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Overlap of concurrent extrahepatic autoimmune diseases is associated with milder disease severity of newly diagnosed autoimmune hepatitis

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Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 21-27页

作者： Tobias Mühling Helmut Rohrbach wolfgang Schepp Felix Gundling Department of Gastroenterology Internal Medicine ⅡUniversity of WürzburgWürzburgGermany Department of Pathology Academic Teaching Hospital BogenhausenTechnical University of MunichMunich 81925Germany Department of Gastroenterology Hepatology and Gastrointestinal OncologyAcademic Teaching Hospital BogenhausenTechnical University of MunichMunich 81925Germany Department of Internal Medicine Division of GastroenterologyGastrointestinal Oncology and DiabetologyKemperhof KoblenzKoblenzGermany

Background:Concurrent extrahepatic autoimmune disorders(CEHAID)are frequently observed in autoimmune hepatitis(AIH).It is not clear whether there is any prognostic significance of CEHAID on *** aim of this study was to examine the prognostic impact of CEHAID and the correlation with the disease severity of ***:This study included 65 hospitalized subjects who fulfilled the accepted criteria for AIH during an 8-year period(2009–2016).All records were manually screened for presence of associated autoimmune *** severity of AIH was assessed by liver laboratory tests including the ratio of aspartate aminotransferase to alanine aminotransferase(AST/ALT)and liver ***:Among the enrolled patients,52(80%)were female(median age 61 years,IQR 45–75).Fifty-six(86.2%)were classified as type-1 *** 26(40%)patients at least one additional extrahepatic autoimmune disease was ***-four subjects were referred to our hospital because of acute presentation of AIH(supposed by an acute elevation of hepatic enzymes)for subsequent liver biopsy resulting in initial diagnosis of *** group was stratified into 3 subgroups:(A)AIH alone(n=14);(B)overlap with primary biliary cirrhosis(PBC)/primary sclerosing cholangitis(PSC)(n=11);and(C)with CEHAID(n=9).AST/ALT ratio was the lowest in subgroup C(median 0.64,IQR 0.51–0.94;P=0.023),compared to subgroup A(median 0.91,IQR 0.66–1.10)and subgroup B(median 1.10,IQR 0.89–1.36).Patients with AIH alone showed a trend to the highest grade of fibrosis(mean 2.3;95%CI:1.5–3.0)with no statistical significance compared to subjects with CEHAID(lowest grade of fibrosis;mean 1.5;95%CI:0.2–2.8;P=0.380)whereas the ongoing inflammation was ***:AST/ALT ratio and extent of fibrosis were lower in subjects with AIH and CEHAID,compared to subjects with only ***,the occurrence of CEHAID might be a predictor for lower disease severity of newly diagnosed acute onset AIH,possibly caused by an e

关键词： Autoimmune hepatitis Concurrent extrahepatic autoimmune disease Serum aminotransferase activities

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Interpreting Morphologically Homogeneous(Paleo-)Populations as Ecological Species Enables Comparison of Living and Fossil Organism Groups,Exemplified by Nummulitid Foraminifera

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Journal of Earth Science 2022年第6期33卷 1362-1377页

作者： Johann Hohenegger Ana Ivis Torres-Silva wolfgang Eder Institute for Paleontology University of Vienna1090ViennaAustria

Morphologically homogeneous groups,either living populations or fossil paleo-populations,must be regarded as ecological species,independent of their molecular genetic resemblance in living *** is always expressed during development by structure genes initiated from a network of regulator genes acting at different times and intensities,additionally being subjected to epigenetic ***,homogeneous populations influenced by the environment represent species better than the reproduction(biological species)or molecular-genetic approach using ancestral sequences like *** and fossil representatives of nummulitid foraminifera were chosen to demonstrate complete reconstruction of morphology using metrical growth-invariant and growth-independent *** these characters,6 models were established to define ecological species in living and fossil ***,a distinction between evolutionary and environmental effects in fossil forms was possible using discriminant analysis showing characters that are responsible for differentiating between evolutionary and environmental trends.

关键词： ecological species growth-invariant metrical characters morphology homogeneity nummulitids

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Formulation of carbon black-ionomer dispersions for thin film formation in fuel cells

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Particuology 2019年第3期17卷 7-21页

作者： Eva Hoffmann Su Zhang Martin Thoma Cornelia Damm wolfgang Peukert Institute of Particle Technology (LFG) Friedrich-Alexander-Universitat Erlangen-Niimberg (FAU) CauerstraJSe 4 D-91058 Erlangen Germany

The performance of proton exchange membrane fuel cells (PEMFC) is strongly determined by the structure and composition of the electrode *** interactions between the ionomer,carbon black particles,and solvent affect the suspension properties and thus the layer *** analyze the effect of the ionomer-to-carbon (I/C) weight ratio for two different types of carbon black on the suspension and layer *** branched carbon blacks with a high surface area tend to form less cracked *** less branched carbons can pack together more closely,a smaller pore size results in a larger capillary pressure during drying and thus more *** added ionomer adsorbs on the carbon particles and improves the colloidal stability of the carbon black *** carbon black aggregates are thus smaller,resulting in closer packing and thinner ***,the addition of the ionomer increases the critical coating thickness (CCT) of the layers because drying stresses are dissipated by the deformation of the ionomer,preventing crack *** optimum I/C weight ratio is identified for optimal layer formation and minimized crack formation.

关键词： Perfluorosulfonic acid (PFSA) ionomer Carbon black Layer formation Cracking Porosity

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Early warning and disaster management:the importance of geographic information(Part B)

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International Journal of Digital Earth 2010年第3期3卷 313-315页

作者： Guest Editors Milan Konecny wolfgang Reinhardt Laboratory on Geoinformatics and Cartography Institute of Geography Faculty of Science Masaryk UniversityKotlarska 261137 BRNOCzech Republic AGIS Geoinformatics Lab Institute of Applied Computer Science(INF4)University of the BundeswehrMu¨nchenGermany

This special issue is part of a double special issue(Part A was published in the previous issue of this journal)dealing with the role of Geographic Information(GI)for Early Warning(EW)and Disaster Management(DM).In the editorial of Part A we gave an introduction to the topic focussing on initiatives from the EU and China and we have highlighted the importance of Digital Earth for EWand *** have also reflected on the outcome of some events organized by the guest editors which were important for the topic and for this special issue.

关键词： journal disaster Early

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New approaches for brazing temperature sensitive materials

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China Welding 2014年第3期23卷 21-25页

作者： wolfgang TiUmann Chunlai Liu Lukas Wojarski Institute of Materials Engineering Technical University of Dortmund

PVD deposited copper interlayers as filler materials were used in order to manufacture TLP brazed magnesium joints. The microstructure and interface characteristics of the overlap joints were investigated by optical microscopy, scanning electron microscope with energy dispersive spectrometer and tensile testing. Sound brazed joints could be achieved. The dwell time is the main factor to control the thickness of the reaction layer. It was shown that the deposited copper filler metal clearly reacted with the magnesium substrate , resulting in the formation of a magnesium solid solution （Mg） with different amount of copper, aluminum and zinc as well as Mg2Cu phases. With the progressing diffusion, the formation of intermetaUic compounds was suppressed and the hardness distribution in the brazing seam homogenized. The joints fractured at the interface, and the maximum average tensile shear strength of overlap joints reached 85 MPa.

关键词： brazing TLP diffusion magnesium

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CONVEXITY AND BERNSTEIN POLYNOMIALS ON k-SIMPLOIDS

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Acta Mathematicae Applicatae Sinica 1990年第1期6卷 50-66页

作者： wolfgang DAHMEN CHARLES A.MICCHELLI Institut fur Mathematik Ⅲ Freie Universitat Berlin Arnimallee 2-61000 Berlin(West)33GermanyIBM T.J.Watson Research CenterP.O.Box 218Yorktown HeightsN.Y.10598U.S.A.

This paper is concerned with Bernstein polynomials on k-simploids by which we mean a crossproduct of k lower dimensional simplices. Specifically, we show that if the Bernstein polynomials ofa given function f on a k-simploid form a decreasing sequence then f+l, where l is any correspondingtensor product of affine functions. achieves its maximum on the boundary of the k-simploid. Thisextends recent results in [1] for bivariate Bernstein polynomials on triangles. Unlike the approachused in [1] our approach is based on semigroup techniques and the maximum principle for secondorder elliptic operators. Furthermore, we derive analogous results for cube spline surfaces.

关键词： Bernstein 多项式凸性

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Entecavir as treatment for reactivation of hepatitis B in immunosuppressed patients

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World Journal of Gastroenterology 2010年第43期16卷 5447-5451页

作者： Sylvia Brost Paul Schnitzler wolfgang Stremmel Christoph Eisenbach Department of Gastroenterology and Infectious Diseases University of Heidelberg Department of Infectious Diseases Virology University of Heidelberg

AIM: To study the efficacy and safety of entecavir (ETV) as first-line therapy for hepatitis B virus (HBV) reactivation due to immunosuppression. METHODS: Four patients that were treated with different immunosuppressive regimens for hematological malignancies, who presented with HBV reactivation were treated with ETV. Clinical outcome, biochemical and virological factors, including quantitative hepatitis B surface antigen (HBsAg) were studied. RESULTS: In all patients, ETV induced suppression of HBV, and rapid clinical improvement without side effects. In one patient with an alanine aminotransferase (ALT) flare, tenofovir was added after 3 mo of treatment. Until death from disease progression at 6 mo after treatment initiation, this patient did not clear HBV infection. Retrospectively, it is highly probable that thepatient had been non-adherent. In the other three patients, the virological responses were associated with an expeditious decrease in quantitative HBsAg titers with negativity after 2 mo, and all three had HBsAg seroconversion. In one patient, HBV DNA reached a plateau after 3 mo, before becoming undetectable after 1 year, despite early ALT normalization and undetectable quantitative HBsAg. CONCLUSION: ETV seems to be effective and safe treatment for HBV reactivation. Monitoring of quantitative HBsAg might be an additional useful tool to monitor treatment response.

关键词： Hepatitis B virus Entecavir Immunosuppression Hepatitis B surface antigen Seroconversion

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Holocene Climate Evolution of the Ugii Nuur Basin, Mongolia

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Advances in Atmospheric Sciences 2008年第6期25卷 986-998页

作者： wolfgang SCHWANGHART Brigitta SCHTT Michael WALTHER Department of Environmental Sciences University of Basel Institute of Geographical Sciences Freie Universitt Berlin Mongolian Landscape Research Centre National University of Mongolia

In order to evaluate the Holocene palaeoenvironmental evolution of the Ugii Nuur basin, central Mongolia, investigations on chemical and mineralogical properties of lacustrine sediments were carried out on a 630 cm sediment core from lake Ugii Nuur. The interpretation of the record is based on a principal component analysis （PCA） of the elemental composition of the samples. The results show that lacustrine deposition started at 10.6 kyr BP. Low lake level conditions were identified during the Early Holocene （10.6-7.9 kyr BP）. The Mid Holocene （7.9-4.2 kyr BP） was characterized by generally higher lake levels and thus higher moisture supply, but it experienced strong climatic fluctuations. Arid conditions prevailed from 4.2-2.8 kyr BP and were followed by a stable, more humid phase until today.

关键词： lake sediments palaeoclimate Central Asia Mongolia Holocene

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PD-1 and LAG-3: synergistic fostering of T cell exhaustion

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SIGNAL TRANSDUCTION AND TARGETED THERAPY 2024年第1期9卷 291页

作者： Hofmann, Maike Thimme, Robert Schamel, wolfgang W. Univ Freiburg Fac Med Med Ctr Dept Med 2 Freiburg Germany Univ Freiburg Signaling Res Ctr BIOSS & CIBSS Freiburg Germany Univ Freiburg Fac Biol Dept Immunol Freiburg Germany Univ Freiburg Fac Med Ctr Chron Immunodeficiency CCI Freiburg Germany

In the August issue of Cell 2024,three back-to-back papers disentangled non-redundant inhibitory mechanisms of PD-1 and LAG-3 in exhausted murine and human CD8+T cells.^(1-3) These findings will have a clear impact on... 详细信息

关键词： synergistic redundant finding

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Multi-cell Monte Carlo method for phase prediction

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npj Computational Materials 2019年第1期5卷 83-87页

作者： Changning Niu You Rao wolfgang Windl Maryam Ghazisaeidi Department of Materials Science and Engineering The Ohio State UniversityColumbusOH 43210USA Department of Physics The Ohio State UniversityColumbusOH 43210USA QuesTek Innovations LLC EvanstonIL 60201USA

We propose a Multi-Cell Monte Carlo algorithm,or(MC)2,for predicting stable phases in chemically complex crystalline *** algorithm takes advantage of multiple cells to represent possible phases,while eliminating the size and concentration restrictions in the previous *** atomic transfer among cells is achieved via the application of the lever rule,where an assigned molar ratio virtually controls the percentage of each cell in the overall simulation,making(MC)2 the first successful algorithm for simulating phase coexistence in crystalline *** the application of this method,all energies are directly computed via density functional theory *** test the method by successful prediction of the stable phases of known binary *** then apply the method to a quaternary high-entropy *** method is particularly powerful in predicting stable phases of multicomponent systems,for which phase diagrams do not exist.

关键词： prediction phase method

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