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Small-scale analysis of brittle-to-ductile transition behavior in pure tungsten

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Journal of Materials Science & Technology 2022年第10期105卷 242-258页

作者： Yeonju Oh won-seok Ko Nojun Kwak Jae-il Jang Takahito Ohmura Heung Nam Han Department of Materials Science and Engineering&Research Institute of Advanced Materials Seoul National UniversitySeoul 08826South Korea School of Materials Science and Engineering University of UlsanUlsan 44610South Korea Division of Materials Science and Engineering Hanyang UniversitySeoul04763South Korea National Institute for Materials Science 1-2-1 SengenTsukubaIbaraki 305-0047Japan

Tungsten as a material exhibits broad and increasingly important applications;however,the characterization of its ductile-to-brittle transition(BDT)is currently limited to large-scale scenarios and destructive *** this study,we overcome this challenge by implementing small-scale techniques to provide a comprehensive understanding of the BDT behavior of pure *** order to predict the failure mode at various temperature ranges,the practical fracture analysis diagram has been proposed to describe the resistance to shear flow and cracking behavior with *** temperature nano-indentation tests have provided the inherent mechanical responses corresponding to the maximum shear stress at various temperatures,which is required for dislocation activities in an atomic scaled activation *** one hand,atomistic simulations have provided the temperature dependence of brittle fracture stress,where the atomic bonds break due to intergranular or intragranular *** considered four tungsten specimens having various microstructures prepared using different processing conditions of cold-rolling and post-annealing,and their BDT ranges were inferred using the obtained fracture analysis diagram with the statistical data *** fracture analysis diagram of each specimen obtained were compared with the direct observation of fracture responses in macroscopic mechanical tests,which conclusively indicated that the small-scale inherent mechanical properties are greatly relevant to the macroscopic BDT behavior in pure *** on the BDT estimations by small-scale characterization,we provided further insights into the factors affecting the BDT behavior of tungsten,focusing on the contributions of different types of dislocations.

关键词： Brittle-to-ductile transition Nano-indentation Molecular dynamics Dislocation Tungsten

Traditional Chinese medicine for foot pain in a patient with complex regional pain syndrome: A case report

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World Journal of Clinical Cases 2023年第30期11卷 7424-7431页

作者： Woo-Chul Shin Hyungsuk Kim won-seok Chung Clinical Korean Medicine Graduate SchoolKyung Hee UniversitySeoul 02447South Korea Korean Medicine Kyung Hee UniversitySeoul 02447South Korea

BACKGROUND Complex regional pain syndrome(CRPS)is characterized by pain as well as sensory,motor,and sudomotor ***,it is classified into two types CRPS-I and *** is no single diagnostic test or treatment approach for CRPS,and a multidisciplinary approach is gaining attention to improve patients’symptoms and their quality of *** SUMMARY A 35-year-old woman with an unremarkable medical history sought treatment for CRPS at a hospital of Korean *** her first visit,she was wheelchairbound due to severe pain in her left lower *** had edema and discoloration of the left *** was treated with a combination of traditional Chinese medicine(TCM)approaches,including acupuncture,moxibustion,pharmacopuncture,and herbal decoction,for approximately 20 *** foot and ankle outcome score(FAOS)and visual analog scale(VAS)score for pain were evaluated,along with general signs and *** symptoms,signs,FAOS,and VAS scores improved after treatment,with a significant 7-degree decrease in the VAS score and a 62-point increase in the FAOS ***,the foot swelling and discoloration gradually *** the phone follow-up,5 mo after the last visit,additional improvements in outcomes were *** Combined TCM treatment may be a reasonable and safe option for alleviating symptoms and improving function in patients with CRPS.

关键词： Complex regional pain syndrome Traditional Chinese medicine Acupuncture Moxibustion Herbal medicine Case report

Risks of non-conservative design according to ASME B31.1 for high-temperature piping subjected to long-term operation in the creep range

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Nuclear Science and Techniques 2019年第5期30卷 59-69页

作者： Hyeong-Yeon Lee seok-Kwon Son Min-Gu won Ji-Young Jeong Korea Atomic Energy Research Institute National Fusion Research Institute School of Mechanical Engineering Sungkyunkwan University

This study investigates the risks of non-conservative piping design according to ASME B31.1 for hightemperature piping subjected to long-term operation at high temperature in a creep regime based on a sensitivity analysis of the hold time. Design evaluations of hightemperature piping were conducted over a range of hold times in the creep regime according to ASME B31.1,which implicitly considers the creep effects, and the French high-temperature design code of the RCC-MRx, which explicitly considers the creep effects. Conservatisms were quantified among the codes in terms of the hold times. In the case of B31.1, the design evaluation results do not change depending on the hold time at high temperature,whereas in the case of RCC-MRx, they do. It was shown that the design limits of RCC-MRx were exceeded when the hold time exceeded certain values, whereas those of B31.1 were satisfied regardless of the hold times. Thus, the design evaluations according to B31.1 did not consistently yield conservative results and might lead to non-conservative results in the case of long-term operations in the creep range.

关键词： ASME B31.1 Creep Hold time Hightemperature piping RCC-MRx Sensitivity analysis

MicroRNA miR-252-5p regulates the Notch signaling pathway by targeting Rab6 in Drosophila wing development

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Insect Science 2023年第5期30卷 1431-1444页

作者： Do-Hwan Lim Min-seok Choi Ji won Jeon Young Sik Lee School of Systems Biomedical Science Soongsil UniversitySeoulRepublic of Korea College of Life Sciences and Biotechnology Korea UniversitySeoulRepublic of Korea Institute of Animal Molecular Biotechnology Korea UniversitySeoulRepublic of Korea

The Notch signaling pathway plays a central role in the development of various ***,dysregulation of microRNAs(miRNAs),which are crucial regulators of gene expression,can disrupt signaling pathways at all stages of *** Notch signaling is involved in wing development in Drosophila,the mechanism underlying miRNA-based regulation of the Notch signaling pathway is ***,we report that loss of Drosophila miR-252 increases the size of adult wings,whereas the overexpression of miR-252 in specific compartments of larval wing discs leads to patterning defects in the adult *** miR-252 overexpression-induced wing phenotypes were caused by aberrant Notch signaling with intracellular accumulation of the full-length Notch receptor during development,which could be due to defects in intracellular Notch trafficking associated with its recycling to the plasma membrane and autophagy-mediated ***,we identified Rab6 as a direct target of miR-252-5p;Rab6 encodes a small Ras-like GTPase that regulates endosomal trafficking *** with this finding,RNAi-mediated downregulation of Rab6 led to similar defects in both wing patterning and Notch ***,co-overexpression of Rab6 completely rescued the wing phenotype associated with miR-252 overexpression,further supporting that Rab6 is a biologically relevant target of miR-252-5p in the context of wing ***,our data indicate that the miR-252-5p-Rab6 regulatory axis is involved in Drosophila wing development by controlling the Notch signaling pathway.

关键词： Drosophila miR-252-5p Notch signaling Rab6 wing development

Optimization of rotor shape for constant torque improvement and radial magnetic force minimization

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Journal of Central South University 2012年第2期19卷 357-364页

作者： CHO Gyu-won WOO seok-hyun JI Seung-hun PARK Kyoung-won JANG Ki-bong KIM Gyu-tak School of Mechatronics Changwon National University

The design of notch and barrier was optimized in order to improve the characteristics of constant torque while minimizing the cogging torque that occurs as a result of teeth and slot structure. The barrier was installed in order to minimize the cogging torque and torque ripple by finite element method (FEM) with a reduced barrier width toward the center of magnetic pole. The position and width of notch, which can offset cogging torque, can be calculated with energy distribution of air-gap using Fourier series. The optimized model demonstrates a 60% decrease in the cogging torque, a 75.3% decrease in the torque ripple and a 3% increase in the operating torque when compared with the basic model.

关键词： permanent magnet synchronous motor barrier notch radial magnetic force cogging torque

Optimal sequential therapy using tyrosine kinase inhibitors as the first-line treatment in patients with metastatic renal cell carcinoma: A nationwide multicenter study

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Asian Journal of Urology 2024年第3期11卷 450-459页

作者： Jung Ki Jo Seong Il Seo MinYong Kang Jinsoo Chung Cheol Kwak Sung-Hoo Hong Cheryn Song Jae Young Park Chang Wook Jeong seok Hwan Choi Sung Han Kim Eu Chang Hwang Chan Ho Lee Hakmin Lee Department of Urology Medical and Digital EngineeringCollege of MedicineHanyang UniversitySeoulRepublic of Korea Department of Urology Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Urology National Cancer CenterGoyangRepublic of Korea Department of Urology Seoul National University HospitalSeoulRepublic of Korea Department of Urology Kangnam St Mary’s HospitalSeoulRepublic of Korea Department of Urology Asan Medical CenterSeoulRepublic of Korea Department of Urology Korea University Ansan HospitalAnsanRepublic of Korea Department of Urology Kyungpook National University HospitalDaeguRepublic of Korea Department of Urology Chonnam National University Hwasun HospitalHwasunRepublic of Korea Department of Urology Inje University Busan Paik HospitalBusanRepublic of Korea Department of Urology Seoul National University Bundang HospitalSeongnamRepublic of Korea

Objective:The purpose of the study was to identify the best sequence of therapy beginning with a tyrosine kinase inhibitor(TKI)as the first-line therapy for patients with metastatic renal cell carcinoma(mRCC)in terms of overall survival(OS),progression-free survival(PFS),and rates of discontinuation and adverse effects during the treatment ***:This is a retrospective,nationwide multicenter study of patients with mRCC after diagnosis at 10 different tertiary medical centers in Korea from January 1992 to December *** focused on patients at either“favorable”or“intermediate”risk according to the International mRCC Database Consortium criteria,and they were followed up(median 335 days).Finally,a total of 1409 patients were selected as the study *** generated a Cox proportional hazard model adjusted for covariates,and the different therapy schemes were statistically tested in terms of OS as well as *** addition,frequencies of discontinuation and adverse events were compared among the therapy ***:Of the primary patterns of treatment sequences(24 sequences),“sunitinib epazopanib”and“sunitinibeeverolimuseimmunotherapy”showed the most beneficial results in both OS and PFS with significantly lower hazards than“sunitinib”,which is the most commonly treated agent in *** that the“TKIeTKI”structure showed relatively higher discontinuation rates with higher adverse effects,the overall beneficial sequence would be“sunitinibeeverolimuseimmunotherapy”.Conclusion:Among several sequential therapy starting with TKIs,“sunitinibeeverolimuse immunotherapy”was found to be the best scheme for mRCC patients with“favorable”or“intermediate”risks.

关键词： Tyrosinekinase inhibitor Metastaticrenalcell carcinoma Overall survival Progression-free survival

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从焦虑到行动

科学新闻 2024年第4期 62-63页

作者： Tae seok Moon 倪伟波美国圣路易斯华盛顿大学

“Tae seok，你知道该怎么做——让大家安静下来，并把他赶出去。”“他”是我最好的研究生之一，在5年内发表了4篇论文，从美国寄钱给在非洲的家人。但当他在走廊接一个公司的面试电话时，与一位教授发生了冲突。鉴于他的肤色，教授以...

“Tae seok，你知道该怎么做——让大家安静下来，并把他赶出去。”“他”是我最好的研究生之一，在5年内发表了4篇论文，从美国寄钱给在非洲的家人。但当他在走廊接一个公司的面试电话时，与一位教授发生了冲突。鉴于他的肤色，教授以为他不是学生，于是报了警，警察把他带走了。除了受到侮辱之外，我的学生还因此失去了他梦寐以求的工作。他向学校反歧视办公室投诉——现在学校领导让我解决这件事。我很愤怒，但无能为力。我的终身职位马上就要接受评估了，我觉得没有能力反击。

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数字化趋势下物流企业资源整合能力对服务效率的影响

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商业经济 2024年第2期 81-83,139页

作者：孙晓维 Young seok Ock 釜庆大学技术经营专门大学院韩国釜山48547

随着数字化趋势的兴起,物流企业面临着资源整合的挑战,数字化趋势下物流企业资源整合能力对服务效率存在重要影响。数字化趋势下,物流企业的资源整合能力对服务效率的影响路径主要包括技术平台整合、数据整合与分析、人力资源整合以及... 详细信息

随着数字化趋势的兴起,物流企业面临着资源整合的挑战,数字化趋势下物流企业资源整合能力对服务效率存在重要影响。数字化趋势下,物流企业的资源整合能力对服务效率的影响路径主要包括技术平台整合、数据整合与分析、人力资源整合以及流程优化与创新,这些路径的有效整合和应用将有助于提升物流企业的服务效率,满足客户的需求并保持竞争优势,因此物流企业可以通过强化内部技术平台整合、优化数据整合与分析、做好人力资源整合、推进流程优化与创新来提升资源整合能力,以此促进服务效率提升。

关键词：数字化趋势资源整合能力服务效率物流企业

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Gas Sensing Characteristics of SnO_2 Whiskers Prepared from SNC_2O_4

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稀有金属材料与工程 2006年第A3期35卷 100-103页

作者： Ki-won Kim Pyeong-seok Cho Jong-Heun Lee Seong-Hyeon Hong Department of Materials Science & Engineering Korea UniversitySeoui 136-713Korea School of Materials Science and Engineering and Nano Systems Institute-National Core Research Center Seoul National UniversitySeoul 151-744Korea

SnO_2 whiskers were prepared from the decomposition of whisker-like SnC_2O_4,which was precipitated by a reaction between an aqueous SnCl_2 and oxalic acid solution at high solution temperatures (80℃).After the decomposition of SnC_2O_4 at 450℃,SnO_2 whiskers containing both of rutile and metastable orthorhombic phases were obtained with the content of the orthorhombic phase decreasing with increasing heat-treatment temperature and *** effect of orthorhombic phase upon CO gas sensitivity was investigated by measuring the evolution of the primary particle size and the CO sensitivity with repeating heat treatment at 450℃.The 50μg/g CO sensitivity increased with decreasing concentration of the orthorhombic phase despite particle coarsening,which suggests that the orthorhombic phase is detrimental to the CO gas sensitivity.

关键词： SnO2 whisker orthorhombic phase gas sensor SnC2O4