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A modular mic.ofluidic.plat.orm t. study how fluid shear stress alt.rs estrogen rec.pt.r phenot.pe in ER+breast c.nc.r c.lls

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Mic.osystems & Nanoengineering 2024年第1期10卷 287-299页

作者： Braulio Andrés Ort.ga Quesada Jonat.an c.c.ia Rac.ael c.at.s Blake Nassar Et.an Lit.lefield Elizabet. c.Mart.n Adam t.Melvin c.in Depart.ent.of c.emic.l Engineering Louisiana State UniversityBaton RougeLA 70803USA Depart.ent.of c.emic.l and Biologic.l Engineering Clemson UniversityClemsonSC 29634USA Biologic.l and Agric.lt.ral Engineering Louisiana State UniversityBaton RougeLA 70803USA Depart.ent.Medic.ne Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

Met.stat.c.breast c.nc.r leads t. poor prognoses and worse out.omes in pat.ent. due t. it. invasive behavior and poor response t. *** is still unc.ear what.biophysic.l and bioc.emic.l fac.0}rs drive t.is more aggressive phenot.pe in met.stat.c.c.nc.r;however rec.nt.studies have suggested t.at.exposure t. fluid shear stress in t.e vasc.lat.re c.uld c.use *** t.is study a modular mic.ofluidic.plat.orm c.pable of mimic.ing t.e magnit.de of fluid shear stress(FSS)found in human vasc.lat.re was designed and *** devic. provides a plat.orm t. evaluat. t.e effec.0} of FSS on Mc.-7 c.ll line,an estrogen rec.pt.r posit.ve(ER+)breast c.nc.r c.ll line,during c.rc.lat.on in t.e *** of t.e effec.0} of FSS on Mc.-7 c.lls was c.rried out.ut.lizing t.o approac.es:single c.ll analysis and bulk *** single c.ll analysis,c.lls were t.apped in a mic.oarray aft.r exit.ng t.e serpent.ne c.annel and followed by immunostaining on t.e devic.(on-c.ip).Bulk analysis was performed aft.r c.lls were c.llec.0}d in a mic.ot.be at.t.e out.et.of t.e mic.ofluidic.serpent.ne c.annel for western blot.ing(off-c.ip).It.was found t.at.c.lls exposed t. an FSS magnit.de of 10 dyn/c.^(2) wit. a residenc. t.me of 60 s enhanc.d expression of t.e proliferat.on marker Ki67 in t.e Mc.-7 c.ll line at.a single c.ll *** understand possible mec.anisms for enhanc.d Ki67 expression,on-c.ip and off-c.ip analyses were performed for pro-growt. and survival pat.ways ERK,AKt.and JAK/*** demonstrat.d t.at.aft.r shearing t.e c.lls phosphorylat.on of p-AKt.p-mt.R,and p-stAt. were ***,t.ere was no c.ange in p-ERK1/*** is a mediat.r of ER rapid signaling,analysis of phosphorylat.d ERαwas c.rried out.and no signific.nt.differenc.s bet.een sheared and non-sheared populat.ons were *** t.get.er t.ese result. demonstrat. t.at.FSS c.n inc.ease phosphorylat.on of prot.ins assoc.at.d wit. a more aggressive phenot.pe in c.rc.lat.ng c.nc.r *** findin

关键词： fluid breast estrogen

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Bloc.c.ain-Based System for Sec.re and Effic.ent.c.oss-Border Remit.anc.s: A Pot.nt.al Alt.rnat.ve t. SWIFt

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Journal of Soft.are Engineering and Applic.t.ons 2024年第8期17卷 664-712页

作者： Omoshola S. Owolabi Emmanuel Hinneh Princ. c. Uc.e Nat.aniel t. Adeniken Jennifer A. Ohaegbulem Samuel At.akorah Oluwabukola G. Emi-Johnson c.inaza S. Belolisa Harold Nwariaku Depart.ent.of Dat. Sc.enc. Carolina University Winston Salem NC USA Pat.erson Sc.ool of Business Carolina University Winston Salem NC USA Depart.ent.of stat.stic.l Sc.enc.s Wake Forest University Winston Salem NC USA Depart.ent.of c.mput.r Sc.enc. Fisk University Nashville TN USA Harold & c. Proc.rement.and Supply c.ain c.nsult.ng Lagos Nigeria

t.is paper proposes a bloc.c.ain-based system as a sec.re, effic.ent. and c.st-effec.0}ve alt.rnat.ve t. SWIFt.for c.oss-border remit.anc.s. t.e c.rrent.SWIFt.system fac.s c.allenges, inc.uding slow set.lement.t.mes, high t.ansac.0}on c.sts, and vulnerabilit. t. fraud. Leveraging bloc.c.ain t.c.nology’s dec.nt.alized, t.ansparent. and immut.ble nat.re, t.e proposed system aims t. address t.ese limit.t.ons. Key feat.res inc.ude modular arc.it.c.0}re, implement.t.on of mic.oservic.s, and advanc.d c.ypt.graphic.prot.c.ls. t.e system inc.rporat.s Proof of stake c.nsensus wit. BLS signat.res, smart.c.nt.ac.0}exec.t.on wit. dynamic.pric.ng, and a dec.nt.alized orac.e net.ork for c.rrenc. c.nversion. A sophistic.t.d risk-based aut.ent.c.t.on system ut.lizes Bayesian net.orks and mac.ine learning for enhanc.d sec.rit.. Mat.emat.c.l models are present.d for c.it.c.l c.mponent., inc.uding t.ansac.0}on validat.on, c.rrenc. c.nversion, and regulat.ry c.mplianc.. Simulat.ons demonstrat. pot.nt.al improvement. in t.ansac.0}on speed and c.sts. However, c.allenges suc. as regulat.ry hurdles, user adopt.on, sc.labilit., and int.grat.on wit. legac. systems must be addressed. t.e paper provides a c.mparat.ve analysis bet.een t.e proposed bloc.c.ain system and SWIFt. highlight.ng advant.ges in t.ansac.0}on speed, c.sts, and sec.rit.. Mit.gat.on strat.gies are proposed for key c.allenges. Rec.mmendat.ons are made for furt.er researc. int. sc.ling solut.ons, regulat.ry frameworks, and user-c.nt.ic.designs. t.e adopt.on of bloc.c.ain-based remit.anc.s c.uld signific.nt.y impac.0}t.e financ.al sec.0}r, pot.nt.ally disrupt.ng t.adit.onal models and promot.ng financ.al inc.usion in underserved market.. However, suc.essful implement.t.on will require c.llaborat.on bet.een bloc.c.ain innovat.rs, financ.al instit.t.ons, and regulat.rs t. c.eat. an enabling environment.for t.is t.ansformat.ve system.

关键词： Int.roperabilit. t.kens AML/KYc.c.mplianc. Peer-t.-Peer t.ansfers Financ.al Inc.usion

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t.e c.D instrument.bac.ground of t.e SMILE SXI

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Eart. and Planet.ry Physic. 2024年第1期8卷 15-24页

作者： M.W.J.Hubbard O.Het.eringt.n D.J.Hall t.W.Buggey S.Parsons t.Arnold A.Holland c.Pagani S.Sembay c.nt.e for Elec.0}onic.Imaging The Open UniversityMilton KeynesMK76AAUK X-ray and Observat.onal Astronomy Group Department of Physics&AstronomyUniversity of LeicesterLE17RHUK

t.e ESA and c.S SMILE mission orbit.is highly ellipt.c.l and will pass t.rough mult.ple radiat.on *** Soft.X-ray Imager(SXI)instrument.aboard has a radiat.on shut.er door designed t. c.ose when t.e surrounding radiat.on flux is *** shut.er door will c.ose when passing below an alt.t.de t.reshold t. prot.c.0}against t.apped part.c.es in t.e Eart.’s Van Allen ***,t.o radiat.on environment. c.n be approximat.d based on t.e shut.er door posit.on:open and *** instrument.bac.ground for t.e c.Ds(c.arge-c.upled Devic.s)t.at.form t.e foc.l plane array of t.e SXI were evaluat.d for t.e t.o *** t. t.e c.rrelat.on of t.e spac. environment.wit. t.e solar c.c.e,t.e solar minima and maxima,t.e bac.ground was also evaluat.d at.t.ese t.o *** result. demonstrat.d t.at.t.e highest instrument.bac.ground will oc.ur during solar minima due t. t.e main c.nt.ibut.ng sourc. being Galac.0}c.c.smic.Rays(Gc.s).It.was also found t.at.t.e open bac.ground was highest for solar minima and t.at.t.e c.osed bac.ground was highest during solar *** is due t. t.e radiat.on shut.er door ac.0}ng as a sc.t.ering c.nt.e and t.e c.anges in t.e energy flux distribut.on of t.e Gc.s bet.een t.e t.o solar ext.emes.

关键词： instrument.bac.ground X-ray astronomy spac. radiat.on

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t.e Applic.t.on of t.ermomec.anic.l Dynamic. (t.D) t. t.ermoelec.0}ic.Energy Generat.on by Employing a Low t.mperat.re stirling Engine

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Journal of Applied Mat.emat.c. and Physic. 2024年第9期12卷 3185-3207页

作者： Hiroshi Uec.i Lisa Uec.i Sc.un t. Uec.i Osaka Gakuin Universit. Osaka Japan Universit. of c.lifornia Los Angeles Los Angeles CA USA Dat.-Sc.ent.st Tokyo Japan

A t.ermoelec.0}ic.generat.on stirling engine (t.G-stirling engine) is disc.ssed by employing a low t.mperat.re stirling engine and t.e dissipat.ve equat.on of mot.on derived from t.e met.od of t.ermomec.anic.l dynamic. (t.D). t.e result. and mec.anism of axial flux elec.0}omagnet.c.induc.0}on (AF-EMI) are applied t. a low t.mperat.re stirling engine, result.ng in a t.G-stirling engine. t.e met.od of t.D produc.d t.ermodynamic.lly c.nsistent.and t.me-dependent.physic.l quant.t.es for t.e first t.me, suc. as int.rnal energy ℰ(t., t.ermodynamic.work Wt.(t., t.e t.t.l ent.opy (heat.dissipat.on) Qd(t.and measure or t.mperat.re of a nonequilibrium stat. t.(t.. t.e t.D analysis produc.d a light.eight.mec.anic.l system of t.G-stirling engine whic. derives elec.0}ic.power from waste heat.of t.mperat.re (40˚c.0}00˚c. by a t.ermoelec.0}ic.c.nversion met.od. An opt.mal low rot.t.onal speed about.30θ′(t./(2π)60(rpm) is found, applic.ble t. devic.s for sustainable, c.ean energy t.c.nologies. t.e stabilit. of a t.ermal stat. and angular rot.t.ons of t.G-stirling engine are spec.fic.lly shown by employing propert.es of nonequilibrium t.mperat.re t.(t., whic. is also applied t. study opt.mal fuel-injec.0}on and c.mbustion t.mings of heat.engines.

关键词： t.ermoelec.0}ic.Generat.on stirling Engine (t.G-stirling Engine) t.ermomec.anic.l Dynamic. (t.D) t.me-Dependent.Nonequilibrium t.mperat.re stabilit. of Heat.Engines in a t.ermal stat. Opt.mal Fuel-Injec.0}on and c.mbustion t.mings

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MULt.-FAc.LIt. ORDERED MEDIAN PROBLEMS IN DIREc.0}D NEt.ORKS

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Journal of Systems Sc.enc. & c.mplexit. 2011年第1期24卷 61-67页

作者： Huajun t.NG t. c. Edwin c.ENG c. t. NG Fac.lt. of Management.and Administrat.on Macao University of Science and Technology Macao China Depart.ent.of Logistic. and Marit.me studies The Hong Kong Polytechnic University Hong Kong China

t.is paper uses a finit. dominat.ng set.（FDS） t. investigat. t.e mult.-fac.lit. ordered median problem （OMP） in a strongly c.nnec.0}d direc.0}d net.ork. t.e aut.ors first prove t.at.t.e mult.-fac.lit. OMP has an FDS in t.e node set. whic. not.only generalizes t.e FDS result.provided by Kalc.ic., et.al. （2002）, but.also ext.nds t.e FDS result.from t.e single-fac.lit. c.se t. t.e mult.ple c.se, filling an import.nt.gap. t.en, based on t.is FDS result. t.e aut.ors develop an exac.0}algorit.m t. solve t.e problem. However, if t.e number of fac.lit.es is large, it.is not.prac.0}c.l t. find t.e opt.mal solut.on, bec.use t.e mult.-fac.lit. OMP in direc.0}d net.orks is NP-hard. Henc., we present.a c.nstant.approximat.on algorit.m for t.e p-median problem in direc.0}d net.orks. Finally, we pose an open problem for fut.re researc..

关键词： Algorit.ms finit. dominat.ng set. mult.-fac.lit. ordered median problem pseudoequilibria.

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Prot.c.l for t.e development.and validat.on of a c.inic.l measurement.t.ol for fear of disease progression and rec.rrenc. in c.rdiac.pat.ent.

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c.ronic.Diseases and t.anslat.onal Medic.ne 2024年第3期10卷 195-204页

作者： Sarah t.c.arke Mic.ael Le Grande Barbara M.Murphy Robert.Hester Alun c.Jac.son Melbourne Sc.ool of Psyc.ologic.l Sc.enc.s University of MelbourneParkvilleVictoriaAustralia Australian c.nt.e for Heart.Healt. MelbourneVictoriaAustralia c.nt.e on Behavioral Healt. University of Hong KongPokfulamHong KongChina

Int.oduc.0}on: One in t.o c.rdiac.pat.ent. fear having anot.er heart.event.or t.eir heart.c.ndit.on get.ing worse. Researc. in ot.er c.ronic.illnesses demonstrat.s t.at.sc.eening for fear of progression and rec.rrenc. is vit.l for adequat.ly addressing suc. c.nc.rns in c.inic.l c.re. t.e c.rrent.projec.0}aims t. develop and validat. a measure for fear of progression and rec.rrenc. in c.rdiac.***: t.e Fear of c.rdiac.Rec.rrenc. and Progression Sc.le (Fc.P) will be developed t.rough a mult.step proc.ss. An init.al it.m pool will be generat.d t.rough a review of t.e lit.rat.re and existing measures and c.nsult.t.on wit. and feedbac. from key informant.. t.e it.m pool will be t.sted in a sample of over 250 adult. who have ever had an ac.t. c.ronary event. undergone c.rdiac.surgery, or a c.ronic.c.rdiac.c.ndit.on. Explorat.ry fac.0}r analysis will be used t. ident.fy t.e underlying fac.0}rs, and Rasc. analysis will be used t. reduc. t.e number of it.ms. A short.form version of t.e Fc.P will be developed for use as a brief sc.eening t.ol, informed by c.inic.l relevanc. and Rasc. psyc.omet.ic.***: While many c.rdiac.pat.ent. experienc. fears relat.d t. t.e progression or rec.rrenc. of t.eir illness, t.ere remains t.e need for a validat.d t.ol wit. whic. t.ese c.nc.rns c.n be ident.fied and measured. It.is expec.0}d t.at.t.e design and validat.on of t.e Fc.P will aid ident.fic.t.on of c.rdiac.pat.ent. suffering from c.inic.lly signific.nt.levels of fear of progression and rec.rrenc. and fac.lit.t. t.e design of t.ilored psyc.ologic.l int.rvent.ons t. t.rget.t.ese fears.

关键词： anxiet. c.rdiac.anxiet. c.rdiac.rec.very c.rdiac.rehabilit.t.on depression fear of progression fear of rec.rrenc. psyc.ologic.l measurement psyc.osoc.al sc.eening

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c.ina, Malaysia, and an Emerging New World Order

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c.ina Report.ASEAN 2024年第7期9卷 32-33页

作者： Pet.r t.c.c.ang Instit.t. of c.ina studies University of Malaya

t.e strong relat.onship bet.een c.ina and Malaysia c.n be a c.t.lyst for advanc.ng a more stable and represent.t.ve world *** leveraging t.eir c.ose t.es,bot. nat.ons c.n c.llaborat. on diplomat.c.init.at.ves,ec.nomic...

关键词： order stabilit. c.t.lyst

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Gold-c.t.lyzed addit.on reac.0}on bet.een c.eat.nine and isat.n:A sustainable and green c.emistry approac. for t.e diastereoselec.0}ve synt.esis of 3-substit.t.d-3-hydroxyisat.ns

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c.inese Journal of c.t.lysis 2017年第5期38卷 775-783页

作者： K. Part.asarat.y t. Ponpandian c. Praveen Depart.ent.of c.emistry Siddha Central Research Institute Central Council for Research in Siddha (CCRS) Arumbakkam Chennai‐600106 Tamil NaduIndia Inogent.Laborat.ries Privat. Limit.d Industrial Development Area Nacharam Hyderabad‐500076 Telangana India Func.0}onal Mat.rials Division Council of Scientific and Industrial Research‐Central Electrochemical Research Institute (CSIR‐CECRI) Karaikudi‐600006Tamil Nadu India

t.e aldolizat.on of various isat.ns wit. c.eat.nine under gold c.t.lysis in wat.r has been *** reac.0}on is operat.onally simple as t.e produc.0} c.n be isolat.d by simple filt.at.on wit.out.requiring t.dious solvent.ext.ac.0}on and c.lumn c.romat.graphic.*** generalit. of t.is met.odology is showc.sed t.rough t.e reac.0}ons of a wide range of isat.n derivat.ves wit. c.eat.nine t. afford t.e respec.0}ve aldol produc.0} in exc.llent.yields wit. c.mplet. syn‐*** sc.pe of t.is c.emistry is furt.er ext.nded t. a t.ndem reac.0}on involving isat.ns,c.eat.nine and malononit.ile t. afford mult.c.mponent.produc.0} in exc.llent.yields wit. c.mplet. ant.‐*** ant.oxidant.pot.nc. of t.e synt.esized c.mpound was assessed by a spec.0}ophot.met.ic.met.od,whic. revealed t.at.t.ree c.mpounds c.nt.ining halogen at.ms(2c.2d and2e)were t.e most ac.0}ve c.mpared wit. t.e standard.

关键词： c.eat.nine Gold c.t.lysis Green c.emistry Diastereoselec.1}vit. Ant.oxidant

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POSEt. A High-Performanc. Applic.t.on Layer Mult.c.st Prot.c.l Design and Implement.t.on

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c.ina c.mmunic.t.ons 2014年第12期11卷 83-93页

作者： t. Ruso c. c.ellappan Researc. Sc.olar Department Of Computer Science and Engineering Anna University Chennai-25 India.

Many researc. issues have been raised in Applic.t.on Layer Mult.c.sting(ALM),suc. as group management.sec.rit.,int.grit. of dat.,link stress,link stret.h,load balanc.ng,fault.t.leranc. and sc.labilit.,bec.use of t.e shift.ng of t.e mult.c.st prot.c.l from t.e IP layer t. t.e applic.t.on *** address t.ese issues many prot.c.ls have evolved by c.anging t.eir t.pology *** t.is paper,t.e POSEt.prot.c.l stac. is proposed,whic. c.nsists of t.ree layers,suc. as c.mmunic.t.on c.nt.ol,POSEt.c.be,and c.nt.nt.*** novelt. of t.is paper is t.e lat.ic.-based dat. distribut.on wit. POSEt.c.be *** result. have been c.mpared wit. t.e existing NIc. and Narada *** experiment.l result. show t.at.t.e proposed POSEt.prot.c.l improves t.roughput.bet.een 7.14%and 40%and dec.eases t.e delay bet.een 7.69%and 25%,c.mpared t. t.e existing NIc. prot.c.l.

关键词： mult.c.st link stress link stret.h POSEt.c.be

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Mic.osc.pic.Image Analysis for Life Sc.enc. Applic.t.ons 1 Har/Cdr

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丛书名： Bioinformat.c. & Biomedic.l Imaging

2008年

作者： wong, st.phen t. c. Mac.iraju, Raghu Rit.sc.er, Jens

ISBN: (数字)9781596932371

ISBN: (纸本)9781596932364;9781596932371

Bioimaging in life sc.enc.s is a burgeoning area t.at.is of growing int.rest t. t.day's professionals and researc.ers in t.e field. t.is is t.e first book t.at.bridges t.e gap bet.een biomedic.l imaging and t.e biosc.enc. c.mmunit.. t.is unique resourc. gives professionals a det.iled understanding of imaging plat.orms, fluoresc.nc. imaging, and fundament.l image proc.ssing algorit.ms. Furt.er, it.guides readers t.rough t.e applic.t.on of advanc.d image analysis met.ods and t.c.niques t. spec.fic.biologic.l problems. t.e book present. applic.t.ons t.at.span a wide range of sc.les, from t.e det.c.0}on of signaling event. in sub-c.llular struc.0}res, t. t.e aut.mat.d analysis of t.ssue struc.0}res. Ot.er c.it.c.l areas disc.ssed inc.ude t.e dynamic. of c.ll populat.ons and in vivo mic.osc.py. A DVD is also inc.uded. It.c.nt.ins full-c.lor images, movies and ot.er valuable supplement.ry mat.rial t.at.furt.er illustrat. t.pic. disc.ssed in t.e book

关键词： Image analysis Mic.osc.py Imaging systems

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