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Sperm hyaluronidase is critical to mammals'fertilization for its ability to disperse cumulus-oocyte complex layer

Asian Journal of Andrology 2022年第4期24卷 411-415页

作者： Dong-won Seol Sang Hoon Joo Young-Hyun Kim Bong-seok Song Bo-Woong Sim Sun-Uk Kim Soojin park Gabbine Wee Ekyune Kim Laboratory Animal Center Daegu-Gyeongbuk Medical Innovation Foundation(DGMIF)Daegu 41061Korea College of Pharmacy Catholic University of DaeguGyeongbuk 38430Korea National Primate Research Center(NPCR) Korea Research Institute of Bioscience and BiotechnologyChungcheongbuk-do 28116Korea Futuristic Animal Resource and Research Center Korea Research Institute of Bioscience and BiotechnologyChungcheongbuk-do 28116Korea Department of Biochemistry and Molecular Biology Melvin and Bren Simon Comprehensive Cancer CenterIndiana University School of MedicineIndianapolisIN 46202USA

Glycosylphosphatidylinositol-anchored sperm hyaluronidases have long been believed to assist in sperm penetration through the cumulus-oocyte complex(COC);however,their role in mammalian fertilization remains ***,we have shown that hyaluronidase 5(Hyal5)/Hyal7 double-knockout(dKO)mice produce significantly fewer offspring than their wild-type(WT)counterparts because of defective COC *** infertility is mainly caused by a low sperm *** can be further exacerbated by the deficiency of sperm hyaluronidase,which disperses the cumulus cells of the outer layer of the *** the current study,we evaluated the effects of a low count of Hyal-deficient sperm and conditions of ovulated oocytes on the fertilization rate using a mouse *** results demonstrated that a low sperm count further decreases the in vitro fertilization(IVF)rate of Hyal-deficient dKO *** addition,the dKO spermatozoa resulted in a fertilization rate of 12.5%upon fertilizing COCs with a thick cumulus layer,whereas the IVF rate was comparable to that of WT spermatozoa when oocytes with a thin or no cumulus layer were ***,we proved that the IVF rate of dKO spermatozoa could be recovered by adding rat spermatozoa as a source of sperm *** results suggest that a deficiency of proteins involved in fertilization,such as sperm hyal,has a vital role in fertilization.

关键词： HYAL5 HYAL7 cumulus-oocyte complex fertilization infertility sperm hyaluronidase

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Enhanced delivery of a low dose of aducanumab via FUS in 5×FAD mice,an AD model

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Translational Neurodegeneration 2022年第1期11卷 31-45页

作者： Chanho Kong Eun-Jeong Yang Jaewoo Shin Junwon park Si-Hyun Kim Seong-Wook park won seok Chang Chang-Han Lee Hyunju Kim Hye-Sun Kim Jin Woo Chang Department of Neurosurgery Yonsei University College of Medicine50 Yonsei-RoSeodaemun-GuSeoulRepublic of Korea Department of Pharmacology College of MedicineSeoul National University103 DaehakroJongro-GuSeoulRepublic of Korea Neuroscience Research Center College of MedicineSeoul National University103 DaehakroJongro-GuSeoulRepublic of Korea Department of Biomedical Sciences College of MedicineSeoul National University103 DaehakroJongro-GuSeoulRepublic of Korea Bundang Hospital Seoul National University College of MedicineBundang-GuSungnamRepublic of Korea.

Background:Aducanumab(Adu),which is a human IgG1 monoclonal antibody that targets oligomer and fibril forms of beta-amyloid,has been reported to reduce amyloid pathology and improve impaired cognition after administration of a high dose(10 mg/kg)of the drug in Alzheimer’s disease(AD)clinical *** purpose of this study was to investigate the effects of a lower dose of Adu(3 mg/kg)with enhanced delivery via focused ultrasound(FUS)in an AD mouse ***:The FUS with microbubbles opened the blood-brain barrier(BBB)of the hippocampus for the delivery of *** combined therapy of FUS and Adu was performed three times in total and each treatment was performed biweekly.Y-maze test,Brdu labeling,and immunohistochemical experimental methods were employed in this *** addition,RNA sequencing and ingenuity pathway analysis were employed to investigate gene expression profiles in the hippocampi of experimental ***:The FUS-mediated BBB opening markedly increased the delivery of Adu into the brain by approximately 8.1 times in the *** combined treatment induced significantly less cognitive decline and decreased the level of amyloid plaques in the hippocampi of the 5×FAD mice compared with Adu or FUS *** treatment with FUS and Adu activated phagocytic microglia and increased the number of astrocytes associated with amyloid plaques in the hippocampi of 5×FAD ***,RNA sequencing identified that 4 enriched canonical pathways including phagosome formation,neuroinflammation signaling,CREB signaling and reelin signaling were altered in the hippocami of 5×FAD mice receiving the combined ***:In conclusion,the enhanced delivery of a low dose of Adu(3 mg/kg)via FUS decreases amyloid deposits and attenuates cognitive function ***-mediated BBB opening increases adult hippocampal neurogenesis as well as drug *** present an AD treatment strategy through the synergistic effect of the combined therapy of

关键词： Aducanumab Alzheimer’s disease Focused ultrasound Transcriptome profiling

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Perspective on the critical role of interface for advanced batteries

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Journal of Energy Chemistry 2020年第8期29卷 217-220,I0008页

作者： Chong Yan Hong Yuan Ho seok park Jia-Qi Huang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China School of Chemical Engineering Sungkyunkwan University(SKKU)Jangan-guSuwon 440-746Republic of Korea

As an efficient and environmental friendly energy storage system, lithium battery has been integrated into daily mobile life [1].Lithium batteries are becoming indispensable to all types of electronic products such as laptop computers, mobile phones, digital cameras [2]. A typical lithium battery consists of positive electrode(cathode), negative electrode(anode), electrolyte and other inactive materials(binder, conductive agent, separator) [3].

关键词： Interface Lithium metal Graphite Solid electrolyte interphase(SEI) Solvation Specific absorption

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Clinical implications of fatty pancreas:Correlations between fatty pancreas and metabolic syndrome

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World Journal of Gastroenterology 2009年第15期15卷 1869-1875页

作者： Jun seok Lee Sang Heum Kim Dae won Jun Jee Hye Han Eun Chul Jang Ji Young park Byung Kwan Son Seong Hwan Kim Yoon Ju Jo Young Sook park Yong Soo Kim Department of Internal Medicine Eulji University School of Medicine Department of Radiology Eulji University School of Medicine Department of Family Medicine Eulji University School of Medicine Department of Occupational and Environmental Medicine College of MedicineSoonchunhyang University Department of Radiology Hanyang University School of Medicine

AIM:To investigate the clinical implications of lipid deposition in the pancreas(fatty pancreas). METHODS:The subjects of this study were 293 patients who had undergone abdominal computed tomography(CT)and *** pancreas was diagnosed by sonographic findings and subdivided into mild,moderate,and severe fatty pancreas groups comparing to the retroperitoneal fat echogenicity. RESULTS:Fatty pancreas was associated with higher levels for visceral fat,waist circumference,aspartate aminotransferase(AST),alanine aminotransferase (ALT),total cholesterol,triglyceride,high density lipoprotein,free fatty acid,γ-GTP,insulin,and the homeostasis model assessment of insulin resistance (HOMA-IR)than the control group(P<0.05).HOMAIR,visceral fat,triglyceride,and ALT also tended to increase with the degree of fat deposition in the pancreas on *** a multivariate logistic regression analysis,HOMA-IR,visceral fat,and ALT level were independently related to fatty pancreas after adjustment for age,body mass index,and lipid *** incidence of metabolic syndrome in the fatty pancreas group was significantly higher than in the control group,and the numbers of metabolic syndrome parameters were significantly higher in the fatty pancreas group(P<0.05).CONCLUSION:Sonographic fatty pancrease showed higher insulin resistance,visceral fat area,triglyceride, and ALT levels than normal *** pancreas also showed a strong correlation with metabolic syndrome.

关键词： Fatty pancreas Metabolic syndrome Insulin resistance

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Anemia after gastrectomy for early gastric cancer:Long-term follow-up observational study

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World Journal of Gastroenterology 2012年第42期18卷 6114-6119页

作者： Chul-Hyun Lim Sang Woo Kim won Chul Kim Jin Soo Kim Yu Kyung Cho Jae Myung park In seok Lee Myung-Gyu Choi Kyo-Young Song Hae Myung Jeon Cho-Hyun park Department of Internal Medicine The Catholic University of Korea College of MedicineSeoul 137-701South Korea Department of Surgery The Catholic University of Korea College of MedicineSeoul 137-701South Korea

AIM:To identify the incidence and etiology of anemia after gastrectomy in patients with long-term follow-up after gastrectomy for early gastric ***:The medical records of those patients with early gastric adenocarcinoma who underwent curative gastrectomy between January 2006 and October 2007 were *** with anemia in the preoperative workup,cancer recurrence,undergoing systemic chemotherapy,with other medical conditions that can cause anemia,or treated during follow up with red cell transfusions or supplements for anemia were *** was defined by World Health Organization criteria(Hb 100 fL) with vitamin B 12 *** profile of anemia over 48 mo of follow-up was ***:One hundred sixty-one patients with gastrectomy for early gastric cancer were *** incidence of anemia was 24.5% at 3 mo after surgery and increased up to 37.1% at 48 mo after *** incidence of iron deficiency anemia increased during the follow up and became the major cause of anemia at 48 mo after *** of chronic disease and megaloblastic anemia were *** incidence of anemia in female patients was significantly higher than in male patients at 12(40.0% vs 22.0%,P = 0.033),24(45.0% vs 25.0%,P = 0.023),36(55.0% vs 28.0%,P = 0.004),and 48 mo(52.0% vs 31.0%,P = 0.022) after *** with total gastrectomy showed significantly higher incidence of anemia than patients with subtotal gastrectomy at 48 mo after surgery(60.7% vs 31.3%,P = 0.008).The incidence of iron deficiency was significantly higher in female patients than in male patients at 6(35.4% vs 13.3%,P = 0.002),12(45.8% vs 16.8%,P

关键词： Gastrectomy Stomach neoplasms Anemia Iron deficiency Vitamin B 12 deficiency

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A case of idiopathic colonic varices: A rare cause of hematochezia misconceived as tumor

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World Journal of Gastroenterology 2006年第16期12卷 2629-2632页

作者： Joung-Ho Han won-Joong Jeon Hee-Bok Chae Seon-Mee park Sei-Jin Youn seok-Hyung Kim Il-Hun Bae Sang-Jeon Lee Department of Internal Medicine College of MedicineChungbuk National UniversityCheongjuRepublic of Korea Department of Pathology College of MedicineChungbuk National UniversityCheongjuRepublic of Korea Department of Radiology College of MedicineChungbuk National UniversityCheongjuRepublic of Korea Department of General Surgery College of MedicineChungbuk National UniversityCheongjuRepublic of Korea

Colonic varices are a very rare cause of lower gastrointestinal bleeding. Fewer than 100 cases of colonic varices, and 30 cases of idiopathic colonic varices （ICV） have been reported in the English literature. Among these 30 cases of ICV, 19 cases were diagnosed by angiography, and 7 operated cases were diagnosed later as ileocecal vein deficit, hemangioma, and idiopathic in 1, 1, 5 cases, respectively. We report the case of a 24-year-old man who suffered from multiple episodes of hematochezia of varying degree at the age of 11 years. He had severe anemia with hemoglobin of 21 g/L. On colonoscopy, tortuously dilated submucosal vein and friable ulceration covered with dark necrotic tissues especially at the rectosigmoid region were seen from the rectum up to the distal descending colon. It initially appeared to be carcinoma with varices. Mesenteric angiographic study suggested a colonic hemangioma. Low anterior resection was done due to medically intractable and recurrent hematochezia. Other bowel and mesenteric vascular structures appeared normal. Microscopic examination revealed normal colonic mucosa with dilated veins throughout the submucosa and serosa without representing new vessel growth. Taken all of these findings together, the patient was diagnosed as ICV. His postoperative course was uneventful.

关键词： Idiopathic colonic varices Hematochezia Colon cancer Hemangioma

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Chronic gastrointestinal symptoms and quality of life in the Korean population

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World Journal of Gastroenterology 2008年第41期14卷 6388-6394页

作者： Jeong-Jo Jeong Myung-Gyu Choi Young-seok Cho Seung-Geun Lee Jung-Hwan Oh Jae-Myung park Yu-Kyung Cho In-seok Lee Sang-Woo Kim Sok-won Han Kyu-Yong Choi In-Sik Chung Department of Internal Medicine the Catholic University of Korea Department of Biostatistics University of North Carolina at Chapel Hill NC

AIM： To evaluate the prevalence of chronic gastroin- testinal symptoms and their impact on health-related quality of life （HRQOL） in the Korean population. METHODS： A cross-sectional survey, using a reliable and valid Rome I] based questionnaire, was per- formed on randomly selected residents, between 18 and 69 years in age. All respondents were interviewed at their homes or offices by a team of interviewers. The impact of chronic gastrointestinal symptoms on HRQOL was assessed using the Korean version of the 36-item Short-Form general health survey （SF-36）. RESULTS： Of the 1807 eligible subjects, 1417 （78.4%： male 762; female 655） were surveyed. Out of the respondents, 18.6% exhibited at least one chronic gastrointestinal symptom. The prevalence of gastro- esophageal reflux disease （GERD）, defined as heart- burn and/or acid regurgitation experienced at least weekly, was 3.5% （95% CI, 2.6-4.5）. The prevalence of uninvestigated dyspepsia, irritable bowel syndrome （IBS） and chronic constipation based on Rome Ⅱ criteria were 11.7% （95% CI, 10.1-13.5）, 2.2% （95% CI, 1.5-3.1）, and 2.6% （95% CI, 1.8-3.5） respectively. Compared with subjects without chronic gastrointesti- nal symptoms （n = 1153）, those with GERD （n = 50）, uninvestigated dyspepsia （n = 166） and IBS （n = 31） had significantly worse scores on most domains of the SF-36 scales. CONCLUSION： The prevalence of GERD, uninvesti- gated dyspepsia and IBS were 3.5%, 11.7% and 2.2% respectively, in the Korean population. The health- related quality of life was significantly impaired in subjects with GERD, uninvestigated dyspepsia and IBS in this community.

关键词： Chronic gastrointestinal symptom Gastroesophageal reflux disease Dyspepsia Irritable bowel syndrome Qaulibl of life

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Simultaneous laparoscopic multi-organ resection combined with colorectal cancer:Comparison with non-combined surgery

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World Journal of Gastroenterology 2012年第8期18卷 806-813页

作者： Hye Jin Kim Gyu-Seog Choi Jun seok park Soo Yeun park Soo Han Jun Department of Surgery Kyungpook National University Hospital School of Medicine Kyungpook National University Department of Surgery Daegu Catholic Medical Center Catholic University of Daegu

AIM: To access the short-term outcomes of simultaneous laparoscopic surgery combined with resection for synchronous lesions in patients with colorectal cancer. METHODS: Between March 1996 and April 2010 prospectively collected data were reviewed from 93 consecutive patients who had colorectal cancer and underwent simultaneous multiple organ resection (combined group) and 1090 patients who underwent conventional laparoscopic right hemicolectomy or laparoscopic low/ anterior resection for colorectal cancer (non-combined group). In the combined group, there were nine gastric resections, three nephrectomies, nine adrenalectomies, 56 cholecystectomies, and 21 gynecologic resections. In addition, f ive patients underwent simultaneous laparoscopic resection for three organs. The patient demographics, intra-operative outcomes, surgical morbidity, and short-term outcomes were compared between thetwo groups (the combined and non-combined groups). RESULTS: There were no signifi cant differences in the clinicopathological variables between the two groups. The operating time was signifi cantly longer in the combined group than in the non-combined group, regardless of tumor location (laparoscopic right hemicolectomy and laparoscopic low/anterior resection groups; P = 0.048 and P < 0.001, respectively). The other intraoperative outcomes, such as the complications and open conversion rate, were similar in both groups. The rate of post-operative morbidity in the combined group was similar to the non-combined group (combined vs non-combined, 15.1% vs 13.5%, P = 0.667). Oncological safety for the colon and synchronous lesions were obtained in the combined group. CONCLUSION: Simultaneous laparoscopic multiple organ resection combined with colorectal cancer is a safe and feasible option in selected patients.

关键词： Laparoscopic combined resection Colorectal cancer Laparoscopic surgery

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Wireless phototherapeutic contact lenses and glasses with red light-emitting diodes

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Nano Research 2020年第5期13卷 1347-1353页

作者： Young-Geun park Eunkyung Cha Hyeon seok An Kyoung-Pil Lee Myoung Hoon Song Hong Kyun Kim Jang-Ung park Nano Science Technology Institute Department of Materials Science and EngineeringYonsei UniversitySeoul 03722Republic of Korea Center for Nanomedicine Institute for Basic Science(IBS)Seoul 03722Republic of Korea Department of Ophthalmology School of MedicineKyungpook National UniversityDaegu41944Republic of Korea School of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea

Light-mediated therapeutics have attracted considerable attention as a method for the treatment of ophthalmologic diseases,such as age-related macular degeneration,because of their non-invasiveness and the effectiveness to ameliorate the oxidative stress of retinal ***,the current phototherapeutic devices are opaque,bulky,and tethered forms,so they are not feasible for use in continuous treatment during the patient’s daily ***,we report wireless,wearable phototherapeutic devices with red light-emitting diodes for continuous *** light-emitting diodes were formed to be conformal to three-dimensional surfaces of glasses and contact ***,fabricated light-emitting diodes had either transparency or a miniaturized size so that the user’s view is not ***,these devices were operated wirelessly with control of the light *** addition,in-vitro and in-vivo tests using human retinal epithelial cells and a live rabbit demonstrated the effectiveness and reliable operation as phototherapeutic devices.

关键词： transparent electronics wearable healthcare red light-emitting diodes phototherapies

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Cancer stem cell markers CD133 and CD24 correlate with invasiveness and differentiation in colorectal adenocarcinoma

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World Journal of Gastroenterology 2009年第18期15卷 2258-2264页

作者： Dongho Choi Hyo won Lee Kyung Yul Hur Jae Joon Kim Gyeong-Sin park Si-Hyong Jang Young Soo Song Ki-seok Jang Seung Sam Paik Department of Surgery College of MedicineSoonchunhyang University140-743 SeoulSouth Korea Department of Surgery Chi Hang Hospital140-741 SeoulSouth Korea Department of Pathology College of MedicineCatholic University137-040 SeoulSouth Korea Department of Pathology College of MedicineHanyang University133-790 SeoulSouth Korea

AIM:To verify that CD markers are available for detecting cancer stem cell populations and to evaluate their clinical significance in colon ***:Immunohistochemistry for CD133,CD24 and CD44 was performed on the tissue microarray of 523 colorectal *** records were reviewed and clinicopathological analysis was ***:In colorectal adenocarcinoma,128 of 523 cases(24.5%) were positive and 395 cases(75.5%) were negative for CD133 *** hundred and sixty-four of 523 cases(50.5%) were positive and 259 cases(49.5%) were negative for CD24 *** hundred and two of 523 cases(96%) were negative and 21 cases(4%) were positive for CD44 *** clinicopathological analysis,CD133 expression was present more in male patients(P = 0.002) and in advanced T stage cancer(P = 0.024).Correlation between CD24 expression and clinicopathological factors was seen in the degree of differentiation(P = 0.006).Correlation between CD44 expression and clinicopathological factors was seen in the tumor size(P = 0.001).Survival was not significantly related to CD133,CD24 and CD44 ***:CD markers were related to invasiveness and differentiation of colorectal ***,CD expression was not closely related to survival.

关键词： CD133 CD24 CD44 Colon cancer stemcells Colorectal adenocarcinoma

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