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西洋参原材料近红外光谱精选研究

仪器仪表学报 2012年第6期33卷 1435-1440页

作者：戚淑叶单婕 Ting wong 凌雷韩东海中国农业大学食品科学与营养工程学院 Afexa生命科学公司

为确保药物成品质量的稳定均一,作为原材料的西洋参应保证纯正。采用近红外积分球漫反射光谱,首先对西洋参、人参原样光谱运用移动窗口偏最小二乘法(moving window partial least-squares regression,MWPLS)选择特征波段,建立最小二乘... 详细信息

为确保药物成品质量的稳定均一,作为原材料的西洋参应保证纯正。采用近红外积分球漫反射光谱,首先对西洋参、人参原样光谱运用移动窗口偏最小二乘法(moving window partial least-squares regression,MWPLS)选择特征波段,建立最小二乘支持向量机(least-squares support vector machine,LS-SVM)种类鉴别模型挑选出西洋参样品,判别正确率为100%。然后将样品粉碎,人参以5%、10%、15%、20%掺入西洋参粉末,为增加样品代表性借助线性加和模拟光谱手段于4 000～7 000 cm-1建立主成分判别分析(principal component analysis discriminant analysis,PCA-DA)掺杂判别模型,预测判别正确率由97.2%上升至100%,区分出少量人参掺杂的西洋参样品,最终精选出西洋参原材料纯品。

关键词：西洋参原材料近红外光谱精选

A Traditional Chinese Medicine Approach in Treating Depression by Promoting Liver Qi Circulation: A Western Medicine Perspective

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Chinese Medicine 2015年第4期6卷 187-195页

作者： Raphaella Wai Lam So Hoi shan wong Kam Ming Ko Division of Life Science Hong Kong University of Science & Technology Hong Kong China

Depression is a prevalent mental illness in developed countries. In Western medicine, experimental and clinical investigations have demonstrated that depression is associated with the dysregulation of neurotransmitter signaling, and symptoms of depression can be alleviated by therapeutic intervention. However, patients taking antidepressant drugs often experience serious side effects and high relapse rates. On the other hand, traditional Chinese medicine (TCM) views depression as a manifestation of liver qi stagnation. Practitioners of TCM have long been treating depression with herbs that promote qi circulation in the liver. In this article, we offer a hypothesis stating the biochemical basis of the linkage between liver qi stagnation and depression. Liver qi is involved in the processing of macronutrients into molecules to fuel energy metabolism in brain neurons, as well as the synthesis of plasma proteins that maintain blood circulation to the brain, thereby enabling these fuel molecules to be delivered to the brain. In cases of liver qi stagnation, the failure in delivering sufficient fuel molecules to the brain disrupts mitochondrial ATP production in neurons. Because neurotransmitter release and neurotropin transport are driven by ATP, the deficiency in release and transport processes resulting from insufficient ATP production could lead to depression. Therefore, if liver qi stagnation is causally related to the pathogenesis of depression, the promotion of liver qi circulation by Chinese herbs might offer a promising prospect for the effective treatment of depression.

关键词： Mitochondrial ATP Liver “Qi” Stagnation Depression Traditional Chinese Medicine

‘Yang-Invigorating’ Chinese Tonic Herbs Enhance Mitochondrial ATP Generation in H9c2 Cardiomyocytes

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Chinese Medicine 2011年第1期2卷 1-5页

作者： Hoi shan wong Hoi Yan Leung Kam Ming Ko 不详

‘Yang-invigorating’ Chinese tonic herbs have been shown to enhance the myocardial mitochondrial ATP generation capacity in mice ex vivo. In the present study, we examined the effect of treatment with the methanol extract of ‘Yang-invigorating’ herbs on mitochondrial ATP generation capacity in H9c2 cardio-myocytes. The effect of ‘Yin-nourishing’ herbs was also investigated for comparison. The results indicated that all ‘Yang-invigorating’ Chinese tonic herbs dose-dependently enhanced the mitochondrial ATP genera-tion capacity in H9c2 cardiomyocytes. Three out of nine ‘Yin-nourishing’ herbs produced a dose-dependent stimulatory effect on ATP generation, but to lesser extents than those of Yang herbs. Results obtained from activity-directed fractionation of the three most potent ‘Yang-invigorating’ herbs suggested that the ATP-stimulating ingredients were rather water insoluble and largely resided in the butanol fraction. In con-clusion, ‘Yang-invigorating’ herbs invariably stimulated mitochondrial ATP generation capacity in H9c2 cardiomyocytes. The cell-based assay of ATP generation capacity may be used as pharmacological test for ‘Yang-invigorating’ Chinese tonic herbs.

关键词： Yang Yin Chinese Medicine ATP Mitochondria Cardiomyocytes

Numerical Study of Two-dimensional Transient Heat Conduction using Finite Element Method

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Numerical Study of Two-dimensional Transient Heat Conduction...

Development of a Novel Tissue-Specific Method to Detect Cytokeratin 20-Positive Circulating Tumor Cells in Metastatic Colorectal Cancer

The 10th EPMESC

作者： Lee yuk Choi wong Sau Keong Ooi Hooi Woon Sia Chee Kiong Faculty of Mechanical Engineering Kolej Universiti Teknikal Kebangsaan Malaysia （KUTKM） Locked Bag 1200 Ayer Keroh Melaka Malaysia Faculty of Mechanical Engineering Kolej Universiti Teknikal Kebangsaan Malaysia （KUTKM） Locked Bag 1200 Ayer Keroh Melaka Malaysia Faculty of Mechanical Engineering Kolej Universiti Teknikal Kebangsaan Malaysia （KUTKM） Locked Bag 1200 Ayer Keroh Melaka Malaysia Department of Material and Design Engineering. Kolej Universiti Teknologi Tun Hussein Onn （KUiTTHO） Locked Bag 101 Batu Pahat Johor Malaysia

A mathematical formulation applied to a numerically study of two dimensional transient heat conduction in a building slab to determine the temperature distribution as a function of time. The finite el

关键词： heat conduction transient finite element method bilinear element temperature

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Advances in Modern Oncology Research 2018年第4期4卷 1-6页

作者： Sze Chuen Cesar wong Charles Chan Ming Lok Chu So shan Department of Health Technology and Informatics Faculty of Health and Social SciencesHong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Clinical Oncology Faculty of MedicineChinese University of Hong KongHong Kong Special Administrative RegionChina

Introduction:Although many studies have shown the vast potential of circulating tumor cells(CTCs)detection in cancer diagnosis and prognosis,our understanding of their clinical significance is still far from complete.A major obstacle arises from the lack of well-established tumor or tissue-specific markers to detect CTCs by immunocytochemical staining after immunomagnetic enrichment(IE).Methods:We have established the utility of cytokeratin 20(CK20),a gastrointestinal tract specific marker,for the specific detection and identification of colorectal cancer(CRC)*** breakthrough was successfully validated in spike-in experiments using CRC cell line models followed by a pilot study which recruited 32 metastatic CRC patients,25 benign colorectal diseases patients and 27 normal ***:CK20-positive CTCs were detected in 90%metastatic CRC patients but not in benign colorectal diseases patients and normal subjects using this refined ***:These impressive results have laid the foundation for further development of CK20-positive CTCs as a promising marker in diagnosis,prognostication and treatment monitoring of metastatic CRC.

关键词： Tissue-specific cytokeratin 20-positive circulating tumor cells metastatic colorectal cancer

Run to Run Control Based on Adaptive Cluster Method for High-mix Semiconductor Manufacturing Processes

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Run to Run Control Based on Adaptive Cluster Method for High...

The Hong Kong consensus recommendations on the diagnosis and management of pancreatic cystic lesions

第二十九届中国控制会议

作者： David shan-Hill wong Shi-shang JANG Department of Chemical Engineering National Tsing-Hua University

In the semiconductor manufacturing process,products with different recipe will be produced on the same tool or products with same recipe will be produced on different tools due to the capacity of ***,it is difficult to control a mixed run production process containing low production frequency products with high *** proposed a control scheme which combines adaptive k-means cluster method and run-to-run control to improve the performance of low frequency products in the mixed run *** products could be classified into the same group adaptively and be controlled by a EWMA *** cluster controller is updated by large and small frequency products,so the low frequency products can be improved by the information from similar large frequency *** proposed control scheme is also evaluated by an industrial application.

关键词： Run-to-Run Control EWMA Mix Product Process k-means Cluster

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 715-735,I0019-I0020页

作者： Tan-To Cheung yuk Tong Lee Raymond Shing-Yan Tang wong Hoi She Kai Chi Cheng Chin Cheung Cheung Keith Wan Hang Chiu Kenneth Siu Ho Chok Wing Sun Chow Tak Wing Lai Wai-Kay Seto Thomas Yau Department of Surgery Queen Mary HospitalThe University of Hong KongHong KongChina Gastroenterologist in private practice Hong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Department of Surgery Kwong Wah HospitalHong KongChina Department of Surgery Tuen Mun HospitalHong KongChina Department of Radiology&Imaging Queen Elizabeth HospitalHong KongChina Department of Medicine The University of Hong KongHong KongChina Department of Surgery Princess Margaret HospitalHong KongChina Department of Medicine School of Clinical MedicineThe University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background:The finding of pancreatic cystic lesions(PCL)on incidental imaging is becoming increasingly *** studies report a prevalence of 2.2-44.7%depending on the population,imaging modality and indication for imaging,and the prevalence increases with *** with PCL are at risk of developing pancreatic cancer,a disease with a poor *** publication summarizes recommendations for the diagnosis and management of PCL and post-operative pancreatic exocrine insufficiency(PEI)from a group of local ***:Clinical evidence was consolidated from narrative reviews and consensus statements formulated during two online meetings in March *** expert panel included gastroenterologists,hepatobiliary surgeons,oncologists,radiologists,and ***:Patients with PCL require careful investigation and follow-up due to the risk of malignant transformation of these *** should undergo clinical investigation and pancreas-specific imaging to classify lesions and understand the risk profile of the *** indicated,patients should undergo pancreatectomy to excise *** pancreatectomy,patients are at risk of PEI,leading to gastrointestinal dysfunction and ***,such patients should be monitored for symptoms of PEI,and promptly treated with pancreatic enzyme replacement therapy(PERT).Patients with poor response to PERT may require increases in dose,addition of a proton pump inhibitor,and/or further investigation,including tests for pancreatic *** are also at risk of new-onset diabetes mellitus after pancreatectomy;they should be screened and treated with insulin if ***:These statements are an accurate summary of our approach to the diagnosis and management of patients with PCL and will be of assistance to clinicians treating these patients in a similar clinical landscape.

关键词： Pancreatic cystic lesions pancreatic endocrine insufficiency pancreatic enzyme replacement therapy

Recent advances of multidimensional sensing: from design to applications

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Science China Chemistry 2019年第12期62卷 1601-1618页

作者： Sihua Qian shan Sun Yuhui Wang Zhongjun Li Hengwei Lin Ningbo Institute of Materials Technology&Engineering(NIMTE) Chinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences Beijing 100049China College of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhou 450001China

Recently,multidimensional(or multi-channel)sensing methodology has attracted broad attention in the field of analytical chemistry due to its fascinating merits.A variety of multidimensional sensors based on sensor arrays,lab-on-a-molecule/nanoparticle and smart chip strategies have been designed to differentiate chemical structure and property similar analytes and complex *** recognition algorithms are usually used and allow these sensors to fulfill such *** this review,the recent advances of multidimensional sensor devices were firstly summarized,and particularly focused on their design strategies and applications in monitoring of biological active molecules,biomarkers,microbes,foods and beverages,***,some limitations and possible solutions of multidimensional sensors were *** finally,potential applications of this technique in the future were *** review would help the readers who are interested in multidimensional sensing methodology to understand the research progresses and trends.

关键词： multidimensional sensor multi-channel sensor sensor arrays smart chip lab-on-a-molecule/nanoparticle

Recombinant chimpanzee adenovirus vector vaccine expressing the spike protein provides effective and lasting protection against SARS-CoV-2 infection in mice

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Virologica Sinica 2022年第4期37卷 581-590页

作者： Mingqing Lu Kunpeng Liu Yun Peng Zhe Ding Yingwen Li Alexander Tendu Xue Hu Ge Gao Weiwei Guo Hang Liu Juhong Rao Jiaxuan Zhao Miaoyu Chen Zhiming Yuan Gary wong Chao shan Yanfeng Yao Jiaming Lan CAS Key Laboratory of Molecular Virology&Immunology Institut Pasteur of ShanghaiChinese Academy of SciencesShanghai200031China State Key Laboratory of Virology Chinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Center for Biosafety Mega-Science Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China

SARS-CoV-2 infection is a global public health *** are considered amongst the most important tools to control the SARS-CoV-2 *** expected,deaths from SARS-CoV-2 infection have dropped dramatically with widespread ***,there are concerns over the duration of vaccine-induced protection,as well as their effectiveness against emerging variants of ***,we constructed a recombinant chimpanzee adenovirus vectored vaccine expressing the full-length spike of SARS-CoV-2(Ad C68-S).Rapid and high levels of humoral and cellular immune responses were observed after immunization of C57BL/6J mice with one or two doses of Ad ***,neutralizing antibodies were observed up to at least six months after vaccination,without substantial *** or double doses Ad C68-S immunization resulted in lower viral loads in lungs of mice against SARS-CoV-2 challenge both in the short term(21 days)and long-term(6 months).Histopathological examination of Ad C68-S immunized mice lungs showed mild histological abnormalities after SARS-CoV-2 *** together,this study demonstrates the efficacy and durability of the Ad C68-S vaccine and constitutes a promising candidate for clinical evaluation.

关键词： SARS-CoV-2 Vaccine Chimpanzee adenovirus vector Neutralizing antibodies Long-term protection