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Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance

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Cellular & Molecular immunology 2024年第4期21卷 393-408页

作者： Sujin Lee Yeunjung Ko Hyun Woo Lee won Joon Oh Hun Gi Hong Dinuka Ariyaratne Se Jin im Tae Jin Kim Department of immunology Graduate School of Basic Medical ScienceSungkyunkwan University School of MedicineSuwon16419Republic of Korea Department of immunology and Molecular Medicine Faculty of Medical SciencesUniversity of Sri JayewardenepuraNugegodaSri Lanka Present address:immunology and Microbiology Graduate Program Baylor College of MedicineHoustonTX77030USA

Marginal zone(MZ)B cells,which are splenic innate-like B cells that rapidly secrete antibodies(Abs)against blood-borne pathogens,are composed of heterogeneous ***,we showed that MZ B cells can be divided into two distinct subpopulations according to their CD80 expression ***80^(high)MZ B cells exhibited greater Ab-producing,proliferative,and IL-10-secreting capacities than did CD80^(low)MZ B ***,CD80^(high)MZ B cells survived 2-Gy whole-body irradiation,whereas CD80^(low)MZ B cells were depleted by irradiation and then repleted with one month after *** of CD80^(low)MZ B cells led to accelerated development of type II collagen(CII)-induced arthritis upon immunization with bovine ***80^(high)MZ B cells exhibited higher expression of genes involved in proliferation,plasma cell differentiation,and the antioxidant ***80^(high)MZ B cells expressed more autoreactive B cell receptors(BCRs)that recognized double-stranded DNA or CII,expressed more immunoglobulin heavy chain sequences with shorter complementarity-determining region 3 sequences,and included more clonotypes with no N-nucleotides or with B-1a BCR sequences than CD80^(low)MZ B *** transfer experiments showed that CD21^(+)CD23^(+)transitional 2 MZ precursors preferentially generated CD80^(low)MZ B cells and that a proportion of CD80^(low)MZ B cells were converted into CD80^(high)MZ B cells;in contrast,CD80^(high)MZ B cells stably remained CD80^(high)MZ B *** summary,MZ B cells can be divided into two subpopulations according to their CD80 expression levels,Ab-producing capacity,radioresistance,and autoreactivity,and these findings may suggest a hierarchical composition of MZ B cells with differential stability and BCR specificity.

关键词： Marginal Zone B Cell CD80 Autoreactivity Radioresistance

Anode surface engineering of zinc-ion batteries using tellurium nanobelt as a protective layer for enhancing energy storage performance

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Journal of Energy Chemistry 2024年第5期92卷 113-123页

作者： Soobeom Lee Yeonjin Je Boeun Seok Hyun Tae Kim Yong-Ryun Jo Soong Ju Oh Byoungyong im Dae Guen Kim sang-Soo Chee Geon-Hyoung An Department of Energy System Engineering Gyeongsang National UniversityJinju 52725Republic of Korea Nano Convergence Materials Center Korea Institute of Ceramic Engineering and Technology(KICET)Jinju 52851Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea School of Materials Science and Engineering Gyeongsang National UniversityJinju 52828Republic of Korea GIST Advanced Insitute of Instrumental Analysis(GAIA) Electron Microscopy LaboratoryGwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Center for Advanced Materials and Processing Institute for Advanced EngineeringYongin 17180Republic of Korea Department of Energy Engineering Gyeongsang National UniversityJinju 52725Republic of Korea

Over the years,zinc-ion batteries(ZIBs)have attracted attention as a promising next-generation energy storage technology because of their excellent safety,long cycling performance,eco-friendliness,and high-power ***,issues,such as the corrosion and dissolution of the Zn anode,limited wet-tability,and lack of sufficient nucleation sites for Zn plating,have limited their practical *** introduction of a protective layer comprising of tellurium(Te)nanobelts onto the surface of Zn anode has emerged as a promising approach to overcome these limitations and improve the electrochemical behav-ior by enhancing the safety and wettability of ZIBs,as well as providing numerous nucleation sites for Zn *** the presence of a Te-based protective layer,the energy power density of the surface-engineered Zn anode improved significantly(ranging from 310 to 144 W h kg^(-1),over a power density range of 270 to 1,800 W kg^(-1)),and the lifespan capability was *** results demonstrate that the proposed strategy of employing Te nanobelts as a protective layer holds great promise for enhancing the energy storage performance of zIBs,making them even more attractive as a viable energy storage solution forthefuture.

关键词： Zn ion battery Anode Protective layer Tellurium Nanobelt

impact of tibial transverse transport in tissue regeneration and wound healing with perspective on diabetic foot ulcers

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World Journal of Diabetes 2024年第5期15卷 810-813页

作者： Sulagna Mukherjee Seung-Soon im Department of Physiology Keimyung University School of MedicineDaegu 42601Republic of Korea

In this editorial,we comment on an article by Liao et al published in the current issue of the World Journal of *** focus on the clinical significance of tibial transverse transport(TTT)as an effective treatment for patients with diabetic foot ulcers(DFU).TTT has been associated with tissue regeneration,improved blood circulation,reduced amputation rates,and increased expression of early angiogenic ***,TTT can influence macrophage polarization and growth factor *** this potential,the limitations and conflicting results of existing studies justify the need for further research into its optimal application and *** clinical implications highlight the efficacy of TTT in recalcitrant DFU and provide lasting stimuli for tissue re-generation,and blood vessel and bone marrow ***-lation via systemic responses contributes to its therapeutic *** studies should investigate the underlying molecular mechanisms to enhance our understanding and the efficacy of *** manuscript emphasizes the potential of TTT in limb preservation and diabetic wound healing and suggests avenues for preventive measures against limb amputation in diabetes and peripheral artery ***,we highlight the clinical significance of the TTT and its importance in healing DFU to promote the use of this technique in tissue regeneration.

关键词： Diabetes foot ulcer Tibial transverse transport Foot surgery Wound healing Tissue regeneration

Biomimetic Fe_(7)S_(8)/Carbon electrocatalyst from[FeFe]-Hydrogenase for improving pH-Universal electrocatalytic hydrogen production Special Collection:Aggregation-Induced Processes and Functions

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Aggregate

Aggregate 2024年第1期5卷 451-459页

作者： Dohun Kim Subramani Surendran Sejin im Jaehyoung Lim Kyoungsuk Jin Ki Tae Nam Uk Sim Department of Energy Science&Engineering Daegu Gyeongbuk Institute of Science&Technology(DGIST)DaeguRepublic of Korea Hydrogen Energy Technology Laboratory Korea Institute of Energy Technology(KENTECH)NajuRepublic of Korea Department of Chemistry Korea UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea

Efficient and cost-effective electrocatalysts that can operate across a wide range of pH conditions are essential for green hydrogen *** by biological systems,Fe_(7)S_(8)nanoparticles incorporated on polydopamine matrix electrocatalyst were synthesized by co-precipitation and annealing *** resulting Fe_(7)S_(8)/C electrocatalyst possesses a three-dimensional structure and exhibits enhanced electrocatalytic performance for hydrogen production across various pH ***,the Fe_(7)S_(8)/C electrocatalyst demonstrates exceptional activity,achieving low overpotentials of 90.6,45.9,and 107.4 mV in acidic,neutral,and alkaline environments,*** impedance spectroscopy reveals that Fe_(7)S_(8)/C exhibits the lowest charge transfer resistance under neutral conditions,indicating an improved proton-coupled electron transfer ***-wave electron paramagnetic resonance results confirm a change in the valence state of Fe from 3+to 1+during the hydrogen evolution reaction(HER).These findings closely resemble the behavior of natural[FeFe]-hydrogenase,known for its superior hydrogen production in neutral *** remarkable performance of our Fe_(7)S_(8)/C electrocatalyst opens up new possibilities for utilizing bioinspired materials as catalysts for the HER.

关键词： biomimetic electrocatalyst hydrogen production renewable energy

Effect of organic mineral supplementation in reducing oxidative stress in Holstein calves during short‑term heat stress and recovery conditions

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Journal of Animal Science and Biotechnology 2024年第2期15卷 812-825页

作者： A-Rang Son Seon-Ho Kim Mahfuzul Islam Michelle Miguel Ye Pyae Naing sang-Suk Lee Ruminant Nutrition and Anaerobe Laboratory Department of Animal Science and TechnologySunchon National UniversitySuncheon 57922Korea Department of Microbiology and Parasitology Sher-e-Bangla Agricultural UniversityDhaka 1207Bangladesh

Background This study investigated the effects of inorganic and organic minerals on physiological responses,oxidative stress reduction,and rumen microbiota in Holstein bull calves(123.81±9.76 kg;5 months old)during short-term heat stress(HS)and recovery *** Holstein calves were randomly assigned to four treatment groups:no mineral supplementation(Con),inorganic minerals(im),organic minerals(OM),and high-concentration organic minerals(HOM)and two thermal environments(HS and recovery)using 4×2 factorial arrangement in a crossover design of four periods of 35 *** were maintained in a temperature-controlled *** experimental period consisted of 14 d of HS,14 d of recovery condititon,and a 7-d washing *** Body temperature and respiration rate were higher in HS than in the recovery conditions(P0.05).The principal coordinate analysis represented that the overall rumen microbiota was not influenced by mineral supplementation;however,temperature-induced microbial structure shifts were indicated(PERMANOVA:P<0.05).At the phylum level,Firmicutes and Actinobacteria decreased,whereas Fibrobacteres,Spirochaetes,and Tenericutes increased(P<0.05),under HS *** genus Treponema increased under HS conditions,while Christensenella was higher in recovery conditions(P<0.05).Conc

关键词： Antioxidant status Heat stress Holstein bull calves Organic mineral supplementation Oxidative stress

Recent trends in the epidemiology and clinical outcomes of inflammatory bowel disease in South Korea,2010-2018

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World Journal of Gastroenterology 2024年第9期30卷 1154-1163页

作者： Seulji Kim Hyun Jung Lee Seung Woo Lee sanghyun Park Seong-Joon Koh Jong Pil im Byeong Gwan Kim Kyung-Do Han Joo Sung Kim Department of Internal Medicine Korea Institute of Radiological and Medical SciencesSeoul 01812South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 03080South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea

BACKGROUND Inflammatory bowel disease(IBD)was previously regarded as a Western disease;however,its incidence is increasing in the *** epidemiology of IBD in Asia differs significantly from the patterns in the *** To comprehensively investigate the epidemiology of IBD in South Korea,inclu-ding its incidence,prevalence,medication trends,and *** We analyzed claims data from the Health Insurance Review and Assessment Service and Rare and Intractable Diseases(RIDs),operated by the National Health Insurance Service of South *** with IBD were identified based on the International Classification of Diseases,Tenth Revision,and RID diagnostic codes for Crohn’s disease(CD)and ulcerative colitis(UC)from 2010 to *** In total,14498 and 31409 patients were newly diagnosed with CD and UC,respectively,between 2010 and *** annual average incidence of CD was 3.11 cases per 105 person-years,and that of UC was 6.74 cases per 10^(5) *** 2014,the incidence rate of CD has been stable,while that of UC has steadily increased,shifting the peak age group from 50-year-olds in 2010 to 20-year-olds in *** CD and UC prevalence increased consistently over the study period;the use of 5-aminosali-cylates and corticosteroids gradually decreased,while that of immunomodulators and biologics steadily increased in both CD and *** clinical outcomes of IBD,such as hospitalization and surgery,decreased during the study *** The CD incidence has been stable since 2014,but that of UC has increased with a shift to a younger age at peak incidence between 2010 and *** clinical outcomes improved over time,with increased use of immunomodu-lators and biologics.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Incidence Prevalence

Clean-DM1, a Korean Polyherbal Formula, improves High Fat Diet-Induced Diabetic Symptoms in Mice by Regulating IRS/PI3K/AKT and AMPK Expressionsin Pancreas and Liver Tissues

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Chinese Journal of Integrative Medicine 2024年第2期30卷 125-134页

作者： Piao Wang Yi Liu Seok Yong Kang Chenzi Lyu Xiang Han Tianjun Ho Kyung Jae Lee Xianglong Meng Yong-Ki Park Hyo won Jung Department of Herbology College of Korean MedicineDongguk UniversityGyeongju 38066Korea College of Pharmacy&Graduate School of Pharmaceutical Sciences Ewha Womans UniversitySeoul 03760Korea Korean Medicine R&D Center Dongguk UniversityGyeongju 38066Korea Shanxi Key Laboratory of Traditional Herbal Medicines Processing Shanxi University of Chinese MedicineJinzhong(030619)ShanxiProvinceChina

Objective:To investigate the effects of Clean-DM1(C-DM1),a polyherbal formulation of Radix Scrophulariae,Radix Astragali,Rhizoma Atractylodis,and Radix Salviae Miltiorrhizae,on high-fat diet(HFD)-induced diabetes ***:The information about active components of C-DM1 extract and molecular mechanism was obtained from network pharmacology *** compounds of C-DM1 extract by high performance liquid chromatography-mass spectrometry(HPLC-MS)analysis were conducted for quality *** in vivo study,mice were induced diabetes by HFD for 12 *** mice in the normal group(Nor)were maintained with a regular diet and treated with saline by *** HFD model mice were randomly divided into 3 groups,including a HFD diabetic model group,a C-DM1 extract-administered group(C-DM1,500 mg/kg),and metformin-administered groups(Met,500 mg/kg),8 mice in each *** intake,body weight(BW),and fasting blood glucose(FBG)levels were recorded weekly for 4 *** 4 weeks of treatment,alanine aminotransferase(ALT),aspartate aminotransferase(AST),blood glucose,low-density lipoprotein cholesterol(LDL-C)were determined using an automated clinical chemistry analyzer,and homeostatic model for assessing insulin resistance(HOMA-IR)levels and oral glucose tolerance test(OGTT)were *** histopathological changes of liver and pancreatic tissues were observed by hematoxylin-eosin *** receptor substrate(IRS)/phosphatidylinositol 3 kinase(PI3K)/protein kinase B(AKT)and adenosine 5'-monophosphate-activated protein kinase(AMPK)expressions in liver and pancreas tissues were detected by Western blot ***:HPLC-MS identified dihydroisotanshinone,dihydroisotanshinone I,cryptotanshinone,harpagoside,and atractyloside A in C-DM1 *** administration of C-DM1 extract significantly decreased body weight,calorie intake,and the levels of blood glucose and insulin in the diabetic mice(Pimproved the im

关键词： high-fat diet type 2 diabetes mellitus herbal formulation insulin receptor substrate/phosphatidylinositol 3 kinase/protein kinase B adenosine 5'-monophosphate-activated protein kinase network pharmacology high performance liquid chromatography-mass spectrometry analysis

论都市农业在城乡一体化发展中的重要意义——以韩国都市农业为鉴

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农业现代化研究 2024年第1期45卷 10-19页

作者：邹毓莹全银华 AN Donghwan im Jeongbin 青岛农业大学外国语学院山东青岛266109 首尔大学农业生命科学院韩国首尔08826

都市农业的有效发展对于促进城乡经济、社会、文化等各类要素的相互渗透,提升城乡相互融合度,最终构建城乡一元的现代化结构有着重要意义。但由于我国都市农业实践时间相对较短且处于初级阶段,在制度、资金、技术等方面仍存在一定的短板... 详细信息

都市农业的有效发展对于促进城乡经济、社会、文化等各类要素的相互渗透,提升城乡相互融合度,最终构建城乡一元的现代化结构有着重要意义。但由于我国都市农业实践时间相对较短且处于初级阶段,在制度、资金、技术等方面仍存在一定的短板,因此有必要借鉴其他国家都市农业推动城乡融合发展的有效经验,驱动我国城乡融合。本文基于对韩国的实地调研,梳理了韩国都市农业的发展历程与现状,分析总结了韩国都市农业促进城乡一体化的过程及效果。结合我国当前都市农业发展的现状与问题,为构建中国特色的城乡一体化提供了有益的参考。研究发现,我国下一步应加快都市农业法律立法并强化规划与引导,扩大都市农业体验渠道与宣传力度,深化城乡一体理念。同时,通过构建都市农业管理师制度来缓解新生代农民工的压力,进一步拓展都市农业的多元功能以推动城乡深度融合。此外,还应完善都市农业人才培养体系,建立国内外技术合作机制。另外,需要正视韩国都市农业面临的问题,合理规划和充分利用城市未利用的空地,科学分配有限资源以实现供需的“动态平衡”。此外,应充分发挥我国气候资源优势,因地制宜推动都市农业的发展,同时也需要提前准备城市居民适应农村生活的相关工作。

关键词：都市农业新型城乡关系城乡一体化统筹发展韩国

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Metasurface doublet-integrated bidirectional grating antenna enabling enhanced wavelength-tuned beam steering

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Photonics Research 2022年第1期10卷 248-255页

作者： WOO-BIN LEE CHUL-SOON im CHANGYI ZHOU BISHAL BHANDARI DUK-YONG CHOI sang-SHIN LEE Department of Electronic Engineering Kwangwoon UniversitySeoul 01897Republic of Korea Nano Device Application Center Kwangwoon UniversitySeoul 01897Republic of Korea Laser Physics Centre Research School of PhysicsAustralian National UniversityCanberraACT 2601Australia

We propose and demonstrate an optical phased-array-based bidirectional grating antenna(BDGA) in silicon nitride *** BDGA is integrated with a miniaturized all-dielectric metasurface doublet(MD) formed on a glass *** BDGA device,which takes advantage of alternately feeding light to its ports in opposite directions,is presumed to effectively provide a doubled wavelength-tuned steering efficiency compared to its unidirectional *** MD,which is based on vertically cascaded convex and concave metalenses comprising circular hydrogenated amorphous silicon nanopillars,is meticulously placed atop the BDGA chip to accept and deflect a beam emanating from the emission area,thereby boosting the beam-steering *** manufactured BDGA could achieve an enhanced beam-steering efficiency of 0.148 deg/nm as well as a stable spectral emission response in the wavelength range of 1530–1600 *** deploying a fabricated MD atop the silicon photonic BDGA chip,the steering efficiency was confirmed to be boosted by a factor of ~3.1,reaching 0.461 deg/nm,as intended.

关键词： beam thereby directions