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Wntl-regu｜ated genetic networks in midbrain dopaminergic neuron development

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Journal of Molecular Cell Biology 2014年第1期8卷 34-41页

作者： wolfgang Wurst Nilima Prakash Institute of Developmental Genetics Helmholtz Zentrum MCinchen German Research Center for Environmental Health and Technische Universit~it MCinchen-Weihenstephan Lehrstuhl for Entwicklungsgenetik Ingolst~idter Landstr. I 85764 Neuherberg Germany Deutsches Zentrum fiJr Neurodegenerative Erkrankungen (DZNE) Standort MiJnchen Schinerstr. 44 80336 MCinchen Germany Max Planck Institute of Psychiatry Kraepelinstrasse 2-10 80804 MiJnchen Germany

Neurons synthesizing the neurotransmitter dopamine exert crucial functions in the mammalian brain. The biggest and most important population of dopamine-synthesizing neurons is located in the mammalian ventral midbrain （VM）, and controls and modulates the exe- cution of motor, cognitive, affective, motivational, and rewarding behaviours. Degeneration of these neurons leads to motor deficits that are characteristic of Parkinson＇s disease, while their dysfunction is involved in the pathogenesis of psychiatric disorders including schizophrenia and addiction. Because the aetiology and therapeutic prospects for these diseases include neurodevelopmental aspects, substantial scientific interest has been focused on deciphering the mechanistic pathways that control the generation and sur- vival of these neurons during embryonic development. Researches during the last decade revealed the pivotal role of the secreted Wntl ligand and its signaUing cascade in the generation of the dopamine-synthesizing neurons in the mammalian VM. Here, we summarize the initial and more recent findings that have unravelled several Wntl-controUed genetic networks required for the proliferation and commitment of VM progenitors to the dopaminergic cell fate during midgestational embryonic stages, and for the correct differentiation of these progenitors into postmitotic dopamine-synthesizing neurons at late midgestational embryonic and foetal stages.

关键词： Wntl dopamine neuron ventral midbrain mouse

Mixed Phase Anatase/rutile Titanium Dioxide Nanotubes for Enhanced Photocatalytic Degradation of Methylene-blue

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Nano-Micro Letters 2011年第4期3卷 236-241页

作者： Mario Boehme wolfgang Ensinger Department of Materials Science Darmstadt University of Technology

Titanium dioxide Nanotubes(TNTs) prepared by electroless deposition have been annealed at air ambient and low temperature. As a result, the anatase/rutile phase composition of the TNTs can be tailored to the needs of later applications. Nanotubes with anatase/rutile mixed phase ratio of 4:1 have been produced in this report and further examined for their photocatalytical behavior. The photocatalytical properties of the TNTs have been observed by degradation of methylene-blue in aqueous solution under low power UV-light irradiation. The results shown in this report are based on the synergetic effect between rutile and anatase,which results in the mixed phase TiO 2 nanotubes having enhanced photocatalytical properties.

关键词： Electroless deposition Degussa P25 Nanotubes Titanium dioxide Anatase

Empirical likelihood-based dimension reduction inference for linear error-in-responses models with validation study

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Science China Mathematics 2004年第6期47卷 921-939页

作者： Wang Qihua Hardie wolfgang Academy of Mathematics and System Sciences Chinese Academy of SciencesBeijing 100080China Heilongjiang University Harbin 150080China Center for Applied Statistics and Economics Humboldt-Universitat zu Berlin10178 BerlinGermany

In this paper, linear errors-in-response models are considered in the presence of validation data on the responses. A semiparametric dimension reduction technique is employed to define an estimator of β with asymptotic normality, the estimated empirical loglikelihoods and the adjusted empirical loglikelihoods for the vector of regression coefficients and linear combinations of the regression coefficients, respectively. The estimated empirical log-likelihoods are shown to be asymptotically distributed as weighted sums of independent X 2 1 and the adjusted empirical loglikelihoods are proved to be asymptotically distributed as standard chi-squares, respectively.

关键词： confidence intervals error-in-response validation data

Seasonal size-segregated PM10 and PAH concentrations in a rural area of sugarcane agriculture versus a coastal urban area in Southeastern Florida, USA

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Particuology 2016年第5期14卷 52-59页

作者： Orhan Sevimoglu wolfgang F. Rogge Department of Civil and Environmental Engineering Florida International University 10555 W. Flagier Street Miami FL 33174 USA School of Engineering and Sierra Nevada Research Institute University of California at Merced 5200 North Lake Road Merced CA 95343 USA

Airborne particulate matter （PM） is of health and environmental concern not only in highly urbanized areas, but also in rural areas that are used for intensive agricultural purposes, In this study, PM size- segregated samples were collected simultaneously for 12 months in a small town （Belle Glade, Florida）, which is the center of a vast sugarcane growing area and at Delray Beach, a coastal city in Palm Beach County, Florida. During the winter sampling period, when sugarcane foliage is burned just before harvest- ing to reduce the amount of plant matter to be handled, PM10 levels were 50% or higher than otherwise measured, indicating that sugarcane harvesting and processing is a major local source for PM10. For the rest of the year, PM10 levels at both sites are similar, suggesting that ambient PM levels at both sites are impacted by the major urban centers in Southern Florida. During late July and early August, the PM10 levels at both sites were substantially elevated and revealed the typical red-brownish color of Saharan dust. This has been reported to occur frequently with suitable meteorological conditions over the Atlantic Ocean coupled with a Sahara dust storm event. During the sugarcane harvesting season at Belle Glade, the concentrations of PAHs associated with PM10 were up to 15 times higher than those measured during the summer growing season, indicating a substantially higher exposure of the rural population to these often mutagenic and carcinogenic compounds.

关键词： Size segregated ambient particles PM10 PAHs Biomass burning Rural versus urban Saharan dust

Control of Strain Hardening Behavior in High-Mn Austenitic Steels

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Acta Metallurgica Sinica(English Letters) 2014年第3期27卷 546-556页

作者： Wenwen Song Tobias Ingendahl wolfgang Bleck Steel Institute RWTH Aachen University Intzestr.1 52072 AachenGermany

Austenitic high-Mn steels with Mn contents between approximately 15 and 30 wt% gain much interest because of their excellent mechanical properties and the option for adjusting strain hardening behavior due to different deformation mechanisms. 2D and 3D composition-dependent stacking fault energy （SFE） maps indicate the effect of chemical composition and temperature on SFE and consequently on the deformation mechanisms. Three steels with different chemical compositions and the same or different SFE are characterized in quasi-static tensile tests. The control parameters of strain hardening behavior in the high-Mn austenitic steels are described, and consequences for future developments are discussed.

关键词： High-Mn austenitic steels Stacking fault energy Strain hardening

Synthesis of iron（ll） complexes with asymmetric N2O2 coordinating Schiff base-like ligands and their spin crossover properties

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Frontiers of Chemical Science and Engineering 2018年第3期12卷 400-408页

作者： wolfgang Bauer Tanja Ossiander Birgit Weber Department of Chemistry University of Bayreuth 95440 Bayreuth Germany

The synthesis of new Schiff base-like ligands with asymmetric substituents pattern and their iron complexes with pyridine as axial ligand is described. Two of the ligands and one of the iron（II） complexes were characterized by single crystal X-ray structure analysis. One of the the iron（II） complexes shows spin crossover behavior while the others remain in the high spin state. The influence of the reduced symmetry of the ligand on the properties of the complexes is discussed.

关键词： iron Schiffbase-like ligands magnetism spin crossover X-ray structures

The orbital g-factor and related sum rules

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Science China(Physics,Mechanics & Astronomy) 2011年第2期54卷 194-197页

作者： BENTZ wolfgang ARIMA Akito Department of Physics School of ScienceTokai University Musashi University

The renormalization of the orbital g-factor in nuclei is discussed on the basis of gauge *** relation of the orbital g-factor to the integrated E1 photoabsorption cross section is reviewed,and its relation to the M1 s... 详细信息

关键词： nuclear magnetic moments g-factors giant resonances sum rules

Accuracy of training blood volume quantifi cation using a visual estimation tool

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World Journal of Emergency Medicine 2021年第3期12卷 174-178页

作者： Janett Kreutziger Philip Puchner Stefan Schmid wolfgang Mayer Harald Prossliner wolfgang Lederer Department of General and Surgical Intensive Care Medicine Medical University of InnsbruckInnsbruck 6020Austria Department of Anesthesiology and Critical Care Medicine Wels-Grieskirchen HospitalWels 4600Austria Department of Transfusion Medicine Medical University of InnsbruckInnsbruck 6020Austria Department of Anaesthesia and Intensive Care Medicine Medical University of InnsbruckInnsbruck 6020Austria

BACKGROUND:We investigated whether the use of a specially designed visual estimation tool may improve accuracy in quantifying blood volumes related to surface ***:A prospective,paired-control,single-blinded experimental study was performed at a medical *** and emergency medical personnel estimated various blood volumes on surfaces with varying absorptivity(carpet,towel,polyvinyl chloride,wooden fl ooring)in an experimental *** assessed the sensitivity of training blood volume quantifi cation using a self-designed visual estimation tool by comparing the accuracy of visual blood volume estimations before and after practical training with the ***:A total of 352 estimations by 44 participants were *** estimations improved significantly from pre-training to post-training(P<0.05).The sensitivity of blood volume quantifi cation was 33.0%after training with the visual estimation *** did not depend on age,profession,gender or years of the estimator’s professional ***:Training with a visual estimation tool by professional rescuers can improve the estimation accuracy of blood volumes spread on surfaces with varying absorptivity.

关键词： Academic training Emergency medicine Hemorrhage control Major bleeding

Seasonal variations of PM10 -- Trace elements, PAHs and Levoglucosan: Rural sugarcane growing area versus coastal urban area in Southeastern Florida, USA. Part II: Elemental concentrations

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Particuology 2019年第5期17卷 99-108页

作者： Orhan Sevim oglu wolfgang F. Rogge Department of Environmental Engineering Cebze Technical University Cebze Kocaeli 41400 Turkey School of Engineering and Sierra Nevada Research Institute University of California Merced. 5200 North Lake Road Merced CA 95343 USA

The largest sugarcane-growing area in the United States is in South Florida. An estimated 7 million tons of dry sugarcane leafy biomass is removed from the fields before harvest by burning the leaves off the sugarcane stalks. Preharvest sugarcane leaf foliage burning is a major source of airborne particulate matter (PM), polycyclic aromatic hydrocarbons (PAHs), biogenic trace elements such as K, volatile hydrocarbons and other pollutants. In one harvesting period, approximately 22 million tons of C02, a greenhouse gas, is released, 7 million tons from leaf foliage preharvest burning alone and 15 million tons from burning sugarcane bagasse in the sugar mills for power generation. In this study, PMio was collected from Belle Glade, close to the sugarcane-growing area, and from Delray Beach, an urbanized area along the East Coast of Florida. The PM samples were analyzed for trace elements and close to organic compounds. To elucidate the importance of preharvest sugarcane biomass smoke emissions on air quality, 39 trace elements, 18 PAHs, and levoglucosan were selected to apportion ambient PM constituents. Al, Ca and to a great extend also Mg are the major soil-related trace elements and key markers for fugitive soil dust emissions. Similarly, sea salt aerosol blown from the Atlantic Ocean into Florida added appreciably to PMio trace elements concentration, especially Na and Cl. Approximately half of the sea salt aerosol (PMjo -portion) by mass is removed from the atmosphere during the transport of ocean air from Delray Beach to Belle Glade. Ambient acid displacement reactions caused a substantial portion of the Cl (30%) to be liberated from the sea salt aerosol to the atmosphere during transport as gaseous HC1. The PAH concentrations at Belle Glade were high when the biomass combustion markers levoglucosan and I< also showed the highest concentrations. This indicates that during the sugarcane harvest season, when leaf foliage is burned off just before harvest, most of

关键词： Urban versus rural Trace elements Sugarcane burning Rare earth elements Sea salt aerosol Potassium Levoglucosan PAHs