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世界核心医学期刊文摘（眼科学分册） 2006年第6期2卷 49-50页

作者： wong t. y. Shankar A. Klein R. 安胜(译) 不详 Cent.e for Ey. Research Aust.alia University of Melbourne 32 Gisborne Street East Melbourne Vic. 3002 Australia

Object.ve: t. examine t.e associat.on bet.een t.e apolipo-prot.in E (APOE) gene and early.age-relat.d maculopat.y.(ARM) in middle-aged persons. Design: Populat.on-based cross-sect.onal st.dy. Part.cipant.: Part.cipant. from t.e At.erosclerosis Risk in Communit.es St.dy.(n=10 139; age range,49-73 y.ars). Met.ods: Ret.nal phot.graphy.as performed on 1 randomly.select.d ey.,and grading for presence of ARMwas carried out.using a modificat.on of t.e Wisconsin ARM Grading Sy.t.m. Early.ARM was defined as t.e presence of eit.er soft.drusen alone,ret.nal pigment.epit.elial depigment.t.on alone,or a combinat.on of soft.drusen wit. increased ret.nal pigment.and/or depigment.t.on. DNA ext.act.d from blood samples of part.cipant. were analy.ed for common allelic variant. of t.e APOE gene ( 2, 3,and  4). Main Out.ome Measures: Presence of early.ARM on ret.nal phot.graphs. Result.: t.e prevalence of early.ARM was similar in part.cipant. wit. different.POE genot.pes:  2/ 2 (5.9% ), 2/ 3 (5.2% ), 2/ 4 (3.2% ), 3/ 3 (5.2% ), 3/ 4 (4.9% ),and  4/ 4 (4.1% ). Aft.r cont.olling for age,gender,race,cigaret.e smoking,and ot.er fact.rs,early.ARM was not.associat.d wit. APOE genot.pes,wit. an odds rat.o (OR) of 1.35 (95% confidence int.rval CI,0.54-3.38) for  2/ 2 genot.pe,an OR of 1.06 (95% CI,0.80-1.40) for  2/ 3 genot.pe,an OR of 0.63 (95% CI,0.32-1.24) for  2/ 4 genot.pe,an OR of 0.99 (95% CI,0.80-1.24) for  3/ 4 genot.pe,and an OR of 0.88 (95% CI,0.47-1.63) for  4/ 4 genot.pe,as compared wit. 3/3 genot.pe (reference). No associat.ons were found for specific early.ARM signs or in analy.es st.at.fied by.age,gender,race,or cigaret.e smoking st.t.s. Conclusions: t.ese dat. provide no evidence of a st.ong associat.on bet.een t.e APOE gene and early.ARM in middle-aged persons. t.is suggest. t.at.APOE is not.likely.a major det.rminant.of t.e early.st.ges of ARM in y.unger people. However,our st.dy.does not.exclude t.e possibilit. of a weaker associat.on or t.at.APOE m

关键词：年龄相关性黄斑变性载脂蛋白E基因人群研究发病风险动脉粥样硬化早期视网膜色素上皮 APOE基因型眼底照相玻璃膜疣

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视网膜微血管异常与MRI确诊的亚临床脑梗死:动脉粥样硬化风险的社区研究

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世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 9-10页

作者： Cooper L S. wong t. y. Klein R. 王文军(译) 不详 Cent.e for Ey. Research Aust.alia University of Melbourne 32 Gisborne St Melbourne Vic. 3002 Australia

Background and Purpose-Ret.nal microvascular abnormalit.es reflect.cumulat.ve small vessel damage from elevat.d blood pressure and may.reflect.subclinical cerebral microvascular *** examined t.eir associat.ons wit. MRI-defined cerebral ***-Populat.on-based,cross-sect.onal st.dy.of 1684 persons 55 t. 74 y.ars of age wit.out.a hist.ry.of clinical st.oke,sampled from 2 US sout.east.rn *** phot.graphs were obt.ined and graded for presence of ret.nal microvascular abnormalit.es,including art.riovenous nicking,focal art.riolar narrowing,ret.nal hemorrhages,soft.exudat.s and *** were also digit.zed,and ret.nal vessel diamet.rs were measured and summarized as t.e art.riole-t.-venule rat.o(AVR).Cerebral MRI scans were graded for presence of cerebral infarct.defined as a lesion ≥ 3 mm diamet.r in a vascular dist.ibut.on wit. t.pical imaging ***-t.ere were a t.t.l of 183 MRI cerebral *** adjust.ent.for age,gender,race,6-y.ar mean art.rial blood pressure,diabet.s,and ot.er st.oke risk fact.rs,cerebral infarct. were associat.d wit. ret.nal microvascular abnormalit.es,wit. odds rat.os 1.90(95% CI,1.25 t. 2.88)for art.riovenous nicking,1.89(95% CI,1.22 t. 2.92)for focal art.riolar narrowing,2.95(95% CI,1.30 t. 6.71)for blot.hemorrhages,2.08(95% CI,0.69,6.31)for soft.exudat.s,3.17(95% CI,1.05 t. 9.64)-for microaneury.ms,and 1.74(95% CI,0.95 t. 3.21)for smallest.compared wit. largest.*** st.at.fied analy.es,t.ese associat.ons were only.present.in persons wit. ***-Ret.nal microvascular abnormalit.es are associat.d wit. MRI-defined subclinical cerebral infarct. independent.of st.oke risk *** dat. suggest.t.at.ret.nal phot.graphy.may.be useful for st.dy.ng subclinical cerebrovascular disease in populat.on-based st.dies.

关键词：视网膜微血管异常 MRI扫描亚临床期社区研究脑梗死动脉粥样硬化确诊微血管收缩

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美国多种族人群的糖尿病性视网膜病变调查

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世界核心医学期刊文摘（眼科学分册） 2006年第6期2卷 4-5页

作者： wong t. y. Klein R. Islam F. M. A. 潘佳鸿(译) 不详 Cent.e for Ey. Research Aust.alia University of Melbourne 32 Gisborne Street Melbourne Vic. 3002 Australia

PURPOSE: t. describe t.e prevalence and risk fact.rs of diabet.c ret.nopat.y.in a mult.-et.nic US populat.on of whit.s,blacks,hispanics,and chinese. DESIGN: Cross-sect.onal st.dy.of 778 individuals from ages 45 t. 85 y.ars wit. diabet.s,part.cipat.ng in t.e Mult.-Et.nic St.dy.of At.erosclerosis (MESA). MEt.ODS: Ret.nal phot.graphs were obt.ined wit. a 45° nonmy.riat.c digit.l fundus camera. Presence and severit. of diabet.c ret.nopat.y.were graded at.a cent.al reading cent.r on t.e basis of a modificat.on of t.e Airlie House classificat.on sy.t.m. All part.cipant. underwent.a st.ndardized int.rview,examinat.on,and laborat.ry.invest.gat.ons. RESULt.: In t.is populat.on wit. diabet.s,t.e prevalence of any.ret.nopat.y.was 33.2% and macular edema 9.0% . t.e prevalence of any.diabet.c ret.nopat.y.and macular edema was significant.y.higher in blacks (36.7% and 11.1% ) and hispanics (37.4% and 10.7% ) t.an in whit.s (24.8% and 2.7% ) and chinese (25.7% and 8.9% ) (P=.01 and P=.007,comparing racial/et.nic differences for ret.nopat.y.and macular edema,respect.vely.. Significant.independent.predict.rs of any.ret.nopat.y.were longer durat.on of diabet.s,higher fast.ng serum glucose,use of diabet.c oral medicat.on or insulin,and great.r waist.hip rat.o. Race was not.an independent.predict.r of any.ret.nopat.y. CONCLUSIONS: t.is st.dy.provides cont.mporary.dat. on t.e prevalence of and risk fact.rs for diabet.c ret.nopat.y.among whit.s,blacks,hispanics,and chinese part.cipat.ng in t.e MESA.

关键词：糖尿病性视网膜病变种族人群美国独立预测因素糖尿病患者数码照相机患病率比动脉粥样硬化黄斑水肿空腹血糖浓度

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隐性远视与高血压之间不存在关联:蓝山眼科研究

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世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 15-16页

作者： Liew G. Mit.hell P. wong t. y. Wang J. J. 曹绪胜(译) Depart.ent.of Opht.almology.(West.ead Hospit.l) Westmead Millennium Institute ney NSW Australia 不详

PURPOSE:An associat.on bet.een hy.ermet.opia and hy.ert.nsion was recent.y.*** sought.t. verify.t.is finding in t.e Blue Mount.ins Ey. St.dy.cohort.n=3654;ages 49 t. 97 y.ars).DESIGN:Cohort.***:We defined hy.ermet.opia as mean spheric equivalent.refract.on(SER)>1.00 diopt.r,my.pia as mean SER t.rs,and emmet.opia as mean SER ≤ 1.00 diopt.rs and t.rs,*** used t.e 2003 World Healt. Organizat.on/Int.rnat.onal Societ. of Hy.ert.nsion guidelines t. define severe hy.ert.nsion as grade 2 or ***:Of 1290 people who were at.risk of t.e development.of hy.ert.nsion,378 people developed incident.severe hy.ert.nsion aft.r five *** mult.variat.-adjust.d relat.ve risk of incident.hy.ert.nsion in persons wit. hy.ermet.opia compared wit. t.ose wit. emmet.opia was 1.06(95% CI,0.89 t. 1.26);t.e relat.ve risk in persons wit. my.pia was 1.22(95% CI,0.96 t. 1.56).CONCLUSION:Neit.er hy.ermet.opia nor my.pia was associat.d wit. incident.hy.ert.nsion in t.is older populat.on.

关键词：高血压协会眼科研究远视隐性相对危险度世界卫生组织近视患者队列研究

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Mechanosy.t.esis and mechanochemical t.eat.ent.of bismut.-doped vanadium phosphorus oxide cat.ly.t. for t.e part.al oxidat.on of n-but.ne t. maleic anhy.ride

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Journal of Nat.ral Gas Chemist.y 2008年第3期17卷 232-237页

作者： y. H. t.ufiq-y.p y.C. wong y. Kamiy. W.J. t.ng Put.a Cent.r for Cat.ly.is Science and t.chnology Department of Chemistry Faculty of Science Universiti Putra Malaysia 43400 UPM Serdang Selangor Darul Ehsan Malaysia Graduat. School of Environment.l Science Hokkaido Universit3 Sapporo 060-0810 Japan

t.ree Bi-doped vanady. py.ophosphat. cat.ly.t. were prepared via dihy.rat. rout. （VPD met.od）, which consist.d of different.preparat.on met.ods including mechanosy.t.esis, mechanochemical t.eat.ent. and t.e convent.onal reflux met.od. t.e cat.ly.t. produced by.t.e above t.ree met.ods were charact.rized by.x-ray.diffract.on （XRD）, scanning elect.on microscopy.（SEM）, and t.mperat.re programmed reduct.on （t.R）. Cat.ly.0}c evaluat.on for t.e part.al oxidat.on of n-but.ne t. maleic anhy.ride （MA） was also carried out. t.e XRD pat.erns of all t.e Bi-doped cat.ly.t. showed t.e main peaks of py.ophosphat. phase. Lower int.nsit. peaks were observed for t.e mechanochemically.t.eat.d Bi-doped cat.ly.t.（VPDBiMill） wit. t.o addit.onal small peaks corresponding t. t.e presence of a small amount.of V5＋ phase. t.e t.R profiles showed t.at.t.e highest.amount.of act.ve oxy.en species, i.e, V4＋–O- pair, responsible for n-but.ne act.vat.on, was removed from VPDBiMill. Furt.ermore, from t.e cat.ly.0}c t.st.result., t.e graph of select.vit. t. MA as a funct.on of t.e conversion of n-but.ne demonst.at.d t.at.VPDBiMill was t.e most.select.ve cat.ly.t. t.is suggest. t.at.t.e mechanochemical t.eat.ent.of vanadium phosphat. cat.ly.t.（VPDBiMill） is a pot.nt.al met.od t. improve t.e cat.ly.0}c propert.es for t.e part.al oxidat.on of n-but.ne t. maleic anhy.ride.

关键词： mechanosy.t.esis mechanochemical t.eat.ent bismut. vanady. py.ophosphat.

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非糖尿病患者的视网膜病表现是否可作为糖尿病发病的预测因子

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世界核心医学期刊文摘（眼科学分册） 2006年第6期2卷 59-59页

作者： wong t. y. Mohamed Q. Klein R. Couper D. J. 安胜(译) 不详 Cent.e for Ey. Research Aust.alia 32 Gisborne Street Vic. 3002 Australia

Background/aims: Isolat.d ret.nopat.y.signs are common in non-diabet.c individuals and have been shown t. be associat.d wit. impaired glucose met.bolism. In a cohort.of people wit.out.diabet.s,t.e associat.on of t.ese ret.nopat.y.signs and subsequent.development.of diabet.s were examined. Met.ods: A populat.on based cohort.st.dy.of 7992 people aged 49-73 y.ars wit.out.diabet.s was conduct.d. Ret.nal phot.graphs of t.ese part.cipant. were evaluat.d for t.e presence of ret.nopat.y.signs according t. a st.ndardised prot.col. Incident.cases of diabet.s were ident.fied prospect.vely. Result.: Aft.r a follow up of 3 y.ars,291 (3.6% ) people developed incident.diabet.s. In t.e t.t.l cohort.ret.nopat.y.was not.significant.y.associat.d wit. incident.diabet.s (4.7% v 3.6% ,mult.variable adjust.d odds rat.o (OR) 1.1,95% confidence int.rvals (CI),0.7 t. 1.9). However,among part.cipant. wit. a posit.ve family.hist.ry.of diabet.s,ret.nopat.y.was associat.d wit. incident.diabet.s (10.4% v 4.8% ,mult.variable adjust.d OR 2.3,95% CI,1.0 t. 5.3). Among part.cipant. wit.out.a family.hist.ry.of diabet.s,ret.nopat.y.was not.associat.d wit. incident.diabet.s Conclusions: In individuals wit. a family.hist.ry.of diabet.s,ret.nopat.y.signs predict.subsequent.risk of clinical diabet.s.

关键词：糖尿病患者视网膜病预测因子发病葡萄糖代谢障碍无糖尿病史糖尿病家族史队列人群队列研究受试者

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QUASI-INt.RPOLAt.NG OPERAt.RS AND t.EIR APPLICAt.ONS IN Hy.ERSINGULAR INt.GRALS

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Journal of Comput.t.onal Mat.emat.cs 1998年第4期16卷 337-344页

作者： wong, RH Lu, y Dalian Univ t.chnol Inst Math Sci Dalian 116024 Peoples R China

t.e purpose of t.is paper is t. propose and st.dy.a class of quasi-int.rpolat.ng operat.rs in mult.variat. spline space S-1/2(Delt.(mn)(2*)) on non-uniform t.pe-2 t.iangulat.on. Based on t.e operat.rs, we const.uct.cubat.re formula for t.o-dimensional hy.ersingular int.grals. Some comput.ng work have been done and t.e result. are quit. sat.sfact.ry.

关键词： hy.ersingular int.gral finit.-part.int.gral quasi-int.rpolat.ng operat.r non-uniform t.pe-2 t.iangulat.on

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Asy.pt.t.c Propert.es of a Modified Semi-Paramet.ic MLE in Linear Regression wit. Right.Censored Dat.

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Act. Mat.emat.ca Sinica,English Series 2002年第2期18卷 405-416页

作者： wong George y.C. St.ang Cancer Prevent.on Cent.r.428 E 72nd St.eet.New y.rk.Ny.10021.USA

Consider a linear regression model y.β'X+*** y.may.be right.censored and t.e cdf F+o of e is *** show t.at.a modified semi-paramet.ic *** by..is st.ongly.consist.nt.under cert.in regularit. *** F_o is discont.nuous,t.en P(≠βi.o.)=0, which means t.at.P(=βif t.e sample size is large)=*** lat.er propert. has not.been report.d for t.e exist.ng *** cont.ast.most.est.mat.rs,such as t.e Buckley.James est.mat.r and M-est.mat.rs .sat.sfy.t.at.P(≠βi.o.)=1.

关键词： Consist.ncy Super-efficiency Semi-paramet.ic MLE

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Comprehensive charact.rizat.on of indoor airborne bact.rial profile

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Journal of Environment.l Sciences 2009年第8期21卷 1148-1152页

作者： P. L. Chan P. H. F. y. y. W. Cheng C. y. Chan P. K. wong Depart.ent.of Biology The Chinese University of Hong Kong Depart.ent.of Applied Biology.and Chemical t.chnology The Hong Kong Polytechnic University Depart.ent.of Microbiology The Chinese University of Hong Kong

t.is is t.e first.det.iled charact.rizat.on of t.e airborne bact.rial profiles in indoor environment.. t.o rest.urant. were select.d for t.is st.dy. Fift.en genera of bact.ria were isolat.d from each rest.urant.and ident.fied by.t.ree different.bact.rial ident.ficat.on sy.t.ms including MIDI, Biolog and Riboprint.r. t.e dominant.bact.ria of bot. rest.urant. were Gram-posit.ve bact.ria in which Micrococcus and Bacillus species were t.e most.abundant. Most.bact.ria ident.fied were represent.t.ve species of skin and respirat.ry.t.act.of human, and soil. Alt.ough t.e bact.rial levels in t.ese t.o rest.urant. were below t.e limit.of t.e Hong Kong Indoor Air Qualit. Object.ve （HKIAQO） Level 1 st.ndard （i.e., 〈 500 cfu/m^3）, t.e majorit. of t.ese bact.ria were opport.nist.c pat.ogens. t.ese result. suggest.d t.at.t.e ident.t. of airborne bact.ria should also be included in t.e IAQ t. ensure t.ere is a safet. guideline for t.e public.

关键词： airborne bact.rial profile bact.rial ident.ficat.on indoor air qualit.

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t.mperat.re Measurement.of Small Object. by.Mach-Zehnder Int.rferomet.r

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Journal of t.ermal Science 1993年第4期2卷 270-274页

作者： y.t.wong W.K.Chin Hong Kong Poly.0}chnic

A Mach-Zehnder Int.rferomet.r incorporat.d wit. image processing has been set.up t. st.dy.t.e t.mperat.re field of small *** object. wit. widt. t. height.rat.os ranging from 0.33 t. 1.0 subject.d t. nat.ral convect.on are used t. simulat. t.e condit.on at.which t.e end effect. are significant. Int.rferogram represent.ng t.e t.mperat.re gradient.is capt.red,digit.zed,and image processed wit. t.e aid of an image processing unit.A simple correct.on model is proposed t. t.eat.t.e st.red int.rferomet.ic *** int.rference dat. are found t. compare well wit. t.ose provided by.t.e t.ermocouples.

关键词： t.mperat.re measurement small object. mach-zehnder int.rferomet.r

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