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Small bowel adenocarcinoma in Crohn's disease:A case report and review of literature

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World Journal of Gastroenterology 2006年第8期12卷 1317-1320页

作者： Irmgard E Kronberger Ivo W Graziadei wolfgang vogel Department of Gastroenterology and Hepatology Medical University InnsbruckAustria

Small bowel adenocarcinomas are remarkable for their rarity, difficult diagnosis and poor prognosis. Here we report an unusual case of a 33-year-old patient in whom infiltrative adenocarcinoma of the small bowel was diagnosed after a 10-year history of Crohn＇s disease. In most previously reported cases, detection of Crohn＇s disease was subsequent tothat of carcinoma of the small bowel or the patients involved had an even longer history of the disease. Our literature review suggests that the risk of small bowel adenocarcinoma is higher in patients with Crohn＇s disease than in the overall population. We present details on epidemiology as well as clinical and diagnostic aspects of this rare disease entity.

关键词： Crohn's disease Small bowel adenocarcinoma Case report

Transjugular intrahepatic portosystemic shunt in liver transplant recipients

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World Journal of Gastroenterology 2009年第16期15卷 1999-2004页

作者： Armin Finkenstedt Ivo W Graziadei Karin Nachbaur Werner Jaschke Walter Mark Raimund Margreiter wolfgang vogel Department of Internal Medicine (Gastroenterology and Hepatology) Medical University of Innsbruck Department of Radiology Medical University of Innsbruck Department of Transplant Surgery Medical University of Innsbruck

AIM： To evaluate the efficacy of transjugular intrahepatic portosystemic shunts （TIPSs） after liver transplantation （LT）. METHODS： Between November 1996 and December 2005, 10 patients with severe recurrent hepatitis C virus infection （n = 4）, ductopenic rejection （n = 5） or portal vein thrombosis （n = 1） were included in this analysis. Eleven TIPSs （one patient underwent two TIPS procedures） were placed for management of therapy-refractory ascites （n = 7）, hydrothorax （n = 2） or bleeding from colonic varices （n = 1）. The median time interval between LT and TIPS placement was 15 （4-158） mo. RESULTS： TIPS placement was successful in all patients. The mean portosystemic pressure gradient was reduced from 12.5 to 8.7 mmHg. Complete and partial remission could be achieved in 43% and 29% of patients with ascites. Both patients with hydrothorax did not respond to TIPS. No recurrent bleeding was seen in the patient with colonic varices. Nine of 10 patients died during the study period. Only one of two patients, who underwent retransplantation after the TIPS procedure, survived. The median survival period after TIPS placement was 3.3 （range 0.4-20） too. The majority of patients died from sepsis with multiorgan failure. CONCLUSION： Indications for TIPS and technical performance in LT patients correspond to those in non-transplanted patients. At least partial control of therapy-refractory ascites and variceal bleeding could be achieved in most patients. Nevertheless, survival rates were disappointing, most probably because of the advanced stages of liver disease at the time of TIPS placement and the high risk of sepsis as a consequence of immunosuppression.

关键词： Portal hypertension Ascites Variceal bleeding Immunosuppression Liver transplantation

Multidimensional assessment of neuro-psychiatric symptoms in patients with low-grade hepatic encephalopathy: A clinical rating scale

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World Journal of Gastroenterology 2005年第37期11卷 5893-5898页

作者： Sergei Mechtcheriakov Ivo W Graziadei André Kugener Julia Wiedemann Chantal Galbavy Hartmann Hinterhuber Josef Marksteiner wolfgang vogel Department of General Psychiatry Medical University Innsbruck Austria Department of Gastroenterology and Hepatology Medical University Innsbruck Anichstrasse 35 AT-6020 Innsbruck Austria

AIM： To evaluate the feasibility of a new clinical rating scale for a standardized assessment of cirrhosis-associated neuro-psychiatric symptoms. METHODS： Forty patients with liver cirrhosis （LC, with or without low-grade hepatic encephalopathy） were investigated using a clinical neuro-psychiatric rating scale based on a comprehensive list of neurological, psychomotor, cognitive, affective, behavioral symptoms, and symptoms of disturbed bioregulation. RESULTS： The analysis revealed that the majodty of cirrhotic patients showed, besides characteristic neurological symptoms of hepatic encephalopathy, various psychomotor, affective and bioregulatory symptoms （disturbed sleep and sexual dysfunction）. Patients were impaired in the following subscales： sleep and biorhythm disorder （75.0% of patients）, Parkinsonoid symptoms （25.0%）, affective symptoms （17.5%）, and psychomotor retardation （12.5%）. The increase of total neuro-psychiatric clinical score was significantly associated with the degree of hepatic encephalopathy. CONCLUSION： This study suggests that a substantial number of patients with LC and low-grade hepatic encephalopathy manifest various clinical neuro-psychiatric symptoms. The use of a rating scale, which explores clinical dimensions of hepatic encephalopathy, would improve the management of patients with LC.

关键词： Liver cirrhosis Hepatic encephalopathy Neuropsychiatric symptoms Clinical neuro-psychiatric rating Bradykinesia

Diagnostic value of fine motor deficits in patients with low-grade hepatic encephalopathy

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World Journal of Gastroenterology 2005年第18期11卷 2777-2780页

作者： Sergei Mechtcheriakov Ivo W. Graziadei Maria Rettenbacher Ingrid Schuster Hartmann Hinterhuber wolfgang vogel Josef Marksteiner Department of General Psychiatry Medical University of Innsbruck Anichstrasse 35 A-6020 Innsbruck Austria Department of Gastroenterology and Hepatology Medical University of Innsbruck Anichstrasse 35 A-6020 Innsbruck Austria Department of Biological Psychiatry Medical University of Innsbruck Anichstrasse 35 A-6020 Innsbruck Austria

AIM: The role of motor dysfunction in early diagnosis of low-grade hepatic encephalopathy remains uncertain. We performed a pilot study to comparatively investigate the kinematic characteristics of small and large rapid alternating movements in patients with liver cirrhosis and low-grade hepatic ***: A kinematic analysis of alternating handwriting (7.5 mm) and large drawing movements (DM, 175 mm) was performed in 30 patients with liver cirrhosis (no hepatic encephalopathy: n = 10; minimal hepatic encephalopathy: n = 9; grade I hepatic encephalopathy: n = 11; healthy controls: n = 12). The correlation between kinematic parameters, clinical neuro-psychiatric symptoms of cerebral dysfunction and the grade of encephalopathy was ***: Both movement types, handwriting and drawing, were significantly slower in cirrhotic patients. In contrast to large DM, the deterioration of handwriting movements significantly correlated with the increase of symptoms of motor dysfunction and differentiated significantly within the group of cirrhosis patients corresponding to the degree of hepatic encephalopathy. CONCLUSION: The deterioration of fine motor control is an important symptom of low-grade hepatic encephalopathy. The kinematic analysis of handwriting allows the quantitative analysis of alterations of motor function and is a possible tool for diagnostics and monitoring of motor dysfunction in patients with low-grade hepatic encephalopathy.

关键词： Hepatic encephalopathy Liver cirrhosis Motor dysfunction Handwriting Kinematic analysis

New insights into the properties of high-manganese steel

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International Journal of Minerals,Metallurgy and Materials 2021年第5期28卷 782-796页

作者： wolfgang Bleck Steel Institute RWTH Aachen UniversityGermany

In the Collaborative Research Centre 761’s“Steel ab initio-quantum mechanics guided design of new Fe based materials,”scientists and engineers from RWTH Aachen University and the Max Planck Institute for Iron Research conducted research on mechanism-controlled material development with a particular focus on high-manganese alloyed *** 2007 to 2019,a total of 55 partial projects and four transfer projects with industrial participation(some running until 2021)have studied material and process design as well as material *** basic idea of the Collaborative Research Centre was to develop a new methodological approach to the design of structural *** paper focuses on selected results with respect to the mechanical properties of high-manganese steels,their underlying physical phenomena,and the specific characterization and modeling tools used for this new class of *** steels have microstructures that require characterization by the use of modern methods at the *** the process routes,the generation of segregations must be taken into ***,the mechanical properties show a characteristic temperature dependence and peculiarities in their fracture *** mechanical properties and especially bake hardening are affected by short-range ordering *** strain hardening can be adjusted in a never-before-possible range,which makes these steels attractive for demanding sheet-steel applications.

关键词： high-manganese steels stacking fault energy twinning short-range ordering mechanical properties

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Cartography and the others-aspects of a complicated relationship

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Geo-Spatial Information Science 2020年第1期23卷 52-60页

作者： wolfgang Kainz Department of Geography and Regional Research University of ViennaWienAustria Collaborative Innovation Center of Geospatial Technology Wuhan UniversityWuhanChina

Cartographic visualizations have been known for thousands of years and have brought forth a wealth of different map projections and cartographic ***,cartography as an independent science has been established only about 100 years ago and sometimes its position among the spatial disciplines is challenged by the scientific *** this respect it is a young science based on a very long tradition of map making,globe production,and the development of map *** and map related visualizations play an important and indispensable role in many other spatial disciplines such as geography and *** has many overlaps with these traditional disciplines as well as with the more recent ones of photogrammetry and remote *** paper reviews fundamental aspects of the conception of space and time throughout human history,the historic development of cartography from a technique of map making to a spatial science,highlighting major milestones in the history of the *** a young science and confronted with major technological developments in the late 20^(th)century cartography underwent several crises as to what exactly is cartography and how it relates to other spatial sciences,in particular to geographic information *** pitfalls and misconceptions are discussed and the three major scientific pillars of cartography are *** relationships of cartography with neighboring disciplines are discussed and the position of cartography vis a vis the others is ***,desirable future developments of scientific cartography are discussed.

关键词： Cartography GIS geodesy photogrammetry remote sensing

How can neuromorphic hardware attain brain-like functional capabilities?

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National Science Review 2024年第5期11卷 11-13页

作者： wolfgang Maass Computer Science and Biomedical Engineering Graz University of Technology

Research on neuromorphic computing is driven by the vision that we can emulate brain-like computing capability, learning capability, and energy-efficiency in novel hardware. Unfortunately, this vision has so far been pursued in a half-hearted manner. Most current neuromorphic hardware (NMHW) employs brain-like spiking neurons instead of standard artificial neurons.

关键词： capabilities attain brain-like functional hardware neuromorphic

Friedrich Ackermann’s scientific research program

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Geo-Spatial Information Science 2023年第2期26卷 141-150页

作者： wolfgang Förstner Department of Photogrammetry UniversityBonnGermany

We sketch Friedrich Ackermann’s research program following the concept of Imre Lakatos,with some historical key developments in the theory and application of aerotriangulation and image *** research program,with its core being statistical estimation theory,has decisively influenced photogrammetry since the 60s,is still fully alive,and a challenge for today’s methods of image *** describe(1)Lakatos’concept of a scientific research program,with its negative and positive heuristics and(2)Ackermann’s research program,clearly made explicit in his PhD,with its mathematical model,the ability to predict theoretical precision and reliability,the potential of analyzing rigorous and approximate method,and the role of *** development of aerotriangulation,later augmented by image matching techniques,is closely connected to Ackermann’s successful attempts to integrate basic research and practical applications.

关键词： Friedrich Ackermann scientific research program aerotriangulation image matching role of theory and application

PREDICTIVE MODELS AND GENERATIVE COMPLEXITY

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Journal of Systems Science & Complexity 2012年第1期25卷 30-45页

作者： wolfgang LHR Max Planck Institute for Mathematics in the Sciences Inselstraβe 22D-04103 LeipziqGermany

The causal states of computational mechanics define the minimal sufficient memory for a given discrete stationary stochastic process. Their entropy is an important complexity measure called statistical complexity （or true measure complexity）. They induce the s-machine, which is a hidden Markov model （HMM） generating the process. But it is not the minimal one, although generative HMMs also have a natural predictive interpretation. This paper gives a mathematical proof of the idea that the s-machine is the minimal HMM with an additional （partial） determinism condition. Minimal internal state entropy of a generative HMM is in analogy to statistical complexity called generative complexity. This paper also shows that generative complexity depends on the process in a nice way. It is, as a function of the process, lower semi-continuous （w.r.t. weak-, topology）, concave, and behaves nice under ergodic decomposition of the process.

关键词： Causal states complexity s-machine generative complexity HMM partially deterministicHMM predictive model statistical.

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