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Challenges confronting rural hospitals accentuated during COVID-19

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The Journal of Biomedical Research 2020年第6期34卷 397-409页

作者： Anthony D.Slonim helen See Sheila Slonim Renown Health RenoNV 89503USA Medicine and Pediatrics University of NevadaReno School of MedicineRenoNV 89557USA Hospital Operations Carilion ClinicRoanokeVA 24017USA.

The Balanced Budget Act of 1997 created a designation for critical access hospitals(CAHs)to sustain care for people living in rural communities who lacked access to care due to hospital closures over the preceding ***-five years later,1350 CAHs serve approximately 18% of the US population and a systematic policy evaluation has yet to be *** policy analysis serves to define challenges faced by CAHs through a literature review addressing the four major categories of payment,quality,access to capital,and ***,this analysis describes how current challenges to maintain sustainability of CAHs over time are accentuated by gaps in public health infrastructure and variability in individual health care plans exhibited during the COVID-19 pandemic.

关键词： rural hospitals critical access hospitals COVID-19 coronavirus

Targeting EGFR and sonic hedgehog pathways for locally advanced eyelid and periocular carcinomas

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World Journal of Clinical Cases 2014年第9期2卷 432-438页

作者： Vivian T Yin helen Merritt Bita Esmaeli Orbital Oncology and Ophthalmic Plastic Surgery Program Department of Plastic Surgery The University of Texas MD Anderson Cancer Center Department of Ophthalmology and Visual Science The University of Texas Medical School

For patients with metastatic or locally advanced eyelid and periocular carcinoma not amenable to surgical excision, targeted therapies have shown efficacy with better tolerability compared to cytotoxic chemotherapy. Overexpression of epithelial growth factor receptor was found in squamous cell carcinomas. Vismodegib targets the mutation in the hedgehog pathway identified in basal cell carcinoma and basal cell nevus syndrome. Targeted therapies provide a novel and potentially effective treatment alternative for patients with eyelid carcinoma not amendable for surgery, including those with metastatic, locally advanced disease, advanced age, and significant comorbidities. High cost, need for long-term treatment, and toxicity are relative limitations.

关键词： Vismodegib Periocular basal cell carcinoma Sonic hedgehog Epithelial growth factor receptor inhibition Periocular squamous cell carcinoma

SCI citation analysis and impact factor prediction of JZUS-A in 2008

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第1期10卷 149-150页

作者： Zi-yang ZHAI Xiu-fang WU Yue-hong (helen) ZHANG Editors Journals of Zhejiang University SCIENCE (A &B) Zhejiang University Press Hangzhou 310027 China

Journal of Zhejiang University-SCIENCE A(JZUS-A),its former version named Journal of Zhejiang University-SCIENCE(ISSN 1009-3095),has been covered by Science Citation Index Expanded(SCI-E)since *** now,all the 500 pape... 详细信息

关键词：期刊编辑出版《浙江大学学报》

A Building Classification System for Multi-hazard Risk Assessment

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International Journal of Disaster Risk Science 2022年第2期13卷 161-177页

作者： Vitor Silva Svetlana Brzev Charles Scawthorn Catalina Yepes Jamal Dabbeek helen Crowley Risk Section Global Earthquake Model27100 PaviaItaly Department of Civil Engineering University of British ColumbiaVancouverBC V6T 1Z4Canada SPA Risk LLC DenverCO 80207USA Department of Civil Engineering An-Najah National UniversityNablusState of Palestine Seismic Risk Section 27100 EucentrePaviaItaly

A uniform and comprehensive classification system, often referred to as taxonomy, is fundamental for the characterization of building portfolios for natural hazard risk assessment. A building taxonomy characterizes assets according to attributes that can influence the likelihood of damage due to the effects of natural *** the scope of the Global Earthquake Model(GEM)initiative, a building taxonomy(GEM Building Taxonomy V2.0) was developed with the goal of classifying buildings according to their seismic vulnerability. This taxonomy contained 13 building attributes, including the main material of construction, lateral load-resisting system, date of construction and number of stories. Since its release in2012, the taxonomy has been used by hundreds of experts working on exposure and risk modeling efforts. These applications allowed the identification of several limitations, which led to the improvement and expansion of this taxonomy into a new classification system compatible with multi-hazard risk assessment. This expanded taxonomy(named GED4ALL) includes more attributes and several details relevant for buildings exposed to natural hazards beyond earthquakes. GED4ALL has been applied in several international initiatives, enabling the identification of the most common building classes in the world, and facilitating compatibility between exposure models and databases of vulnerability and damage databases.

关键词： Disaster risk Exposure Multihazard Taxonomy

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World Journal of Emergency Medicine 2024年第4期15卷 256-262页

作者： Jie Er Janice Soo Yuan helen Zhang Gek Hsiang Lim Fatimah Lateef Department of Emergency Medicine Singapore General HospitalSingapore 168753Singapore Health Services Research Unit Singapore General HospitalSingapore168753Singapore

BACKGROUND:This study aimed to review bicycle-related injuries during the COVID-19 pandemic to assist with reinforcement or implementation of new policies for injury ***:This is a retrospective descriptive analysis of injuries sustained during cycling for patients 18 years old and above who presented to Singapore General Hospital from January to June *** records were reviewed and *** analyses were used to summarize patient characteristics,and differences in characteristics subgrouped by triage acuity and discharge status were ***:The study included 272 patients with a mean age of 43 years and a male predominance(71.7%).Most presented without referrals(88.2%)and were not conveyed by ambulances(70.6%).Based on acuity category,there were 24(8.8%)Priority 1(P1)patients with 7 trauma activations,174(64.0%)and 74(27.2%)P2 and P3 patients *** most common injuries were fractures(34.2%),followed by superficial abrasion/contusion(29.4%)and laceration/wound(19.1%).Thirteen(4.8%)patients experienced head injury and 85 patients(31.3%)were documented to be wearing a *** majority occurred on the roads as traffic accidents(32.7%).Forty-two patients(15.4%)were admitted with a mean length of stay of 4.1 d and 17(6.3%)undergone surgical *** of 214(78.7%)discharged patients,no re-attendances or mortality were *** the subgroup analysis,higher acuity patients were generally older,with higher proportions of head injuries leading to ***:Our study highlights significant morbidities in bicycle-related *** is also a high proportion of fractures in the young healthy male *** prevention is paramount and we propose emphasizing helmet use and road user safety.

关键词： Cycling Injuries Emergency department

Hybrid Sooty Tern Optimization and Differential Evolution for Feature Selection

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Computer Systems Science & Engineering 2021年第12期39卷 321-335页

作者： Heming Jia Yao Li Kangjian Sun Ning Cao helen Min Zhou College of Information Engineering Sanming UniversitySanming365004China College of Mechanical and Electrical Engineering Northeast Forestry UniversityHarbin150040China School of Engineering Manukau Institute of TechnologyAuckland2241New Zealand

In this paper,a hybrid model based on sooty tern optimization algo-rithm(STOA)is proposed to optimize the parameters of the support vector machine(SVM)and identify the best feature sets *** selec-tion is an essential process of data preprocessing,and it aims to find the most rele-vant subset of *** recent years,it has been applied in many practical domains of intelligent *** application of SVM in many fields has proved its effectiveness in classification tasks of various *** performance is mainly determined by the kernel type and its *** of the most challenging process in machine learning is feature selection,intending to select effective and representative *** main disadvantages of feature selection processes included in classical optimization algorithm are local optimal stagnation and slow ***,the hybrid model proposed in this paper merges the STOA and differential evolution(DE)to improve the search efficiency and con-vergence rate.A series of experiments are conducted on 12 datasets from the UCI repository to comprehensively and objectively evaluate the performance of the proposed *** superiority of the proposed method is illustrated from dif-ferent aspects,such as the classification accuracy,convergence performance,reduced feature dimensionality,standard deviation(STD),and computation time.

关键词： sooty tern optimization algorithm hybrid optimization feature selection support vector machine

Expression of androgen receptor target genes in skeletal muscle

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Asian Journal of Andrology 2014年第5期16卷 675-683,I0006页

作者： Kesha Rana Nicole KL Lee Jeffrey D Zajac helen E MacLean Department of Medicine Austin Health University of Melbourne Heidelberg Victoria Australia

We aimed to determine the mechanisms of the anabolic actions of androgens in skeletal muscle by investigating potential androgen receptor （AR）-regulated genes in in vitro and in vivo models. The expression of the myogenic regulatory factor myogenin was significantly decreased in skeletal muscle from testosterone-treated orchidectomized male mice compared to control orchidectomized males, and was increased in muscle from male AR knockout mice that lacked DNA binding activity （AR△ZF2） versus wildtype mice, demonstrating that myogenin is repressed by the androgen/AR pathway. The ubiquitin ligase Fbxo32 was repressed by 12 h dihydrotestosterone treatment in human skeletal muscle cell myoblasts, and c-Myc expression was decreased in testosterone-treated orchidectomized male muscle compared to control orchidectomized male muscle, and increased in AR△ZF2 muscle. The expression of a group of genes that regulate the transition from myoblast proliferation to differentiation, Tceal7, p57Kip2, IEf2 and calcineurin Aa, was increased in AR△ZF2 muscle, and the expression of all but p57kip2 was also decreased in testosterone-treated orchidectomized male muscle compared to control orchidectomized male muscle. We conclude that in males, androgens act via the AR in part to promote peak muscle mass by maintaining myoblasts in the proliferative state and delaying the transition to differentiation during muscle growth and development, and by suppressing ubiquitin ligase-mediated atrophy pathways to preserve muscle mass in adult muscle.

关键词： androgen receptor anabolic atrophy gene expression skeletal muscle

AN INTEGRATED ASSESSMENT OF THE SUSTAINABILITY OF GREEN AND BUILT-UP ROOFS

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Journal of Green Building 2008年第2期3卷 106-127页

作者： helen Muga Amlan Mukherjee James Mihelcic Department of Civil and Environmental Engineering Michigan Tech.University1400 Townsend Dr.HoughtonMI 49931

There is growing demand to develop methods that integrate environmental and economic assessment of more sustainabletechnologies incorporated into commercial and residential buildings. In this paper, we incorporate economic and energyuse data obtained for a green roof operating in the Midwest U.S. at latitude 42.94N into an integrated approach toestimate and compare the economic and environmental impacts of an intensive (or extensive) green roof with a built-uproof. The life cycle stages included in the analysis were material acquisition life stage which including the transportationeffects from material extraction through manufacturing to the fi nished products, and the use and maintenance life stageof the building. Environmental impact analysis indicates that green roof emits three times more environmental pollutantsthan built-up roofs in the material acquisition life stage. However, in the use and maintenance life stage, built-uproof emits three times more pollutants than a green roof. Overall, when emissions from both material acquisition lifestage and use and maintenance life stage are combined, the built-up roof contributes almost 3 times more (or 46% more)environmental emissions than green roof over a 45-year building life span. Furthermore the overall energy use, specifi -cally energy involved in the transportation from material extraction through to the fi nished product indicate that greenroof uses 2.5 times less energy than a built-up roof. An Economic Input and Output life cycle assessment (EIO-LCA) wasused to estimate the environmental impacts. The economic impact over an assumed 45-year building life was determinedusing life cycle costing, taking into account Net Present Value (NPV) calculations. Life cycle costing results indicate thatgreen roof costs approximately 50% less to maintain over a 45 year-building life than a built-up roof. A Monte Carlosimulation is also performed to account for any variability in cost data. In addition, the paper presents

关键词： sustainability green roof built-up roof life cycle assessment life cycle costing net present value Monte Carlo

Microwave-assisted catalyst-free hydrolysis of fibrous cellulose for deriving sugars and biochemicals

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Frontiers of Chemical Science and Engineering 2019年第4期13卷 718-726页

作者： Songshan Jiang helen Daly Huan Xiang Ying Yan Huiping Zhang Christopher Hardacre Xiaolei Fan School of Chemical Engineering and Analytical Science The University of ManchesterManchester M139PLUK School of Chemistry and Chemical Engineering Chongqing University of Science and TechnologyChongqing 401331China School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510640China

Microwave(MW)assisted catalyst-free hydrolysis of fibrous cellulose(FC,cellulolysis)at 200℃promoted a cellulose conversion o f ca.37.2%and quantitative production o f valuable C5/C6 sugars(e.g.,glucose)and the according platform biochemicals(e.g.,5-hydroxymethylfurfliral),corresponding to an overall selectivity o f 96.5%.Conversely,conventional hydrothermal cellulolysis under similar conditions was not effective,even after 24 h,carbonising the *** on the systematic study of MW-assisted cellulolysis,the specific interaction between water molecules and macroscopic FC under the MW irradiation was proposed,accounting for the interpretation o f the experimental *** kinetic energy o f water molecules under the MW irradiation facilitated the C-C(in the non-hindered surface-CH2OH groups)and C-O-C bond breaking(inside the cellulose cavities)in FC,producing primary cellulolysis products of xylose,glucose and cellobiose.

关键词： microwave fibrous cellulose hydrolysis sugars mechanism