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Treatment strategies using adefovir dipivoxil for individuals with lamivudine-resistant chronic hepatitis B

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World Journal of Gastroenterology 2012年第47期18卷 6987-6995页

作者： Tae Jung Yun Jin Yong Jung Chang Ha Kim Soon Ho Um Hyonggin An Yeon seok Seo Jin Dong Kim Hyung Joon Yim Bora Keum Yong Sik Kim Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu Department of Internal Medicine Korea University College of MedicineSeoul 136-705South Korea Department of Biostatistics Korea University College of MedicineSeoul 136-705South Korea

AIM:To investigate retrospectively the long-term efficacy of various treatment strategies using adefovir dipivoxil(adefovir) in patients with lamivudine-resistant chronic hepatitis ***:We included 154 consecutive patients in two treatment groups:the "add-on" group(n = 79),in which adefovir was added to ongoing lamivudine treatment due to lamivudine resistance,and the "switch/combination" group(n = 75),in which lamivudine was first switched to adefovir and then re-added later as *** "switch/combination" group was then divided into two subgroups depending on whether participants followed(group A,n = 30) or violated(group B,n = 45) a proposed treatment strategy that determined whether to add lamivudine based on the serum hepatitis B virus(HBV) DNA levels(< 60 IU/mL or not) after 6 mo of treatment(roadmap concept).RESULTS:The cumulative probability of virologic response(HBV DNA < 60 IU/mL) was higher in group A than in the "add-on" group and in group B(P < 0.001).In contrast,the cumulative probability of virologic breakthrough was lower in the "add-on" group than in group B(P = 0.002).Furthermore,the risk of virologic breakthrough in the multivariate analysis was significantly lower in the "add-on" group than in group A(hazard ratio = 0.096;95%CI,0.015-0.629;P = 0.015).CONCLUSION:The selective combination of adefovir with lamivudine based upon early treatment responses increased the odds of virologic breakthrough relative to the use of uniform combination therapy from the beginning of treatment.

关键词： Chronic hepatitis B Lamivudine-resistant Adefovir Combination therapy Roadmap concept

Weave-pattern-dependent fabric piezoelectric pressure sensors based on polyvinylidene fluoride nanofibers electrospun with 50 nozzles

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npj Flexible Electronics 2022年第1期6卷 699-707页

作者： Da Bin Kim Ju Han Sun Min Sung Min Seong Kim Bo Kyoung Choi Sung Jun Park Hyae Rim Hong Hong Je Choi Byeong Kon Kim Chung Hee Park Jong Hoo Paik Joon-seok Lee Yong Soo Cho Department of Materials Science and Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Textile Engineering and Technology Yeungnam UniversityGyeongsan 38541Republic of Korea Deparment of Textile Merchandising and Fashion DesignSeoul National UniversitySeoul 08826Republic of Korea Samsung Electro-Mechanics Co.Ltd. Suwon 16674Republic of Korea Ceratorq Inc. Seoul 08511Republic of Korea Electronic Materials and Component Center Korea Institute of Ceramic Engineering and TechnologyJinju 52851Republic of Korea

Wearable pressure sensors having versatile device structures have been extensively investigated to achieve high sensitivity under mechanical ***,we introduce piezoelectric pressure sensors based on fabrics woven using polyvinylidene fluoride(PVDF)weft and polyethylene terephthalate(PET)warp yarns with different weave structures:1/1(plain),2/2,and 3/3 weft rib *** dependence of the pressure-sensing performance on the weave pattern is demonstrated with an actual large-scale fabric up to the~2 m *** optimized pressure sensor with a 2/2 weft rib pattern produced a high sensitivity of 83 mV N−1,which was 245%higher than that of the 1/1 *** detection performance of the optimal fabric was extensively evaluated with a variety of ambient input sources,such as pressing,bending,twisting,and crumpling,as well as various human ***,a large allfabric pressure sensor with arrayed touch pixel units demonstrated highly sensitive and stable sensing performance.

关键词： pattern fluoride piezoelectric

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砼修补用改性聚合物砂浆基本性能的实验研究

国外建材科技 2000年第3期21卷 38-41页

作者：管斌君 Kyu-seok 武汉理工大学材料学院(西院) 430070

市场上使用各种各样的建筑材料,而水泥砼制品应用最广泛。除了工作性、耐久性和经济性外,随着各种改善和提高其质量的外加剂的发展,水泥砼的应用日益增长。然而由于水泥砼的干缩大、抵抗化学侵蚀反应和抗冻性差,以及由于化学离子浸透... 详细信息

市场上使用各种各样的建筑材料,而水泥砼制品应用最广泛。除了工作性、耐久性和经济性外,随着各种改善和提高其质量的外加剂的发展,水泥砼的应用日益增长。然而由于水泥砼的干缩大、抵抗化学侵蚀反应和抗冻性差,以及由于化学离子浸透而引起的钢筋锈蚀、碱—集料反应等,使水泥砼的强度降低和应用领域缩小。七十年来有关用以改善水泥砼缺点的各种聚合物外加剂的研制和发展一直很活跃,现在这些外加剂正广泛用于各种建筑和土木工程领域。

关键词：聚合物砂浆改性水泥砂浆性能混凝土修复

The Occurrence and Spreading Pattern of Virus Diseases on Cucumber（Cucumis sativus L.） in Korea

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The Occurrence and Spreading Pattern of Virus Diseases on Cu...

Label-Free White Blood Cell Classification Using Refractive Index Tomography and Deep Learning

中国植物病理学会2011年学术年会

作者： Joong-Hwan Lee seok-Hee Park Seong-Yong Choi Hong-Sik Shim Department of Agricultral Environment Gyeongsangbuk-do Agricultural Research and ExtentionDongho-dongDaegu702-708Republic of Korea Crop Protection Division National Academy of Agricultural ScienceRDASuwon 441-707Republic of Korea

＜正＞Cucumber which is grown during the winter season in plastic house is high valued cash crop in ***,virus disease spread widely in cucumber growing area and cause severe income ***,virus disease on cucumber were surveyed in chief producing *** 217 samples showing virus symptoms were analyzed by RT-PCR using appropriate detection *** yellow mosaic virus（ZYMV） has the highest infection rate（detected over 85%） and followed by Cucumber green mottle mosaic

关键词： Cucumber Zucchini yellow mosaic virus Cucumber green mottle mosaic virus Infection pattern

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Biomedical Engineering Frontiers 2021年第1期2卷 18-26页

作者： DongHun Ryu Jinho Kim Daejin Lim Hyun-seok Min In Young Yoo Duck Cho YongKeun Park Department of Physics Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea KAIST Institute for Health Science and Technology KAISTDaejeon 34141Republic of Korea Department of Health Sciences and Technology Samsung Advanced Institute For Health Sciences and TechnologySungkyunkwan UniversitySeoul 06355Republic of Korea Department of Health and Safety Convergence Science Korea UniversitySeoul 02841Republic of Korea Department of Laboratory Medicine and Genetics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Tomocube Inc.Daejeon 34051Republic of Korea Department of Laboratory Medicine Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Stem Cell&Regenerative Medicine Institute Samsung Medical CenterSeoul 06531Republic of Korea

Objective and Impact *** propose a rapid and accurate blood cell identification method exploiting deep learning and label-free refractive index(RI)*** computational approach that fully utilizes tomographic information of bone marrow(BM)white blood cell(WBC)enables us to not only classify the blood cells with deep learning but also quantitatively study their morphological and biochemical properties for hematology *** methods for examining blood cells,such as blood smear analysis by medical professionals and fluorescence-activated cell sorting,require significant time,costs,and domain knowledge that could affect test *** label-free imaging techniques that use a specimen’s intrinsic contrast(e.g.,multiphoton and Raman microscopy)have been used to characterize blood cells,their imaging procedures and instrumentations are relatively time-consuming and *** RI tomograms of the BM WBCs are acquired via Mach-Zehnder interferometer-based tomographic microscope and classified by a 3D convolutional neural *** test our deep learning classifier for the four types of bone marrow WBC collected from healthy donors(n=10):monocyte,myelocyte,B lymphocyte,and T *** quantitative parameters of WBC are directly obtained from the *** results show>99%accuracy for the binary classification of myeloids and lymphoids and>96%accuracy for the four-type classification of B and T lymphocytes,monocyte,and *** feature learning capability of our approach is visualized via an unsupervised dimension reduction *** envision that the proposed cell classification framework can be easily integrated into existing blood cell investigation workflows,providing cost-effective and rapid diagnosis for hematologic malignancy.

关键词： Blood diagnosis utilize

A case of plantar epidermal cyst associated with human papillomavirus

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A case of plantar epidermal cyst associated with human papil...

Clinicopathological features of familial adenomatous polyposis in Korean patients

International Forum 2003 Academic Conference of Dermatology of the Integration of TCM with Western Medicine

作者： ParkHyung-seok KimSoo-Hong LeeDong-Youn LeeJoo-Heung YangJun-Mo LeeEil-Soo Department of Dermatology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea Department of Dermatology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea Department of Dermatology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea Department of Dermatology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea Department of Dermatology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea Department of Dermatology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea

Palmoplantar epidermal cysts are generally regarded to develop secon-darily to penetrating injury resulting in traumatic inclusion of the epidermisinto the dermis. However there are many views about the pathogenesis ofnon-traumatic epidermal cysts on palms and soles. Recently, evidence ofthe infection of human papillomavirus (HPV) in plantar epidermal cysts

关键词： HPV A case of plantar epidermal cyst associated with human papillomavirus

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World Journal of Gastroenterology 2016年第17期22卷 4380-4388页

作者： Sung Min Jung Yong Sik Yoon seok-Byeong Lim Chang Sik Yu Jin Cheon Kim Division of Colon and Rectal Surgery Department of Surgery University of Ulsan College of Medicine Seoul 05505 South Korea Asan Medical Center Seoul 05505 South Korea

AIM: To identify prognostic factors and to correlate APC mutations with clinical features, including extracolic manifestations. METHODS: One hundred thirty-five patients who underwent surgical procedures for familial adenomatous polyposis(FAP) were included. FAP was diagnosed when the number of adenomatous polyps was > 100. Data related to patient, extracoloic manifestations, cancer characteristics, operative procedure, follow up and surveillance were collected. APC mutation testing was performed in the 30 most recent patients. DNA was extracted from peripheral blood and polymerase chain reaction products using 31 primer pairs on APC gene were sequenced. A retrospective study was performed to investigate a causal relationship between prognosis and feature of ***: The mean age of the 51 patients with colorectal cancer(CRC) was older than that of those without CRC(30.5 vs 36.9, P = 0.002). Older individuals were more likely to have colon cancer at the time of FAP diagnosis [odds ratio, 4.75(95%CI: 1.71-13.89) and 5.91(1.76-22.12) for 40-49 years and age > 50 vs age < 30). The number of confirmed deaths was 13 and the median age at death was 40 years(range, 27 to 85 years). Ten of the deaths(76.9%) were from CRC. Another cause of two cases of death were desmoid tumors(15.4%). Development of cancer on remnant rectal or ileal mucosa after surgery was not observed. The APC mutation testing revealed 23 pathogenic mutations and one likely pathogenic mutation, among which were four novel mutations. The correlation between mutational status and clinical manifestations was investigated. Mutations that could prodict poor prognosis were at codon 1309 which located on mutation cluster region, codon 1465 and codon ***: Identification of APC mutations should aid in the diagnosis and counseling of family members in terms of early diagnosis and management of FAP.

关键词： Adenomatous polyposis coli Colorectal neoplasms APC gene Prognosis Survival

论《岳阳楼记》对韩国岳阳楼题诗的影响与流变

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湖南大学学报（社会科学版） 2011年第2期25卷 83-84页

作者：权锡焕刘果祥明大学中文系岳麓书社湖南长沙410006

《岳阳楼记》对韩国岳阳楼题诗的影响,主要体现在其体现的以天下为己任的儒家社会责任感。通过对韩国岳阳楼题诗中意象的统计学分析,我们还看到了《岳阳楼记》在文本营建层面对题诗的影响及其流变。

关键词：家国之思意象雁鹤

Clinical analysis of forearm free flap application on oral cancer patients

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中国口腔颌面外科杂志 2008年第B5期6卷 94-95页

作者： Uk-Kyu Kim Jin-Ho Heo Dae-seok Hwang Yong-Deok Kim Sang-Hun Shin Department of Oral and Maxillofacial Surgery Pusan National University Hospital Pusan National University Pusan 602-739 S. Korea

Purpose: Various ablative defects after tumor removal on oral cavity have been remnant。To make a satisfactory reconstruction, functional recovery as well as esthetics must be considered。Among repair methods, forearm free flap (FFF) has been demonstrated as a workhorse flap after oral cancer ablation since 1980s。We have analyzed the patients with oral cancer who had been applied with FFF and tried to explore merits, shortcoming of the flaps on oral cavity。In addition, designs and harvesting techniques according to defects on oral cavity have been compared。Methods: 12 Patients had visited Pusan National University Hospital and been treated with ablation, FFF for two year recently。Clinical data on tile patients has been reviewed and the prognosis of patients was follow-up。The indications, designs and operative techniques were reviewed respectively。Results: Floor of mouth and tongue were mostly involved with squamous cell carcinoma。Next, buccal cheek and retromolar sites on mandible, maxilla also could be reconstructed with FFF。The various designs, sizes of forearm flap were made prior harvesting。Selection of the donor vessels for adequate vessel size, drainage like superior thyroid artery, internal jugular vein was important for prevention of vessel thrombosis。Skin grafting on donor forearm with plaster splint and overextension of donor wrist were essential。All patients except one were healed uneventfully without any complications。

关键词：口腔癌割补法整形技术临床分析