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Multi-scale habitat influences sprainting and group size of a freshwater-obligate smooth-coated otter(Lutrogale perspicillata) in tungabhadra Otter Conservation Reserve, India

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Ecological Processes 2024年第1期13卷 159-175页

作者： Ankit Moun P.Ramesh Kumar M.Malathi Priya t.Ramesh Riddhika Kalle Sálim Ali Centre for Ornithology and Natural History Deputy Conservator of Forests Bellary Territorial Forest Division Deputy Conservator of Forests Working Plan and Survey and Research WingBellary Territorial Forest Division Centre for Functional Biodiversity University of Kwa Zulu-Natal

Background the impact of changing land-use patterns and associated anthropogenic threats on scale-dependent habitat use of semi-aquatic mustelids in scent-marking and social behaviour can provide important insights into the habitat ecology of smooth-coated otters(Lutrogale perspicillata).Methods We sampled 180 stream segments(100–400 m) as spat.a. replicates of 60 1-km2 sites to record indirect evidence(i.e. spraints and mass latrine sites) and group sizes of smooth-coated otters along the tungabhadra Otter Conservation Reserve(tOCR) during the dry season. to quantify habitat, we recorded stream characteristics, riparian vegetation, and anthropogenic disturbances at the local scale, and hydro-environmental characteristics and land uses at the landscape scale. Using Markovian-chain detection and occupancy models, we assessed the multi-scale habitat use of otters in their selection of suitable areas for scent-marking based on repeated presence-absence data on spraint/latrine locations along the tOCR. We further used linear regression techniques to explore relationships between the number of individuals in smooth-coated otter group and hydro-environmental characteristics, spraint/latrine encounter rate, anthropogenic pressure, land cover, topography, and *** At the local scale, the probability of spraint deposition and group size decreased with anthropogenic disturbance while the probability of spraint detections decreased with grass cover. At the landscape scale, the probability of otter site use for spraint deposition and group sizes increased in southeast flowing streams. Spraint deposition increased with the proportion of sugarcane fields, whereas in cont.a.t, group size decreased with proportion of sugarcane *** Our findings highlight the first empirical evidence on multi-scale habitat use of a southern Indian population of smooth-coated otters in an inland freshwater ecosystem surrounded by the scrub jungle–agriculture matrix. We sug

关键词： Presence-absence modelling Inland river Freshwater ecosystem Semi-aquatic mammal Smooth-coated otter

Dynamic Forecasting of t.a.fic Event Duration in Istanbul:A Classification Approach with Real-time Data Integration

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Computers, Materials & Continua 2024年第8期80卷 2259-2281页

作者： Mesut Ulu Yusuf Sait türkan Kenan Menguc Ersin Namlı tarık Kucukdeniz Occupational Health and Safety Department Bandirma Onyedi Eylul UniversityBalikesir10200Türkiye Department of Industrial Engineering Istanbul University-CerrahpasaIstanbul34320Türkiye Department of Industrial Engineering Istanbul Technical UniversityIstanbul34467Türkiye

today,urban t.a.fic,growing populations,and dense t.a.sportation networks are contributing to an increase in t.a.fic *** incidents include t.a.fic accidents,vehicle breakdowns,fires,and t.a.fic disputes,resulting in long waiting times,high carbon emissions,and other undesirable *** is vital to estimate incident response times quickly and accurately after t.a.fic incidents occur for the success of incident-related planning and response *** study presents a model for forecasting the t.a.fic incident duration of t.a.fic events with high *** proposed model goes through a 4-stage process using various features to predict the duration of four different t.a.fic events and presents a feature reduction approach to enable real-time data collection and *** the first stage,the dataset consisting of 24,431 data points and 75 variables is prepared by data collection,merging,missing data processing and data *** the second stage,models such as Decision trees(Dt),K-Nearest Neighbour(KNN),Random Forest(RF)and Support Vector Machines(SVM)are used and hyperparameter optimisation is performed with *** the third stage,feature selection and reduction are performed and real-time data are *** the last stage,model performance with 14 variables is evaluated with metrics such as accuracy,precision,recall,F1-score,MCC,confusion matrix and *** RF model outperforms other models with an accuracy of 98.5%.the study’s prediction results demonst.a.e t.a. the proposed dynamic prediction model can achieve a high level of success.

关键词： t.a.fic event duration forecasting machine learning feature reduction shapley additive explanations(SHAP)

Advances in oral mesenchymal stem cell-derived ext.a.ellular vesicles in health and disease

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Genes & Diseases 2024年第1期11卷 346-357页

作者： Huanyu Luo Anahid Ahmadi Birjandi Feilong Ren t.a.meng Sun Paul t.Sharpe Hongchen Sun Zhengwen An Department of Oral Biology Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool and Hospital of StomatologyJilin UniversityChangchunJilin 130021China Faculty of Dentistry Oral&Craniofacial SciencesCentre for Craniofacial and Regenerative BiologyKing's College LondonLondonSE19RTUK Department of Oral Pathology Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool and Hospital of StomatologyJilin UniversityChangchunJilin 130021China

Ext.a.ellular vesicles(EVs)are nano-size vesicles secreted naturally by all cells into the ext.a.ellular space and have been recognized as important cell-cell mediators in multicel-lular *** contain nucleic acids,proteins,lipids,and other cellular components,regulating many basic biological processes and playing an important role in regenerative med-icine and *** can be t.a.ed to their cells of origin and exhibit.a.similar ***,EVs demonst.a.e low immunogenicity,good biocompatibility,and fewer side ef-fects,compared to their parent *** stem cells(MsCs)are one of the most important resource cells for EVs,with a great capacity for self-renewal and multipotent differ-ent.a.ion,and play an essent.a. role in stem cell *** mechanism of MsC therapy was thought to be attributed to the different.a.ion of MsCs after targeted migration,as previously ***,emerging evidence shows the previously unknown role of MsC-derived para-crine factors in stem cell *** EVs derived from oral tissue MSCs(OMSC-EVs),show more advantages t.a. those of all other MsCs in tissue repair and regeneration,due to their lower invasiveness and easier accessibility for sample ***,we systematically review the biogenesis and biological characteristics of OMSC-EVs,as well as the role of OMsC-EVs in intercellular ***,we discuss the potent.a. therapeutic roles of OMSC-EVs in oral and systemic *** highlight the current challenges and future directions of OMSC-EVs to focus more attention on clinical *** aim to provide valuable insights for the explorative clinical application of OMSC-EVs.

关键词： Disease Ext.a.ellular vesicles Oral tissue MSC therapeutic application tissue regeneration

MicroRNAs in hepatocellular carcinoma treatment:Charting the path forward

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World Journal of Gastroenterology 2024年第11期30卷 1470-1474页

作者： Hong t Lin Antonio F Alvarez Castaneda Somashekar G Krishna Khalid Mumtaz Division of Gastroenterology Hepatology and NutritionDepartment of MedicineThe Ohio State University Wexner Medical CenterColumbusOH 43210United States

MicroRNAs(miRNAs)are recognized for their involvement in the regulation of gene expression and exhibit significant potent.a. in both the prognostic assessment.a.d treatment of hepatocellular carcinoma(HCC).HCC,like other tumors,seldom occurs in isolation;inst.a.,it evolves within a microenvironment featuring oncogenic and tumor-suppressive *** combined with suitable delivery vehicles,miRNA technology provides the capability to directly engage with these elements,thereby hindering tumor formation and *** research in this domain holds the promise of enabling a more efficacious and multi-modal treatment.a.proach for HCC in the near future.

关键词： Hepatocellular carcinoma tumor microenvironment MicroRNA Mesenchymal stem cell Exosome

theoretical and experimental investigations on an X-shaped vibration isolator with active controlled variable stiffness

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1371-1386页

作者： Zeyu CHAI J.t.HAN Xuyuan SONG Jian ZANG Yewei ZHANG Zhen ZHANG College of Aerospace Engineering Shenyang Aerospace University Jacobs School of Engineering University of California San Diego Key Laboratory of Vibration and Control of Aero-Propulsion System Ministry of EducationNortheastern University

A novel X-shaped variable stiffness vibration isolator(X-VSVI) is *** Runge-Kut.a.method, harmonic balance method, and wavelet t.a.sform spect.a.are introduced to evaluate the performance of the X-VSVI under various excitations. the layer number, the installation angle of the X-shaped structure, the stiffness, and the active control parameters are systematically analyzed. In addition, a prototype of the X-VSVI is manufactured, and vibration tests are carried out. the results show t.a. the proposed X-VSVI has a superior adaptability to t.a. of a t.a.itional X-shaped mechanism, and shows excellent vibration isolation performance in response to different.a.plitudes and forms of excitations. Moreover, the vibration isolation efficiency of the device can be improved by appropriate adjustment of parameters.

关键词： 70J35 70K30 70K50 bionic vibration isolation nonlinear dynamics O322 prototype experiment variable stiffness structure X-shaped structure

Facile synthesis of int.a.nanogap enhanced Raman tags with different shapes

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Nano Research 2024年第9期17卷 8415-8423页

作者： Sanjun Fan Brian t.Scarpitti Zhewen Luo Abigail E.Smith Jian Ye Zachary D.Schultz Department of Chemistry and Biochemistry The Ohio State UniversityColumbusOhio 43210USA School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200030China

Hot spot engineering in plasmonic nanostructures plays a significant role in surface-enhanced Raman scattering(SERS)for bioanalysis and cell ***,creating stable,reproducible,and strong SERS signals remains challenging due to the potent.a. interference from surrounding chemicals and locating SERS-active analytes into hot-spot ***,we developed a st.a.ghtforward approach to synthesize int.a.gap nanoparticles encapsulating 4-nitrobenzenethiol(4-NBt.a. a reporter molecule within these gaps to avoid outside *** made three kinds of int.a.gap nanoparticles using nanorods,bipyramids,and nanospheres as cores,in which the nanorods based int.a.gap nanoparticles exhibit the highest SERS *** advantage of our method is the ease of preparation of high-yield and stable int.a.gap nanoparticles characterized by a short incubation time(10 min)with 4-NBt.a.d quick synthesis without requiring an additional step to centrifuge for the purification of core *** intense localized field in the synthesized hot spots of these plasmonic gap nanostructures holds great promise as a SERS subst.a.e for a broad range of quantitative optical applications.

关键词： hot spot engineering surface enhanced Raman scattering int.a.gap nanoparticles 4-nitrobenzenethiol

Spatiotemporal mapping of(ult.a.)mafic magmatic mine areas:Implications of economic and political realities in China

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Deep Underground Science and Engineering 2024年第1期3卷 91-102页

作者： Heling Li Liang tang tim t.Werner Zhengmeng Hou Fan Meng Jingjing Li College of Earth Sciences Chengdu University of TechnologyChengduChina Institute of Subsurface Energy Systems Clausthal University of TechnologyClausthal ZellerfeldGermany School of Geography Earth and Atmospheric SciencesFaculty of ScienceThe University of MelbourneMelbourneVictoriaAustralia

the spatiotemporal extension/expansion of mine areas is affected by multiple *** far,very little has been done to examine the interaction between mine areas and political or economic ***(ult.a.)mafic magmatic mines in China played a specific role in supporting national development.a.d providing an ideal research subject for monitoring their *** this study,remote sensing and mining‐related GIS data were used to identify and analyze 1233(ult.a.)mafic magmatic mine area polygons in China,which covered approximately 322.96 km2 of land and included a V–ti–Fe mine,a copper–nickel mine,a chromite mine,an asbestos mine,and a diamond *** was found t.a.(1)the areal expansion of mines is significantly related to the mine types,perimeter,topography,and population density.(2)the mine area variation also reflects market.a.d policy *** temporal expansion of the mine area from 2010 to 2020 followed an S‐shaped pattern(with the turning point occurring in 2014),closely related to iron overcapacity and tightened mining policies.(3)the complexity(D)of the mine area may reflect mine design and excavation *** be specific,lower D indicates early‐stage or artisanal/small‐scale mining,whereas higher D represents large‐scale *** study demonst.a.es t.a. the detailed mapping of mine land can serve as an indicator to implement miningrelated market.a.d policy ***(ult.a.)mafic mines area data set can be accessed at https://***/record/7636616#.Y-p0uXaZOa0.

关键词： complexity mine area mining and socioeconomic interaction spatiotemporal distribution (ult.a.)mafic magmatic mine

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Hydrothermal treatment of pearl millet grains:Effects on nutritional composition,antinutrients and flour properties

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Grain & Oil Science and technology 2024年第2期7卷 87-95页

作者： P.Prashanth t.Jayasree Joshi Shagolshem Mukta Singh P.Srinivasa Rao Agricultural and Food Engineering Department Indian Institute of Technology KharagpurKharagpurWest Bengal 721302India

Pearl millet(Pennisetum glaucum)is one of the major millets with high nutritional *** crop exhibits exceptional resilience to drought.a.d high ***,the processing of pearl millet poses a significant challenge due to its high lipid content,enzyme activity,and presence of ***,it becomes imperative to enhance the quality and prolong the shelf life of pearl millet flour by employing suitable *** treatment in the food industry has long been seen as promising due to its potent.a. to reduce microbial load,inactivate enzymes,and improve nutrient *** study aims to investigate the effects of hydrothermal treatment on the quality characteristics of pearl *** independent variables of the study were soaking temperature(35,45,55℃),soaking time(2,3,4 h),and st.a.ing time(5,10,15 min).treatment conditions had a statistically significant effect on nutrient *** antinutrients like tannins and phytates were reduced by 0.99% to 5.94% and 0.36% to 6.00%,respectively,after the *** activity decreased significantly up to 10% with the treatment *** findings of this study could potent.a.ly encourage the use of pearl millet flour in the production of various food items and promote the application of hydrothermal treatment in the field of food processing.

关键词： Pearl millet Hydrothermal treatment Nutritional properties Antinutrients

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Life under tension: the relevance of force on biological polymers

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Biophysics Reports 2024年第1期10卷 48-56页

作者： Matthew t.J.Halma Longfu Xu Department of Physics and Astronomy and Laser Lab Vrije Universiteit Amsterdam LUMICKS B.V.

Optical tweezers have elucidated numerous biological processes, particularly by enabling the precise manipulation and measurement of tension. One question concerns the biological relevance of these experiments and the generalizability of these experiments to wider biological systems. Here, we categorize the applicability of the information garnered from optical tweezers in two distinct categories: the direct relevance of tension in biological systems, and what experiments under tension can tell us about biological systems, while these systems do not reach the same tension as the experiment, still, these artificial experimental systems reveal insights into the operations of biological machines and life processes.

关键词： tension Optical tweezers Molecular force