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Analysis of the lifetime and culling reasons for AI boars

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Journal of Animal Science and Biotechnology 2017年第4期8卷 866-874页

作者： Damian knecht Anna Jankowska-Maosa Kamil Duziński Institute of Animal Breeding Wroclaw University of Environmental and Life SciencesChelmonskiego 38C51–630 WroclawPoland

Background: The aim of the study was to analyze the lifetime and culling reasons for boars used in insemination centers(AI centers).Methods: The data collected from 355 culled boars from 1998 to 2013 included: age at start of semen collection,boar herd life, culling reason, daily gain and lean meat content, and number of ejaculates not meeting sales requirements after dilution. Culling reasons were divided into 7 groups: low semen value(LSV), low or lack of libido(LL), leg problems(LP), infectious diseases(ID), old age(OA), reduced demand for semen from the given boar(RD),and others(OT).Results: The most common culling reasons for boars were LSV(23.7%) and RD(22.5%). It was observed that the lowest daily gains were noted in boars culled due to OA. Boars culled due to OA and RD were maintained in production for the longest time(over 1000 d), for LSV and ID retention was about 700 d, and due to LL below 400 d. The survival probability was over 0.9 until 1.5 yr, and just over 0.2 until 4 yr. The highest relative frequency was observed in the 36 ^(th) and 42 ^(nd) mo of life(over 16%). Hazard risk analysis revealed a more than 10 times higher risk of culling in the case of LL, ID or OT, in comparison to ***: The results can be used as a direct point of reference for the identification of emerging problems in AI boar exploitation and the development of an appropriate culling policy in AI centers.

关键词： AI centers Boars Culling Exploitation Management

Non-Viral Deoxyribonucleoside Kinases——Diversity and Practical Use

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Journal of genetics and genomics 2015年第5期42卷 235-248页

作者： Louise Slot Christiansen Birgitte Munch-Petersen wolfga.g knecht Department of Biology Lund University Department of Science Systems and ModelsRoskilde University Lund Protein Production Platform Lund University

Deoxyribonucleoside kinases （dNKs） phosphorylate deoxyribonucleosides to their corresponding monophosphate compounds, dNks also phosphorylate deoxyribonucleoside analogues that are used in the treatment of cancer or viral infections. The study of the mammalian dNKs has therefore always been of great medical interest. However, during the last 20 years, research on dNKs has gone into non- mammalian organisms. In this review, we focus on non-viral dNKs, in particular their diversity and their practical applications. The diversity of this enzyme family in different organisms has proven to be valuable in studying the evolution of enzymes. Some of these newly discovered enzymes have been useful in numerous practical applications in medicine and biotechnology, and have contributed to our understanding of the structural basis of nucleoside and nucleoside analogue activation.

关键词： Nucleosides Nucleotides Nucleoside salvage pathway Evolution Suicide gene therapy Deoxynucleosides Deoxynucleotides Deoxy-nucleoside kinases

The ‘Urban Elements'method for teaching parametric urban design to professionals

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Frontiers of Architectural Research 2018年第4期7卷 573-587页

作者： Aurel yon Richthofen Katja knecht Yufan Miao Reinhard Konig ETH Zurich Future Cities Laboratory SingaporeSingapore-ETH CentreSingapore Bauhaus University Weimar Belvederer Allee 199423 WeimarGermany Austrian Institute of Technology Vienna TECHbase ViennaGiefinggasse 21210 ViennaAustria

The article proposes a method for teaching advanced urban design to working professionals in Singapore. The article aims to expand the discourse on parametric urban design education by introducing ‘Urban Elements’ as conceptual urban design instruments with an inherent rule-based logic, which can help to bridge gaps in teaching parametric urban design thinking. As case study we present a course developed for and delivered to the Urban Redevelopment Authority (URA) in Singapore in 2017 by the Future Cities Laboratory at the Singapore-ETH Centre. The article reports on the pedagogical method, course results and course feedback. The main difficulties of teaching professionals in parametric urban design are described and possible reasons and improvements are discussed. The results show that participants using the ‘Urban Elements’ method successfully linked theoretical input to urban design problems, applied evidence-based urban design strategies to these problems, and developed parametric definitions to explore the solution spaces of these urban design challenges. The teaching methodology presented opens up a new research field for urban design pedagogy at the intersection of explicating urban design intent, integrating multidisciplinary knowledge and exploring new software driven tools.

关键词： Urban design education Parametric urban design Singapore Urban Elements

血管免疫母细胞淋巴腺病；——10年经验和现今的知识状态

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国外医学（输血及血液学分册） 1990年第3期13卷 162-163页

作者： knecht H 杜心垿

美国文献中此病被称为免疫母细胞淋巴腺病(IBL)或血管免疫母细胞淋巴腺病伴异常蛋白血症(AILD),Kiel淋巴瘤组称它为淋巴肉芽肿病X(LgX).组织病理学定义AILD、IBL和LgX的组织学诊断依据的主要表现是一致的,即淋巴结结构被涂抹、血管增生... 详细信息

美国文献中此病被称为免疫母细胞淋巴腺病(IBL)或血管免疫母细胞淋巴腺病伴异常蛋白血症(AILD),Kiel淋巴瘤组称它为淋巴肉芽肿病X(LgX).组织病理学定义AILD、IBL和LgX的组织学诊断依据的主要表现是一致的,即淋巴结结构被涂抹、血管增生和多样性的细胞学.但三者的附加表现不同,IBL的诊断还需有淋巴细胞消减和间质中PAS阳性物质,以及无残存滤泡的表现.

关键词： AILD 病理淋巴细胞病

转抗性基因甘蓝型油菜对甜菜孢囊线虫抗性的影响

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植物保护学报 2008年第6期35卷 571-572页

作者：唐桂香秦叶波杨晓风 knecht Katrin DaguangCai 浙江大学农业与生物技术学院作物科学研究所杭州310029 德国基尔大学分子植物病理研究所基尔德国

全世界每年由线虫造成的农作物经济损失约达100亿美元[1]。生产上常用化学杀虫剂、作物轮作、选育抗性品种和种植抗性诱捕植物控制线虫[2]。随着植物抗性基因的克隆,寄主与病原物相互作用机制的探明,抗性基因在抗性育种中展示了诱人前景... 详细信息

全世界每年由线虫造成的农作物经济损失约达100亿美元[1]。生产上常用化学杀虫剂、作物轮作、选育抗性品种和种植抗性诱捕植物控制线虫[2]。随着植物抗性基因的克隆,寄主与病原物相互作用机制的探明,抗性基因在抗性育种中展示了诱人前景[1-2]。油菜是重要的油料作物,也是孢囊线虫的寄主[3],但油菜本身不含孢囊线虫抗性基因,国内外学者采用与抗孢囊线虫的野生油萝卜***.和白芥Sinapis albaL.种间杂交的方法将抗性基因引入甘蓝型油菜BrassicanapusL.中,但油菜附加系在后代表达不稳定[4-5]。为此,本研究采用农杆菌介导法将抗性基因cZR3转入甘蓝型油菜中,并采用离体鉴定方法研究转基因油菜对甜菜孢囊线虫抗性的影响。1材料与方法1.1材料:转化受体材料为甘蓝型油菜品种浙双758。农杆菌菌株为gV3101,含有植物表达载体PAM194-cZR3。

关键词：植物抗性基因孢囊线虫甘蓝型油菜甜菜相互作用机制化学杀虫剂经济损失作物轮作

gradients of a state-averaged DMRg wave function

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Gradients of a state-averaged DMRG wave function

Density-matrix renormalization group utility in MOLCAS

中国化学会第十二届全国量子化学会议

作者： Yingjin Ma Sebastian Keller Stefan knecht Markus Reiher ETH Zürich Laboratorium für Physikalische Chemie

The present study suggests an approximation for the construction of an effective density for geometry gradient evaluations in State-Averaged Density-Matrix Renormalization group Self-Consistent Field（SA-DMRg-SCF）*** algorithm used here is based on the SA Multi-Configurational SCF（SA-MCSCF）gradient equation[1-3],in which Lagrange multipliers are indispensable in order to get a fully variational MCSCF state in the state-averaged ***,x is a coordinate,denotes the state,is the Lagrangian of given state energy,is the orbital Lagrange multiplier and is the CI Lagrange multiplier,p,q,r,s denote orbitals,denotes a determinant,and denotes any state-averaged state with *** solving for the Lagrange multipliers（and,together denoted as）used in the gradient equation,the linear response（LR）equation,where E[2]is the electronic Hessian,has to be constructed and *** there are no CI coefficients and the Hamiltonian is large in the DMRg algorithm,we use our sampling-reconstruction technique to construct the most important CI coefficients from a DMRg wavefunction[4]and then use the reconstructed CI coefficients together with the LR equation to get the Lagrange ***,the gradient equation can be solved,so that the geometry optimization aiming at a specific electronic state in SA-DMRg-SCF can be carried out.

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Density-matrix renormalization group utility in MOLCAS

中国化学会第十二届全国量子化学会议

作者： Sebastian Keller Yingjin Ma Stefan knecht Markus Reiher ETH Zürich Laboratorium für Physikalische Chemie

In this work,we set up the Density-Matrix Renormalization group（DMRg）interface in MOLCAS *** the DMRg interface,MOLCAS can handle a much larger active space（e.g,40 electrons in 40 orbitals）than that of the standard Full Configuration Iteration（FCI）method（at most 18 electrons in 18 orbitals）.At this stage,we already combined the DMRg with the"RASSCF"module in MOLCAS,so that one can use MOLCAS to do single-point DMRg-SCF calculations with or without state-averaged（SA）treatment,as well as geometry optimization with state-specific（SS）DMRg-SCF[1].The DMRg utility integrated in MOLCAS is a new and highly efficient program based on the MAQUIS DMRg project for quantum chemical DMRg calculations[2].The Matrix-Product-State（MPS）DMRg algorithm is used in this *** algorithm allows to 1)solve the Schrdinger equation in the orthogonal complement of one or several given states,and as such,the preserved states used in DMRg is quite small in contrast to the traditional DMRg algorithm in SA treatment;2)get 1’-,2’-or even higher reduced density matrices more straightforwardly than in the traditional DMRg[3],which is an advantage when combining DMRg with orbital optimization or multi-reference ***,spin-adapted MPS-DMRg,DMRg with perturbation theory,as well as geometry optimization of a specific state in SA-DMRg-SCF are under developing in our *** will also be included in Molcas in the near future.

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节省大量空间

现代制造 2014年第5期 46-47页

作者： Dietmar knecht

几乎在所有的机床设备制造领域中：都采用了IPC工业计算机或者工业PC平台来完成各种各样的自动化控制任务，而各种各样的生产环境又对如今的工业PC提出了种种不同的要求。冲击、振动以及很高或很低的温度都对PC系统的使用寿命有着重要... 详细信息

几乎在所有的机床设备制造领域中：都采用了IPC工业计算机或者工业PC平台来完成各种各样的自动化控制任务，而各种各样的生产环境又对如今的工业PC提出了种种不同的要求。冲击、振动以及很高或很低的温度都对PC系统的使用寿命有着重要的影响。

关键词：空间工业计算机自动化控制制造领域机床设备 PC平台工业PC 生产环境

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欧瑞康赐来福短纤行业的风向标

江苏纺织 2008年第7期 21-22页

作者： Ralph knecht

中国国际纺织机械展览会暨ITMA亚洲展览会于2008年7月27日至2008年7月31日在上海举行，作为全球短纤行业的风向标，欧瑞康赐来福将向所有参观者呈现其在环锭纺、转杯纺、自动络筒领域无可取代的创新技术和领先设备，以及大量来自德国的... 详细信息

中国国际纺织机械展览会暨ITMA亚洲展览会于2008年7月27日至2008年7月31日在上海举行，作为全球短纤行业的风向标，欧瑞康赐来福将向所有参观者呈现其在环锭纺、转杯纺、自动络筒领域无可取代的创新技术和领先设备，以及大量来自德国的最新科研技术成果和专业的纺纱方案。

关键词：风向标中国国际纺织机械展览会行业短纤 ITMA 创新技术技术成果环锭纺