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Screening of biological activities of Polygonum maritimum *** A lgerian coast

Asian Pacific Journal of Tropical Biomedicine 2013年第8期3卷 611-616页

作者： Imad Abdelhamid El-Haci Fawzia Atik Bekkara wissame mazari Fay al Hassani Mohamed AmineDidi Laboratoire des Produits Naturels BP 119 Imama13000Université Abou Bekr Belkaid-Tlemcen-Algérie Laboratoire d'Ecologie et Gestion des Ecosystèmes Naturels BP 119 Imama13000Université Abou Bekr Belkaid-Tlemcen-Algérie Laboratoire des Technologies de Séparations et de Purifications BP 119 Imama13000Université Abou Bekr Belkaid-Tlemcen-Algérie

Objective:To investigate the antioxidant and the antibacterial activities of crude extract from aerial part of Polygonum maritimumL.(Polygonaceae)(***)and to find new actives ***:The whole plant was collected from the Rechgoune coast(West of Algeria),and methanolic crude extract of aerial parts ***(PMCE)was *** extract was tested against different bacterial strain and tested for his ability to neutralize free radical(DPPH)and to scavenge the ***:PMCE had a very high content of total phenol,which was(352.49依18.03)mg/g dry weight,expressed as gallic acid *** exhibited excellent antioxidant activity,as measured using DPPH and H2O2 scavenging *** also showed a high antibacterial activity against gram-positive bacterial strains:Bacillus cereus,Bacillus subtilisandStaphylococcus aureus with an highest MIC of 120μg/***:The antioxidant and antibacterial activity of the PMCE is probably due to phenolic compounds present in the *** contemporary presence of antioxidant and antibacterialactivities in the PMCE suggests that this plant may be a source of bioactive substances with multifaceted activity.

关键词： Polygonum maritimumL. Phenolic compounds Antioxidant activity Antibacterial activity

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Visual Disorders Outcome after Endoscopic Endonasal Trans-Sphenoidal Surgery of Pituitary Macroadenomas

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International Journal of Otolaryngology and Head & Neck Surgery 2016年第3期5卷 134-140页

作者： wissame El Bakkouri Picard Hervé Brice Dzidzinyo Abdellaoui Anis Boyeldieu Louise Corré Alain Vignal Catherine Boucenna Malika Ayache Denis ENT Department Fondation Ophtalmologique Adolphe de Rothschild Paris France Clinical Research Unit Fondation Ophtalmologique Adolphe de Rothschild Paris France OPH Department Fondation Ophtalmologique Adolphe de Rothschild Paris France Radiological Department Fondation Ophtalmologique Adolphe de Rothschild Paris France

Objective: Describe the outcome of visual disorders after endonasal transsphenoidal (EET) surgery of pituitary macroadenomas with preoperative chiasmal compression. Patients and Methods: From 2009 to 2013, 225 patients underwent EET surgery for sellar tumor. Among them, 168 suffered from visual disorders induced by chiasmatic compression, of which 88 met the inclusion criteria for this study. Average duration of follow up was 1.8 yrs ± 0.4 yrs. All patients had sellar MRI before surgery and yearly postoperatively, visual acuity (VA) and/or visual field (VF) measurements before, 3 months after surgery and yearly postoperatively. Results: All tumors were macroadenomas with a mean preoperative MRI-estimated volume of 10.0 {plus minus} 9.07 cm3. Preoperative VA was impaired with an average of 0.43 ± 0.13 LogMAR (left eye) and 0.36 ± 0.14 LogMAR (right eye) and VF was disturbed in 99% ± 2% of the cases with the most frequent disorder being bitemporal hemianopsia (38 patients). Post-operatively, the mean residual MRI-estimated tumor volume was 3.15 ± 3.71 cm3. Mean tumor volume reduction was 62% ± 9% (p < 0.001). Optic chiasmal compression resolved in 72% ± 10% of the cases. Visual function improved in 86% ± 7% of cases (p < 0.001). Conclusion: Endoscopic endonasal management of pituitary gland neoplasms is effective to reduce tumor volume. This technique achieved significant visual improvement in the majority of cases presenting with chiasmal compression syndrome.

关键词： Pituitary Macroadenoma Visual Disorder Chiasm Compression Endoscopy Transsphenoidal

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