate human *** the mechanisms of these systems that induce sensory reactions and respond to disease remains one of the greatest challenges in science,engineering,and *** advances in nanomaterials and nanotechnologies have led to the extensive research of electronic devices for brain interfaces to better understand the neural activities of the brains complex nervous *** development of sensor devices for monitoring the physiological signals of the brain related to traumatic injury status has accompanied by the progress of electronic neural probes in *** addition,these neurological and stereotactic surgical revolutions hold immense potential for clinical analysis of pharmacological systems within cerebral ***,we review the progress of electronic devices interfacing with brain in terms of the materials,fabrication technologies,and device *** activity can be measured and modulated by brain probes based on newly developed nanofabrication ***,in vivo pathological monitoring of the brain and pharmacological assessment has been developed in miniaturized and wireless *** also consider the key challenges and prospects for further development,and explore the future directions emerging in the latest research.

关键词： neural interfaces neural recording neuromodulation intracranial pressure monitoring microfluidic drug delivery

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混联Ⅱ型惯容非线性能量阱的动力学特性研究

应用数学和力学 2024年第7期45卷 907-921页

作者：吴子英朱荣贤姜东贵晁国强张禹轩西安理工大学机械与精密仪器工程学院西安710048

分别使用非线性恢复力、非线性阻尼替代惯容减振系统中的线性恢复力、线性阻尼,并考虑摩擦力的影响,提出了混联Ⅱ型惯容非线性能量阱.建立了主系统的动力学方程,利用谐波平衡法求解系统在简谐激励下的幅频响应曲线.采用弧长算法和数值... 详细信息

分别使用非线性恢复力、非线性阻尼替代惯容减振系统中的线性恢复力、线性阻尼,并考虑摩擦力的影响,提出了混联Ⅱ型惯容非线性能量阱.建立了主系统的动力学方程,利用谐波平衡法求解系统在简谐激励下的幅频响应曲线.采用弧长算法和数值法相结合的方法研究了系统的惯质比、非线性阻尼、非线性刚度和摩擦力单个参数对其减振性能的影响.发现非线性刚度和非线性阻尼数值的增大会使峰值先减小后增大,不同的是,前者幅频响应曲线逐渐向右上方向弯曲,后者产生峰值的位置向低频段转移.分析了惯质比、非线性阻尼、非线性刚度3种参数两两组合下对系统减振效果的影响.研究表明,在激励幅值为0.005 m时,惯质比和阻尼同时变化减振效果最好:当ε=0.1时,系统主结构位移峰值的最小值约为0.01 m;而在参数ε=0.001时,整体取值范围内其最大值约为0.061 m;当惯质比取得最佳值0.1时,非线性阻尼和非线性刚度κ_(21)的取值范围变大.在摩擦力的作用下,系统的最大幅值都有不同程度的增加.上述研究可为振动系统减振的研究提供参考.

关键词：谐波平衡法非线性惯容器振动控制

Neglected corticospinal tract injury for 10 months in a stroke patient

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Neural Regeneration Research 2015年第12期10卷 2060-2061页

作者： Sung Ho jang Chul Hoon Chang Woo Hyuk jang Department of Physical Medicine and Rehabilitation College of MedicineYeungnam University Department of Neurosurgery College of MedicineYeungnam University

The corticospinal tract（CST）is an essential motor pathway in the human brain：particularly,it is essential for fine hand movements（jang,2014）.Stroke patients can show more severe weakness when a partial injury of ... 详细信息

关键词： MCA Neglected corticospinal tract injury for 10 months in a stroke patient CST

Recovery of an injured corticospinal tract by subcortical peri-lesional reorganization in a patient with intracerebral hemorrhage

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Neural Regeneration Research 2016年第7期11卷 1191-1192页

作者： Sung Ho jang Woo Hyuk jang Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityDaemyungdong

The corticospinal tract （CST） is a neural tract responsible for motor function in the human brain. It is mainly related to hand movements （Iang, 2014）. Therefore, recovery of an injured CST contributes to good recovery in stroke patients and a thorough knowledge of the recovery mechanism regarding an injured CST is required for successful brain rehabilitation.

关键词： reorganization subcortical intracerebral injured radiata cortex rehabilitation ganglia corona ventricle