检索结果-南通市图书馆

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： Ling-Xiao Yi Hui Ren Woon Genevieve saw Li Zeng Eng King Tan Zhi Dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

siRNA therapeutics:a clinical reality

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2020年第4期63卷 485-500页

作者： Phei Er saw Er-Wei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Breast Tumor Center Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Zhongshan School of Medicine Breast SurgeryGuangzhou 510080China

Since the revolutionary discovery of RNA interference(RNAi),a remarkable progress has been achieved in understanding and harnessing gene silencing mechanism;especially in small interfering RNA(siRNA)*** its tremendous potential benefits,major challenges in most siRNA therapeutics remains unchanged-safe,efficient and target oriented delivery of *** years after the discovery of RNAi,siRNA therapeutics finally charts its way into *** we journey through the decades,we reminisce the history of siRNA discovery and its application in a myriad of disease ***,we highlight the breakthroughs in si RNA therapeutics,with special feature on the first FDA approved RNAi therapeutics Onpattro(Patisiran)and the consideration of effective siRNA delivery system focusing on current siRNA nanocarrier in clinical ***,we present some challenges and multiple barriers that are yet to be fully overcome in siRNA therapeutics.

关键词： siRNA therapeutic disease treatment systemic siRNA delivery clinical application

Time-resolved impact electrochemistry for quantitative measurement of single-nanoparticle reaction kinetics

在线全文

学校读者我要写书评

暂无评论

Nano Research 2017年第11期10卷 3680-3689页

作者： En Ning saw Markus Kratz Kristina Tschulik Micro-&Nano-Electrochemistry and Centre for Electrochemical Sciences(CES) Ruhr-University BochumBochum D-44780Germany

Single-nanoparticle electrochemistry has been established as a tool to characterize various nanomaterials based on the charge passed during their random impact at an *** it is demonstrated that the duration and shape of the resulting current peak can be used to quantify the reaction kinetics on a single-particle *** the chemical rate constant and reaction mechanism for oxidation of single nanoparticles in different electrolytes can be determined directly from the duration of the current signal recorded in high-speed,high-sensitivity current *** 29-nm-sized Ag particles in four different electrolytes as a proof of concept for this general approach,hitherto inaccessible insights into single-particle reactivity are *** comparable rate constants were measured for the four electrolytes at low overpotentials,transport-limited impacts at high overpotentials were found to depend strongly on the type and quantity of anions present in solution.

关键词： single-particle reactivity electrochemical kinetics nano-impact method silver reaction mechanism

Phage display screening of therapeutic peptide for cancer targeting and therapy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2019年第11期10卷 787-807页

作者： Phei Er saw Er-Wei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Recently,phage display technology has been announced as the recipient of Nobel Prize in Chemistry *** display technique allows high affinity target-binding peptides to be selected from a complex mixture pool of billions of displayed peptides on phage in a combinatorial library and could be further enriched through the biopanning process;proving to be a powerful technique in the screening of peptide with high affinity and *** this review,we will first discuss the modifications in phage display techniques used to isolate various cancer-specific ligands by in situ,in vitro,in vivo,and ex vivo screening *** will then discuss prominent examples of solid tumor targeting-peptides;namely peptide targeting tumor vasculature,tumor microenvironment(TME)and overexpressed receptors on cancer cells identified through phage display *** will also discuss the current challenges and future outlook for targeting peptidebased therapeutics in the clinics.

关键词： phage display tumor targeting peptide,tumor vasculature tumor microenvironment tumor stromal cells over-expressed receptor

A Field Observation and Significant Range Extension of Manouria impressa in Myanmar

在线全文

学校读者我要写书评

暂无评论

Asian Herpetological Research 2016年第4期7卷 295-297页

作者： saw HTUN Steven G. PLATT Wildlife Conservation Society Myanmar Program Office Block C- 1 Aye Yeik Mon 1st Street Hlaing Township YangonMyanmar

Few records of the impressed tortoise （Manouria impressa） are available from Myanmar and most are based on historic accounts, old museum specimens, and shells obtained from villagers and wildlife traffickers. We herein report the observation of a living M. impressa in the Hukaung Valley Wildlife Sanctuary of northern Myanmar. Our observation extends the known distribution of M. impressa in Myanmar approximately 850 km northwards from previously reported populations in the Rakhine Hills of Magway Region.

关键词： conservation Hukaung Valley Wildlife Sanctuary impressed tortoise Myanmar

Challenges and strategies for next-generation bispecific antibody-based antitumor therapeutics

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2020年第5期17卷 451-461页

作者： Heliang Li Phei Er saw Erwei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research CenterSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Breast Tumor Center Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Zhongshan School of Medicine Sun Yatsen University74 Zhongshan Road IIGuangzhou 510080China Guangzhou Regenerative Medicine and Health Guangdong Laboratory Guangzhou 510005China

Bispecific antibodies(bsAbs)refer to a large family of molecules that recognize two different epitopes or *** a series of challenges,especially immunogenicity and chain mispairing issues,once hindered the development of bsAbs,they have been gradually overcome with the help of rapidly developing technologies in the past 5 *** the meantime,an increasing number of bsAb platforms have been designed to satisfy different clinical ***,numerous preclinical and clinical trials are underway,portraying a promising future for bsAb-based cancer ***,bsAb drugs still face enormous challenges in their application as cancer therapeutics,including tumor heterogeneity and mutational burden,intractable tumor microenvironment(TME),insufficient costimulatory signals to activate T cells,the necessity for continuous injection,fatal systemic side effects,and off-target toxicities to adjacent normal ***,we provide several strategies as solutions to these issues,which comprise generating multispecific bsAbs,discovering neoantigens,combining bsAbs with other anticancer therapies,exploiting natural killer(NK)-cell-based bsAbs and producing bsAbs in *** this review,we mainly discuss previous and current challenges in bsAb development and underscore corresponding strategies,with a brief introduction of several typical bsAb formats.

关键词： Bispecific antibodies(bsAbs) Tumor microenvironment(TME) Tumor immunotherapy Monoclonal antibodies(mAbs)

Nanomedicine targeting ferroptosis to overcome anticancer therapeutic resistance

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第1期67卷 19-40页

作者： Jing Cai Xiaoding Xu Phei Er saw Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineMedical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Nanhai Translational Innovation Center of Precision Immunology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityFoshan 528200China

A potential reason for the failure of tumor therapies is treatment *** to chemotherapy,radiotherapy,and immunotherapy continues to be a major obstacle in clinic,resulting in tumor recurrence and *** major mechanisms of therapy resistance are inhibitions of cell deaths,like apoptosis and necrosis,through drug inactivation and excretion,repair of DNA damage,tumor heterogeneity,or changes in tumor microenvironment,*** studies have shown that ferroptosis play a major role in therapies resistance by inducing phospholipid peroxidation and iron-dependent cell *** ferroptosis inducers in combination with clinical treatment techniques have been used to enhance the effect in tumor ***,versatile ferroptosis nanoinducers exhibit an extensive range of functions in reversing therapy resistance,including directly triggering ferroptosis and feedback ***,we provide a detailed description of the design,mechanism,and therapeutic application of ferroptosis-mediated synergistic tumor *** also discuss the prospect and challenge of nanomedicine in tumor therapy resistance by regulating ferroptosis and combination therapy.

关键词： ferroptosis cancer therapy therapy resistance nanoinducers

The contribution of a non-governmental organisation’s Community Based Tuberculosis Care Programme to case finding in Myanmar:trend over time

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2017年第1期6卷 449-454页

作者： Htet Myet Win Maung saw saw Petros Isaakidis Mohammed Khogali Anthony Reid Nguyen Binh Hoa Ko Ko Zaw saw Thein Si Thu Aung National Tuberculosis Programme Ministry of Health and SportsZabuthiri townshipPostcode 15011 Nay Pyi TawMyanmar Department of Medical Research Ministry of Health and SportsYangonMyanmar Medecins Sans Frontieres Operational Research UnitMSF-LuxembourgLuxembourgLuxembourg National Tuberculosis Programme HanoiVietnam Centre for Operational Research International Union Against Tuberculosis and Lung DiseaseParisFrance

Background:It is estimated that the standard,passive case finding(PCF)strategy for detecting cases of tuberculosis(TB)in Myanmar has not been successful:26%of cases are ***,alternative strategies,such as active case finding(ACF)by community volunteers,have been initiated since *** study aimed to assess the contribution of a Community Based TB Care Programme(CBTC)by local non-government organizations(NGOs)to TB case finding in Myanmar over 4 ***:This was a descriptive study using routine,monitoring *** data from the NGOs were sent to a central registry within the National TB Programme and data for this study were extracted from that *** from all 84 project townships in five regions and three states in Myanmar were *** project was launched in ***:Over time,the number of presumptive TB cases that were referred decreased,except in the Yangon Region,although in some areas,the numbers *** the same time,there was a trend for the proportion of cases treated,compared to those referred,that decreased over time(P=0.051).Overall,among 84 townships,the contribution of CBTC to total case detection deceased from 6%to 4%over time(P<0.001).Conclusions:Contrary to expectations and evidence from previous studies in other countries,a concerning reduction in TB case finding by local NGO volunteer networks in several areas in Myanmar was recorded over 4 *** suggests that measures to support the volunteer network and improve its performance are *** may include discussion with local NGOs human resources personnel,incentives for the volunteers,closer supervision of volunteers and improved monitoring and evaluation tools.

关键词： Operational research Community based tuberculosis care Contribution SORT IT

Non-coding RNAs:the new central dogma of cancer biology

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2021年第1期64卷 22-50页

作者： Phei Er saw Xiaoding Xu Jianing Chen Er-Wei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China

The central dogma of molecular biology states that the functions of RNA revolve around protein *** the last decade,most researches were geared towards characterization of RNAs as intermediaries in protein translation,namely,messenger RNAs(mRNAs)as temporary copies of genetic information,ribosomal RNAs(rRNAs)as a main component of ribosome,or translators of codon sequence(t RNAs).The statistical reality,however,is that these processes account for less than 2%of the genome,and insufficiently explain the functionality of 98%of transcribed *** discoveries have unveiled thousands of unique non-coding RNAs(ncRNAs)and shifted the perception of them from being"junk"transcriptional products to"yet to be elucidated"—and potentially monumentally important—*** ncRNAs are now known as key regulators in various networks in which they could lead to specific cellular responses and *** major cancers,ncRNAs have been identified as both oncogenic drivers and tumor suppressors,indicating a complex regulatory network among these ***,we provide a comprehensive review of the various ncRNAs and their functional roles in cancer,and the pre-clinical and clinical development of nc RNA-based therapeutics.A deeper understanding of ncRNAs could facilitate better design of personalized therapeutics.

关键词： non-coding RNAs anti-cancer therapeutics personalized intervention miRNA lncRNA circRNA