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Long-term clinical outcomes of drug-eluting stents ***-metal stents in Chinese geriatric patients

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Journal of Geriatric Cardiology 2013年第4期10卷 330-335页

作者： Pak-Hei Chan Sha-Sha Liu Hung-Fat Tse wing-hing chow Man-Hong Jim Hee-Hwa HO Chung Wah Siu Department of Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong 102 Pokfulam Rd Hong Kong China Cardiac Medical Unit Grantham Hospital 125 Wong Chuk Hang Rd Aberdeen Hong Kong China

BACKGROUND & OBJECTIVE: Little is known about the relative efficacies of percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and bare-metal stents (BMS) in elderly patients。 The objective of this study was to evaluate the clinical outcome for geriatric patients who received either DES or BMS。 METHODS: From January 2002 to October 2005, 199 consecutive Chinese geriatric patients (≥ 75 years old) underwent PCI with coronary DES or BMS implantation at our institution。 We analyzed the major clinical end points that included all-cause mortality, cardiovascular death, myocardial infarction, target lesion revascularization (TLR), stent thrombosis, and bleeding complications。 RESULTS: The three-year cumulative rates of all-cause mortality, cardiovascular death, and myocardial infarction were significantly lower in the DES group (6.3%,3.6%,5.4%) compared with the BMS group (16.2%,11.5%,14.9%; P <0.05)。 No significant differences were found in the three-year cumulative rate for target lesion revascularization (6.3% vs4.6%, P =0.61) or stent thrombosis (3.6% vs2.3%, P =0.70)。 Likewise, there were no statistically significant differences in the cumulative rate for intracranial hemorrhage, or major and minor hemorrhage at three years。 CONCLUSIONS: DES-based PCI was associated with a significant reduction in the three-year cumulative rate of all-cause mortality, cardiovascular death, and myocardial infarction compared with BMS, without increased risk of TLR, stent thrombosis, or bleeding complications at three years in this group of Chinese geriatric patients。

关键词： Bare-metal stents Drug-eluting stents Geriatric patients Percutaneous coronary intervention

Sungai Lembing’s green tourism: Pioneering the future of resourcebased urban renewal

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The Innovation 2024年第3期5卷 19-20页

作者： Haoxuan Yu Ginura Gunaratna Izni Zahidi chow Ming Fai Department of Civil Engineering School of EngineeringMonash University MalaysiaBandar SunwaySelangor 47500Malaysia

HOW DID SUNGAI LEMBING PAVE ITS PATH TO A GREEN EVOLUTION?Sungai Lembing,a resource-based town situated in Pahang,Malaysia,has historically positioned itself as a pivotal hub in the global tin mining ***,Sungai Lembing’s history dates back to the Paleozoic and Mesozoic *** eras were marked by the closure of the Tethyan Ocean and the convergence of continental landmasses from the eastern part of the Gondwana *** complex geological background resulted in a wide variety of mineral resources.

关键词： situated eastern Pioneer

Synthesis,Structures,and Chiroptical Properties of NBN-Doped Helicenes with Boron Atoms in the Inner Rims

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Precision Chemistry 2024年第1期2卷 28-39页

作者： Weiwen Zhuang Yujian Liu Ziqi Deng Yu Guo Philip C.Y.chow David Lee Phillips Wei Jiang Zhaohui Wang Junzhi Liu State Key Laboratory of Synthetic Chemistry HKU-CAS Joint Laboratory on New Materials and Department of ChemistryThe University of Hong KongPokfulamHong KongChina Key Laboratory of Organic Optoelectronics and Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084China Department of Mechanical Engineering The University of Hong KongPokfulamHong KongChina

The precise synthesis of helicenes with topologically defined length and specific heteroatomic perturbation in the screw-like conjugated skeletons plays an emerging role in the manipulation of chiral ***,selective,and programmable routes to helicenes or heterohelicenes are highly desirable yet challenging for structure-chiroptical property relationship ***,we report the synthesis and characterization of NBN-doped helicenes with boron atoms in the inner rims,enabled by the highly regioselective one-pot borylation of rationally designed precursors with,namely,fold-in or pan-out *** incorporation of nonbonded boron and nitrogen atoms resulted in narrow-band emission and improved optical properties for the single-stranded carbon *** addition,numbers and arrangement modes of fused six-membered rings have distinct effects on configurational stability and chiroptical properties,revealing that BN-[6]H with strong circular dichroism is a promising candidate for chiral *** combination of experimental and theoretical studies on these helical structures might provide insights into the design of helically chiral small-molecule-based sensors or emitters.

关键词： Nitrogen-boron Helicenes Borylation Chiroptical properties Narrow-band emission

变废为宝:“蓝色循环”海洋塑料废物管理新策略

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Science Bulletin 2024年第8期69卷 993-996页

作者：余灏轩 Izni Zahidi chow Ming Fai 梁东方 DagØivind Madsen Department of Civil Engineering School of EngineeringMonash University MalaysiaBandar Sunway 47500Malaysia Monash Climate-Resilient Infrastructure Research Hub(M-CRInfra) School of EngineeringMonash University MalaysiaBandar Sunway 47500Malaysia Department of Engineering University of CambridgeCambridge CB21PZUK Davis School of Business Colorado Mesa UniversityGrand Junction 81501-3122USA

The"Blue Circle"vision,initiated by Zhejiang Province in China,represents a groundbreaking advancement in addressing marine plastic *** more than just an innovative concept,it embodies a future-forward approach to managing marine plastic waste,revealing the untapped potential in what was previously considered mere *** initiative,marrying scientific innovation with advanced technology,has been rightfully acknowledged with the prestigious2023 United Nations"Champions of the Earth"award,recognizing its innovative strategy in environmental stewardship(https://***/a/202310/31/***).

关键词： breaking debris initiated

Drosophila adhesion GPCR Remoulade regulates axon growth, branching, and guidance by modulating Rac1 GTPase

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Journal of Genetics and Genomics 2024年第4期51卷 458-461页

作者： Xi Yang Changkun Pan Meitong Ye Jinshuo Liang Haoyang Cheng Qing Liang Shu Huang Jianshu Wang Hoi Yee chow Haihuai He Cancer Center and State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuan 610041China National Clinical Research Center for Geriatrics and State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuan 610041China Department of Neurosurgery Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China

The assembly of neurons into complex circuits relies upon appropriate axonal navigation to distant *** considerable progress has been made toward understanding the regulation of the guidance and branching of axon extension,the molecular and cellular mechanisms underlying the coordination of the motility of the axon tip,axon growth,and branching remain largely unknown(Sudhof,2017).The Drosophila mushroom body(MB),the major site for associative learning and memory,is a powerful model system to investigate complex axon *** MB is a bilaterally symmetric central brain structure,mainly composed of Kenyon cells,MB output neurons,and dopaminergic neurons(Li et al.,2020).Among the seven neuronal subtypes of~2000 Kenyon cells,Y,a/β,and a/β'subtypes extend axons in a fascicle and bifurcate to produce two sister branches,one projecting into the dorsal lobe and the other into the medial lobe.

关键词： branching medial axon

ChatGPT智能处理器使用我们的语言吗?

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哲学分析 2024年第4期15卷 3-16,196页

作者：周柏乔香港公开大学中国香港

有人说ChatGPT智能处理器只会吐出话语,不(会)说话。尽管它的话有意思,而且可以被理解,但理解它的话真的在于挖掘它的“心思”或“心意”吗?假定与其对话的自然人都认为ChatGPT没有“心思”或“心意”,却发现对话有意思,起码有助于一般... 详细信息

有人说ChatGPT智能处理器只会吐出话语,不(会)说话。尽管它的话有意思,而且可以被理解,但理解它的话真的在于挖掘它的“心思”或“心意”吗?假定与其对话的自然人都认为ChatGPT没有“心思”或“心意”,却发现对话有意思,起码有助于一般人通过ChatGPT的话语进一步认识自己的“心思”或“心意”,这是否意味着ChatGPT是个语言使用者,和人类的语言使用者一样,可通过与人们的对话帮助自然人认识自己的想法?如果是这样,就会出现矛盾:它不(会)说话却成为语言使用者。借用蒯因的翻译理论、戴维森的诠释理论以及维特根斯坦的后期论述,可以说明自然人有哪些语言本领,AI工程当予以实现,ChatGPT智能处理器方可媲美自然人的语言使用能力。

关键词： ChatGPT 蒯因戴维森维特根斯坦

Soft,body conformable electronics for thermoregulation enabled by kirigami

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Bio-Design and Manufacturing 2024年第4期7卷 453-462页

作者： Lung chow Guangyao Zhao Pengcheng Wu Xingcan Huang Jiyu Li Jian Li Wanying Wang Guihuan Guo Zhiyuan Li Jiachen Wang Jingkun Zhou Yawen Yang Yuyu Gao Binbin Zhang Qiang Zhang Dengfeng Li Ya Huang Kuanming Yao Jian Lu Xinge Yu Department of Biomedical Engineering City University of Hong KongHong Kong 999077China Hong Kong Centre for Cerebro-Cardiovascular Health Engineering Hong Kong 999077China Department of Biomedical Sciences City University of Hong KongHong Kong 999077China Department of Mechanical Engineering City University of Hong KongHong Kong 999077China

The application of thermoelectric devices(TEDs)for personalized thermoregulation is attractive for saving energy while balancing the quality of *** that directly attach to human skin remarkably minimized the energy wasted for cooling the entire ***,facing the extreme dynamic geometry change and strain of human skin,conventional TEDs cannot align with the contour of our bodies for the best thermoregulation ***,we designed a kirigami-based wearable TED with excellent water vapor permeability,flexibility,and *** analysis and experimental results reveal that our product can withstand various types of large mechanical deformation without circuit *** stated outcome and proposed facile approach not only reinforce the development of wearable TEDs but also offer an innovative opportunity for different electronics that require high conformability.

关键词： Thermoregulation Thermoelectric Kirigami Body conformable Wearable

Prevalence and risk factors for impaired renal function among Asian patients with nonalcoholic fatty liver disease

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 241-248页

作者： Chao Sun George Boon-Bee Goh Wan-Cheng chow Wah-Kheong Chan Grace Lai-Hung Wong Wai-Kay Seto Yi-Hsiang Huang Han-Chieh Lin I-Cheng Lee Hye Won Lee Seung Up Kim Vincent Wai-Sun Wong Jian-Gao Fan Center for Fatty Liver Disease Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China Department of Gastroenterology&Hepatology Singapore General HospitalSingaporeSingapore Gastroenterology and Hepatology Unit Department of MedicineFaculty of MedicineUniversity of MalayaKuala LumpurMalaysia Department of Medicine and Therapeutics and State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina Institute of Clinical Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Division of Gastroenterology and Hepatology Taipei Veterans General HospitalTaipeiTaiwanChina Faculty of Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Department of Internal Medicine Yonsei University College of MedicineSeoulKorea

Background:Nonalcoholic fatty liver disease(NAFLD)is associated with impaired renal function,and both diseases often occur alongside other metabolic ***,the prevalence and risk factors for impaired renal function in patients with NAFLD remain *** objective of this study was to identify the prevalence and risk factors for renal impairment in NAFLD ***:All adults aged 18-70 years with ultrasound-diagnosed NAFLD and transient elastography examination from eight Asian centers were enrolled in this prospective *** fibrosis and cirrhosis were assessed by FibroScan-aspartate aminotransferase(FAST),Agile 3+and Agile 4 *** renal function and chronic kidney disease(CKD)were defined by an estimated glomerular filtration rate(eGFR)with value of<90 mL/min/1.73 m^(2) and<60 mL/min/1.73 m^(2),respectively,as estimated by the CKD-Epidemiology Collaboration(CKD-EPI)***:Among 529 included NAFLD patients,the prevalence rates of impaired renal function and CKD were 37.4%and 4.9%,*** multivariate analysis,a moderate-high risk of advanced liver fibrosis and cirrhosis according to Agile 3+and Agile 4 scores were independent risk factors for CKD(P<0.05).Furthermore,increased fasting plasma glucose(FPG)and blood pressure were significantly associated with impaired renal function after controlling for the other components of metabolic syndrome(P<0.05).Compared with patients with normoglycemia,those with prediabetes[FPG≥5.6 mmol/L or hemoglobin A1c(HbA1c)≥5.7%]were more likely to have impaired renal function(P<0.05).Conclusions:Agile 3+and Agile 4 are reliable for identifying NAFLD patients with high risk of *** glycemic control in the prediabetic stage might have a potential renoprotective role in these patients.

关键词： Nonalcoholic fatty liver disease Impaired renal function Agile 3+ Agile 4 Metabolic syndrome

Congophilic fibrils in the glomeruli with polyclonal immunoglobulin gamma staining-another cause for diagnostic overlap:A case report

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World Journal of Clinical Cases 2024年第17期12卷 3200-3205页

作者： Maria Bernadette Che-Ying chow Lucas Bushrow Irmeen Siddiqui April Chiu Mirza Hamirani Anjali A Satoskar Department of Pathology The Ohio State University Medical CenterColumbusOH 43210United States Department of Pathology North District HospitalSheung ShuiHong KongChina Department of Laboratory Medicine and Pathology Mayo ClinicRochesterMN 55905United States Department of Internal Medicine S.Joseph's HospitalParkersburgWV 26101United States

BACKGROUND Glomerulopathy with fibrillary deposits is not uncommon in routine nephropathology practice,with amyloidosis and fibrillary glomerulonephritis being the two most frequently encountered *** amyloid heavy and light chain(AHL)is relatively uncommon and its biopsy diagnosis is usually limited to cases that show strong equivalent staining for a single immunoglobulin(Ig)heavy chain and a single light chain,further supported by mass spectrometry(MS)and serum studies for monoclonal *** polyclonal light chain staining can pose a *** SUMMARY Herein we present a challenging case of renal AHL with polyclonal and polytypic Ig gamma(IgG)staining pattern by *** patient is a 62-yearold Caucasian male who presented to an outside institution with a serum creatinine of up to 8.1 mg/dL and nephrotic range *** the finding of a polyclonal and polytypic staining pattern on immunofluorescence,ultrastructural study of the renal biopsy demonstrated the presence of fibrils with a mean diameter of 10 *** red was positive while DNAJB9 was *** suggested a diagnosis of amyloid AHL type with IgG and lambda,but kappa light chains were also present supporting the immunofluorescence staining *** immunofixation studies demonstrated IgG lambda monoclonal *** patient was started on *** chronic renal injury however was quite advanced and he ended up needing dialysis shortly *** Tissue diagnosis of AHL amyloid can be *** confirmation using other available diagnostic techniques is recommended in such cases.

关键词： Heavy and light chain amyloid Fibrillary glomerulonephritis DNAJB9 Serum immunofixation Protein electrophoresis Mass spectrometry Congo red Case report