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High numerical aperture RGB achromatic metalens in the visible

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Photonics Research 2022年第12期10卷 I0001-I0010页

作者： SANGwon BAEK JOOHOON KIM YESEUL KIM won SEOK CHO TREVON BADLOE SEONG-won moon JUNSUK RHO JONG-LAM LEE Department of Materials Science and Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea POSCO-POSTECH-RIST Convergence Research Center for Flat Optics and Metaphotonics Pohang 37673Republic of Korea National Institute of Nanomaterials Technology(NINT) Pohang 37673Republic of Korea

We theoretically and experimentally demonstrate an RGB achromatic metalens that operates concurrently at three visible wavelengths(λ=450, 532, and 700 nm) with a high numerical aperture of 0.87. The RGB metalens is designed by simple integration of metalens components with the spatial interleaving method. The simulated spatial interleaving metalens shows RGB achromatic operation with focusing efficiencies of 25.2%, 58.7%, and66.4% at the wavelengths of 450, 532, and 700 nm, respectively. A 450 μm diameter metalens operating at three designated wavelengths is fabricated with low-loss hydrogenated amorphous silicon. The fabricated metalens has the measured focusing efficiencies of 5.9%, 11.3%, and 13.6% at λ = 450, 532, and 700 nm, respectively. The Strehl ratios of 0.89, 0.88, and 0.82 are obtained at given wavelengths, which show a capability of diffractionlimited operation.

关键词： RGB visible numerical

Optimization of adipose tissue-derived mesenchymal stromal cells transplantation for bone marrow repopulation following irradiation

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World Journal of Stem Cells 2022年第3期14卷 245-263页

作者： Min-Jung Kim won moon Jeonghoon Heo Sangwook Lim Seung-Hyun Lee Jee-Yeong Jeong Sang Joon Lee Department of Biochemistry Cancer Research Institute Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of Internal Medicine Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of Molecular Biology and Immunology Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of Radiation Oncology Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of General Surgery Kosin University College of MedicineSeogu 49267BusanSouth Korea Department of Ophthalmology Gospel HospitalKosin University College of MedicineSeo-gu 49267BusanSouth Korea

BACKGROUND Bone marrow(BM)suppression is one of the most common side effects of radiotherapy and the primary cause of death following exposure to *** concerted efforts,there is no definitive treatment method *** studies have reported using mesenchymal stromal cells(MSCs),but their therapeutic effects are *** We administered and examined the effects of various amounts of adipose-derived MSCs(ADSCs)in mice with radiation-induced BM *** Mice were divided into three groups:Normal control group,irradiated(RT)group,and stem cell-treated group following whole-body irradiation(WBI).Mouse ADSCs(mADSCs)were transplanted into the peritoneal cavity either once or three times at 5×10^(5) cells/200μ*** white blood cell count and the levels of,plasma cytokines,BM mRNA,and BM surface markers were compared between the three *** BM-derived CD34+hematopoietic progenitor cells were co-cultured with human ADSCs(hADSCs)or incubated in the presence of hADSCs conditioned media to investigate the effect on human cells in *** The survival rate of mice that received one transplant of mADSCs was higher than that of mice that received three *** transplantations of ADSCs delayed the repopulation of BM hematopoietic stem ***-inflammatory effects and M2 polarization by intraperitoneal ADSCs might suppress erythropoiesis and induce myelopoiesis in sub-lethally RT *** The results suggested that an optimal amount of MSCs could improve survival rates post-WBI.

关键词： Adipose tissue-derived stem cells Bone marrow suppression Mesenchymal stromal cells Radiation Cell therapy

Development of XY scanner with minimized coupling motions for high-speed atomic force microscope

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Journal of Central South University 2011年第3期18卷 697-703页

作者： PARK Jong-kyu moon won-kyu Department of Mechanical Engineering Changwon National University Department of Mechanical Engineering Pohang Univer sity of Science and Technology

The design and fabrication processes of a novel scanner withminimized coupling motions for a high-speed atomic force microscope (AFM) were *** appropriate design modification was proposed through the analyses of the dynamic characteristics of existing linear motion stages using a dynamic analysis program,*** the scanning speed of each direction may differ,the linear motion stage for a high-speed scanner was designed to have different resonance frequencies for the modes,with one dominant displacement in the desired *** objective was achieved by using one-direction flexure mechanisms for each direction and mounting one stage for fast motion on the other stage for slow *** unsymmetrical configuration separated the frequencies of two vibration modes with one dominant displacement in each desired direction,and hence suppressed the coupling between motions in two directions.A pair of actuators was used for each axis to decrease the crosstalk between the two motions and give a sufficient force to actuate the slow motion stage,which carried the fast motion stage.A lossy material,such as grease,was inserted into the flexure hinge to suppress vibration problems that occurred when using an input triangular *** these design modifications and the vibration suppression method,a novel scanner with a scanning speed greater than 20 Hz is achieved.

关键词：高速扫描仪原子力显微镜耦合直线运动动态特性分析振动模式修改设计扫描速度

Changing trends and characteristics of peptic ulcer disease:A multicenter study from 2010 to 2019 in Korea

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World Journal of Gastroenterology 2023年第44期29卷 5882-5893页

作者： Yoon Jin Choi Tae Jun Kim Chang Seok Bang Yong Kang Lee moon won Lee Su Youn Nam Woon Geon Shin Seung In Seo Department of Internal Medicine National Cancer CenterGoyang-si 13620South Korea Department of Internal Medicine Samsung Medical CenterSeoul 06351South Korea Department of Internal Medicine Chuncheon Sacred Heart HospitalChuncheon 24253South Korea Department of Internal Medicine National Health Insurance Service Ilsan HospitalGoyang-si 10444South Korea Department of Internal Medicine Pusan National University School of MedicineBusan 50463South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineKyungpook National University Chilgok HospitalDaegu 41404South Korea Department of Internal Medicine Kangdong Sacred Heart HospitalHallym University College of MedicineSeoul 05355South Korea Institute for Liver and Digestive Diseases Hallym UniversityChuncheon 24253South Korea Division of Gastroenterology Department of Internal MedicineKangdong Sacred Heart HospitalSeoul 05355South Korea

BACKGROUND The clinical trend and characteristics of peptic ulcer disease(PUD)have not fully been investigated in the past *** To evaluate the changing trends and characteristics of PUD according to age and METHODS We analyzed seven hospital databases converted into the Observational Medical Outcomes Partnership-Common Data Model between 2010 and *** classified patients with PUD who underwent rapid urease tests or Helicobacter pylori(***)serology into three groups:***-related,drug[nonsteroidal anti-inflammatory drugs(NSAIDs)or aspirin]-related,and idiopathic(***/NSAID/aspirin-negative)PUD and compared the yearly trends and characteristics among the three *** We included 26785 patients in 7 databases,and the proportion of old age(≥65 years)was 38.8%.The overall number of PUD exhibited no decrease,whereas PUD in old age revealed an increasing trend(P=0.01 for trend).Of the 19601 patients,41.8%had ***-related,36.1%had drug-related,and 22.1%had idiopathic *** PUD exhibited a decreasing trend after 2014(P=0.01),drug-related PUD demonstrated an increasing trend(P=0.04),and idiopathic PUD showed an increasing trend in the old-age group(P=0.01)during 10 *** with drug-related PUD had significantly more comorbidities and concomitant ulcerogenic *** idiopathic PUD group had a significantly higher number of patients with chronic liver *** With the aging population increase,the effects of concomitant ulcerogenic drugs and preventive strategies should be investigated in drug-induced *** studies are required to clarify the relationship between idiopathic PUD and chronic liver disease.

关键词： Peptic ulcer disease Drug Idiopathic Trend Characteristics

Successful resolution of gastric perforation caused by a severe complication of pancreatic walled-off necrosis:A case report

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世界临床病例杂志 2023年第26期11卷 6298-6303页

作者： Byeong Gwan Noh Myunghee Yoon Young Mok Park Hyung-Il Seo Suk Kim Seung Baek Hong Jae Kyun Park moon won Lee Department of Surgery Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea

BACKGROUND Pancreatic walled-off necrosis(won)rarely causes critical gastric necrosis and perforation,which may develop when pancreatic won squashes against the *** Atlanta 2012 guidelines were introduced for acute pancreatitis and its related clinical ***,there are few reported cases describing the clinical course and resolution of pancreatic *** SUMMARY We report the case of a 45-year-old man who presented to the urgent emergency department with gastric perforation caused by a severe complication of pancreatic won on computed *** patient underwent an emergency distal pancreatectomy,splenectomy,and gastric wedge *** findings showed re-perforation of the gastric wall at a previously resected ***,endoscopic examination revealed an ulcerative area with a defect in the *** diagnostic endoscopy,endoscopic vacuum-assisted closure was performed,and continuous suction was transferred over all tissues in contact with the sponge *** patient recovered without any further complications and was discharged in good condition at postoperative week *** recurrence occurred during the 6-mo follow-up *** When managing a patient with serious gastric perforation complicated by pancreatic won,a multidisciplinary treatment approach should be considered.

关键词： Acute necrotizing pancreatitis Endoscopy Vacuum assisted closure Gastric rupture Surgery Case report

Highly Aligned Ternary Nanofiber Matrices Loaded with MXene Expedite Regeneration of Volumetric Muscle Loss

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Nano-Micro Letters 2024年第4期16卷 269-292页

作者： moon Sung Kang Yeuni Yu Rowoon Park Hye Jin Heo Seok Hyun Lee Suck won Hong Yun Hak Kim Dong‑Wook Han Department of Cogno‑Mechatronics Engineering College of Nanoscience and NanotechnologyPusan National UniversityBusan 46241Republic of Korea Medical Research Institute School of MedicinePusan National UniversityYangsan 50612Republic of Korea Department of Anatomy School of MedicinePusan National UniversityYangsan 50612Republic of Korea Engineering Research Center for Color‑Modulated Extra‑Sensory Perception Technology Pusan National UniversityBusan 46241Republic of Korea Department of Biomedical Informatics School of MedicinePusan National UniversityYangsan 50612Republic of Korea Periodontal Disease Signaling Network Research Center and Dental and Life Science Institute School of DentistryPusan National UniversityYangsan 50612Republic of Korea BIO‑IT Fusion Technology Research Institute Pusan National UniversityBusan 46241Republic of Korea Present Address:Osstem Implant Inc. Seoul 07789Republic of Korea

Current therapeutic approaches for volumetric muscle loss(VML)face challenges due to limited graft availability and insufficient *** overcome these limitations,tissue-engineered scaffolds have emerged as a promising *** this study,we developed aligned ternary nanofibrous matrices comprised of poly(lactide-co-ε-caprolactone)integrated with collagen and Ti_(3)C_(2)T_(x)MXene nanoparticles(NPs)(PCM matrices),and explored their myogenic potential for skeletal muscle tissue *** PCM matrices demonstrated favorable physicochemical properties,including structural uniformity,alignment,microporosity,and *** vitro assays revealed that the PCM matrices promoted cellular behaviors and myogenic differentiation of C2C12 ***,in vivo experiments demonstrated enhanced muscle remodeling and recovery in mice treated with PCM matrices following VML *** insights from next-generation sequencing revealed that MXene NPs facilitated protein and ion availability within PCM matrices,leading to elevated intracellular Ca^(2+)levels in myoblasts through the activation of inducible nitric oxide synthase(i NOS)and serum/glucocorticoid regulated kinase 1(SGK1),ultimately promoting myogenic differentiation via the m TOR-AKT ***,upregulated i NOS and increased NO–contributed to myoblast proliferation and fiber fusion,thereby facilitating overall myoblast *** findings underscore the potential of MXene NPs loaded within highly aligned matrices as therapeutic agents to promote skeletal muscle tissue recovery.

关键词： Ti_(3)C_(2)T_(x)MXene nanoparticle Ternary nanofibrous matrices Myogenesis Regeneration of volumetric muscle loss Next generation sequencing

A compact polymer–inorganic hybrid gas barrier nanolayer for flexible organic light-emitting diode displays

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npj Flexible Electronics 2022年第1期6卷 204-209页

作者： Seung Hun Kim Seung Yong Song Soo Youn Kim moon won Chang Hyo Jeong Kwon Kwan Hyuck Yoon Woo Yong Sung Myung Mo Sung Hye Yong Chu Display Research Center Samsung DisplayYongin-siGyeonggi-do 17113Republic of Korea Department of Chemistry Hanyang UniversitySeoul 04763Republic of Korea

Atomic layer infiltration technology allows the formation of a nanometer-thick polymer-inorganic hybrid barrier layer in polymer material for flexible organic light-emitting diode(OLED)*** this study,according to transmission electron microscopy and secondary-ion mass spectrometry analysis results under various process conditions,a compact polymer-inorganic hybrid nanolayer was successfully formed in a polymer and good barrier performance was revealed with a low water vapor transmission rate under optimal process ***,through gas chromatography-mass spectrometry measurements after ultra-violet radiation testing,polymer out-gassing decreased compared to bare *** on barrier properties,the polymer with a polymer-inorganic hybrid barrier nanolayer was applied to a flexible OLED display as a *** storage tests and folding tests,the flexible OLED display exhibits good reliability and better flexibility compared to those with an inorganic barrier *** results confirm that the polymer-inorganic hybrid nanolayer is suitable for barrier layer formation in flexible OLED displays.

关键词： diode barrier layer

Transparent-cap-fitted colonoscopy shows higher performance with cecal intubation time in difficult cases

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World Journal of Gastroenterology 2012年第16期18卷 1953-1958页

作者： Hyung Hun Kim Seun Ja Park Moo In Park won moon Sung Eun Kim Department of Internal Medicine Kosin University College of MedicineBusan 602-702South Korea

AIM:To investigate the efficacy of cap-fitted colonoscopy(CFC) with regard to cecal intubation ***:Two hundred and ninety-five patients undergoing screening colonoscopy at Gospel Hospital,Kosin University College of Medicine were enrolled in this randomized controlled trial between January and December *** were conducted by a single *** characteristics including age,sex,body mass index,history of abdominal surgery,quality of preparation,and the presence of diverticulosis were ***:One hundred and fifty patients were allocated into a CFC group and 145 into a non-CFC(NCF) *** intubations were achieved in all *** intubation time in the CFC group was significantly shorter than in the NCF group for specific conditions:age ≥ 60 years,prior abdominal surgery,and poor bowel *** number of detected adenomas was higher in the CFC group than in the NCF group(P = 0.040).CONCLUSION:CFC facilitated shortening of the cecal intubation time in difficult cases,and was more sensitive for detecting adenomas than was NCF.

关键词：插管盲肠检查时间大肠显示性能腹部手术

Laboratory characteristics of recent hepatitis A in Korea:Ongoing epidemiological shift

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World Journal of Gastroenterology 2010年第9期16卷 1115-1118页

作者： Hee won moon Jin Hee Cho Mina Hur Yeo-Min Yun won Hyeok Choe So Young Kwon Chang Hong Lee Department of Laboratory Medicine Konkuk University School of MedicineKonkuk University Medical Center Department of Internal Medicine Konkuk University School of MedicineKonkuk University Medical Center

AIM:To evaluate seroprevalence of hepatitis A virus (HAV) antibody and investigate demographic,clinical,and laboratory features of recent cases in ***:For the evaluation of hepatitis A seroprevalence,we analyzed the data from 3127 subjects including,healthcare workers and patients who visited Konkuk University Hospital,a secondary referral center,from January to October *** sera with positive IgM were excluded from seroprevalence data for total HAV *** retrospectively reviewed the electronic medical records of 419 patients with HAV,who were diagnosed by the presence of serum IgM antibodies against *** patients presented at Konkuk University Hospital between August 2005 and September ***:Among 3127 sera tested,1428 (45.7%)were positive for anti-HAV *** seroprevalence was very low in teenagers or those in their twenties,increased in those in their thirties,and was > 90% in older *** children younger than 10 years,seroprevalence was increased *** patients with HAV hepatitis were in their twenties and *** γ-glutamyl transpeptidase increased with age and was significantly higher in patients older than 30 *** of severity,such as decreased albumin and increased bilirubin,were also more prominent in the older age group;however,the leukocyte count was higher and the frequency of leukopenia was lower in younger patients than in older ***:There has been an apparent epidemiological shift in HAV seroprevalence and a change in the peak age of HAV *** study could provide baseline data of recent hepatitis A in Asia.

关键词： Hepatitis A virus Seroprevalence Epidemiology Korea