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Modern approaches for detection of volatile organic compounds in metabolic studies focusing on pathogenic bacteria:Current state of the art

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Journal of Pharmaceutical Analysis 2024年第4期14卷 483-505页

作者： Karolina Zuchowska wojciech Filipiak Department of Pharmacodynamics and Molecular Pharmacology Faculty of PharmacyCollegium Medicum in BydgoszczNicolaus Copernicus University in Torun85-089 BydgoszczPoland

Pathogenic microorganisms produce numerous metabolites,including volatile organic compounds(VOCs).Monitoring these metabolites in biological matrices(e.g.,urine,blood,or breath)can reveal the presence of specific microorganisms,enabling the early diagnosis of infections and the timely implementation of tar-geted ***,complex matrices only contain trace levels of VOCs,and their constituent com-ponents can hinder determination of these ***,modern analytical techniques enabling the non-invasive identification and precise quantification of microbial VOCs are *** this paper,we discuss bacterial VOC analysis under in vitro conditions,in animal models and disease diagnosis in humans,including techniques for offline and online analysis in clinical *** also consider the advantages and limitations of novel microextraction techniques used to prepare biological samples for VOC analysis,in addition to reviewing current clinical studies on bacterial volatilomes that address inter-species in-teractions,the kinetics of VOC metabolism,and species-and drug-resistance specificity.

关键词： Volatile organic compounds Pathogenic bacteria metabolites Metabolomics Microextraction techniques Gas chromatography-mass spectrometry In vivo breath analysis In vitro model

Microfluidic bubble-generator enables digital light processing 3D printing of porous structures

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Aggregate 2024年第1期5卷 280-291页

作者： Philipp Weber Ling Cai Francisco Javier Aguilar Rojas Carlos Ezio Garciamendez-Mijares Maria Celeste Tirelli Francesco Nalin Jakub Jaroszewicz wojciech Swi eszkowski Marco Costantini Yu Shrike Zhang Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMassachusettsUSA Institute of Physical Chemistry—Polish Academy of Sciences KasprzakaPoland Biomaterials Group Materials Design DivisionFaculty of Materials Science and EngineeringWarsaw University of TechnologyWoloskaPoland

Three-dimensional(3D)printing is an emerging technique that has shown promising success in engineering human tissues in recent *** development of vatphotopolymerization printing modalities has significantly enhanced the complexity level for 3D printing of various functional structures and ***,the development of microfluidic chip systems is an emerging research sector with promising medical *** work demonstrates the coupling of a digital light processing(DLP)printing procedure with a microfluidic chip system to produce size-tunable,3D-printable porosities with narrow pore size distributions within a gelatin methacryloyl(GelMA)hydrogel *** is found that the generation of size-tunable gas bubbles trapped within an aqueous GelMA hydrogel-precursor can be controlled with high ***,the porosities are printed in two-dimensional(2D)as well as in 3D using the DLP *** addition,the cytocompatibility of the printed porous scaffolds is investigated using fibroblasts,where high cell viabilities as well as cell proliferation,spreading,and migration are *** is anticipated that the strategy is widely applicable in a range of application areas such as tissue engineering and regenerative medicine,among others.

关键词： 3D printing biofabrication bubble digital light processing microfluidics porous

Targeting miRNA by CRISPR/Cas in cancer:advantages and challenges

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Military Medical Research 2024年第3期11卷 345-373页

作者： Bashdar Mahmud Hussen Mohammed Fatih Rasul Snur Rasool Abdullah Hazha Jamal Hidayat Goran Sedeeq Hama Faraj Fattma Abodi Ali Abbas Salihi Aria Baniahmad Soudeh Ghafouri-Fard Milladur Rahman Mark C.Glassy wojciech Branicki Mohammad Taheri Department of Biomedical Sciences Cihan University-ErbilErbilKurdistan Region 44001Iraq Department of Clinical Analysis College of PharmacyHawler Medical UniversityErbilKurdistan Region 44001Iraq Department of Pharmaceutical Basic Science Faculty of PharmacyTishk International UniversityErbilKurdistan Region 44001Iraq Medical Laboratory Science Lebanese French UniversityErbilKurdistan Region 44001Iraq Department of Biology College of EducationSalahaddin University-ErbilErbilKurdistan Region 44001Iraq Department of Medical Laboratory Science Komar University of Science and TechnologySulaymaniyah 46001Iraq Department of Medical Microbiology College of Health SciencesHawler Medical UniversityErbilKurdistan Region 44001Iraq Department of Biology College of ScienceSalahaddin University-ErbilErbilKurdistan Region 44001Iraq Center of Research and Strategic Studies Lebanese French UniversityErbil 44001Iraq Institute of Human Genetics Jena University Hospital07747 JenaGermany Department of Medical Genetics School of MedicineShahid Beheshti University of Medical SciencesTehran 374-37515Iran Department of Clinical Sciences MalmöSection for SurgeryLund University22100 MalmöSweden Translational Neuro-Oncology Laboratory San Diego(UCSD)Moores Cancer CenterUniversity of CaliforniaSan DiegoCA 94720USA Faculty of Biology Institute of Zoology and Biomedical ResearchJagiellonian University31-007 KrakówPoland Urology and Nephrology Research Center Shahid Beheshti University of Medical SciencesTehran 374-37515Iran

Clustered regulatory interspaced short palindromic repeats(CRISPR)has changed biomedical research and provided entirely new models to analyze every aspect of biomedical sciences during the last *** the study of cancer,the CRISPR/CRISPR-associated protein(Cas)system opens new avenues into issues that were once unknown in our knowledge of the non-coding genome,tumor heterogeneity,and precision ***/Cas-based geneediting technology now allows for the precise and permanent targeting of mutations and provides an opportunity to target small non-coding RNAs such as microRNAs(miRNAs).However,the development of effective and safe cancer gene editing therapy is highly dependent on proper design to be innocuous to normal cells and prevent introducing other *** study aims to highlight the cutting-edge approaches in cancer-gene editing therapy based on the CRISPR/Cas technology to target miRNAs in cancer ***,we highlight the potential challenges in CRISPR/Cas-mediated miRNA gene editing and offer advanced strategies to overcome them.

关键词： CRISPR CRISPR/Cas9 CRISPR/Cas12 Gene editing miRNAs Cancer therapy

Surgical and non-surgical risk factors affecting the insufficiency of ileocolic anastomosis after first-time surgery in Crohn’s disease patients

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3253-3260页

作者： Jaroslaw Cwaliński Filip Lorek Łukasz Mazurkiewicz MichałMazurkiewicz wojciech Lizurej Jacek Paszkowski Hanna Cholerzyńska Wiktoria Zasada Department of General Endocrinological Surgery and Gastroenterological OncologyPoznan University of Medical SciencesPoznan 60-355Poland

BACKGROUND Crohn's disease(CD)often necessitates surgical intervention,particularly when it manifests in the terminal ileum and ileocecal *** undergoing radical surgery,a subset of patients experiences recurrent inflammation at the anasto-motic site,necessitating further medical *** To investigate the risk factors associated with anastomotic insufficiency following ileocecal resection in CD *** This study enrolled 77 patients who underwent open ileocolic resection with pri-mary stapled *** were stratified into two groups:Group I co-mprised individuals without anastomotic insufficiency,while Group II included patients exhibiting advanced anastomotic destruction observed endoscopically or those requiring additional surgery during the follow-up *** and non-surgical factors potentially influencing anastomotic failure were evaluated in both *** Anastomotic insufficiency was detected in 12 patients(15.6%),with a mean time interval of 30 months between the initial surgery and *** predomi-nant reasons for re-intervention included stenosis and excessive perianastomotic *** associated with a heightened risk of anastomotic failure encompassed prolonged postoperative obstruction,anastomotic bleeding,and clinically confirmed ***,patients in Group II exhibited preoperative malnutrition and early recurrence of symptoms related to *** Successful surgical outcomes hinge on the attainment of a fully functional anastomosis,optimal metabolic status,and clinical remission of the underlying *** endoscopic surveillance following primary resection facilitates the timely identification of anastomotic failure,thereby enabling noninvasive interventions.

关键词： Crohn’s disease Ileocolic resection Anastomotic insufficiency Endoscopic surveillance Surgery Risk factors

Particle electrification in an apparatus with a draft tube operating in a fast circulating dilute spout-fluid bed regime

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Particuology 2019年第1期17卷 146-153页

作者： wojciech Ludwig Wroclaw University of Science and Technology Faculty of Chemistry. Department of Chemical EngineeringNorwida 4/650-373 WroclawPoland

The intensity of the electrostatic charge accumulated during the flow of Cellets^■ particles in a modified Wurster apparatus is investigated in terms of the bed mass, and the initial moisture and velocity of the spouting gas. Particle electrification is proportional to the increase in the velocity of the spouting gas, which is connected with a higher velocity of the cores and the strength of their impact on the walls of the device. The presence of moisture in the bed facilitates electrification, but does not affect circulation, since moisture simultaneously lowers the bed resistance and reduces the relaxation time of particles, leading to rapid discharging if brought into contact with the conducting elements of the apparatus. Therefore, with regard to classic dry-powder coating, the velocity of the spouting gas should be minimized to ensure good circulation, with the particle moisture held at the maximum level admissible for a given product. The investigations show that a unique construction of the apparatus, which brings about an intense natural electrification of the cores, makes it suitable for the electrostatic dry-coating process by means of a high-voltage feeder with the controlled charging of coating powder in the spray nozzle.

关键词： Electrification Electrostatic charge Spout-fluid bed Wurster apparatus

Wave Propagation in A Converging Channel of Arbitrary Configuration

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China Ocean Engineering 2015年第5期29卷 771-782页

作者： wojciech SULISZ Institute of Hydroengineering Polish Academy of Sciences

A numerical solution was derived to determine wave field in a converging channel bounded by rubble-mound jetties. The solution was achieved by applying boundary element method. The model was applied to analyze the effect of channel convergence, the cross-section of the jetties and their physical and damping properties on wave field in the channel. The study reveals numerous non-intuitive results specific for jetted and convergent channels. The analysis shows that wave reflection is usually low and is of secondary practical importance. Wave transmission strongly depends on the channel geometry and transmitted waves may be higher than incident waves, despite reflection and damping processes. Moreover, wave transmission depends on physical and damping properties of rubble jetties and the results show that wave transmission may increase with the increasing damping properties of jetties, which is a non-intuitive feature of wave fields in jetted channels. The analysis reveals several novel results of practical importance. It is shown that the rubble-mound jetties should be constructed from the material of high porosity, which ensures low transmission. More attention should be devoted to hydraulic properties of porous materials. It is recommended to use the material of moderate damping properties. The material of high damping properties often increases the wave transmission. It is possible, by a selection of rubble-mound material, to obtain lower transmission level for steep waves than for waves of moderate steepness. A series of laboratory experiments were conducted in the wave flume to verify the theoretical results. The comparisons show that theoretical results are in fairly good agreement with experimental data.

关键词： jetted converging channel wave propagation wave damping numerical modeling

AUGMENTED REALITY SYSTEM FOR AIDING ENGINEERING DESIGN PROCESS OF MACHINERY SYSTEMS

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Journal of Systems Science and Systems Engineering 2011年第3期20卷 294-309页

作者： Marcin JANUSZKA wojciech MOCZULSKI Department of Fundamentals of Machinery Design Silesian University of TechnologyKonarskiego 18A44-100 GliwicePoland

The paper presents the application of augmented reality for aiding product design and development of machinery systems. Augmented reality technology integrates an interactive computer-generated word with an interactive real word in such a way that they appear as one environment. AR technology can enhance a user＇s perception of the real world with information that is not actually part of the scene but is relevant to the user＇s present activity. Presented in the AR system is a mode for changing views of data - especially 3D models - allowing the user to understand the prospective machinery system in a more comprehensive way, thus making the design process more efficient than the one supported by conventional present-day CAD systems. The presented prototype system contains an expert system integrated with AR system and allows the delivering of knowledge to the designer about successive steps of the design process of a mobile robot and practical solutions of realized constructional problems. An approach concerning AR enables the system user to analyze and verify solutions （represented as 3D models） relative to real scenes/objects. This approach is advantageous because the real environment around us often provides a vast amount of information that is difficult to duplicate in a computer. In some cases, the application of an AR system could be an optimal way to verify developed products.

关键词： Augmented reality human-computer interface CAD design for customer satisfaction computer-aided decision making

The Impact of Bed Temperature on Heat Transfer Characteristic between Fluidized Bed and Vertical Rifled Tubes

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Journal of Thermal Science 2016年第5期25卷 476-483页

作者： Artur Blaszczuk wojciech Nowak Czestochowa University of Technology Institute of Advanced Energy Technologies Dabrowskiego 73 AGH University Science and Technology Faculty of Energy and Fuels Czarnowiejska 30

In the present work,the heat transfer study focuses on assessment of the impact of bed temperature on the local heat transfer characteristic between a fluidized bed and vertical rifled tubes(38mm-O.D.) in a commercial circulating fluidized bed(CFB) *** transfer behavior in a 1296t/h supercritical CFB furnace has been analyzed for Geldart B particle with Sauter mean diameter of 0.219 and 0.246 *** heat transfer experiments were conducted for the active heat transfer surface in the form of membrane tube with a longitudinal fin at the tube crest under the normal operating conditions of CFB boiler.A heat transfer analysis of CFB boiler with detailed consideration of the bed-to-wall heat transfer coefficient and the contribution of heat transfer mechanisms inside furnace chamber were investigated using mechanistic heat transfer model based on cluster renewal *** predicted values of heat transfer coefficient are compared with empirical correlation for CFB units in large-scale.

关键词： Cluster renewal approach heat transfer coefficient bed temperature suspension density circulating fluidized bed

Simulation of Fluid Flow in a Channel Induced by Three Types of Fin-Like Motion

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Journal of Bionic Engineering 2007年第3期4卷 165-176页

作者： wojciech Kowalczyk Antonio Delgado Institute of Fluid Mechanics University of Erlangen-NurembergCauerstr. 4D-91058 ErlangenGermany

One of many interesting research activities in biofluidmechanics is dedicated to investigations of locomotion in water. Some of propulsion mechanisms observed in the underwater world are used in the development process of underwater autonomic vehicles （AUV）. In order to characterise several solutions according to their manoeuvrability, influence on the surrounding fluid and energetic efficiency, a detailed analysis of fin-like movement is indispensable. In the current paper an analysis of undulatory, oscillatory and combined fin-like movements by means of numerical simulation is carried out. The conservation equation of mass and the conservation equation of momentum axe solved with the Finite Volume Method （FWM） by use of the software CFX-10.0. The undulatory and oscillatory fin movements axe modelled with an equation that is implemented within an additional subroutine and joined with the main solver. N carried out in the computational domain, in which one fin is fixed in a flow-through water duct. Simulations axe carded out in the range of the Re number up to 105. The results show significant influence of applied fin motion on the velocity distribution in the surrounding fluid.

关键词： biofluid dynamics fro-like movement fish propulsion computational fluid dynamics