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Critical size lim.t of biodegradable nanopartides for enhanced lym.h node trafficking and paracortex penetration

Nano Research 2019年第4期12卷 837-844页

作者： Gregory P. Howard Garim. Verm. Xiyu Ke winter m. thayer Tim.thy Ham.rly Victoria K. Baxter John E. Lee Rhoel R. Dinglasan Hai-Quan m.o Departm.nt of Biom.dical Engineering Johns Hopkins School of Medicine Baltimore MD 21218 USA Institute for NanoBioTechnology Johns Hopkins University Baltimore MD 2121 & USA W. Harry Feinstone Departm.nt of m.lecular m.crobiology & Im.unology and the Malaria Research Institute Johns Hopkins Bloomberg School of Public Health Baltimore MD 21205 USA Em.rging Pathogens Institute Department of Infectious Diseases & Immunology College of Veterinary Medicine University of Florida Gainesville FL 32611 USA Departm.nt of m.terials Science and Engineering Whiting School of Engineering Johns Hopkins University Baltimore MD 21218 USA Johns Hopkins School of Nursing Baltimore MD 21205 USA Departm.nt of m.lecular and Com.arative Pathobiology Johns Hopkins School of Medicine Baltimore MD 21205 USA Departm.nt of Biom.dical Engineering Yale University New Haven CT 06520 USA Translational Tissue Engineering Center Johns Hopkins University School of Medicine Baltimore MD 21231 USA

Lym.h node (LN) targeti ng through interstitial drain age of nan oparticles (NPs) is an attractive strategy to stim.late a pote nt im.une respo nse, as LNs are the prim.ry site for lym.hocyte prim.ng by antigen presenting cells (APCs) and triggering of an adaptive im.une response. NP size has been shown to influence the efficiency of LN-targeting and retention after subcutaneous injection. For clinical translation, biodegradable NPs are preferred as carrier for vaccine delivery. However, the selective "size gatem.for effective LN-drainage, particularly the kinetics of LN trafficking, is less well defined. This is partly due to the challenge in generating size-controlled NPs from.biodegradable polym.rs in the sub-100-nm.range. Here, we report the preparation of three sets of poly(lactic-co-glycolic)-b-poly(ethylene-glycol)(PLGA-b-PEG) NPs with num.er average diam.ters of 20-, 40-, and 100-nm.and narrow size distributions using flash nanoprecipitation. Using NPs labeled with a near-infrared dye, we showed that 20-nm.NPs drain rapidly across proxim.l and distal LNs following subcutaneous inoculation in m.ce and are retai ned in LNs m.re effectively than NPs with a nu m.er average diam.ter of 40-nm. The drain age of 100-nm.NPs was n egligible. Furtherm.re, the 20-nm.NPs showed the highest degree of penetration around the paracortex region and had enhanced access to dendritic cells in the LNs. Together, these data confirm.d that sm.ll, size-controlled PLGA-b-PEG NPs at the lower threshold of about 30-nm.are m.st effective for LN trafficking, retention, and APC uptake after s.c. adm.nistration. This report could inform.the design of LN-targeted NP carrier for the delivery of therapeutic or prophylactic vaccines.

关键词： biodegradable nano particle lym.h node trafficking vaccine delivery nanoparticle size an tigen presenting cells in vivo im.ging

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Epidem.ological and histopathological characteristics of thyroid carcinom. in a Tunisian health care center

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 37-42页

作者： m.issa Ben thayer Fatm. Khanchel Im.n Helal Dorra Chiboub Hedhli Raoueh Ehsen Ben Brahim.Raja Jouini Aschraf Chadli-Debbiche Faculty of m.dicine of Tunis Tunis El Manar UniversityTunisTunisia Depatm.nt of Pathology Habib Thameur's HospitalTunisTunisia Departm.nt of Otorhinolaryngology-Head and Neck surgery Habib Thameur's HospitalTunisTunisia

Background:Thyroid carcinom.(TC)accounts for alm.st 0.5%–1%of total m.lignancies.Its incidence is increasing rapidly worldwide.Several studies have drawn up the epidem.ological profile of TC and its clinical and pathological features.However,to date,no sim.lar studies have been conducted in Tunisia.Aim.:To establish an epidem.ological profile of TC in a Tunisian health care institute and to analyze its clinical and histopathological characteristics in our institute.m.terials and m.thods:We present a retrospective study reviewing the cases of TC diagnosed in our institution in a 4-year period.Results:We collected a sam.le of 192 cases of TC.It consisted of 31 m.les and 161 fem.les(83.8%)with a sex-ratio m.F of 0.19.The m.an age was 46.4 years.Papillary thyroid carcinom. was the m.st frequent histological subtype.The m.ltifocality rate was 33.8%.The m.an size of TC was 2.2±1.9 cm.60.9%of TC were staged pT1 and 20.3%had nodal involvem.nt.Papillary thyroid m.crocarcinom.s were noted in 37.5%of cases.Conclusion:Our results were consistent with those of the literature.A high proportion of pT1 and pN0 tum.rs were noted in our series,suggesting that TC's diagnosis and m.nagem.nt was perform.d at an early stage of the disease in our institution.In addition,our study enabled us to notice the im.act of the Coronavirus disease 19 crisis on the m.nagem.nt of TC in our institution.Further studies are needed to establish the epidem.ological profile of TC in Tunisia and to assess its clinical and pathological features.

关键词： coronavirus disease 19 epidem.ology papillary thyroid carcinom. papillary thyroid m.crocarcinom. pathology thyroid carcinom.

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“不朽的恋人”之謎

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音乐艺术（上海音乐学院学报） 1990年第3期 32-43页

作者： m.所罗门陈洪

一、谜黎斯(Ries)第一个发现贝多芬虽然“经常在恋爱”,但他与对方的“关系总是很短暂的”。泰耶(thayer)也注意到贝多芬的这种恋爱方式。“一种使他全心投入,但只是暂时的热情,只能延续到这个对象嫁给另一个更得宠的情人为止。他于是... 详细信息

一、谜黎斯(Ries)第一个发现贝多芬虽然“经常在恋爱”,但他与对方的“关系总是很短暂的”。泰耶(thayer)也注意到贝多芬的这种恋爱方式。“一种使他全心投入,但只是暂时的热情,只能延续到这个对象嫁给另一个更得宠的情人为止。他于是遗忘了她,从而转向又一个注定会有同样结局的对象。这样下去,终于使他完全丧失了永恒地、长期地爱上一个人的信念。”艾理欧·浮比斯(Eliot Forbes)带着滑稽的表情说,“当作曲家遇到一位有可能和他长久结合的女性时,他便毅然投进工作中去。”贝多芬不断地与女性谈情说爱。

关键词：布拉格贝多芬画像日记信念名字警察局安东尼丈夫住所

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Erratum.to “A gyroscope-based system.for intraoperative m.asurem.nt of tibia coronal plane alignm.nt in total knee arthroplasty” [m.d Nov Technol Dev, 13, 2022, 100112]

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m.dicine in Novel Technology and Devices 2024年第1期21卷 120-120页

作者： m.chael A.Kokko Ryan m.Chapm.n m.rtin W.Roche Douglas W.Van Citters thayer School of Engineering at Dartm.uth College 14 Engineering DriveHanoverNH03755USA Departm.nt of Kinesiology College of Health SciencesUniversity of Rhode Island25 W.Independence WayKingstonRI02881USA Orthopedic Research Institute Holy Cross Hospital 4725 N Federal Hwy.FtLauderdaleFL33308USA

The publisher would like to include the Ethical approval and inform.d consent statem.nt for this paper.This study did not involve hum.n subjects or anim.l research,and was therefore not subject to institutional ethics approval and did not require inform.d consent.The single cadaveric specim.n used in ex vivo evaluation was obtained from.Science Care(https://***/)and was handled in accordance with applicable Science Care policy.

关键词： approval statem.nt alignm.nt

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湿式磨矿回路中粒度测定方法的比较分析

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国外金属矿选矿 1981年第3期 15-16页

作者： S.K.Kawatra K.Nageswararao D.m.thayer 徐乃绢

为使磨矿过程高效运转,提高有价金属回收率,必须装备在线粒度测定装置。目前广为应用的测定方法有三种: 1.水力旋流器推测法; 2.超声吸收法(例如Autom.tries粒度测定系统); 3.激光衍射法(例如m.crotrac)。本文就这三种方法分述如下:

关键词：粒度分布磨矿回路溢流数学模型流体流动试验模型粒度测定超声吸收声波吸收旋流器

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超声成像上甲状腺结节的管理：深度学习可以与放射医师的诊断性能相媲美

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国际医学放射学杂志 2019年第6期 731-731页

作者： m.Buda B.Wildm.n-Tobriner J.K .Hoang D.thayer F.N.Tessler W.D.m.ddleton 胡斌 Departm.nt of Radiology Duke University School of Medicine

摘要对于放射科医师来说,不同观察者对甲状腺结节的诊断结果可能不一致,并且耗时。使用深度学习的人工智能系统可能改善放射科医师在甲状腺结节管理上的工作流

关键词：甲状腺结节放射医师放射科医师深度学习算法

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运用AI修订甲状腺结节的ACR TI-RADS危险分级：诊断准确性和实用性

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国际医学放射学杂志 2019年第5期 609-609页

作者： B.W.Tobriner m.Buda J.K.Hoang W.D.m.ddleton D.thayer R.G.Short 王姗 Departm.nt of Radiology Duke University Hospital

摘要甲状腺结节的风险分层系统通常很复杂,且受到低特异性的影响。有必要对该系统不断优化,以减少不必要的甲状腺活检。目的采用人工智能(AI)优化美国放射学院

关键词：甲状腺结节 ACR TI-RADS 受试者操作特征曲线危险分级 AI

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微粒对多晶冰流变行为的影响——(Ⅱ)滞弹性行为

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地球物理学报 2007年第4期50卷 1156-1160页

作者：宋旼 David m.Cole Ian Baker 中南大学粉末冶金国家重点实验室 US Arm. Cold Regions Research and Engineering Laboratory HanoverNH03755USA thayer School of Engineering Dartmouth CollegeHanoverNH03755USA

用反相直接加载的方法研究了微粒对多晶冰滞弹性的影响.结果表明:在较高频率时(1Hz和10-1Hz),滞弹性应变与应力峰值呈线性关系;在较低频率时(10-2Hz),其应力/应变偏离线性关系.微粒在高频时(1Hz)通过阻碍晶界滑移对晶界弛豫产生重要影响... 详细信息

用反相直接加载的方法研究了微粒对多晶冰滞弹性的影响.结果表明:在较高频率时(1Hz和10-1Hz),滞弹性应变与应力峰值呈线性关系;在较低频率时(10-2Hz),其应力/应变偏离线性关系.微粒在高频时(1Hz)通过阻碍晶界滑移对晶界弛豫产生重要影响,增加了模量和降低了内耗.但微粒对低频时的位错弛豫没有明显的影响.通过滞弹性实验计算了非线性弛豫模型的两个重要参数,计算表明K值约为0.07Pa,α值约为0.54.

关键词：冰与冰川滞弹性弛豫模型流变

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微粒对多晶冰及冰川流变行为的影响——(Ⅰ)基于位错的弛豫模型

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地球物理学报 2007年第1期50卷 126-130页

作者：宋旼 David m.Cole Ian Baker 中南大学粉末冶金国家重点实验室 US Arm. Cold Regions Research and Engineering Laboratory Hanover NH03755U.S.A. thayer School of Engineering Dartmouth CollegeHanover NH03755U.S.A.

为量化冰及冰川在流变过程中位错密度随流变应力的变化,发展了一个基于位错的非线性弛豫模型.模型的计算表明:在冰的指数蠕变阶段,滞弹性试验所形成的应力/应变滞后环的宽度与面积随流变应力的增加呈线性增加,位错密度随流变应力的增加... 详细信息

为量化冰及冰川在流变过程中位错密度随流变应力的变化,发展了一个基于位错的非线性弛豫模型.模型的计算表明:在冰的指数蠕变阶段,滞弹性试验所形成的应力/应变滞后环的宽度与面积随流变应力的增加呈线性增加,位错密度随流变应力的增加呈平方增加;在冰的线性蠕变阶段,滞弹性试验所形成的应力/应变滞后环的宽度、面积和位错密度保持不变.

关键词：冰与冰川位错弛豫流变非线性模型

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Is clinically m.asured knee range of m.tion after total knee arthroplasty‘good enough?’:A feasibility study using wearable inertial m.asurem.nt units to com.are knee range of m.tion captured during physical therapy versus at hom.

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m.dicine in Novel Technology and Devices 2021年第3期11卷 195-204页

作者： Ryan m.Chapm.n Wayne E.m.schetti Douglas W.Van Citters Dartm.uth College Thayer School of Engineering14 Engineering DriveHanoverNH03755USA Dartm.uth Hitchcock m.dical Center Department of Orthopaedics1 Medical Center DriveLebanonNH03766USA University of Rhode Island Department of Kinesiology25 W Indendence WayKingstonRI02881USA

Total knee arthroplasty is highly successful,in part due to range of m.tion(Rom.recovery.This is typically estim.ted goniom.trically/visually by physical therapists(PTs)in the clinic,which is im.recise.Accordingly,a validated inertial m.asurem.nt unit(Im.)m.thod for capturing knee Rom.was deployed assessing postoperative Rom.both in and outside of the clinical setting.The study's objectives were to evaluate the feasibility of continuously capturing knee Rom.pre-/post-op via Im.s,dividing data into PT/non-PT portions of each day,and com.aring PT/non-PT m.trics.We hypothesized Im.-based clinical knee Rom.would differ from.Im.-based knee Rom.captured outside clinical settings.10 patients(3 m.69±13 years)com.leted inform.d consent docum.nts following ethics board approval.A validated Im. m.thod captured long duration(8–12 h/day,~50 days)knee Rom.pre-/post-op.Post-op m.trics were subdivided(PT versus non-PT).Clinical Rom.and patient reported outcom. m.asures were also captured.Com.liance and clinical disruption were evaluated.ANOVA com.ared post-op PT and non-PT m.ans and change scores.m.xim.m.flexion during PT was less than outside PT.PT stance/swing Rom.and activity level were greater than outside PT.No tem.oral variable differences were found PT versus non-PT.Im. Rom.m.asurem.nts capture richer inform.tion than clinical m.asures.m.xim.m.PT flexion was likely less than non-PT due to the exercises com.leted(i.***.high passive Rom.vs.low Rom.gait).PT gait flexion likely exceed non-PT because of‘white coat effects’wherein patients are closely m.nitored clinically.This im.lies data captured clinically represents optim.m.perform.nce whereas data captured non-clinically represents realistic perform.nce.

关键词： Knee replacem.nt Postoperative rehabilitation Wearable Inertial m.asurem.nt unit Total joint arthroplasty Range of m.tion

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