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Fine-sca.e a.a.ysis revea.s a.potentia. influence of forest ma.a.ement on the spa.ia. genetic structure of Erema.thus erythropa.pus

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Journa. of Forestry Resea.ch 2021年第4期32卷 1567-1578页

作者： Luca. Ferna.des Rocha.Na.ália.Ribeiro de Pa.la.Dulcinéia.De Ca.va.ho Depa.tment of Forest Science Federal University of Lavras(UFLA)Av.Doutor Sylvio Menicucci1001 Aquental SolLavrasMinas Gerais State 37200-000Brazil Depa.tment of Forest Science College of Agricultural Sciences(FCA/UNESP)São Paulo State UniversityAv.Universitária3780Altos do ParaísoBotucatuSão Paulo State 18610-034Brazil

Forest ma.a.ement ma. ha.e significa.t effects on forest connectivity a.d na.ura. popula.ion *** old-growth single trees ma. a.so cha.ge na.ura. pa.terns of genetic va.ia.ion a.d spa.ia. genetic *** study eva.ua.ed the impa.ts of forest ma.a.ement using a.silvicultura. system of seed trees on the genetic diversity a.d spa.ia. genetic structure of Erema.thus erythropa.pus(DC.)Ma.Leish.a.complete survey of 275 trees on four plots wa. underta.en out to compa.e the genetic va.ia.ion of a.ma.a.ed sta.d with a. unma.a.ed *** genotyped a.l a.ult a.d juvenile individua.s 60 months a.ter the ma.a.ement a.d compa.ed the genetic diversity a.d the spa.ia. genetic structure *** diversity wa. considered high beca.se of a. efficient gene flow between *** were no genetic differences between sta.ds a.d no evidence of *** clustering identified a.single popula.ion(K=1),indica.ing no genetic differentia.ion between ma.a.ed a.d unma.a.ed *** a.d juvenile individua.s of the unma.a.ed sta.d were more geogra.hica.ly structured tha. individua.s from the ma.a.ed *** wa. a.tendency of coa.cestry a.ong juveniles a. the first cla.s of dista.ce of the ma.a.ed sta.d,suggesting a.drift of genetic structure possibly ca.sed by *** ea.ly responses to ma.a.ement on genetic diversity a.d sta.d structure is a.first step to ensuring the effectiveness of conserva.ion pra.tices of tree *** susta.na.ility of forest ma.a.ement of *** on genetic diversity,a.d more a.cura.ely,on spa.ia. genetic structure needs eva.ua.ion over time to promote effective conserva.ion of the popula.ion size a.d genetic va.ia.ility.

关键词： Genetic diversity Microsa.ellite ma.kers Gene flow Silvicultura. ma.a.ement Bra.ilia. Cerra.o

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Ta.geting hepa.ic cerulopla.min mitiga.es nona.coholic stea.ohepa.itis by modula.ing bile a.id meta.olism

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Journa. of Molecula. Cell Biology 2023年第9期15卷 53-68页

作者： Qua.xin Jia.g Ning Wa.g Sĳia.Lu Jie Xiong Ya.mei Yua. Junli Liu Suzhen Chen Sha.gha. Dia.etes Institute Department of Endocrinology and MetabolismShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

Nona.coholic stea.ohepa.itis(Na.H)is a.condition tha. progresses from nona.coholic fa.ty liver disea.e(Na.LD)a.d is cha.a.terized by hepa.ic fa. a.cumula.ion,infla.ma.ion,a.d *** ha. the potentia. to develop into cirrhosis a.d liver ca.cer,a.d currently no effective pha.ma.ologica. trea.ment is *** this study,we investiga.e the thera.eutic potentia. of ta.geting cerulopla.min(Cp),a.copper-conta.ning protein predomina.tly secreted by hepa.ocytes,for trea.ing *** result show tha. hepa.ic Cp is rema.kedly upregula.ed in individua.s with Na.H a.d the mouse Na.H ***-specific Cp a.la.ion effectively a.tenua.es the onset of dieta.y-induced Na.H by decrea.ing lipid a.cumula.ion,curbing infla.ma.ion,mitiga.ing fibrosis,a.d a.eliora.ing liver *** employing tra.scriptomics a.d meta.olomics a.proa.hes,we ha.e discovered tha. hepa.ic deletion of Cp brings a.out rema.ka.le restora.ion of bile a.id(Ba.meta.olism during *** deletion of Cp effectively remodels Ba.meta.olism by upregula.ing Cyp7a. a.d Cyp8b1,which subsequently lea.s to enha.ced Ba.synthesis a.d nota.le a.tera.ions in Ba.*** conclusion,our studies elucida.e the crucia. involvement of Cp in Na.H,highlighting its significa.ce a. a.promising thera.eutic ta.get for the trea.ment of this disea.e.

关键词： cerulopla.min nona.coholic stea.ohepa.itis bile a.id infla.ma.ion fibrosis

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Ground motion prediction equa.ions ba.ed on sha.low crusta. ea.thqua.es in Georgia.a.d the surrounding Ca.ca.us

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Ea.thqua.e Science 2022年第6期35卷 497-509页

作者： Jorjia.hvili Na.o Shengelia.ia.Godola.ze Tea.Gunia.Ira.li a.uba.dia.Dimitri Institute of Ea.th Sciences a.d Na.iona. Seismic Monitoring Center Ilia State UniversityTbilisi 0177Georgia

Strong ground motions ca.sed by ea.thqua.es with ma.nitudes ra.ging from 3.5 to 6.9 a.d hypocentra. dista.ces of up to 300km were recorded by loca. broa.ba.d sta.ions a.d three-component a.celerogra.s within Georgia.s enha.ced digita. seismic *** da.a.mixing is pa.ticula.ly effective in a.ea. where strong ground motion da.a.a.e *** da.a.were used to produce models ba.ed on ground-motion prediction equa.ions(GMPEs),one benefit of which is tha. they ta.e into considera.ion informa.ion from wa.eforms a.ross a.wide ra.ge of *** this study,models were developed to predict ground motions for pea. ground a.celera.ion a.d 5%-da.ped pseudo-a.solute-a.celera.ion spectra.for periods between 0.01 a.d 10 ***-period ground motions deca.ed fa.ter tha. long-period motions,though deca. wa. still in the order of a.proxima.ely 1/*** mecha.isms a.d loca. soil conditions grea.ly influence *** spectra. a.celera.ion(Sa.of thrust fa.lts wa. higher tha. tha. for either strike-slip or norma. fa.lts but the influence of strike-slip fa.lting on Sa.wa. slightly grea.er tha. tha. for norma. *** soils a.so ca.sed significa.tly more a.plifica.ion tha. rocky sites.

关键词： strong ground motion pea. ground a.celera.ion spectra. a.celera.ion sha.low ea.thqua.e

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Ta. Reforms for Better Ta. a.ministra.ion:Georgia. Experience

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Belt a.d Roa. Initia.ive Ta. Journa. 2021年第1期2卷 41-46页

作者： Ia.Mikhelidze Interna.iona. Rela.ions Depa.tment Georgia.Revenue Service

This a.ticle sets out to sha.e the experience of the ma.or ta. reforms in Georgia.which is eventua.ly recognized worldwide by reputa.le interna.iona. orga.iza.ions,including the Interna.iona. Moneta.y Fund,the World Ba.k a.d *** a.ticle highlights,in pa.ticula.,three fa.tors tha. we believe were a.d rema.n key to Georgia.s *** fa.tors a.e:*** ta. policy;*** a.ministra.ion process;a.d *** communica.ion with ta.pa.ers.

关键词： Single-window concept e-filing e-invoice a.toma.ic Va. refund system Ta.a. a.sessment Doing Business

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Digita. Tra.sforma.ion of Georgia.Revenue Service

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Belt a.d Roa. Initia.ive Ta. Journa. 2020年第2期1卷 18-23页

作者： Ia.Mikhelidze Interna.iona. Rela.ions Depa.tment Georgia.Revenue Service

The a.ticle reviews the most inspiring steps a.d a.tions Georgia.Revenue Service(RS)took in the pa.t *** structura.,mora. a.d fina.ly digita. tra.sforma.ion,RS ma.e grea. efforts to build up a.ta.pa.er-friendly environment a.d a. a.result,wa. ra.ked the 14th a.ong 190 countries/regions a.ound the globe by"Ea.e of Doing Business"for the"Pa.ing Ta.es"*** RS is conducting to strengthen level a.d qua.ity of tra.spa.ency,find solutions to the cha.lenges driven by digita.iza.ion,*** is hoped tha. exa.ples described in this a.ticle will serve a. a.good exa.ple for those who yet ha.e to fa.e tra.sforma.ion process.

关键词： Ta.pa.er-friendly Digita.iza.ion E-services Blockcha.n

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COVID-19 in Bra.il:Epidemiologica. upda.e a.d perspectives

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a.ia. Pa.ific Journa. of Tropica. Medicine 2020年第5期13卷 193-196页

作者： Ma.li C Cupertino Gra.iela.a.Cupertino a.dréia.P Gomes Nichola. a. Ma.ers R Siqueira.Ba.ista Medica. School Faculdade Dinamica do Vale do PirangaPonte NovaMinas GeraisBrazil La.ora.ory of Epidemiologica. a.d Computa.iona. Methods in Hea.th Department of Medicine and NursingUniversidade Federal de VicosaVicosaMinas GeraisBrazil Depa.tment of Veterina.y Medicine Universidade Federal de VicosaVicosaMinas GeraisBrazil

Corona.iruses a.e RNa.viruses (Fa.ily: Corona.irida.) constituents of a.significa.t number of viruses tha. provoke disea.es in a.ima.s a.d huma. beings. There a.e four genera.of these microorga.isms: a.pha.orona.irus, Beta.orona.irus, Delta.orona.irus a.d Ga.ma.orona.irus. From this group, the a.pha. a.d beta.corona.iruses a.e designa.ed a. huma. corona.irus (HCoV) for their propensity to infect huma. beings[1].

关键词： disea.es Corona Bra.il

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Georgia.s Response to COVID-19

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Belt a.d Roa. Initia.ive Ta. Journa. 2020年第1期1卷 23-25页

作者： Ia.Mikhelidze Interna.iona. Rela.ions Depa.tment Georgia.Revenue Service

a. the va.t ma.ority of coun-tries a.ound the globe could not a.oid the sprea. of COVID-19,G eorgia.tha.ks to the government’s quick rea.tion to the potentia. pa.demic threa. decla.ed by the WHO,could keep the ra.e of infection rela.ively low,compa.ed with its neighbours in the region a.d ma.y other countries in *** a.ticle introduces the countermea.ures ta.en by Georgia.from the following a.pects.

关键词： Georgia.s Response COVID-19 following a.pects

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Eva.ua.ion of a.ti-infla.ma.ory potentia. of lea. extra.ts of Skimmia.a.quetilia

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a.ia. Pa.ific Journa. of Tropica. Biomedicine 2012年第8期2卷 627-630页

作者： Vijender Kuma. Zulfiqa. a.i Bha. Dinesh Kuma. Na.Kha. Ia.Cha.hoo Depa.tment of Pha.ma.eutica. Sciences University of Kashmir

Objective:To eva.ua.e a.ti-infla.ma.ory potentia. of lea. extra.t of Skimmia.a.quetilia.by invitro a.d in-vivo a.ti-infla.ma.ory ***:a.ute toxicity study wa. ca.ried out to determine the toxicity level of different extra.t using a.ute toxic cla.s method a. described in Orga.iza.ion of Economic Co-opera.ion a.d Development Guidelines ***(1% w/w) wa. a.ministered a.d infla.ma.ion wa. induced in ra. *** lea. extra.ts of Skimmia.a.quetilia.were eva.ua.ed for a.ti-infla.ma.ory a.tivity by in-vitro huma. red blood cell(HRBC) membra.e sta.iliza.ion method a.d in-vivo ca.ra.geena.-induced ra. pa. edema.method. Results:The in-vitro membra.e sta.ilizing test showed petroleum ether(PE),chloroform(CE), ethyl a.eta.e(EE),metha.ol(ME) a.d a.ueous extra.ts(a.) showed 49.44%,59.39%,60.15%,68.40% a.d 52.18%protection,respectively a. compa.ed to control *** in-vivo results of CE,EE a.d ME showed 58.20%.60.17%a.d 67.53%inhibition of infla.ma.ion a.ter 6h a.ministra.ion of test drugs in a.bino *** potency of the lea. extra.ts of Skimmia.a.quetilia.were compa.ed with sta.da.d diclofena.(10 mg/kg) which showed 74.18%protection in in-vitro HRBC membra.e sta.iliza.ion test a.d 71.64%inhibition in in-vivo ca.ra.geena.-induced ra. pa. edema.model. The ME showed a.dose dependent significa.t(Pa.ti-infla.ma.ory a.tivity in huma. red blood cell membra.e sta.iliza.ion test a.d reduction of edema.in ca.ra.eena. induced ra. pa. ***:The present investiga.ion ha. confirmed the a.ti-infla.ma.ory a.tivity of Skimmia.a.quetilia.due to presence of bioa.tive phytoconstitutes for the first lime a.d provide the pha.ma.ologica. evidence in fa.or of tra.itiona. cla.m of Skimmia.a.quetilia.a. a. a.tiinfla.ma.ory a.ent.

关键词： Skimmia a.quetilia a.ti-infla.ma.ory Ca.ra.eena. Diclofena. Lea. extra.t Phytochemica. a.a.ysis

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COVID-19 impa.t on the liver

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World Journa. of Clinica. Ca.es 2021年第16期9卷 3814-3825页

作者： Lilia.a.Ba.oiu Ca.erina.Dumitru a.ina.ia.cu a.a.Cristina.Leșe Miruna.Drăgănescu Nicușor Ba.oiu Lucreția.a.ghel Clinica. Medica. Depa.tment Faculty of Medicine and Pharmacy“Dunarea de Jos”University of GalatiGalati 800008Romania Pha.ma.eutica. Sciences Depa.tment Faculty of Medicine and Pharmacy“Dunarea de Jos”University of GalatiGalati 800008Romania Depa.tment of Morphologica. a.d Functiona. Sciences Faculty of Medicine and Pharmacy“Dunarea de Jos”University of GalatiGalati 800008Romania Design Depa.tment Faculty of Visual Arts and Design“George Enescu”National University of ArtsIasi 700451Romania Depa.tment of Ma.ufa.turing Engineering Faculty of Engineering“Dunarea de Jos”University of GalatiGalati 800008Romania

The corona.irus disea.e 2019(COVID-19)pa.demic imposed a.estructuring of globa. hea.th systems by rethinking spa.es used for the ca.e of these pa.ients a.d the a.ditions of intensive ca.e,infectious disea.es a.d pneumology *** pa.er provides evidence on the presence of severe a.ute respira.ory syndrome corona.irus 2 in hepa.ocytes a.d its direct cytopa.hic a.tivity,a. well a. the degree of liver da.a.e due to drug toxicity,infla.ma.ion a.d hypoxia.in COVID-19.a.review of clinica. tria.s ha. qua.tified liver da.a.e through both pa.hology a.d biochemistry ***,we briefly present the results of a.study conducted in our clinic on 849 pa.ients a.mitted for COVID-19 trea.ment,of which 31 pa.ients ha. pre-existing chronic liver disea.e a.d 388 pa.ients ha. va.ues a.ove the norma. limit for a.a.ine a.inotra.sfera.e,a.pa.ta.e a.inotra.sfera.e,a.d tota. *** wa. observed tha. pa.ients with a.norma. liver tests were significa.tly sta.istica.ly older,ha. more comorbidities a.d ha. a.higher percenta.e of unfa.oura.le evolution(dea.h or tra.sfer to intensive ca.e).The conclusion of this pa.er is tha. the ma.n ca.ses of liver da.a.e a.e direct vira. a.gression,coa.ula.ion dysfunction a.d endothelia. da.a.e,a.d pa.ients with impa.red liver function develop more severe forms of COVID-19 which requires specia. ca.e by a.multidisciplina.y tea. tha. includes a.hepa.ologist.

关键词： COVID-19 Liver injury Cytopa.hic effect Hyper-infla.ma.ory rea.tion Drug toxicity Biochemica. cha.ges

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受火灾温度影响的隧道的结构分析

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隧道译丛 1993年第8期 50-56页

作者： EL-a.,Ia.王华

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