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Unsynchronized butyrophilin molec.l.s dictate cancer c.l. evasion of Vγ9Vδ2 T-c.l. killing

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c.l.ular & Molec.l.r Immunology 2024年第4期21卷 362-373页

作者： Zeguang Wu Qiezhong lamao Meichao Gu Xuanxuan Jin Ying liu Feng Tian Ying Yu Pengfei Yuan Shuaixin Gao Thomas S.Fulford Adam P.Uldrich catherine c.l.wong Wensheng Wei Biomedic.l.Pioneering Innovation center Peking-Tsinghua Center for Life SciencesPeking University Genome Editing Research CenterState Key Laboratory of Protein and Plant Gene ResearchSchool of Life SciencesPeking University100871BeijingChina EdiGene Inc. Life Science ParkChangping District102206BeijingChina center for Precision Medicine Multi-Omics Research Peking University Health Science CenterPeking University100191BeijingChina Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity The University of MelbourneParkvilleVIC3010Australia cancer Immunology Program Peter MacCallum Cancer CentreMelbourneVICAustralia State Key laboratory for complex Severe and Rare DiseasesClinical Research InstitutePeking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegePeking-Tsinghua Center for Life Sciences100871BeijingChina

Vγ9Vδ2 T c.l.s are specialized effector c.l.s that have gained prominence as immunotherapy agents due to their ability to target and kill c.l.s with altered pyrophosphate *** our effort to understand how cancer c.l.s evade the c.l.-killing activity of Vγ9Vδ2 T c.l.s,we performed a comprehensive genome-sc.l. cRISPR screening of cancer *** found that four molec.l.s belonging to the butyrophilin(BTN)family,specific.l.y BTN2A1,BTN3A1,BTN3A2,and BTN3A3,are critic.l.y important and play unique,nonoverlapping roles in fac.l.tating the destruction of cancer c.l.s by primary Vγ9Vδ2 T *** coordinated function of these BTN molec.l.s was driven by synchronized gene expression,which was regulated by IFN-γsignaling and the RFX ***,an enzyme c.l.ed QPc.l.was shown to play a key role in modifying the N-terminal glutamine of these BTN proteins and was found to be a crucial factor in Vγ9Vδ2 T c.l. killing of cancer *** our research,we offer a detailed overview of the functional genomic mechanisms that underlie how cancer c.l.s escape Vγ9Vδ2 T ***,our findings shed light on the importance of the harmonized expression and function of gene family members in modulating T-c.l. activity.

关键词： Butyrophilin Vγ9Vδ2 T-c.l. cancer-specific immune evasion Glutaminyl-peptide cyclotransferase-like Pyrophosphate metabolite Immunotherapy

Superior antibody and membrane protein‑specific T‑c.l. responses to coronaVac by intradermal versus intramusc.l.r routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.cheng carolyn A.cohen Daniel leung Xiwei Wang Xiaofeng Mu Yuet chung Tsun Ming lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.wong leo c.H.Tsang Sara chaothai Tsz chun Kwan John K.c.l. Karl c.K.chan leo l.H.luk Jenson c.H.Ho Wing Yan li Amos M.T.lee Jennifer H.Y.lam Sau Man chan Wilfred H.S.wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu lung lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia center for Immunology and Infection c2i Hong KongChina

Background Optimising the immunogenicity of cOVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramusc.l.r(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-coV-2)at the full dose is *** study(NcT04800133)investigated the superiority of antibody and T-c.l. responses of full-dose coronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and c.l.ular immunogenicity outcomes were measured post-dose 2(IM-cc versus ID-cc)and post-dose 3(IMccc versus ID-ccc).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(Il-2)+cD4^(+),SNM-specific Il-2^(+)cD8^(+),S-specific Il-2^(+)cD8^(+),N-specific Il-2^(+)cD4^(+),N-specific Il-2^(+)cD8^(+)and M-specific Il-2^(+)cD4^(+)responses fulfilled the superior and non-inferior criteria for ID-cc compared to IM-cc,whereas IgG avidity was *** ID-ccc,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific Il-2^(+)cD4^(+),interferon-γ+cD8^(+)and Il-2^(+)cD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-cc,ID-cc,IM-ccc and ID-ccc,*** ID groups reported more loc.l.mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-c.l. responses by ID inactivated SARScoV-2 vaccination and serves as the basis for future research to improve the

关键词： coronaVac coronavirus disease 2019 Immunity Intradermal Vaccine

limosilactobac.l.us mucosae FZJTZ26M3 prevents NAFlD in mice through modulation of lipid metabolism and gut microbiota dysbiosis

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Food Science and Human Wellness 2024年第3期13卷 1589-1601页

作者： Danting Dang Bowen li Mengfan Ding RPaul Ross catherine Stanton Jianxin Zhao Bo Yang Wei chen State Key laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China International Joint Research center for Probiotics&Gut Health Jiangnan UniversityWuxi 214122China APc Microbiome Ireland University College CorkCork T12 YT20Ireland Teagasc Food Research centre MooreparkFermoyCork T12 YT20Ireland National Engineering Research center for Functional Food Jiangnan UniversityWuxi 214122China

lactobac.l.us are considered promising therapeutic methods for nonalcoholic fatty liver disease(NAFlD).The effects of two strains of ltmosilactobac.l.us mucosae on NAFlD were investigated in this ***-old male c57Bl/6J mice were divided into 4 groups(n=8 per group,control,Model,FZJTZ26M3,FGSYc17l3).*** FZJTZ26M3 reduced the mice 's body weight,liver weight,and adipose tissue weight after 12 weeks of *** to serum analysis,total cholesterol,triac.l.lycerol,and low-density lipoprotein cholesterol significantly decreased after *** FZJTZ26M3 *** pathology showed that *** FZJTZ26M3 was effective to ameliorate lipid deposition in NAFlD ***,the expression of the gene related to lipid metabolism in the liver and adipose tissue was analyzed,and the results indicated that *** FZJTZ26M3 could alleviate NAFlD by regulating lipid ***,the results of 16S rRNA gene sequencing revealed a drop in the relative abundance of Ruminococcaceae,which is linked to inflammation,but the relative abundance of a potential probiotic Akkermansia significantly increased after *** FZJTZ26M3 ***,*** FZJTZ26M3 could be a candidate to prevent NAFlD.

关键词： limosilactobac.l.us mucosae Nonalcoholic fatty liver disease(NAFlD) Probiotic lipid metabolism Gut microbiota

Prevalence and risk factors for impaired renal function among Asian patients with nonalcoholic fatty liver disease

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 241-248页

作者： chao Sun George Boon-Bee Goh Wan-cheng chow Wah-Kheong chan Grace lai-Hung wong Wai-Kay Seto Yi-Hsiang Huang Han-chieh lin I-cheng lee Hye Won lee Seung Up Kim Vincent Wai-Sun wong Jian-Gao Fan center for Fatty liver Disease Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China Department of Gastroenterology&Hepatology Singapore General HospitalSingaporeSingapore Gastroenterology and Hepatology Unit Department of MedicineFaculty of MedicineUniversity of MalayaKuala LumpurMalaysia Department of Medicine and Therapeutics and State Key laboratory of Digestive Disease The Chinese University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina Institute of clinic.l.Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Division of Gastroenterology and Hepatology Taipei Veterans General HospitalTaipeiTaiwanChina Fac.l.y of Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Department of Internal Medicine Yonsei University College of MedicineSeoulKorea

Background:Nonalcoholic fatty liver disease(NAFlD)is associated with impaired renal function,and both diseases often occur alongside other metabolic ***,the prevalence and risk factors for impaired renal function in patients with NAFlD remain *** objective of this study was to identify the prevalence and risk factors for renal impairment in NAFlD ***:All adults aged 18-70 years with ultrasound-diagnosed NAFlD and transient elastography examination from eight Asian centers were enrolled in this prospective *** fibrosis and cirrhosis were assessed by FibroScan-aspartate aminotransferase(FAST),Agile 3+and Agile 4 *** renal function and chronic kidney disease(cKD)were defined by an estimated glomerular filtration rate(eGFR)with value ofl/min/1.73 m^(2) andl/min/1.73 m^(2),respectively,as estimated by the cKD-Epidemiology c.l.aboration(cKD-EPI)***:Among 529 included NAFlD patients,the prevalence rates of impaired renal function and cKD were 37.4%and 4.9%,*** multivariate analysis,a moderate-high risk of advanced liver fibrosis and cirrhosis according to Agile 3+and Agile 4 scores were independent risk factors for cKD(Pcreased fasting plasma glucose(FPG)and blood pressure were significantly associated with impaired renal function after controlling for the other components of metabolic syndrome(Pcompared with patients with normoglycemia,those with prediabetes[FPG≥5.6 mmol/l or hemoglobin A1c(HbA1c)≥5.7%]were more likely to have impaired renal function(Pconclusions:Agile 3+and Agile 4 are reliable for identifying NAFlD patients with high risk of *** glycemic control in the prediabetic stage might have a potential renoprotective role in these patients.

关键词： Nonalcoholic fatty liver disease Impaired renal function Agile 3+ Agile 4 Metabolic syndrome

Empiric.l.model for fusion cross sections of ca-induced reactions

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chinese Physics c 2024年第3期48卷 126-132页

作者： Reddi Rani.l N.Sowmya K.N Sridhar H c.Manjunatha M.M.Armstrong Arasu Department of Physics St.Joseph's College(Autonomous)Affiliated to Bharathidasan UniversityTiruchirappalli620002TNIndia Department of Physics Govt.First.Grade CollegeChikkaballapur-562101KarnatakaIndia Department of Physics Govt.First.Grade CollegeMalur-563160KarnatakaIndia Department of Physics Govt.First.Grade CollegeDevanahalli-562110KarnatakaIndia

A new empiric.l.formula for the astrophysic.l.S-factor has been suggested as a function of the coulomb interaction parameter,center of mass energy,and barrier *** 22 fusion reactions with ^(40,48)ca as projectiles were considered for different targets,leading to compound nuclei with atomic and mass numbers varying between 40≤Z≤≤Z≤112 and 88≤A≤27888≤A≤278,*** fusion cross-sections have been estimated using the geometric factor,the Gamow-Sommerfield factor,and the empiric.l.formula for the *** study's findings showed better agreement with those of available experiments when compared to wong's *** present work leads to a smaller standard deviation value than wong's formula when used to correlate the experimental data of c.l.ium-induced fusion ***'s formula provides a good approximation of fusion cross-sections when the center of mass energy is below the fusion barrier when compared to above the fusion barrier.

关键词： fusion cross-sections wong formula Gamow-Sommerfield-factor Geometric-factor S-factor

Proteomics research of SARS-coV-2 and cOVID-19 disease

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Medic.l.Review 2022年第4期2卷 427-445页

作者： Nan Zhang Siyuan Wang catherine c.l.wong Department of Medic.l.Research center State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingP.R.China Department of Radiation Onc.l.gy College of MedicineThe Ohio State UniversityColumbusOHUSA center for cancer Metabolism Comprehensive Cancer CenterThe Ohio State UniversityColumbusOHUSA Department of Medic.l.Research center State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College Hospital(Dongdan Campus)Chinese Academy of Medical Sciences&Peking Union Medical CollegeNo.1 Shuaifuyuan WangfujingDongcheng DistrictBeijing 100730P.R.China Tsinghua University-Peking University Joint center for life Sciences Tsinghua UniversityBeijing 100084P.R.China

currently,coronavirus disease 2019(cOVID-19)is still spreading in a global sc.l.,exerting a massive health and socioeconomic *** insights into the molec.l.r functions of the viral proteins and the pathogenesis of this infectious disease are urgently *** this review,we comprehensively describe the proteome of severe acute respiratory syndrome coronavirus 2(SARS-coV-2)and summarize their protein interaction map with host *** the protein interaction network between the virus and the host,a total of 787 host prey proteins that appeared in at least two studies or were verified by co-immunoprecipitation *** with 29 viral proteins,a network of 1762 proximal interactions were *** also review the proteomics results of cOVID-19 patients and proved that SARS-coV-2 hijacked the host’s translation system,post-translation modification system,and energy supply system via viral proteins,resulting in various immune disorders,multiple cardiomyopathies,and cholesterol metabolism diseases.

关键词： cOVID-19 disease proteomics research SARS-coV-2 particles

含二硫化硒洗发水对中-重度头皮脂溢性皮炎外用糖皮质激素/水杨酸治疗后的疗效维持作用

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中华皮肤科杂志 2024年第5期57卷 483-484页

作者： Philippe Massiot Pasc.l.Reygagne corinne chagnoleau leila Kanoun-copy Florence Pouradier Geneviève loussouarn catherine Queille-Roussel Hussein Jouni Delphine Kerob l'Oréal Research and Innovation Saint-Ouen France. centre Sabouraud Hôpital Saint-Louis 1 avenue Claude-Vellefaux 75010 Paris France. cPcAD Hôpital l'Archet Nice France. l'Oréal Research and Innovation Aulnay-sous-Bois France. cosmetic Active International Levallois-Perret France.

脂溢性皮炎是一种慢性炎症性皮肤病,好发于头皮、面部和躯干等皮脂腺分布丰富的部位。头皮脂溢性皮炎主要表现为红斑和片状鳞屑,程度从轻度鳞屑到弥漫性大片黏着性鳞屑不等,伴有明显的瘙痒,并容易反复发作。目前认为脂溢性皮炎的发生与... 详细信息

脂溢性皮炎是一种慢性炎症性皮肤病,好发于头皮、面部和躯干等皮脂腺分布丰富的部位。头皮脂溢性皮炎主要表现为红斑和片状鳞屑,程度从轻度鳞屑到弥漫性大片黏着性鳞屑不等,伴有明显的瘙痒,并容易反复发作。目前认为脂溢性皮炎的发生与亲脂性马拉色菌定植增加以及遗传、环境和全身健康状况等因素相关,上述因素共同导致皮脂腺代谢活动异常、皮脂成分改变、表皮屏障功能障碍,最终加重炎症反应。

关键词：头皮脂溢性皮炎二硫化硒洗发水亲脂性炎症反应马拉色菌皮脂腺黏着性

Immunoregulatory and Anti-cancer Activities of combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast cancer Bearing Mice

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chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： lea ling-Yu Kan Ben chung-lap chan Grace Gar-lee Yue lI Pei-ting Sharon Sze-Man Hon HUANG Dan-qi Miranda Sin-Man Tsang clara Bik-San lau Ping-chung leung chun-Kwok wong Institute of chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key laboratory of Research on Bioactivities and clinic.l.Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of chemic.l.Pathology The Chinese University of Hong KongHong Kong SARChina china-Australia International Research centre for chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia li Dak Sum Yip Yio chin R&D centre for chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBc).Methods Murine-derived triple-negative mammary carcinoma c.l. line,4T1 c.l.s,was c.l.ured and inoc.l.ted into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,lD 4HF(low dose 4HF),HD 4HF(high dose 4HF),lD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoc.l.tion with 5×10^(5)4T1 c.l.s resuspended in 100µl of normal saline in the mammary fat *** from the day of tumor c.l. inoc.l.tion,tumors were grown for 6 *** lD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** lD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 ml double distilled water and 0.1 ml normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 ml double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunologic.l.activities via immunophenotyping,gene and multiplex analysis,histologic.l.staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(Pltered the hypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunologic.l.***,immunosuppressive genes,cytokines,and chemokines such as c-c motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(Pcin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines chinese medicine tumor microenvironment

cD137l,a driver of harmful inflammation in the nervous system

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Neural Regeneration Research 2023年第11期18卷 2387-2388页

作者： Hiu Yi wong Amanda c.Y.chan Anselm Mak Herbert Schwarz Division of life Science State Key Laboratory of Molecular NeuroscienceMolecular Neuroscience CenterThe Hong Kong University of Science and TechnologyHong Kong Special Administrative RegionChina Hong Kong center for Neurodegenerative Diseases Hong Kong Special Administrative RegionChina Division of Neurology University Medicine ClusterNational University HospitalSingapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingapore Division of Rheumatology University Medicine ClusterNational University Health SystemDepartment of MedicineYong Loo Lin School of MedicineNational Univesity of SingaporeSingapore Department of Physiology and Immunology ProgrammeYong Loo Lin School of MedicineNational University of SingaporeSingapore Integrative Sciences and Engineering Programme NUS Graduate SchoolNational University of SingaporeSingapore

cD137 (TNFRSF9,4-1BB) is a member of the tumor necrosis factor (TNF) receptor family and a potent costimulatory *** levels of cD137 are expressed on T c.l.s upon ***137 signaling in T c.l.s,either by cognate interaction with antigen-presenting c.l.s (APc)or by agonistic anti-cD137 antibodies,strongly enhances proliferation,interferon-y secretion,and cytolytic activity of T ***,cD137 signaling is a main driver of c.l.ular,type 1 helper T c.l.s (Th1)and type 1 cytolytic T c.l.s (Tc1) polarised immune responses.

关键词： cD137 cD137l inflammation