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Overlap of concurrent extrahepatic autoimmune diseases is associated with milder disease severity of newly diagnosed autoimmune hepatitis

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Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 21-27页

作者： Tobias Mühling Helmut Rohrbach wolfgang Schepp Felix Gundling Department of Gastroenterology Internal Medicine ⅡUniversity of WürzburgWürzburgGermany Department of Pathology Academic Teaching Hospital BogenhausenTechnical University of MunichMunich 81925Germany Department of Gastroenterology Hepatology and Gastrointestinal OncologyAcademic Teaching Hospital BogenhausenTechnical University of MunichMunich 81925Germany Department of Internal Medicine Division of GastroenterologyGastrointestinal Oncology and DiabetologyKemperhof KoblenzKoblenzGermany

Background:Concurrent extrahepatic autoimmune disorders(CEHAID)are frequently observed in autoimmune hepatitis(AIH).It is not clear whether there is any prognostic significance of CEHAID on *** aim of this study was to examine the prognostic impact of CEHAID and the correlation with the disease severity of ***:This study included 65 hospitalized subjects who fulfilled the accepted criteria for AIH during an 8-year period(2009–2016).All records were manually screened for presence of associated autoimmune *** severity of AIH was assessed by liver laboratory tests including the ratio of aspartate aminotransferase to alanine aminotransferase(AST/ALT)and liver ***:Among the enrolled patients,52(80%)were female(median age 61 years,IQR 45–75).Fifty-six(86.2%)were classified as type-1 *** 26(40%)patients at least one additional extrahepatic autoimmune disease was ***-four subjects were referred to our hospital because of acute presentation of AIH(supposed by an acute elevation of hepatic enzymes)for subsequent liver biopsy resulting in initial diagnosis of *** group was stratified into 3 subgroups:(A)AIH alone(n=14);(B)overlap with primary biliary cirrhosis(PBC)/primary sclerosing cholangitis(PSC)(n=11);and(C)with CEHAID(n=9).AST/ALT ratio was the lowest in subgroup C(median 0.64,IQR 0.51–0.94;P=0.023),compared to subgroup A(median 0.91,IQR 0.66–1.10)and subgroup B(median 1.10,IQR 0.89–1.36).Patients with AIH alone showed a trend to the highest grade of fibrosis(mean 2.3;95%CI:1.5–3.0)with no statistical significance compared to subjects with CEHAID(lowest grade of fibrosis;mean 1.5;95%CI:0.2–2.8;P=0.380)whereas the ongoing inflammation was ***:AST/ALT ratio and extent of fibrosis were lower in subjects with AIH and CEHAID,compared to subjects with only ***,the occurrence of CEHAID might be a predictor for lower disease severity of newly diagnosed acute onset AIH,possibly caused by an e

关键词： Autoimmune hepatitis Concurrent extrahepatic autoimmune disease Serum aminotransferase activities

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Formulation of carbon black-ionomer dispersions for thin film formation in fuel cells

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Particuology 2019年第3期17卷 7-21页

作者： Eva Hoffmann Su Zhang Martin Thoma Cornelia Damm wolfgang Peukert Institute of Particle Technology (LFG) Friedrich-Alexander-Universitat Erlangen-Niimberg (FAU) CauerstraJSe 4 D-91058 Erlangen Germany

The performance of proton exchange membrane fuel cells (PEMFC) is strongly determined by the structure and composition of the electrode *** interactions between the ionomer,carbon black particles,and solvent affect the suspension properties and thus the layer *** analyze the effect of the ionomer-to-carbon (I/C) weight ratio for two different types of carbon black on the suspension and layer *** branched carbon blacks with a high surface area tend to form less cracked *** less branched carbons can pack together more closely,a smaller pore size results in a larger capillary pressure during drying and thus more *** added ionomer adsorbs on the carbon particles and improves the colloidal stability of the carbon black *** carbon black aggregates are thus smaller,resulting in closer packing and thinner ***,the addition of the ionomer increases the critical coating thickness (CCT) of the layers because drying stresses are dissipated by the deformation of the ionomer,preventing crack *** optimum I/C weight ratio is identified for optimal layer formation and minimized crack formation.

关键词： Perfluorosulfonic acid (PFSA) ionomer Carbon black Layer formation Cracking Porosity

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Early warning and disaster management:the importance of geographic information(Part B)

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International Journal of Digital Earth 2010年第3期3卷 313-315页

作者： Guest Editors Milan Konecny wolfgang Reinhardt Laboratory on Geoinformatics and Cartography Institute of Geography Faculty of Science Masaryk UniversityKotlarska 261137 BRNOCzech Republic AGIS Geoinformatics Lab Institute of Applied Computer Science(INF4)University of the BundeswehrMu¨nchenGermany

This special issue is part of a double special issue(Part A was published in the previous issue of this journal)dealing with the role of Geographic Information(GI)for Early Warning(EW)and Disaster Management(DM).In the editorial of Part A we gave an introduction to the topic focussing on initiatives from the EU and China and we have highlighted the importance of Digital Earth for EWand *** have also reflected on the outcome of some events organized by the guest editors which were important for the topic and for this special issue.

关键词： journal disaster Early

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Flicker defined form and RareBit measurements lack in specificity of visual pathways

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International Journal of Ophthalmology(English edition) 2020年第3期13卷 417-424页

作者： Justyna Szkudlarek-Wodzinska Joanna Przezdziecka-Dolyk Olaf fuchs Ziemowit Poznanski Marta Misiuk-Hojlo Department of Ophthalmology Wroclaw Medical UniversityWroclaw 50-370Poland Department of Optics and Photonics University of Science and TechnologyWybrzeze Wyspianskiego 27Wroclaw 50-370Poland University of Edinburgh Old CollegeSouth BridgeEdinburgh EH89YLUK

AIM:To evaluate the different visual pathways represented by the Heidelberg Engineering Perimeter flicker defined form and RareBit(magnocellular and parvocellular respectively)in different age-groups and according to the ***:Totally 64 eyes of 32 healthy subjects were included in the prospective *** participant underwent screening—ophthalmic examination including best-corrected visual acuity,anterior and posterior segment assessment,and visual field examination with Heidelberg Edge Perimetry(HEP)-standard automated perimeter(SAP)*** were observed for 2 y previously to the *** helped to define that the enrolled patients did not bear the glaucoma-developing *** the screening and after two years the HEP had been conducted in the standard protocol 24-2 and RareBit perimetry(RBP)in accordance with the manufacturer’s *** were randomly assigned to the groups:flicker defined form(FDF)-first or *** defined from which additional visual field test the participant *** were additionally subdivided to younger and older study *** effect of subject variables was explored with Mann-Whitney *** for the presence of correlations between parameters was performed using the Spearman Rank Order Correlations and confirmed by the parametric *** the influence of additional factors,the Kruskal-Wallis test was ***:The positive correlation between meandeviation(MD)and mean hit rate(MHR)and pattern standard deviation(PSD)and standard deviation of MHR(±MHR)were found in younger study group(P=0.005,r=0.481 and P=0.0074,r=0.465),whereas in the older subgroup no correlation was ***,the randomization protocol helped in defining the role of fatigue on the HEP-FDF *** for whom the HEPFDF was performed after RareBit had significantly worse results than those for whom the HEP-FDF was *** the younger group,the MHR and±MHR depend from

关键词： perimetry RareBit flicker defined form

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类雇员——法制史、法教义学及法政治学上的思考

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法治现代化研究 2024年第1期8卷 179-191页

作者： [德]沃尔夫冈·赫罗马德卡李比特(译) 不详南京师范大学法学院中国法治现代化研究院

在发表《雇员概念及劳动法》(NZA 1997,569)这一基础理论性文章后,笔者又撰文对类雇员制度进行进一步探讨。从“类雇员”法律历史渊源到法教义学基础的长期发展最终形成该术语的定义。最后,笔者以相关法政治学上的思考作为结尾为本文画... 详细信息

在发表《雇员概念及劳动法》(NZA 1997,569)这一基础理论性文章后,笔者又撰文对类雇员制度进行进一步探讨。从“类雇员”法律历史渊源到法教义学基础的长期发展最终形成该术语的定义。最后,笔者以相关法政治学上的思考作为结尾为本文画上句号。

关键词：法教义学法制史法政治学理论性文章类雇员劳动法历史渊源

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New approaches for brazing temperature sensitive materials

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China Welding 2014年第3期23卷 21-25页

作者： wolfgang TiUmann Chunlai Liu Lukas Wojarski Institute of Materials Engineering Technical University of Dortmund

PVD deposited copper interlayers as filler materials were used in order to manufacture TLP brazed magnesium joints. The microstructure and interface characteristics of the overlap joints were investigated by optical microscopy, scanning electron microscope with energy dispersive spectrometer and tensile testing. Sound brazed joints could be achieved. The dwell time is the main factor to control the thickness of the reaction layer. It was shown that the deposited copper filler metal clearly reacted with the magnesium substrate , resulting in the formation of a magnesium solid solution （Mg） with different amount of copper, aluminum and zinc as well as Mg2Cu phases. With the progressing diffusion, the formation of intermetaUic compounds was suppressed and the hardness distribution in the brazing seam homogenized. The joints fractured at the interface, and the maximum average tensile shear strength of overlap joints reached 85 MPa.

关键词： brazing TLP diffusion magnesium

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CONVEXITY AND BERNSTEIN POLYNOMIALS ON k-SIMPLOIDS

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Acta Mathematicae Applicatae Sinica 1990年第1期6卷 50-66页

作者： wolfgang DAHMEN CHARLES A.MICCHELLI Institut fur Mathematik Ⅲ Freie Universitat Berlin Arnimallee 2-61000 Berlin(West)33GermanyIBM T.J.Watson Research CenterP.O.Box 218Yorktown HeightsN.Y.10598U.S.A.

This paper is concerned with Bernstein polynomials on k-simploids by which we mean a crossproduct of k lower dimensional simplices. Specifically, we show that if the Bernstein polynomials ofa given function f on a k-simploid form a decreasing sequence then f+l, where l is any correspondingtensor product of affine functions. achieves its maximum on the boundary of the k-simploid. Thisextends recent results in [1] for bivariate Bernstein polynomials on triangles. Unlike the approachused in [1] our approach is based on semigroup techniques and the maximum principle for secondorder elliptic operators. Furthermore, we derive analogous results for cube spline surfaces.

关键词： Tensor Product Recent Result Maximum Principle Cross Product Analogous Result

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Holocene Climate Evolution of the Ugii Nuur Basin, Mongolia

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Advances in Atmospheric Sciences 2008年第6期25卷 986-998页

作者： wolfgang SCHWANGHART Brigitta SCHTT Michael WALTHER Department of Environmental Sciences University of Basel Institute of Geographical Sciences Freie Universitt Berlin Mongolian Landscape Research Centre National University of Mongolia

In order to evaluate the Holocene palaeoenvironmental evolution of the Ugii Nuur basin, central Mongolia, investigations on chemical and mineralogical properties of lacustrine sediments were carried out on a 630 cm sediment core from lake Ugii Nuur. The interpretation of the record is based on a principal component analysis （PCA） of the elemental composition of the samples. The results show that lacustrine deposition started at 10.6 kyr BP. Low lake level conditions were identified during the Early Holocene （10.6-7.9 kyr BP）. The Mid Holocene （7.9-4.2 kyr BP） was characterized by generally higher lake levels and thus higher moisture supply, but it experienced strong climatic fluctuations. Arid conditions prevailed from 4.2-2.8 kyr BP and were followed by a stable, more humid phase until today.

关键词： lake sediments palaeoclimate Central Asia Mongolia Holocene

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The chromosome as a dynamic structure of the cell nucleus

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Cell Research 1993年第1期3卷 1-9页

作者： wolfgang Hennig Deparment of Molecular and Developmental Genetics University of Nijmegen Faculty of Science Toernooiveld The Netherlands Maχ-PlanckGuest Laboratory Shanghai Institute of Cell Biology Academia Sinica Shanghai China

Our view of eukaryotic chromosomes is still very much dictated by the classic ideas of geneticists and cytologists considering the chromosome just as a vehicle for genes. This one-sided view of chromosomes may have been strongly influenced by the many cytological observations made on polytene chromosomes. They, in particular, revealed that the activation of genes for transcription is accompanied by local decondensation of the chromosome as it becomes evident in the formation of puffs in polytene chromosomes. The studies of chromosomes have for many years been focused on the relationship between genes and bands or interbands as they are seen in polytene chromosomes (or in the supposed equivalents, the chromomeres, of meiotic prophase chromosomes). This has yielded much fruitful informations such as the first direct evidence for the relationship between differential gene activity and cellular differentiation by the demonstration by Clever that steroid hormones directly regulate gene activity at the chromosomal level.

关键词： Cell The chromosome as a dynamic structure of the cell nucleus cell

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Multi-cell Monte Carlo method for phase prediction

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npj Computational Materials 2019年第1期5卷 83-87页

作者： Changning Niu You Rao wolfgang Windl Maryam Ghazisaeidi Department of Materials Science and Engineering The Ohio State UniversityColumbusOH 43210USA Department of Physics The Ohio State UniversityColumbusOH 43210USA QuesTek Innovations LLC EvanstonIL 60201USA

We propose a Multi-Cell Monte Carlo algorithm,or(MC)2,for predicting stable phases in chemically complex crystalline *** algorithm takes advantage of multiple cells to represent possible phases,while eliminating the size and concentration restrictions in the previous *** atomic transfer among cells is achieved via the application of the lever rule,where an assigned molar ratio virtually controls the percentage of each cell in the overall simulation,making(MC)2 the first successful algorithm for simulating phase coexistence in crystalline *** the application of this method,all energies are directly computed via density functional theory *** test the method by successful prediction of the stable phases of known binary *** then apply the method to a quaternary high-entropy *** method is particularly powerful in predicting stable phases of multicomponent systems,for which phase diagrams do not exist.

关键词： prediction phase method

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