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Proton pump inhibitors and all-cause mortality risk among cancer patients

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World Journal of Clinical Oncology 2025年第1期16卷 34-42页

作者： Arunkumar Krishnan Carolin Victoria schneider Declan Walsh Department of Supportive Oncology Atrium Health Levine CancerCharlotteNC 28204United States Department of Medicine Section of Hematology and OncologyWake Forest University School of MedicineWinston-SalemNC 27101United States Department of Medicine Ⅲ GastroenterologyMetabolic Diseasesand Intensive CareUniversity Hospital RWTH AachenAachen 52074Germany

BACKGROUND Proton pump inhibitors(PPIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related *** evidence suggests associations between long-term PPI use and higher risks for various adverse health outcomes,including greater *** To investigate the association between PPI use and all-cause mortality among cancer patients by a comprehensive analysis after adjustment for various confounders and a robust methodological approach to minimize *** This retrospective cohort study used data from the TriNetX research network,with electronic health records from multiple healthcare *** study employed a new-user,active comparator design,which compared newly treated PPI users with non-users and newly treated histamine2 receptor antagonists(H2RA)users among adult cancer *** prescribed PPIs(esomeprazole,lansoprazole,omeprazole,pantoprazole,or rabeprazole)users were compared to non-users or newly prescribed H2RAs(cimetidine,famotidine,nizatidine,or ranitidine)*** primary outcome was all-cause *** patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding *** Cox regression models were used to estimate hazard ratios(HRs)and 95% confidence interval(CI).RESULTS During the follow-up period(median 5.4±1.8 years for PPI users and 6.5±1.0 years for non-users),PPI users demonstrated a higher all-cause mortality rate than non-users after 1 year,2 years,and at the end of follow up(HRs:2.34-2.72).Compared with H2RA users,PPI users demonstrated a higher rate of all-cause mortality HR:1.51(95%CI:1.41-1.69).Similar results were observed across sensitivity analyses by excluding deaths from the first 9 months and 1-year post-exposure,confirming the robustness of these *** a sensitivity analysis,we analyzed all-cause mortality outcomes between former PPI users and individual

关键词： All-cause mortality Cancer Histamine-2 receptor antagonists Mortality Malignancy Proton pump inhibitors Carcinoma Outcome

PROPERTIES　OF　ULTRAFINE　SnOx　THIN　FILM　MADE　BY　PLASMA　POLYMERIZATION

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Chinese Chemical Letters 1996年第5期7卷 493-494页

作者： Zhang, Y Zhou, KL Cao, wm Liu, wm ACAD SINICA CHENGDU INST ORGAN CHEMCHENGDU 610011PEOPLES R CHINA ACAD SINICA LANZHOU INST CHEM PHYSLAB SOLID LUBRICATLANZHOU 730000PEOPLES R CHINA

Abstract: Ultrafine SnOx thin films were prepared from tetrabtltyltin by RF glow dis charge polymerization. Annealing behaviour of films under air and gas-sensitive probesty were investigated. The ultrafine SnOx thin film with average part ide size of 6nm exhibited a high sensitivity of 30 to 500ppm EtOH at 200℃.

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SEPARATION　CHARACTERISTICS　OF　THE　HYDROCYCLONE　WITH　A　CENTRAL　CONE　AND　ANNULAR　TEETH

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中国有色金属学会会刊：英文版 1996年第4期6卷 11-15页

作者： Chu, LY Chen, wm Luo, Q NORTHEASTERN UNIV DEPT MINERAL ENGN SHENYANG 110006 PEOPLES R CHINA SICHUAN UNION UNIV DEPT CHEM PROC MACHINERY CHENGDU 610065 PEOPLES R CHINA

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关键词： ydrocyclone central cone annular teeth separation sharpness classification efficiency separation characteristics

A Continuum Model for Heavy-electron Metal

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Journal of Materials Science & Technology 1997年第2期13卷 133-136页

作者： Liu, wm Yu, Z Pu, FC YUNNAN NORMAL UNIV DEPT PHYSKUNMING 650092PEOPLES R CHINA CHINESE ACAD SCI INST PHYSBEIJING 100080PEOPLES R CHINA

The exact eigenstates of the Hamiltonian of a continuum model for heavy-electron metal are constructed by using the Bethe ansatz. The Bethe ansatz equations are obtained from the periodic boundary conditions. The resu... 详细信息

关键词： Metals

THERMODYNAMICS OF THERMAL DECOMPOSITION OF ALUMINUM HYDROXIDE

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中国有色金属学会会刊：英文版 1997年第3期7卷 133-135页

作者： Zeng, wm Chen, NY Chen, QY CHINESE ACAD SCI SHANGHAI INST METSHANGHAI 200050PEOPLES R CHINA CENT S UNIV TECHNOL DEPT CHEMCHANGSHA 410083PEOPLES R CHINA

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关键词： Al(OH) 3 thermal decomposition thermodynamics

Calculation of Thermodynamic Properties from Phase Diagram of the Pb-Zn System

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Journal of Materials Science & Technology 1997年第3期13卷 233-234页

作者： Zeng, wm Chen, NY Qiu, GF Shanghai Institute of Metallurgy Chinese Academy of Sciences Shanghai 200050 China

The formulas for obtaining the interaction parameters of the liquid solution were first deduced from the immiscible phase diagram of binary system. Then, the relationships between activity coefficients and interaction parameters of the binary system were also deduced. Finally, thermodynamic properties of the Pb-Zn system were calculated by using these formulas.

关键词： Lead alloys

Electrochemical characteristics of poly(ophenylendiamine) film electrodes in phosphatic solution

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Chinese Journal of Chemistry 1997年第4期15卷 343-352页

作者： Ye, BX Zhang, wm Zhou, XY WUHAN UNIV DEPT CHEMWUHAN 430072PEOPLES R CHINA

The electrochemical characteristics of poly(o-phenylendiamine) (POPD) film modified electrodes have been investigated using different electrochemical techniques. The main interest is focused on the effect of potential and film thickness on the electrode process. Good agreement has been found for the apparent diffusion coefficient estimated by chronocoulometry and impedance spectroscopy. The charge transfer process within POPD films is diffusion processes at negative and positive overpotentials and electron hopping mechanism at formal potential. The POPD film conductivity of the oxidized state is better than that of the reduced state. For all electrode processes, the H+ may penetrate the film/electrolyte interface and take part in charge transfer or protonation-deprotonation of phenazine rings.

关键词： electropolymerization o-phenylendiamine electrochemistry

Recurrence properties of sequences of integers

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Science China Mathematics 2010年第3期53卷 641-656页

作者： schneider Dominique CNRS LMPA J. Liouville FR 2956 University Lille Nord de France

In order to study the recurrence of sequences of integers, we investigate their L2-exactness and Θ-Hartman property (Θ being a set of rational numbers). Two classes of sequences of integers are well studied, which a... 详细信息

关键词： recurrent set random sequence Wiener-Wintner theorem

Insights into manganese transport: A matter of phosphorylation

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Molecular Plant 2022年第3期15卷 385-387页

作者： Anja schneider Plant Science Faculty of BiologyLudwig-Maximilians-Universität MünchenMunichGermany

Manganese(Mn)is an essential element required for the growth of all known living *** plants acquire Mn from the rhizosphere,and its translocation into,and distribution within,the plant involves a multitude of transporters(Alejandro et al.,2020).In the aerial part of the green plant,the most prominent reaction that depends on Mn is the water-splitting reaction of photosystem II,which employs a tetra-Mn cluster located in the thylakoid lumen of ***,no less important reactions take place in mitochondria,where a Mn superoxide dismutase acts as a scavenger of reactive oxygen species,and in the Golgi apparatus,where Mn-dependent glycosyltransferases are involved in cell wall biosynthesis.

关键词： manganese apparatus splitting