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4 - 16 Dissociative Recombination of Imidogen Radical Ions

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IMP & HIRFL Annual Report 2012年第1期 215-216页

作者： Yang Bian Novotny Oldnich KrantzClaude BuhrHenrik MendesMario Nordhorn Christian Geppert Dietrich wolf Berg Max BingDennis Domesle Christian Grussie Florian Savin wolf Daniel Schwalm Dirk CaiXiaohong wolf andreas

Data-driven prediction of plate velocities and plate deformation of explosive reactive armor

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Defence Technology（防务技术） 2022年第12期18卷 2141-2149页

作者： Marvin Becker andreas Klavzar Thomas wolf Melissa Renck Institute of Saint-Louis 5 Rue du Général Cassagnou68330Saint LouisCedexFrance Ecole Centrale de Lille CitéScientifique59651Villeneuve d'AscqCedexFrance

Explosive reactive armor(ERA)is currently being actively developed as a protective system for mobile devices against ballistic threats such as kinetic energy penetrators and shaped-charge *** mobility,the aim is to design a protection system with a minimal amount of required *** efficiency of an ERA is sensitive to the impact position and the timing of the ***,different designs have to be tested for several impact scenarios to identify the best *** analytical models are not predicting the behavior of the ERA accurately enough and experiments,as well as numerical simulations,are too time-consuming,a data-driven model to estimate the displacements and deformation of plates of an ERA system is proposed *** ground truth for the artificial neural network(ANN)is numerical simulation results that are validated with *** ANN approximates the plate positions for different materials,plate sizes,and detonation point positions with sufficient accuracy in *** a future investigation,the results from the model can be used to estimate the interaction of the ERA with a given ***,a measure for the effectiveness of an ERA can be ***,an optimal ERA can be designed and analyzed for any possible impact scenario in negligible time.

关键词： Artificial neural network Explosive reactive armor Finite element simulation Particle simulation Flash X-ray

Stroke recovery enhancing therapies:lessons from recent clinical trials

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Neural Regeneration Research 2022年第4期17卷 717-720页

作者： andreas Rogalewski wolf-Rüdiger Schäbitz Department of Neurology Bethel-EVKBUniversity of BielefeldBielefeldGermany

Poststroke recovery processes include restoration or compensation of function,respectively functions initially lost or new functions acquired after an *** interventions can enhance these processes and/or reduce processes impeding *** experimental studies suggest great opportunities for such treatments,but the results from recent large clinical trials using neuromodulators such as dopamine and fluoxetine are *** reasons for this are manifold affecting forward translation of results from animals models into the human ***"translational road block"is defined by differences between animals and humans with regard to the genetic and epigenetic background,size and anatomy of the brain,cerebral vascular anatomy,immune system,as well as clinical function and *** blockade includes the incompatible adaption of targets and outcomes in clinical trials with regard to prior preclinical *** example,the design of clinical recovery trials varies widely and was characterized by the selection of different clinical endpoints,the inclusion a broad spectrum of stroke subtypes and clinical syndromes as well as different time windows for treatment initiation after infarct *** review will discuss these aspects based on the results of the recent stroke recovery trials with the goal to contribute to the currently biggest unmet need in stroke research-the development of a recovery enhancing therapy that improves the functional outcome of a chronic stroke patient.

关键词： amphetamine brain chronic stroke clinical trial dopamine fluoxetine recovery regeneration serotonin reuptake inhibitor translation

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Asian Journal of Andrology 2007年第3期9卷 299-304页

作者： Raft Henkel Gesa Maaβ andreas Jung Gerhard Haidl wolf-Bernhard Schill Hans-Christian Schuppe Department of Medical Biosciences University of the Western Cape Bellville 7535 South Africa Centre for Dermatology and Andrology Justus Liebig University 35385 Giessen Germany Department of Dermatology Rheinische Friedrich-Wilhelms University 53105 Bonn Germany

Aim： To investigate age-related inflammatory events in the male genital tract. Methods： In a total of 4 265 randomly collected patients attending the andrological outpatient clinic of the Center for Dermatology and Andrology, University of Giessen, Germany, ejaculate volume, pH-value, sperm concentration, total and progressive sperm motility, concentration of polymorphonuclear （PMN） elastase, number of peroxidase-positive cells and fructose were measured and correlated with patient＇s age. Results： While ejaculate volume, motility and fructose all correlated negatively with age, sperm concentration, PMN elastase and the pH-value showed a positive correlation. The prevalence of male genital tract inflammation （as defined by PMN elastase 〉 250 ng/mL） and its severity increased significantly. PMN elastase did not correlate with sperm motility. Fructose as a marker of seminal vesicle function showed a significant negative relationship with the PMN elastase levels, the number of peroxidase-positive cells and sperm motility. Conclusion： The significant increases of PMN elastase levels as marker of male genital tract inflammation in older men appear to be indicative of age-related changes in local immunoregulatory mechanisms. Because there is no association of PMN elastase with sperm motility, a direct inhibitory effect of this enzyme can be excluded.

关键词： aging men male genital tract inflammation polymorphonuclear elastase leukocytes infertility human semen

Exploring the degradation behavior of MgXAg alloys by in vitro electrochemical methods

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Bioactive Materials 2022年第1期7卷 441-452页

作者： Yuqiuhan Zhang Tycho Zimmermann wolf-Dieter Mueller Frank Witte Florian Beuer andreas Schwitalla Charit´e-Universit¨atsmedizin Berlin corporate member of Freie Universit¨at Berlin and Humboldt-Universit¨at zu BerlinDental Materials and Biomaterial ResearchDepartment of ProsthodonticsGeriatric Dentistry and Craniomandibular DisordersAßmannshauser Str.4-614197BerlinGermany

Magnesium as biodegradable biomaterial could serve as bone augmentation material in implant *** knowledge about the predictability of the biodegradation process is essential as this process needs to go hand in hand with the formation of new bone to gradually replace the augmentation ***,this work aimed to assess if the electrochemistry(EC)measurements of the corrosion process correlate with the surface features at various time points during the surface degradation,in order to describe the degradation process of Mg and Mg alloys more reliably,under the assumption that differences in EC behavior can be detected and related to specific patterns on the *** this test setup,a special optical chamber was used for electrochemical measurements on Mg and Mg-alloys(Mg2Ag,Mg4Ag,and Mg6Ag).Specimens were investigated using different circulating cell culture solutions as electrolytes,these were minimum essential medium(MEM),Hank’s Balanced Salt Solution(HBSS),and MEM+(MEM with added sodium hydrogen carbonate)at 37℃.Open circuit potential measurements(OCP)over 30 min followed by cyclic polarization were *** electrochemistry data,including OCP,exchange current density and corrosion potential,were compared with visible changes at the surface during these treatments over *** results show that the addition of silver(Ag)leads to a“standardization”of the degradation regardless of the selected test *** is currently difficult to correlate the visible microscopic changes with the data taken from the ***,further investigations are necessary.

关键词： Biodegradable magnesium Magnesium silver alloys Electrochemistry Hydrogen evolution

Multiple cerebral lesions in a patient with refractory celiac disease:A case report

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World Journal of Gastroenterology 2020年第47期26卷 7584-7592页

作者： Lena Horvath Georg Oberhuber andreas Chott Maria Effenberger Herbert Tilg Eberhard Gunsilius Dominik wolf Sarah Iglseder Department of Internal Medicine V(Hematology and Medical Oncology) Medical University InnsbruckInnsbruck 6020Austria InnPath GmbH Institute of PathologyInnsbruck 6020Austria Ottakring Clinic Institute of Pathology and MicrobiologyVienna 1160Austria Department of Internal Medicine I(Gastroenterology HepatologyEndocrinology and Metabolism)Medical University InnsbruckInnsbruck 6020Austria Department of Neurology Medical University InnsbruckInnsbruck 6020Austria

BACKGROUND Enteropathy-associated T cell lymphoma(EATL)is an aggressive intestinal T cell lymphoma derived from intraepithelial lymphocytes,which occurs in individuals with celiac disease(CD).Cerebral involvement is an extremely rare condition and as described so far,lymphoma lesions may present as parenchymal predominantly supratentorial or leptomeningeal *** describe a case of EATL with multifocal supra-and infratentorial brain involvement in a patient with refractory celiac disease(RCD).CASE SUMMARY A 58-years old man with known CD developed ulcerative jejunitis and was diagnosed with RCD type *** months later he presented with subacute cerebellar symptoms(gait ataxia,double vision,dizziness).Cranial magnetic resonance imaging(MRI)revealed multifocal T2 hyperintense supra-and infratentorial *** studies of blood and cerebrospinal fluid were inconspicuous for infectious,inflammatory or autoimmune diseases.18Ffluorodeoxyglucose-positron emission tomography/computed tomography(18FDG-PET/CT)scan showed a suspect hypermetabolic lesion in the left upper abdomen and consequent surgical jejunal resection revealed the diagnosis of *** the diagnostic work-up,neurological symptoms aggravated and evolved refractory to high-dosage *** MRI scans showed progressive cerebral lesions,highly suspicious for lymphoma and methotrexate chemotherapy was ***,clinically the patient responded only ***,cerebral biopsy confirmed the diagnosis of cerebral involvement of *** the poor prognosis and deterioration of the performance status,best supportive care was *** patient passed away three weeks after *** EATL with cerebral involvement must be considered as a possible differential diagnosis in patients with known RCD presenting with neurological symptoms.

关键词： Enteropathy-associated T cell lymphoma Brain neoplasm Celiac disease Cerebellar syndrome Case report

Human primary muscle stem cells regenerate injured urethral sphincter in athymic rats

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Animal Models and Experimental Medicine 2022年第5期5卷 453-460页

作者： Biniam M.Bekele Verena Schöwel-wolf Janine Kieshauer andreas Marg andreas Busjahn Sarah Davis Gayle Nugent Anne-Karoline Ebert Simone Spuler Muscle Research Unit Experimental and Clinical Research Centera cooperation between the Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association and the CharitéUniversitätsmedizin BerlinBerlinGermany CharitéUniversitätsmedizin BerlinGermany Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association BerlinGermany Berlin Institute of Health at CharitéUniversitätsmedizin BelrinGermany HealthTwist GmbH BerlinGermany Charles River Laboratories MattawanMichiganUSA Department of Urology and Pediatric Urology University Hospital UlmUlmGermany

Background:The aim of the study was to demonstrate the efficacy of human muscle stem cells(MuSCs)isolated using innovative technology in restoring internal urinary sphincter function in a preclinical animal ***:Colonies of pure human MuSCs were obtained from muscle biopsy *** rats were subjected to internal urethral sphincter damage by *** days after injury,2×105 muscle stem cells or medium as control were injected into the area of sphincter damage(n=5 in each group).Peak bladder pressure and rise in pressure were chosen as outcome *** repeatedly obtain the necessary pressure values,telemetry sensors had been implanted into the rat bladders 10 days prior to ***:There was a highly significant improvement in the ability to build up peak pressure as well as a pressure rise in animals that had received muscle stem cells as compared to control(p=0.007)3 weeks after the cells had been *** mini-mal histologic evidence of scarring was observed in treated ***:Primary human muscle stem cells obtained using innovative technology functionally restore internal urethral sphincter function after *** into use in clinical settings is foreseeable.

关键词： human muscle stem cells sphincter injury telemetry urinary incontinence urodynamics

Field-effect passivation on silicon nanowire solar cells

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Nano Research 2015年第2期8卷 673-681页

作者： Anna Dalmau Mallorqui Esther Alarcon-Llado Ignasi Canales Mundet Amirreza Kiani Benedicte Demaurex Stefaan De wolf andreas Menzel Margrit Zacharias Anna Fontcuberta i Morra Laboratoire des Materiaux Semiconducteurs Ecole Polytechnique Federale de Lausanne 1015 Lausanne Switzerland Photovoltaics and Thin Film Electronics Laboratory Institute o fMicroengineering (IMT) E-cole Polytechnique Federale de Lausanne 2000 Neuchotel Switzerland Nanotechnology Institute of Microsystems Engineering(IMTEK) Albert-Ludwigs-University 79110 Freiburg Germany

Surface recombination represents a handicap for high-efficiency solar cells. This is especially important for nanowire array solar cells, where the surface-to-volume ratio is greatly enhanced. Here, the effect of different passivation materials on the effective recombination and on the device performance is experimentally analyzed. Our solar cells are large area top-down axial n-p junction silicon nanowires fabricated by means of Near-Field Phase-Shift Lithography （NF-PSL）. We report an efficiency of 9.9% for the best cell, passivated with a SiO2/SiNx stack. The impact of the presence of a surface fixed charge density at the silicon/oxide interface is studied.

关键词： field-effect passivation nanowire surface recombination solar cell

Yangtze Three Gorges Reservoir, China: A holistic assessment of organic pollution, mutagenic effects of sediments and genotoxic impacts on fish

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Journal of Environmental Sciences 2015年第12期27卷 63-82页

作者： Tilman Floehr Bj?rn Scholz-Starke Hongxia Xiao Josef Koch Lingling Wu Junli Hou Anja wolf Axel Bergmann Kerstin Bluhm Xingzhong Yuan Martina Ro?-Nickoll andreas Sch?ffer Henner Hollert Department of Ecosystem Analysis Institute for Environmental ResearchRWTH Aachen University Key Laboratory of Yangtze River Water Environment Ministry of EducationTongji University East China Sea Fisheries Research Institute IWW Rhenish-Westfalian Institute for Water Research Institute for Applied Geosciences Technische Universit?t Darmstadt College of Resources and Environmental Science Chongqing University State Key Laboratory of Pollution Control and Research Reuse School of the EnvironmentNanjing University

Besides obvious benefits,the Three Gorges Dam＇s construction resulted in new pollution scenarios with the potentials to threaten the Three Gorges Reservoir（TGR） *** order to record organic contamination,to find links to ecotoxicological impacts and to serve as reference for ensuing monitoring,several sites in the TGR area were screened applying the triad approach with additional lines-of-evidence as a holistic assessment *** and the benthic fish species Pelteobagrus vachellii were sampled in 2011 and 2012 to determine organic pollution levels,mutagenic potentials and genotoxic *** regional hot-spots near the cities of Chongqing and Kaixian were identified and further investigated in *** polycyclic aromatic hydrocarbons（PAHs） could be detected in sediments in 2011（165-1653 ng/g）,emphasizing their roles as key pollutants of the *** ubiquity was confirmed at Chongqing（150-433 ng/g） and Kaixian（127-590 ng/g） *** were comparable to other major Chinese and German ***,the immense sediment influx suggested a deposition of 216-636 kg PAH/day（0.2-0.6 mg PAH/（m2·day））,indicating an ecotoxicological *** source analysis highlighted primary impacts of combustion sources on the more industrialized upper TGR section,whereas petrogenic sources dominated the mid-low ***,sediment extracts from several sites exhibited significant activities of frameshift promutagens in the Ames fluctuation ***,significant genotoxic impairments in erythrocytes of *** were detected（Chongqing/Kaixian）,demonstrating the relevance of genotoxicity as animportant mode of action in the TGR＇s ***,their derivatives and non-target compounds are considered as main causative agents.

关键词： Yangtze Three Gorges Reservoir Triad approach Sediment Fish Mutagenicity Genotoxicity PAH