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Effect of methoxychlor on antioxidant system of goat epididymal sperm in vitro

Asian Journal of Andrology 2001年第4期3卷 285-288页

作者： Bindu Gangadharan m.Arul murugan P.P.mathur school of Life sciences Pondicherry University Pondicherry 605 014 IndiaSchool of Life Sciences Pondicherry University Pondicherry 605 014 IndiaSchool of Life Sciences Pondicherry University Pondicherry 605 014 India

Aim: To evaluate the effect of methoxychlor on the antioxidant system of goat epididymal sperm. methods:Epididymis of adult goat was obtained from local slaughter houses and sperm were collected by chopping the epididymisin modified Ringer's phosphate solution (RPs). After several washings, the sperm samples were dispersed in RPs andincubated with methoxychlor (1μmol/L, 10μmol/L and 100μmol/L) and methoxychlor + vitamin C (100μmol/Leach) for 3 h at 32℃. After incubation, the sperm motility and viability were assessed. An aliquot of sperm samplewas homogenized, centrifuged and used for the assay of superoxide dismutase, glutathione peroxidase, glutathione re-ductase and lipid peroxidation. Results; in methoxychlor-incubated sperm and in sperm co-incubated with methoxy-chlor and vitamin C, the sperm motility and viability showed no significant changes as compared to the correspondingcontrols. in methoxychlor-incubated sperm the activity of superoxide dismutase, glutathione reductase and glutathioneperoxidase were decreased while lipid peroxidation was increased in a dose-dependent manner. Co-incubation of spermwith methoxychlor and vitamin C showed no changes in the activity of superoxide dismutase, glutathione reductase andglutathione peroxidase and in the level of lipid peroxidation. Conclusion; methoxychlor induced oxidative stress inepididymal sperm of goats by decreasing the levels of antioxidant enzymes. Co-incubation of sperm with methoxychlorand vitamin C, a natural antioxidant, reversed the effect of methoxychlor. (Asian J Androl 2001 Dec; 3; 285 - 288)

关键词： methoxychlor vitamin C epididymis spermatozoa antioxidants reactive oxygen species goats

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Association of farnesyl diphosphate synthase polymorphisms and response to alendronate treatment in Chinese postmenopausal women with osteoporosis

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Chinese medical Journal 2014年第4期127卷 662-668页

作者： Liu Y Li m Zhou PR Xing XP Xia WB Xu L Liu h J Zhang ZL LiaoEY Chen DC Liu J Tao TZ Wu W Department of Endocrinology Key Laboratory of EndocrinologyMinistry of HealthPeking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China Department of Endocrinology People&#39 s hospital of Liaocheng Liaocheng Shandong 252002 China metabolic Bone Disease and Genetics Research Unit Department of Osteoporosis and Bone Diseases Shanghai Sixth People&#39 s hospital Affiliated with shanghai Jiao Tong University Shanghai 200233 China Osteoporosis and Bone Diseases Shanghai Sixth People's HospitalAffiliated with Shanghai Jiao Tong University Shanghai 200233China institute of Endocrinology and metabolism Second Xiangya Hospitalof Central South University Changsha Hunan 410011 China Department of Endocrinology Osteoporosis Education Center WestChina Hospital Sichuan University Chengdu Sichuan 610041China Department of Orthopedics Xijing Hospital Fourth Liberation ArmyUniversity Xi'an Shannxi 710032 China Department of Orthopedics Harbin Medical University AffiliatedSecond Hospital Harbin Heilongjiang 150081 China Department of Endocrinology Guangdong General HospitalGuangzhou Guangdong 510080 China

Background Genetic factors are important in the pathogenesis of osteoporosis,but less is known about the genetic determinants of osteoporosis *** aimed to explore the association between the gene polymorphisms of key enzyme farnesyl diphosphate synthase （FDPs） in mevalonate signaling pathway of osteoclast and response to alendronate therapy in osteoporotic postmenopausal women in *** The study group comprised 639 postmenopausal women aged （62.2＆#177;7.0） years with osteoporosis or osteopenia who had been randomly assigned to low dose group （70 mg/2w） or standard dose group （70 mg/w） of alendronate in this 1-year *** identified allelic variant of the FDPs gene using the polymerase chain reaction and restriction enzyme *** and after treatment,serum levels of calcium,phosphate,alkaline phosphatase （ALP）,cross linked C-telopeptide of type Ⅰ collagen （β-CTX） were *** mineral density （BmD） at lumbar spine and proximal femur was *** association was analyzed between the polymorphisms of FDPs gene and the changes of BmD,bone turnover biomarkers after the *** The FDPs rs2297480 polymorphisms were associated with baseline BmD at femoral neck,and patients with CC genotype had significantly higher baseline femoral neck BmD （（733.6＆#177;84.1） mg/cm2） than those with AC genotypes （（703.0＆#177;86.9） mg/cm2） and AA genotypes （（649.8＆#177;62.4） mg/cm2）（P 〈0.01）.No significant difference in BmD at lumbar spine was observed among different genotypes of *** percentage change of serum ALP level was significantly lower in patients with CC genotype （-22.9%） than that in those with AC genotype （-24.1%） and AA genotype （-29.8%） of FDPs after 12 months of alendronate treatment （P 〈0.05）.Neither percentage change of BmD nor β-CTX level after alendronate treatment had association with FDPs *** FDPs gene was probably a candidate gene to predict femoral neck BmD at *** gene alleles could predict chan

关键词： farnesyl diphosphate synthase polymorphism alendronate osteoporosis pharmacogenomics

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Expeditious method for the synthesis of novel 2,3,5,6-tetrahydrobenzo[g] [1,3,5]oxadiazocine-4-thiones linked with isoxazole

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Chinese Chemical Letters 2008年第12期19卷 1415-1418页

作者： E.Rajanarendar A.siva Rami Reddy m.srinivas Department of Chemistry Kakatiya UniversityWarangal 506009India

synthesis of novel 3-aryl-5-（3,5-dimethylisoxazol-4-yl）-2,3,5,6-tetrahydrobenzo[g][1,3,5],oxadiazocine-4-thiones 5 has been accomplished from 3,5-dimethylisoxazol-4-amine 1 by condensation with salicylaldehydes, followed by reduction, treatment with aryl isothiocyanates and subsequent smooth ring closure via acetal formation in the presence of formaldehyde.

关键词： isoxazolyl-2,3,5,6-tetrahydrobenzo[g]oxadiazocine-4-thiones Ring closure New methodology

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CT检查前5h静脉内给予皮质醇激素预处理与传统13h口服方案的比较

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国际医学放射学杂志 2018年第1期 91-91页

作者： B.m.mervak R.h.Cohan J.h.Ellis s.Khalatbari m.s.Davenport 张俊峰 Departments of Radiology and Urology University of Michigan Health System 1500 E Medical Center Dr

摘要目的明确增强CT检查前5 h静脉内给予皮质醇激素预处理的过敏样反应发生率是否不低于传统13 h口服给药方案。材料与方法本回顾性非劣性研究已获得机构伦

关键词：静脉内预处理皮质醇激素 CT

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Therapeutic aspects of c-mYC signaling in inflammatory and cancerous colonic diseases

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World Journal of Gastroenterology 2016年第35期22卷 7938-7950页

作者： Ferenc sipos Gábor Firneisz Györgyi mũzes 2nd Department of internal medicine Semmelweis UniversityH-1088 Budapest Hungary

Colonic inflammation is required to heal infections, wounds, and maintain tissue homeostasis. As the seventh hallmark of cancer, however, it may affect all phases of tumor development, including tumor initiation, promotion, invasion and metastatic dissemination, and also evasion immune surveillance. inflammation acts as a cellular stressor and may trigger DNA damage or genetic instability, and, further, chronic inflammation can provoke genetic mutations and epigenetic mechanisms that promote malignant cell transformation. Both sporadical and colitis-associated colorectal carcinogenesis are multi-step, complex processes arising from the uncontrolled proliferation and spreading of malignantly transformed cell clones with the obvious ability to evade the host's protective immunity. in cells upon DNA damage several protooncogenes, including c-mYC are activated in parelell with the inactivation of tumor suppressor genes. The target genes of the c-mYC protein participate in different cellular functions, including cell cycle, survival, protein synthesis, cell adhesion, and microRNA expression. The transcriptional program regulated by c-mYC is context dependent, therefore the final cellular response to elevated c-mYC levels may range from increased proliferation to augmented apoptosis. Considering physiological intestinal homeostasis, c-mYC displays a fundamental role in the regulation of cell proliferation and crypt cell number. however, c-mYC gene is frequently deregulated in inflammation, and overexpressed in both sporadic and colitis-associated colon adenocarcinomas. Recent results demonstrated that endogenous c-mYC is essential for efficient induction of p53-dependent apoptosis following DNA damage, but c-mYC function is also involved in and regulated by autophagy-related mechanisms, while its expression is affected by DNA-methylation, or histone acetylation. molecules directly targeting c-mYC, or agents acting on other genes involved in the c-mYC pathway could be sele

关键词： c-mYC Therapy Apoptosis Autophagy Colon inflammation Colorectal cancer

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Variability in the Light Absorption Coefficient by Phytoplankton,Non-Algal Particles and Colored Dissolved Organic matter in the Northern Gulf of California

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Open Journal of marine science 2018年第1期8卷 20-37页

作者： stella P.Betancur-Turizo Adriana G.González-silvera Eduardo santamaría-Del-Angel Roberto millán-Núnez Eduardo millán-Núnez héctor García-Nava Víctor m.Godínez Laura sánchez-Velasco Facultad de Ciencias marinas Universidad Autonoma de Baja CaliforniaEnsenadaMéxico Grupo de investigacion en Oceanología Facultad de Oceanografía FísicaEscuela Naval de Cadetes“Almirante Padilla”Barrio BosqueSector ManzanilloCartagena de IndiasColombia Departamento de Ecología marina CICESEEnsenadaMéxico instituto de investigaciones Oceanológicas Universidad Autónoma de Baja CaliforniaEnsenadaMéxico Departamento de Oceanografía Física CICESEEnsenadaMéxico Departamento de Plancton y Ecología marina CICIMAR-IPN.Av.Instituto Politécnico Nacional s/nLa PazMéxico

Variability of the optical properties of the northern Gulf of California (méxico) were analyzed for the first time based on six cruises performed from spring to summer (march to september) between 2008 and 2013. The changes observed in the absorption by three seawater components (phytoplankton, detritus and chromophoric dissolved organic matter or CDOm) were analyzed in relation to changes in bio-optical regions and composition of the phytoplankton community (determined based on phytoplankton pigments). Two regions with unique bio-optical characteristics were identified separated by a narrow transition zone: the Upper Gulf of California (UGC) and Northern Gulf of California (NGC). Despite the temporal changes in their spatial distribution they maintained particular characteristic. UGC is characterized by an average Chla of 1.78 mg/m3, the dominance of microphytoplankton (diatoms and dinoflagellates) and a stronger contribution of detritus to total light absorption. NGC is characterized by an average Chla of 0.7 mg/m3 and the predominance of picophytoplankton, characterized by the dominance of zeaxanthin (marker pigment for cyanobacteria) and/or chlorophyll b (marker pigment for green algae), along with a co-dominium by CDOm and phytoplankton to light absorption. Results indicate that Case ii waters can be very different when evaluating the individual contribution by phytoplankton, detritus and CDOm to total light absorption what has to be considered for the selection of bio-optical models for each specific region what can also help to a better definition of the related uncertainties.

关键词： Light Absorption Phytoplankton CDOm Detritus Ocean Color Gulf of California

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PET/CT引导经皮穿刺消融前后分次注射FDG扫描的方法:一种定位准确且能实时评价疗效的方法

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国际医学放射学杂志 2013年第5期 477-478页

作者： E.R.Ryan C.T.sofocleous h.schoder J.A.Carrasquillo s.Nehmeh s.m.Larson 彭贵娟 Department of Radiology Division of Interventional RadiologyMemorial Sloan-Kettering Cancer Center

摘要目的介绍一种PET/CT引导经皮穿刺消融术前后分次注射18F-FDG扫描的方法,能够实现肿瘤准确定位及实时疗效评价。材料与方法本研究获得机构审查委员会的批准。2011年6月—2011年12月期间的病例23例(35～87岁,平均59岁,女13例,男10例)... 详细信息

摘要目的介绍一种PET/CT引导经皮穿刺消融术前后分次注射18F-FDG扫描的方法,能够实现肿瘤准确定位及实时疗效评价。材料与方法本研究获得机构审查委员会的批准。2011年6月—2011年12月期间的病例23例(35～87岁,平均59岁,女13例,男10例),共有FDG浓聚的肿瘤灶29个(直径0.6～4.4 cm,平均1.4 cm),肝脏23个,肺4个,肾上腺1个,大腿1个。对其中17个瘤灶行射频消融,6个行微波消融,5个行电凝,1个行冷冻消融。肿瘤的病理学类型

关键词： FDG 分次 PET/CT 经皮穿刺 CT 疗效

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Effect of samarium doping on structural, optical and magnetic properties of vertically aligned ZnO nanorod arrays

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Journal of Rare Earths 2017年第10期35卷 1002-1007页

作者： D.Ranjith Kumar K.s.Ranjith L.R.Nivedita R.T.Rajendra Kumar Department of Nanoscience and Technology Bharathiar University Coimbatore India Advanced materials and Devices Laboratory (AmDL) Department of Physics Bharathiar University Coimbatore India

samarium doped vertically aligned one dimensional ZnO nanorod（NR） arrays were grown by vapor phase transport（VPT） method through vapor solid（Vs） growth process. influence of different concentrations（0% to 8%） of sm（all sm contents in the paper are in mass fraction） on the ZnO NR arrays were investigated by X-ray diffraction（XRD）, field emission scanning electron microscopy（FEsEm）, photoluminescence（PL）, Raman spectroscopy and vibrating sample magnetometry（Vsm） techniques, respectively. X-ray diffraction studies revealed that the ZnO NR arrays were perfectly oriented along（002） crystallographic orientation with wurtzite crystal structure. Photoluminescence results showed an increase in oxygen vacancies due to increase in sm doping. m-h curves revealed enhanced ferromagnetic behavior, and the magnetic moment values were 0.45, 0.363, 1.694, 3.613 and 2.197 emu/cm^3 for（0–8%） sm doped ZnO NR arrays respectively. The curve revealed that paramagnetic behavior was observed for undoped ZnO NR arrays and on increasing the sm dopant to 4%, paramagnetic switched to ferromagnetic behavior.

关键词： sm doped ZnO room temperature ferromagnetism(RTFm) defects rare earths

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氟mRi监测高强度超声射频消融后的肿瘤炎症反应

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国际医学放射学杂志 2018年第4期 470-470页

作者： s.h.shin s.h.Park s.W.Kim m.Kim D.Kim 王诗渝 molecular imaging Branch Division of Convergence TechnologyNational Cancer Center

目的研究高强度聚焦超声（hiFU）诱导的巨噬细胞浸润是否可以用;F mRi进行定量动态监测。材料与方法将皮下接种4T1细胞的BALB/c小鼠分成3组:未治疗的小鼠（对照,n=9）,hiFU处理的小鼠（hiFU,n=9）和hiFU+氯膦酸盐处理的小鼠（hiFU+Clod,... 详细信息

目的研究高强度聚焦超声（hiFU）诱导的巨噬细胞浸润是否可以用;F mRi进行定量动态监测。材料与方法将皮下接种4T1细胞的BALB/c小鼠分成3组:未治疗的小鼠（对照,n=9）,hiFU处理的小鼠（hiFU,n=9）和hiFU+氯膦酸盐处理的小鼠（hiFU+Clod,n=9）。所有小鼠静脉内给予全氟化碳乳剂,并在行hiFU治疗后的第2、4、7、10和14天进行mRi检查。采用双向重复测量方差分析来检验;F信号随时间的变化和组间的差异。组织学检查以确认活体内数据。结果在肿瘤边缘和消融病灶周围检测到19F信号。hiFU治疗后前4天,hiFU组小鼠的;F信号明显大于对照组（0.82±0.26∶0.42±0.17,PhiFU治疗后第4;4天,hiFU+Clod组小鼠平均;F信号显著高于对照组小鼠（0.55±0.16∶0.28±0.06,PmRi可以在临床前肿瘤模型中动态捕获和定量分析hiFU诱导的巨噬细胞。

关键词： mRi 巨噬细胞

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Omeprazole induces gastric transmucosal permeability to the peptide bradykinin

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World Journal of Gastroenterology 2010年第9期16卷 1097-1103页

作者： melissa Gabello mary Carmen Valenzano E Peter Zurbach James m mullin Lankenau institute for medical Research 100 Lancaster AvenueWynnewoodPA 19096United States Department of Biology Saint Joseph's University5600 City AvenuePhiladelphiaPA 19131United States Department of Chemistry Saint Joseph's University5600 City AvenuePhiladelphiaPA 19131United States Division of Gastroenterology Lankenau Hospital100 Lancaster AvenueWynnewoodPA 19096United States

Aim:To investigate omeprazole-induced transepithelial gastric leak and its effects on the permeability of the peptides bradykinin and ***:Rat gastric corpus tissue was isolated and mounted in an Ussing chamber apparatus to evaluate the permeability of 3h-bradykinin,3h-oxytocin,and 14CEDTA in the presence or absence of *** chromatography was performed to identify any metabolic breakdown products of the peptides resulting from permeation through the gastric tissue,and thereby calculate the true flux of the ***:The flux rate ofintact 3h-bradykinin increased substantially after omeprazole addition (109.5%) compared to the DmsO vehicle control (14%).No corresponding change in flux ofintact 3h-oxytocin was observed under the same conditions (11.9% and 6.4% in the DmsO-and omeprazole-treated conditions,respectively).After exposure to omeprazole,the flux rate of 14C-EDTA also increased dramatically (122.3%) compared to the DmsO condition (36.3%).CONCLUsiON:The omeprazole-induced gastric leak allows for transmucosal permeability to charged molecules as well as *** induced leak will allow certain peptides to permeate.

关键词： Proton pump inhibitor Paracellular Drug delivery Tight junction Transepithelial

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