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Collective migrations in an epithelial-cancerous cell monolayer

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Acta Mechanica Sinica 2021年第5期37卷 773-784,I0001页

作者： Jian‑Qing Lv Peng‑Cheng Chen Liu‑Yuan Guan wojciech T.Góźdź Xi‑Qiao Feng Bo Li Institute of Biomechanics and Medical Engineering Applied Mechanics LaboratoryDepartment of Engineering MechanicsTsinghua UniversityBeijing 100084China Institute of Physical Chemistry Polish Academy of SciencesKasprzaka 44/5201‑224 WarsawPoland

Collective cell migration is extensively observed in embryo development and cancer *** these processes,the interactions between cells with distinct identities and fates are of importance for boundary formation and host defense against *** this paper,we explore the collective dynamics of a two-dimensional cell mixing monolayer consisting of non-tumorigenic mammary epithelial cells and breast cancer *** show that the epithelial-cancerous cell mixing system displays unique sorting *** epithelial cells aggregate to form scattered clusters,which perform random motion with simultaneous translation and rotation,strikingly distinct from the classical persistent random walk of individual migratory *** motility of cancer cells is markedly promoted by the epithelial clusters,exhibiting remarkable contact enhancement of locomotion.A discrete model based on the Johnson-Kendall-Roberts contact mechanics is proposed to identify the influence of intercellular interactions,active migration forces and cell-substrate friction forces on the collective cell *** findings could advance our understanding of many biological processes,such as cancer metastasis and tissue morphogenesis.

关键词： Collective cells Cell mixing Dynamics Cell-cell interaction

Nanoscale image of the drug/metal mono-layer interaction:Tapping A FM-IR investigations

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Nano Research 2020年第4期13卷 1020-1028页

作者： Natalia Piergies Alexandre Dazzi Ariane Deniset-Besseau Jeremie Mathurin Magdalena Ocwieja Czeslawa Paluszkiewicz wojciech M.Kwiatek Institute of Nuclear Physics Polish Academy of SciencesPL-31342 KrakowPoland Laboratoire de Chimie Physique(LCP) CNRS UMR 8000Univ.of Paris-SudUniversite Paris-Saclay91405 OrsayFrance Jerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences Niezapominajek 8PL-30239 KrakowPoland

The application of metal nanoparticles as an efficient drug delivery system is one of the directions of cancer therapy ***,this strategy requires precise information about how the drug interacts with the applied *** this study,atomic force microscopy combined with infrared spectroscopy(AFM-IR)was used for the first time to investigate the erlotinib adsorption structure on two different types of 15 nm metal nanoparticle mono-layers,namely,silver nanoparticle(AgNP)and gold nanoparticle(AuNP)*** the metal nanoparticles are loosely bound samples,only the tapping AFM-IR mode is suitable for the collection of IR maps and spectra for such a *** obtained results indicated the relevance of the AFM-IR technique for characterizing drug interactions with a metal mono-layer *** investigated drug interacts with the AgNPs mainly through phenyl rings and methoxy moieties,while quinazoline,amino,and ethoxy moieties appear to be farther from the *** the AuNPs,the interaction occurs through both the phenyl ring and the quinazoline ***,the aliphatic groups of erlotinib directly participate in this *** novelty of the present work is also related to the use of the tapping AFM-IR mode to study metal NP mono-layers with a drug adsorbed on *** collected IR maps for the most enhanced erlotinib bands show specific areas with very high signal *** connection between these areas and the"hot spots"typical for the surface plasmon resonance phenomenon of metals is considered.

关键词： metal nanoparticle mono-layer drug's adsorption infrared nanospectroscopy atomic force microscopy erlotinib

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塑料回收的真相

商业周刊（中文版） 2022年第6期 66-71页

作者： Kit Chellel wojciech Moskwa 不详

当英国连锁超市乐购(Tesco Plc)于2021年3月首次开始从顾客那里收集塑料袋和包装纸以进行回收时,卡罗琳·拉格诺(Caroline Ragueneau)非常激动。当第一个白色收集箱出现时,她正在英格兰西南部的一家乐购超市担任零售助理。这些收集箱承... 详细信息

当英国连锁超市乐购(Tesco Plc)于2021年3月首次开始从顾客那里收集塑料袋和包装纸以进行回收时,卡罗琳·拉格诺(Caroline Ragueneau)非常激动。当第一个白色收集箱出现时,她正在英格兰西南部的一家乐购超市担任零售助理。这些收集箱承诺将通常被丢弃的东西变成有用之物。

关键词：连锁超市塑料回收收集箱卡罗琳包装纸乐购塑料袋英格兰

In-depth analysis of the influence of bio-silica filler(Didymosphenia geminata frustules)on the properties of Mg matrix composites

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Journal of Magnesium and Alloys 2023年第8期11卷 2853-2871页

作者： Izabela B.Zgłobicka Anna Dobkowska Aleksandra Zielińska Ewa Borucinska Mirosław J.Kruszewski RafałZybała Tomasz Płociński Joanna Idaszek Jakub Jaroszewicz Krystian Paradowski Bogusława Adamczyk-Cieślak Kostiantyn Nikiforow Bartosz Bucholc wojciechŚwięszkowski Krzysztof J.Kurzydłowski Faculty of Mechanical Engineering Bialystok University of TechnologyWiejska 45C15-351 BialystokPoland Faculty of Materials Science and Engineering Warsaw University of TechnologyWoloska 14102-507 WarsawPoland Lukasiewicz Research Network–Institute of Microelectronics and Photonics Al.Lotnikow 32/4602-668 WarsawPoland Institute of Physical Chemistry Polish Academy of Sciences Kasprzaka 44/5201-224 WarsawPoland Institute of Fundamental Technological Research Polish Academy of Sciences Pawinskiego 5B02-106WarsawPoland

A novel metal matrix composites(MMC)with Mg matrix reinforced with natural filler in the form of Didymosphenia geminata frustules(algae with distinctive siliceous shells)are presented in this *** plasma sintering(PPS)was used to manufacture Mg-based composites with 1,5 and 10 vol.%ceramic *** a reference,pure Mg was *** results show that the addition of 1 vol.%Didymosphenia geminata frustules to the Mg matrix increases its corrosion resistance by supporting passivation reactions,and do not affect the morphology of L929 *** of 5 vol.%the filler does not cause cytotoxic effects,but it supports microgalvanic reactions leading to the greater corrosion *** content than 5 vol.%the filler causes significant microgalvanic corrosion,as well as increases cytotoxicity due to the greater micro-galvanic effect of the composites containing 10 and 15 vol.%*** results of contact angle measurements show the hydrophilic character of the investigated materials,with slightly increase in numerical values with addition of amount of ceramic *** addition of Didymosphenia geminata frustules causes changes in a thermo-elastic properties such as mean apparent value of coefficient of thermal expansion(CTE)and thermal conductivity(λ).The addition of siliceous reinforcement resulted in a linear decrease of CTE and reduction in thermal conductivity over the entire temperature *** the increasing addition of Didymosphenia geminata frustules,an increase in strength with a decrease in compressive strain is *** all composites an increase in microhardness was *** results clearly indicate that filler in the form of Didymosphenia geminata frustules may significantly change the most important properties of pure Mg,indicating its wide potential in the application of Mg-based composites with a special focus on biomedical use.

关键词： Metal-matrix composites(MMCs) Pulse plasma sintering(PPS) Ceramic filler Microstructure Properties

Brain GABA and glutamate levels in workers of two ant species （Hymenoptera： Formicidae）： Interspecific differences and effects of queen presence/absence

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Insect Science 2014年第5期21卷 647-658页

作者： Andrzej Wnuk wojciech Kostowski Julita Korczynska Anna Szczuka Beata Symonowicz Przemyslaw Bienkowski Pawel Mierzejewski Ewa Joanna Godzinska Laboratory of Ethology Department of Neurophysiology Nencki Institute of Experimental Biology PAS Warsaw Department of Pharmacology and Physiology of the Nervous System Institute of Psychiatry and Neurology Warsaw Poland

Presence of amino acid neurotransmitters gamma-aminobutyric acid （GABA） and glutamate （Glu） in ant brains was reported in very few studies. To learn more about factors influencing GABA and Glu levels in ant brains, we applied high-performance liquid chromatography to measure levels of these compounds in single brains of workers of 2 ant species, Myrmica ruginodis （subfamily Myrmicinae） and Formica polyctena （subfamily Formicinae） taken from queenright/queenless colony fragments and tested in dyadic aggression tests consisting of an encounter with a nestrnate, an alien conspecific or a small cricket. Brain glutamate levels were higher than those of GABA in both tested species. Brain GABA levels （in μmol/brain） and GABA ： Glu ratio were higher in M. ruginodis （a submissive species） than in E polyctena （a dominant, aggressive species） in spite of smaller brain weight of M. ruginodis. Brain glutamate levels （in μmol/brain） did not differ between the tested species, which implies that glutamate concentration （in μmol/mg of brain tissue） was higher in M. ruginodis. Queen absence was associated with increased worker brain GABA levels in E polyctena, but not in M. ruginodis. No significant effects of opponent type were discovered. As GABA agonists enhance friendly social behavior in rodents, we hypothesize that elevated brain GABA levels of orphaned workers of *** facilitate the adoption of a new queen. This is the first report providing information on GABA and glutamate levels in single ant brains and documenting the effects of queen presence/absence on brain levels of amino acid neurotransmitters in workers of social Hymenoptera.

关键词： Formica polyctena GABA glutamate interspecific differences Myrmica ruginodis queen

Stepping Outside the Tao-Aquinas and the Challenge of Emotivism

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宗教与历史 2018年第2期 24-31页

作者： wojciech Golubiewski Academia Catholica

This paper reflects on the challenge that emotivism in moral philosophy sets for traditional cultures rooted in and shaped by natural wisdom. One could argue that Western and Chinese civilizations remain utterly incommensurable and incommunicable to each other unless they share in some common source.C. S. Lewis describes 'the sole source of all value judgments'by the notion of the'Tao'. The reflection points to Matteo Ricci’s appreciation of natural reason as providing the means for dialogue between distant cultures. To give a further account of the sapiential dimension of natural reason,this paper offers some insight into Thomas Aquinas ’ metaethical doctrine. His medieval teaching sheds light on the natural sources of moral wisdom,practical reasoning,and human goodness,and thus helps to secure their philosophical account from the 'stepping outside the Tao'of emotivism.

关键词： Metaethics Natural Reason Practical Wisdom Emotivism

Rough sets:the classical and extended views

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重庆邮电大学学报（自然科学版） 2008年第3期20卷 254-265页

作者： ZIARKO wojciech Department of Computer Science University of ReginaSK S4S 0A2 Canada

The article is a comprehensive review of two major approaches to rough set theory:the classic rough set model introduced by Pawlak and the probabilistic *** classic model is presented as a staging ground to the discussion of two varieties of the probabilistic approach,*** the variable precision and Bayesian rough set *** of these models extend the classic model to deal with stochastic interactions while preserving the basic ideas of the original rough set theory,such as set approximations,data dependencies,reducts *** probabilistic models are able to handle weaker data interactions than the classic model,thus extending the applicability of the rough set *** extended models are presented in considerable detail with some illustrative examples.

关键词：粗糙集或然率数学理论计算方法

Randomized Trial of Ciclosporin with 2-h Monitoring *** with Trough Monitoring in Liver Transplantation:DELTA Study

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Journal of Clinical and Translational Hepatology 2023年第4期11卷 839-849页

作者： Bastian N.Ruijter Akin Inderson Aad Pvan den Berg Herold J.Metselaar Jeroen Dubbeld Maarten E.Tushuizen Robert J.Porte wojciech Polak Danny van der Helm Marjolein van Reeven Mar Rodriguez-Girondo Bart van Hoek Department of Gastroenterology and Hepatology LUMC Transplantation CenterLeiden University Medical CenterLeidenThe Netherlands Department of Gastroenterology and Hepatology University Medical Center GroningenGroningenThe Netherlands Department of Gastroenterology and Hepatology Erasmus MC Transplant InstituteErasmus Medical CenterRotterdamThe Netherlands Department of Surgery LUMC Transplantation CenterLeiden University Medical CenterLeidenThe Netherlands Department of Surgery Section HPB Surgery and Liver TransplantationUniversity of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Department of Surgery Division of HPB and Transplant SurgeryErasmus MC Transplant InstituteErasmus Medical CenterRotterdamThe Netherlands Department of Biomedical Data Sciences Leiden University Medical CenterLeidenThe Netherlands.

Background and Aims:Previous trials comparing cyclosporine and tacrolimus after liver transplantation(LT)showed conflicting *** used trough monitoring for cyclosporine(C0),leading to less accurate dosing than with 2-h monitoring(C2).Only one larger trial compared C2 with tacrolimus based on trough level(T0)after LT,with similar treated biopsy-proven acute rejection(tBPAR)and graft loss,while a smaller trial had less tBPAR with C2 compared to ***,it is still unclear which calcineurin inhibitor is preferred after *** aimed to demonstrate superior efficacy(tBPAR),tolerability,and safety of C2 or T0 after first ***:Patients after first LT were randomized to C2 or ***,patient-and graft survival,safety and tolerability were the main endpoints,with analysis by Fisher test,Kaplan-Meier survival analysis and log-rank ***:In intention-totreat analysis 84 patients on C2 and 85 on T0 were *** incidence of tBPAR C2 vs.T0 was 17.7%vs.8.4%at 3 months(p=0.104),and 21.9%vs.9.7%at 6 and 12 months(p=0.049).One-year cumulative mortality C2 vs.T0 was 15.5%vs.5.9%(p=0.049)and graft loss 23.8%vs.9.4%(p=0.015).Serum triglyceride and LDL-cholesterol was lower with T0 than with *** of diarrhea in T0 vs,C2 was 64%vs.31%(p≤0.001),with no other differences in safety and ***:In the first year after LT immunosuppression with T0 leads to less tBPAR and better patient-/re-transplant-free survival as compared to C2.

关键词： Adverse effects Ciclosporin Liver transplantation Outcome Randomized controlled trial Rejection Survival Renal function Tacrolimus

Field test and probabilistic analysis of irregular steel debris casualty risks from a person-borne improvised explosive device

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Defence Technology（防务技术） 2021年第6期17卷 1852-1863页

作者： Piotr W.Sielicki Mark G.Stewart Tomasz Gajewski MichałMalendowski Piotr Peksa Hasan Al-Rifaie Robert Studzinski wojciech Sumelka Institute of Structural Analysis Faculty of Civil and Transport EngineeringPoznan University of Technology5 Maria Skłodowska-Curie Square60-965PoznanPoland Institute of Building Engineering Faculty of Civil and Transport EngineeringPoznan University of Technology5 Maria Skłodowska-Curie Square60-965PoznanPoland Centre for Infrastructure Performance and Reliability The University of NewcastleUniversity DriveCallaghanNSW2308Australia

Person-borne improvised explosive devices(PBIEDs)are often used in terrorist attacks in Western *** study aims to predict the trajectories of PBIED fragments and the subsequent safety risks for people exposed to this *** explosive field test with a typical PBIED composed of a plastic explosive charge and steel nut enhancements was performed to record initial fragment behaviour,including positions,velocity,and trajectory *** data were used to predict the full trajectory of PBIED fragments using a probabilistic *** the probabilistic analyses a probability of fatality or serious injury was *** on the results presented,many practical conclusions can be drawn,for instance,regarding safe evacuation distances if a person were exposed to a suspected PBIED.

关键词： Flying fragments Human safety Person-borne improvised explosive device experiment Probabilistic analysis