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Bedside index for severity in acute pancreatitis:comparison with other scoring systems in predicting severity and organ failure

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Hepatobiliary & Pancreatic Diseases International 2013年第6期12卷 645-650页

作者： Ji Young Park Tae Joo Jeon Tae Hwan Ha Jin Tae Hwang Dong Hyun Sinn Tae-Hoon Oh won chang shin won-Choong Division of Gastroenterology Department of Internal MedicineInje University Sanggye Paik Hospital

BACKGROUND:The early identification of severe acute pancreatitis is important for the management and for improving *** bedside index for severity in acute pancreatitis(BISAP)has been considered as an accurate method for risk stratification in patients with acute *** study aimed to evaluate the comparative usefulness of the ***:We retrospectively analyzed 303 patients with acute pancreatitis diagnosed at our hospital from March 2007to December ***,APACHE-II,Ranson criteria,and CT severity index(CTSI)of all patients were *** stratified the number of patiants with severe pancreatitis,pancreatic necrosis,and organ failure as well as the number of deaths by BISAP *** used the area under the receiveroperating curve(AUC)to compare BISAP with other scoring systems,C-reactive protein(CRP),hematocrit,and body mass index(BMI)with regard to prediction of severe acute pancreatitis,necrosis,organ failure,and ***:Of the 303 patiants,31(10.2%)were classified as having severe acute *** failure occurred in 23(7.6%)patients,pancreatic necrosis in 40(13.2%),and death in6(2.0%).A BISAP score of 2 was a statistically significant cutoff value for the diagnosis of severe acute pancreatitis,organ failure,and *** for BISAP predicting severe pancreatitis and death were 0.80 and 0.86,respectively,which were similar to those for APACHE-II(0.80,0.87)and Ranson criteria(0.74,0.74)and greater than AUCs for CTSI(0.67,0.42).The AUC for organ failure predicted by BISAP,APACHE-II,Ranson criteria,and CTSI was 0.93,0.95,0.84 and 0.57,*** for BISAP predicting severity,organ failure,and death were greater than those for CRP(0.69,0.80,0.72),hematocrit(0.45,0.35,0.14),and BMI(0.41,0.47,0.17).CONCLUSION:The BISAP predicts severity,death,and especially organ failure in acute pancreatitis as well as APACHE-II does and better than Ranson criteria,CTSI,CRP,hematocrit,and BMI.

关键词： acute pancreatitis scoring system pancreatic necrosis organ failure

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Appropriate empirical antibiotic use and 30-d mortality in cirrhotic patients with bacteremia

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World Journal of Gastroenterology 2015年第12期21卷 3587-3592页

作者： Hyun Park Ki Jun Jang won Jang Sang Hoon Park Ji Young Park Tae Joo Jeon Tae Hoon Oh won chang shin won-Choong Choi Dong Hyun Sinn Department of Internal Medicine Sanggye Paik Hospital Inje University Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine

AIM: To analyze whether prompt and appropriate empirical antibiotic(AEA) use is associated with mortality in cirrhotic patients with bacteremia. METHODS: A total of 102 episodes of bacteremia in 72 patients with cirrhosis were analyzed. AEA was defined as a using or starting an antibiotic appropriate to the isolated pathogen at the time of bacteremia. The primary endpoint was 30-d mortality. RESULTS: The mortality rate at 30 d was 30.4%(31/102 episodes). Use of AEA was associated with better survival at 30 d(76.5% vs 46.9%, P = 0.05), and inappropriate empirical antibiotic(IEA) use was an independent factor associated with increased mortality(OR = 3.24; 95%CI: 1.50-7.00; P = 0.003, adjusted for age, sex, ChildPugh Class, gastrointestinal bleeding, presence of septic shock). IEA use was more frequent when the isolated pathogen was a multiresistant pathogen, and when infection was healthcare-related or hospital-acquired. CONCLUSION: AEA use was associated with increased survival of cirrhotic patients who developed bacteremia. Strategies for AEA use, tailored according to the local epidemiological patterns, are needed to improve survival of cirrhotic patients with bacteremia.

关键词： Liver cirrhosis Bacteremia Appropriate antibiotics

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A study on hydrogen uptake and release of a eutectic mixture of biphenyl and diphenyl ether

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Journal of Energy Chemistry 2020年第3期29卷 11-16页

作者： Munjeong Jang Byeong Soo shin Young Suk Jo Jeong won Kang Sang Kyu Kwak chang won Yoon Hyangsoo Jeong Center for Hydrogen Fuel Cell Research Korea Institute of Science and Technology(KIST)5 Hwarang-ro 14-gilSeongbuk-guSeoul 02792Republic of Korea Divison of Energy and Environment Technology KIST SchoolKorea University of Science and Technology5 Hwarang-ro 14-gilSeongbuk-guSeoul 02792Republic of Korea Department of Chemical and Biological Engineering Korea UniversityAnam-ro 145Seongbuk-guSeoul 02841Republic of Korea School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology50UNIST-gilUlsan 44919Republic of Korea KHU-KIST Department of Converging Science and Technology Kyung Hee University26 Kyungheedae-roDongdaemun-guSeoul 02447Republic of Korea

Hydrogen storage in Liquid Organic Hydrogen Carrier(LOHC)systems is appealing for the safe storage and distribution of excess renewable energy via existing gasoline infrastructures to *** present the eutectic mixture of biphenyl and diphenyl ether of its first use as a LOHC *** material is hydrogenated with 99%selectivity without the cleavage of C–O bond,with commercial heterogeneous catalysts,which is confirmed by nuclear magnetic spectroscopy and gas chromatography-mass *** concentration,dehydrogenation enthalpy,and thermo-neutral temperature are calculated using a density functional *** results indicate that O-atom-containing material exhibits more favorable dehydrogenation thermodynamics than that of the hydrocarbon *** H2-rich material contains6.8 wt%of gravimetric hydrogen storage capacity.A preliminary study of catalytic dehydrogenation on a continuous reactor is presented to demonstrate a reversibility of this material.

关键词： Hydrogen storage Liquid organic hydrogen carrier Diphenyl ether Dehydrogenation Thermodynamics

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Integration of climate change considerations into environmental impact assessment- implementation, problems and recommendations for China

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Frontiers of Environmental Science & Engineering 2013年第4期7卷 598-607页

作者： I-shin chang Jing WU College of Environment and Resources Inner Mongolia University Huhhot 010021 China College of Environmental Science and Engineering Nankai University Tianjin 300071 China

Climate change plays an important role in affecting and altering the course of human development. So far, there have been no effective and efficient techniques to directly quantify the influences of climate change on human development, but there have been rough estimation and qualitative description of the effects. Since the 1990s, climate change considerations have been required to be included in environmental impact assess- ment, which is a flexible institutional framework of environmental risk evaluation and management. However, there have been no concrete achievements demonstrated. The purpose of this study was first to summarise the practical experience and to disclose the existing problems during the implementation of the process of integrating climate change considerations into environmental impact assessment in China through a case study. Currently in China, the practice of integrating climate change con- siderations into environmental impact assessment is mainly concentrated on the strategic environmental assessment level. The influences of climate change were identified as energy consumption, greenhouse gases emission, and the restraint of development under abnormal or extreme weather or climate conditions. Because of a lack of related technical guidelines and practical experi- ence, the climate change considerations that have been selected and the evaluation methods that have been applied are quite different. Recommendations on policies, laws, and institutional regulations institution are proposed to better utilise environmental impact assessment to integrate climate change considerations into economic, social, and environmental decisions and actions.

关键词： climate change considerations environmental

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Wiener's lemma:localization and various approaches

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Applied Mathematics(A Journal of Chinese Universities) 2013年第4期28卷 465-484页

作者： shin chang Eon SUN Qi-yu Department of Mathematics Sogang UniversitySeoul 121-742 Korea Department of Mathematics University of Central FloridaOrlando FL 32816 USA

Matrices and integral operators with off-diagonal decay appear in numerous areas of mathematics including numerical analysis and harmonic analysis, and they also play impor-tant roles in engineering science including signal processing and communication engineering. Wiener’s lemma states that the localization of matrices and integral operators are preserved un-der inversion. In this introductory note, we re-examine several approaches to Wiener’s lemma for matrices. We also review briefly some recent advances on localization preservation of operations including nonlinear inversion, matrix factorization and optimization.

关键词： Wiener’s lemma infinite matrix stability Wiener algebra Beurling algebra off-diagonal decay inverse closedness

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Three-dimensional free view reconstruction in axially distributed image sensing

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Chinese Optics Letters 2017年第8期15卷 40-43页

作者： chang-taek seo shin-won kang myungjin cho 3d display components support center gumi electronics and information technology research instituteGumi-siGyeongsangbuk-do 730-853Korea school of electronics engineering college of it engineeringkyungpook national universityDaegu 702-701Korea department of electrical electronicand control engineeringiitchankyong national university327 Chungang-roAnseong-siGyonggi-do 456-749Korea

Three-dimensional （3D） acquisition has been the most important technique for augmented reality or virtual reality industries. Stereo vision can obtain 3D infor- mation of objects using disparity between two images captured by a stereo camera. However, due to lack of per- spectives for 3D objects in this technique, accurate 3D information may not be generated and the number of viewing points is limited. By contrast, multi-view or super multi-view imaging techniques can obtain more accurate 3D information because they use multiple cameras for pickup of 3D objects so that more perspec- tives and viewing points of 3D objects can be recorded.

关键词： view free Three-dimensional free view reconstruction in axially distributed image sensing

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MRI of gastric carcinoma:Results of T and N-staging in an in vitro study

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World Journal of Gastroenterology 2009年第32期15卷 3992-3998页

作者： Il Young Kim Sang won Kim Hyeong Cheol shin Moon Soo Lee Dong Jun Jeong chang Jin Kim Young Tong Kim Department of Radiology Soonchunhyang University Cheonan Hospital23-20 BongmyungdongCheonanChoongnam 330-720South Korea Department of Surgery Soonchunhyang University Cheonan Hospital23-20 BongmyungdongCheonanChoongnam 330-720South Korea Department of Pathology Soonchunhyang University Cheonan Hospital23-20 BongmyungdongCheonanChoongnam 330-720South Korea

AIM： To determine the accuracy of 1.5-T magnetic resonance imaging （MRI） in the evaluation of gastric wall invasion and perigastric lymph node metastasis in gastric adenocarcinoma.METHODS： Twenty resected gastric specimens containing 20 tumors were studied with a 1.5-T MR system using a commercial head surface coil. MR scanning was performed with a T1 weighted image （TR/TE = 500/20）, and a T2 weighted image （TR/TE = 2500/90）. MR findings were compared with pathologic findings.RESULTS： A T1-weighted image demonstrated three layers in the normal gastric wall. All of the gastric tumors were well demonstrated by lesions and location. In a MRI findings of gastric wall invasion, there was 1 case of T1, 7 of T2, 11 of T3. Pathologic results of resected specimens included 3 cases of pT1, 4 of pT2, and 12 of pT3. The accuracy of T staging with MRI was 74% （14 of 19）. MRI findings of lymph node metastasis included 6 cases of NO, 13 cases of N1. The accuracy of the N staging with MRI was 47% （9 of 19）.CONCLUSION： MRI has a high diagnostic accuracy in the evaluation of the T staging of gastric cancerin vitro and thus potentially enables preoperative histopathologic staging.

关键词： Gastric cancer Magnetic resonance imaging Neoplasm Staging Stomach Depiction of walllayer

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Optimal three-dimensional impact time guidance with seeker’s field-of-view constraint

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Chinese Journal of Aeronautics 2021年第2期34卷 240-251页

作者： Shaoming HE chang-Hun LEE Hyo-Sang shin Antonios TSOURDOS School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Department of Aerospace Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea School of Aerospace Transport and ManufacturingCranfield UniversityCranfiehMK43 OALUnited Kingdom

This paper proposes a new three-dimensional optimal guidance law for impact time control with seeker’s Field-of-View(FOV) constraint to intercept a stationary target. The proposed guidance law is devised in conjunction with the concept of biased Proportional Navigation Guidance(PNG). The guidance law developed leverages a nonlinear function to ensure the boundedness of velocity lead angle to cater to the seeker’s FOV limit. It is proven that the impact time error is nullified in a finite-time under the proposed method. Additionally, the optimality of the biased command is theoretically analyzed. Numerical simulations confirm the superiority of the proposed method and validate the analytic findings.

关键词： Applied optimal control Field-of-view constraint Impact time control Missile guidance Optimal error dynamics

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Enhanced delivery of a low dose of aducanumab via FUS in 5×FAD mice,an AD model

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Translational Neurodegeneration 2022年第1期11卷 31-45页

作者： Chanho Kong Eun-Jeong Yang Jaewoo shin Junwon Park Si-Hyun Kim Seong-Wook Park won Seok chang chang-Han Lee Hyunju Kim Hye-Sun Kim Jin Woo chang Department of Neurosurgery Yonsei University College of Medicine50 Yonsei-RoSeodaemun-GuSeoulRepublic of Korea Department of Pharmacology College of MedicineSeoul National University103 DaehakroJongro-GuSeoulRepublic of Korea Neuroscience Research Center College of MedicineSeoul National University103 DaehakroJongro-GuSeoulRepublic of Korea Department of Biomedical Sciences College of MedicineSeoul National University103 DaehakroJongro-GuSeoulRepublic of Korea Bundang Hospital Seoul National University College of MedicineBundang-GuSungnamRepublic of Korea.

Background:Aducanumab(Adu),which is a human IgG1 monoclonal antibody that targets oligomer and fibril forms of beta-amyloid,has been reported to reduce amyloid pathology and improve impaired cognition after administration of a high dose(10 mg/kg)of the drug in Alzheimer’s disease(AD)clinical *** purpose of this study was to investigate the effects of a lower dose of Adu(3 mg/kg)with enhanced delivery via focused ultrasound(FUS)in an AD mouse ***:The FUS with microbubbles opened the blood-brain barrier(BBB)of the hippocampus for the delivery of *** combined therapy of FUS and Adu was performed three times in total and each treatment was performed biweekly.Y-maze test,Brdu labeling,and immunohistochemical experimental methods were employed in this *** addition,RNA sequencing and ingenuity pathway analysis were employed to investigate gene expression profiles in the hippocampi of experimental ***:The FUS-mediated BBB opening markedly increased the delivery of Adu into the brain by approximately 8.1 times in the *** combined treatment induced significantly less cognitive decline and decreased the level of amyloid plaques in the hippocampi of the 5×FAD mice compared with Adu or FUS *** treatment with FUS and Adu activated phagocytic microglia and increased the number of astrocytes associated with amyloid plaques in the hippocampi of 5×FAD ***,RNA sequencing identified that 4 enriched canonical pathways including phagosome formation,neuroinflammation signaling,CREB signaling and reelin signaling were altered in the hippocami of 5×FAD mice receiving the combined ***:In conclusion,the enhanced delivery of a low dose of Adu(3 mg/kg)via FUS decreases amyloid deposits and attenuates cognitive function ***-mediated BBB opening increases adult hippocampal neurogenesis as well as drug *** present an AD treatment strategy through the synergistic effect of the combined therapy of

关键词： Aducanumab Alzheimer’s disease Focused ultrasound Transcriptome profiling

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High-efficiency single and tandem fullerene solar cells with asymmetric monofluorinated diketopyrrolopyrrole-based polymer

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Journal of Energy Chemistry 2022年第1期31卷 236-245,I0007页

作者： Shafket Rasool Quoc Viet Hoang Doan Van Vu chang Eun Song Hang Ken Lee Sang Kyu Lee Jong-Cheol Lee Sang-Jin Moon won Suk shin Institute of Chemical Technology(KRICT) 141 Gajeong-roYuseongDaejeon 34114Republic of Korea Advanced Materials and Chemical Engineering University of Science and Technology(UST)217 CajeongroYuseongDaejeon 34113Republic of Korea Vietnam Standards and Quality Institute(VSQI) Directorate for StandardsMetrology and Quality(STAMEQ)No.8.Hoang Quoc VietCau GiayHanoiViet Nam

Design and synthesis of low bandgap(LBG) polymer donors is inevitably challenging and their processability from a non-halogenated solvent system remains a hurdle to overcome in the area of highperformance polymer solar cells(PSCs).Due to a high aggregation tendency of LBG polymers,especially diketopyrrolopyrrole(DPP)-based polymers coupled with bithiophenes in the polymer backbones,their widespread adoption in non-ha logena ted solvent-processed PSCs has been ***,a novel LBG DPP-based polymer,called PDPP4 T-1 F with asymmetric arrangement of fluorine atom,has been successfully synthesized and showed an outstanding power conversion efficiency(PCE) of 10.10% in a singlejunction fullerene-based ***,an impressive PCE of 13.21% has been achieved in a tandem device from a fully non-halogenated solvent system,which integrates a wide bandgap PDTBTBz-2 F polymer in the bottom cell and LBG PDPP4 T-1 F polymer in the top *** achieved efficiency is the highest value reported in the literature to date in fullerene-based tandem *** found that a uniformly distributed interpenetrating fibril network with nano-scale phase separation and anisotropy of the polymer backbone orientation for efficient charge transfer/transport and suppressed charge recombination in PDPP4 T-1 F-based PSCs led to outstanding PCEs in single and tandem-junction PSCs.

关键词： Low bandgap polymers Diketopyrrolopyrrole Tandem polymer solar cells Non-halogenated solvent Monofluoro-bithiophene

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