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Effect of Temperatures on Polymerization Stress and Microleakage of Class V Composite Restorations

Open Journal of Composite Materials 2013年第4期3卷 107-112页

作者： Pavinee Padipatvuthikul Didron wojciech chrzanowski Ayman Ellakwa Department of General Dentistry Srinakharinwirot University Bangkok Thailand

The loss of interfacial integrity was identified as one of the major causes for replacement of resin composite restorations. Preheating procedure has been proven to enhance flowability and adaptation of resin composites and increase their degree of conversion. The purpose of this study was to investigate polymerization contraction stress produced in resin composites after preheating to 37℃ and 60℃, and measure microleakage of Class V restorations restored with preheated composites. Three resin composites (GC Kalore, Gradia Direct X, Filtek Supreme XT) at room temperature, 37℃, and 60℃ were investigated. Maximum contraction stress of the composites (n = 5) was evaluated in a modified low-compliance device. Samples were light-cured for 40 seconds and the maximum force was recorded during 15 minutes. Calculations were done to adjust for the system’s compliance and obtain linear shrinkage values of composites. Data were analyzed by Multivariated Analysis of Variance (MANOVA) and Tukey’s test for multiple comparisons (α = 0.05). Seventy-two Class V cavities were prepared on the buccal surfaces of extracted premolars and divided into 9 groups. The teeth were restored with composites at 3 temperatures and were thermo-cycled between 5℃ and 55℃ with a one-minute dwell-time for 1000 cycles. The teeth were sealed with wax and nail vanish before placed in 0.5% toluidine blue dye for 24 hours. The teeth were embedded in self-curing resin and sectioned bucco-lingually with a slow-speed diamond saw, providing 3 sections per restoration. Microleakage was rated by two evaluators using a 0 - 4 ordinal scale at the occlusal and cervical margins under light microscope. Microleakage data were analyzed with Kruskal-Wallis ANOVA and Mann-Whitney U test (α = 0.05). Results indicate that preheating composites to 37℃ and 60℃ significantly increased polymerization contraction stress of composites (p 0.05). A significantly greater amount of leakage was found at the cervical margins (p 0.05). F

关键词： Preheating Dental Composite Polymerization Shrinkage Contraction Stress Microleakage

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Skin 11β-hydroxysteroid dehydrogenase type 1 enzyme expression regulates burn wound healing and can be targeted to modify scar characteristics

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Burns & Trauma 2023年第1期11卷 32-45页

作者： Kevin H.-Y.Tsai Huaikai Shi Roxanne J.Parungao Sina Naficy Xiaotong Ding Xiaofeng Ding Jonathan J.Hew Xiaosuo Wang wojciech chrzanowski Gareth G.Lavery Zhe Li Andrea C.Issler-Fisher Jun Chen Qian Tan Peter K.Maitz Mark S.Cooper Yiwei Wang Adrenal Steroid Group ANZAC Research InstituteConcord HospitalThe University of SydneySydneyNSW 2137Australia Burns and Reconstructive Surgery Research Group ANZAC Research InstituteConcord HospitalThe Uni-versity of SydneySydneyNSW 2137Australia School of Chemical and Biomolecular Engineering The University of SydneySydneyNSW 2006Australia Jiangsu Provincial Engineering Research Centre of TCM External Medication Development and Application Nanjing University of Chinese MedicineNanjingJiangsu210023China Department of Burns and Plastic Surgery Nanjing Drum Tower Hospital Clinical CollegeNanjing University of Chinese MedicineNanjingJiangsu210008China Heart Research Institute The University of SydneySydneyNSW 2006Australia Sydney Nano Institute Sydney Pharmacy SchoolFaculty of Medicine and HealthThe University of SydneySydneyNSW2006Australia Department of Biosciences Centre for Healthy Ageing and Understanding DiseaseNottingham Trent UniversityNG14BUUK Burns and Reconstructive Surgery Unit Concord Repatriation General HospitalSydneyNSW 2137Australia

Background:Excessive scarring and fibrosis are the most severe and common complications of burn *** exposure to high levels of glucocorticoids detrimentally impacts on skin,leading to skin thinning and impaired wound *** can generate active glucocorticoids locally through expression and activity of the 11β-hydroxysteroid dehydrogenase type 1 enzyme(11β-HSD1).We hypothesised that burn injury would induce 11β-HSD1 expression and local glucocorticoid metabolism,which would have important impacts on wound healing,fibrosis and *** additionally proposed that pharmacological manipulation of this system could improve aspects of post-burn ***:Skin 11β-HSD1 expression in burns patients and mice was *** impacts of 11β-HSD1 mediating glucocorticoid metabolism on burn wound healing,scar formation and scar elas-ticity and quality were additionally examined using a murine 11β-HSD1 genetic knockout ***-release scaffolds containing therapeutic agents,including active and inactive glucocorticoids,were developed and pre-clinically tested in mice with burn ***:We demonstrate that 11β-HSD1 expression levels increased substantially in both human and mouse skin after burn injury.11β-HSD1 knockout mice experienced faster wound healing than wild type mice but the healed wounds manifested significantly more collagen deposition,tensile strength and stiffness,features characteristic of excessive *** of slow-release prednisone,an inactive glucocorticoid,slowed the initial rate of wound closure but significantly reduced post-burn scarring via reductions in inflammation,myofibroblast generation,collagen production and scar ***:Skin 11β-HSD1 expression is a key regulator of wound healing and scarring after burn *** of an inactive glucocorticoid capable of activation by local 11β-HSD1 in skin slows the initial rate of wound closure but significantlyimproves scar characteristics po

关键词： Wound healing Burn injury Scarring Skin 11β-HSD1 11β-HSD1 knockout Glucocorticoid metabolism Polycaprolactone scaffold Drug delivery

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